Clopidogrel_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.140809
COL6A3 collagen, type VI, alpha 3 0.107709
B2M beta-2-microglobulin 0.10291
TMSB10 thymosin beta 10 0.0992887
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0835771
MT2A metallothionein 2A 0.0774745
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0699807
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0675478
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0631729
TRA2A transformer 2 alpha homolog (Drosophila) 0.0609376
ELL2 elongation factor, RNA polymerase II, 2 0.0545743
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0533551
FNDC3B fibronectin type III domain containing 3B 0.0531872
HIP1 huntingtin interacting protein 1 0.0514842
SOD2 superoxide dismutase 2, mitochondrial 0.0509343
NAMPT nicotinamide phosphoribosyltransferase 0.0500441
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0483809
COPA coatomer protein complex, subunit alpha 0.0463954
TRIO trio Rho guanine nucleotide exchange factor 0.0462944
ZNF292 zinc finger protein 292 0.0454476
COL1A2 collagen, type I, alpha 2 0.0450716
SEC24D SEC24 family member D 0.0433744
AFF4 AF4/FMR2 family, member 4 0.0431112
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0413457
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0407163
NDRG1 N-myc downstream regulated 1 0.0405821
JARID2 jumonji, AT rich interactive domain 2 0.0405491
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0364211
UBA6 ubiquitin-like modifier activating enzyme 6 0.0363095
HILPDA hypoxia inducible lipid droplet-associated 0.0358028
COG5 component of oligomeric golgi complex 5 0.0347989
SEC23A Sec23 homolog A (S. cerevisiae) 0.0342931
RTN4 reticulon 4 0.0341963
CALR calreticulin 0.0339225
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0334888
SKIC3 SKI3 subunit of superkiller complex 0.0329876
IGFBP7 insulin-like growth factor binding protein 7 0.0322571
SEPTIN2 septin 2 0.0321143
KMT2E lysine (K)-specific methyltransferase 2E 0.0317145
ESYT2 extended synaptotagmin-like protein 2 0.0310902
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0310099
SETD5 SET domain containing 5 0.0308563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.030774
SDC4 syndecan 4 0.0306527
SEC24A SEC24 family member A 0.03059
FTL ferritin, light polypeptide 0.0304994
DSCAM Down syndrome cell adhesion molecule 0.0304893
LOXL2 lysyl oxidase-like 2 0.0304104
AKAP9 A kinase (PRKA) anchor protein 9 0.029903
SEC31A SEC31 homolog A (S. cerevisiae) 0.029705
MYH9 myosin, heavy chain 9, non-muscle 0.0295126
ADM adrenomedullin 0.0293772
OGA O-GlcNAcase 0.029285
PKM pyruvate kinase, muscle 0.0292635
RNF24 ring finger protein 24 0.029138
AKAP12 A kinase (PRKA) anchor protein 12 0.0288108
SEPTIN7 septin 7 0.0286163
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0285845
RAB1A RAB1A, member RAS oncogene family 0.0285578
HOOK2 hook microtubule-tethering protein 2 0.0284735
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0280238
RAP1B RAP1B, member of RAS oncogene family 0.0280158
LIMS1 LIM and senescent cell antigen-like domains 1 0.0277208
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0275493
GLS2 glutaminase 2 (liver, mitochondrial) 0.0273472
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0272278
COPB1 coatomer protein complex, subunit beta 1 0.027136
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0269786
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0263583
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0262277
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0261528
SBF2 SET binding factor 2 0.0259242
UBC ubiquitin C 0.0258352
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0255714
ANKHD1 ankyrin repeat and KH domain containing 1 0.0254219
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0254058
BHLHE40 basic helix-loop-helix family, member e40 0.025187
ATP13A3 ATPase type 13A3 0.0250971
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.024951
PDIA6 protein disulfide isomerase family A, member 6 0.0248557
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0248279
CD44 CD44 molecule (Indian blood group) 0.0247837
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0246284
TENT2 terminal nucleotidyltransferase 2 0.0245256
ACBD3 acyl-CoA binding domain containing 3 0.0244421
TNIP1 TNFAIP3 interacting protein 1 0.0242509
SFPQ splicing factor proline/glutamine-rich 0.0238292
GOLGA4 golgin A4 0.0237223
S100A10 S100 calcium binding protein A10 0.0232247
DLG1 discs, large homolog 1 (Drosophila) 0.0230952
SUCO SUN domain containing ossification factor 0.0229594
NKTR natural killer cell triggering receptor 0.0227946
PRRC1 proline-rich coiled-coil 1 0.022792
GLG1 golgi glycoprotein 1 0.0227111
RAB8B RAB8B, member RAS oncogene family 0.0226136
RLF rearranged L-myc fusion 0.0225439
EIF1 eukaryotic translation initiation factor 1 0.022365
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0223617
KLHDC10 kelch domain containing 10 0.0222751
