Clopidogrel_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.144602
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.123247
LDHA lactate dehydrogenase A 0.102685
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0791162
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0685981
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0657584
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0645853
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0639419
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0617347
RPS12 ribosomal protein S12 0.0553953
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0537853
EIF1 eukaryotic translation initiation factor 1 0.0534596
SMC4 structural maintenance of chromosomes 4 0.0520989
OSMR oncostatin M receptor 0.0486847
RPL26 ribosomal protein L26 0.0452477
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0436342
RAB10 RAB10, member RAS oncogene family 0.0432697
ITCH itchy E3 ubiquitin protein ligase 0.0430205
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0424834
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0422597
AKAP10 A kinase (PRKA) anchor protein 10 0.0415702
PTMA prothymosin, alpha 0.0411787
RSRC2 arginine/serine-rich coiled-coil 2 0.0411053
MBNL1 muscleblind-like splicing regulator 1 0.0405995
DIAPH3 diaphanous-related formin 3 0.0405256
TAS2R14 taste receptor, type 2, member 14 0.0400222
RPL12 ribosomal protein L12 0.0396421
DERA deoxyribose-phosphate aldolase (putative) 0.039583
WAC WW domain containing adaptor with coiled-coil 0.039165
NFE2L2 nuclear factor, erythroid 2-like 2 0.0390538
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0389195
RTN4 reticulon 4 0.038611
CALU calumenin 0.0385919
NUP58 nucleoporin 58 0.0385842
DSCAM Down syndrome cell adhesion molecule 0.0385604
COPB1 coatomer protein complex, subunit beta 1 0.0379756
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.03791
DEK DEK proto-oncogene 0.0374751
SMAD3 SMAD family member 3 0.0356998
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0354081
RPLP2 ribosomal protein, large, P2 0.0353941
GOLGA4 golgin A4 0.0352128
MARCHF6 membrane associated ring-CH-type finger 6 0.0350791
TPX2 TPX2, microtubule-associated 0.0349345
SGO2 shugoshin 2 0.0349306
RPLP1 ribosomal protein, large, P1 0.0347766
CTNND1 catenin (cadherin-associated protein), delta 1 0.0342866
SMYD3 SET and MYND domain containing 3 0.0341307
NAP1L1 nucleosome assembly protein 1-like 1 0.0338398
SOD2 superoxide dismutase 2, mitochondrial 0.03369
OLA1 Obg-like ATPase 1 0.0335752
KIAA1328 KIAA1328 0.0333744
TNRC6B trinucleotide repeat containing 6B 0.03296
OGA O-GlcNAcase 0.0329364
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0329321
CENPE centromere protein E, 312kDa 0.032896
SEPTIN7 septin 7 0.0323432
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0323396
PTGES2 prostaglandin E synthase 2 0.0321542
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0317759
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0315873
CANX calnexin 0.031549
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0315103
DLG1 discs, large homolog 1 (Drosophila) 0.0311331
AHCTF1 AT hook containing transcription factor 1 0.0310786
SRSF11 serine/arginine-rich splicing factor 11 0.0310586
RPS13 ribosomal protein S13 0.030976
YBX3 Y box binding protein 3 0.0308747
NCEH1 neutral cholesterol ester hydrolase 1 0.0306814
NAP1L4 nucleosome assembly protein 1-like 4 0.0306733
FMNL2 formin-like 2 0.0303476
JMJD1C jumonji domain containing 1C 0.0302641
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0302428
C6ORF62 chromosome 6 open reading frame 62 0.0301241
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.030057
CEP295 centrosomal protein 295kDa 0.0300327
CCDC88A coiled-coil domain containing 88A 0.0299111
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0296188
SEPTIN2 septin 2 0.0295295
RPL37A ribosomal protein L37a 0.0293944
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0293696
RACK1 receptor for activated C kinase 1 0.0292728
ANLN anillin, actin binding protein 0.0291403
RPL32 ribosomal protein L32 0.0290407
SENP5 SUMO1/sentrin specific peptidase 5 0.028796
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0287174
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0286344
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.028615
MYH9 myosin, heavy chain 9, non-muscle 0.0280512
ZCCHC7 zinc finger, CCHC domain containing 7 0.0277446
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0277357
CKAP2 cytoskeleton associated protein 2 0.0276129
BZW1 basic leucine zipper and W2 domains 1 0.0273757
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0273414
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0268974
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0268074
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0264617
APOLD1 apolipoprotein L domain containing 1 0.0264543
TRA2A transformer 2 alpha homolog (Drosophila) 0.0263891
SLF1 SMC5-SMC6 complex localization factor 1 0.0263017

decreased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0716078
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0582242
IGF2 insulin-like growth factor 2 -0.0504698
DST dystonin -0.0483516
FTH1 ferritin, heavy polypeptide 1 -0.0463638
TMSB10 thymosin beta 10 -0.043826
PRKCA protein kinase C, alpha -0.0421043
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0408889
CD44 CD44 molecule (Indian blood group) -0.0402264
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0358189
PCED1B PC-esterase domain containing 1B -0.0357309
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0348895
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0339869
TRIO trio Rho guanine nucleotide exchange factor -0.0334517
PRR16 proline rich 16 -0.0320061
RIGI RNA sensor RIG-I -0.0313654
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0309533
ZBTB20 zinc finger and BTB domain containing 20 -0.0301621
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0295225
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0292916
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.029183
WARS1 tryptophanyl-tRNA synthetase 1 -0.0290956
ANGPTL4 angiopoietin-like 4 -0.0286937
AHNAK AHNAK nucleoprotein -0.0270641
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0270055
NDRG1 N-myc downstream regulated 1 -0.0262294
IER3 immediate early response 3 -0.0260522
VEGFA vascular endothelial growth factor A -0.0260422
PKM pyruvate kinase, muscle -0.0257848
FMN1 formin 1 -0.025738
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0256636
PRSS23 protease, serine, 23 -0.024622
ITGB4 integrin, beta 4 -0.0244018
SDCCAG8 serologically defined colon cancer antigen 8 -0.0243946
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.024169
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0240427
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0236281
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0234862
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0233174
DENND5B DENN/MADD domain containing 5B -0.0