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0221829

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138366
FN1 fibronectin 1 -0.0995716
IGFBP3 insulin-like growth factor binding protein 3 -0.0430973
EXT1 exostosin glycosyltransferase 1 -0.0355398
TNS3 tensin 3 -0.0315425
POTEF POTE ankyrin domain family, member F -0.0265921
NIPBL Nipped-B homolog (Drosophila) -0.0255166
FLOT1 flotillin 1 -0.0254961
PDE10A phosphodiesterase 10A -0.0249614
PSD3 pleckstrin and Sec7 domain containing 3 -0.0238698
QKI QKI, KH domain containing, RNA binding -0.0226679
EFNA5 ephrin-A5 -0.0224758
JMJD1C jumonji domain containing 1C -0.0224516
PDE4D phosphodiesterase 4D, cAMP-specific -0.0223794
EXOC4 exocyst complex component 4 -0.022189
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0221858
ZMYND8 zinc finger, MYND-type containing 8 -0.0219383
CDK6 cyclin-dependent kinase 6 -0.0216324
GSE1 Gse1 coiled-coil protein -0.0212823
HLA-A major histocompatibility complex, class I, A -0.0212485
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0210906
PTMA prothymosin, alpha -0.0209622
TRPS1 trichorhinophalangeal syndrome I -0.0207137
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0206944
AHNAK AHNAK nucleoprotein -0.0198172
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0196425
ACTG1 actin gamma 1 -0.0192962
GLIS3 GLIS family zinc finger 3 -0.0192802
SPDYA speedy/RINGO cell cycle regulator family member A -0.0192278
EPAS1 endothelial PAS domain protein 1 -0.0190887
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0189268
ZFAND3 zinc finger, AN1-type domain 3 -0.0188549
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0186968
TAS2R14 taste receptor, type 2, member 14 -0.0182544
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0181836
RPL38 ribosomal protein L38 -0.0177609
SLC38A1 solute carrier family 38, member 1 -0.0175692
MPG N-methylpurine-DNA glycosylase -0.0174729
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0174623
PURA purine-rich element binding protein A -0.0173258
TPGS2 tubulin polyglutamylase complex subunit 2 -0.017228
CBX3 chromobox homolog 3 -0.0171786
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0171496
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0170253
RPLP1 ribosomal protein, large, P1 -0.0167735
NAV2 neuron navigator 2 -0.0167472
HLA-E major histocompatibility complex, class I, E -0.0164315
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0164153
BACE2 beta-site APP-cleaving enzyme 2 -0.0163783
RBMX RNA binding motif protein, X-linked -0.0162987
PCOLCE procollagen C-endopeptidase enhancer -0.0162695
PRDX1 peroxiredoxin 1 -0.0162474
PCNX2 pecanex 2 -0.0162174
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0161839
SNW1 SNW domain containing 1 -0.0161749
EZR ezrin -0.0161714
RPS23 ribosomal protein S23 -0.0161438
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0161146
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0158538
EEF2 eukaryotic translation elongation factor 2 -0.0156934
ACTN4 actinin, alpha 4 -0.0156751
SETBP1 SET binding protein 1 -0.0156346
PCNX4 pecanex 4 -0.0156236
RPLP2 ribosomal protein, large, P2 -0.0156074
NCOR2 nuclear receptor corepressor 2 -0.0154038
ENAH enabled homolog (Drosophila) -0.0153455
RAD51B RAD51 paralog B -0.0152906
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0152848
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0151148
SOX5 SRY (sex determining region Y)-box 5 -0.0150609
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0150261
RPS11 ribosomal protein S11 -0.0147862
RPS24 ribosomal protein S24 -0.0146723
RNF213 ring finger protein 213 -0.0146705
FBXO11 F-box protein 11 -0.0146616
TM4SF1 transmembrane 4 L six family member 1 -0.0146219
FAM20C family with sequence similarity 20, member C -0.0146117
NSD3 nuclear receptor binding SET domain protein 3 -0.0145808
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0145334
PTPRK protein tyrosine phosphatase, receptor type, K -0.0144574
SSBP1 single-stranded DNA binding protein 1, mitochondrial -0.0144111
STK17A serine/threonine kinase 17a -0.0143852
FBXW11 F-box and WD repeat domain containing 11 -0.0142688
PRKCA protein kinase C, alpha -0.0142032
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0140567
MED13 mediator complex subunit 13 -0.0139962
FGF14 fibroblast growth factor 14 -0.0139506
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0139159
NUBPL nucleotide binding protein-like -0.0139145
RPL5 ribosomal protein L5 -0.0137713
RPL26 ribosomal protein L26 -0.0137566
SAMD9L sterile alpha motif domain containing 9-like -0.0137541
RNF216 ring finger protein 216 -0.0136964
YAF2 YY1 associated factor 2 -0.0136927
RPL35A ribosomal protein L35a -0.0136818
CEP104 centrosomal protein 104kDa -0.0136487
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0135724
HMGB1 high mobility group box 1 -0.0135175
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0134999
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.013435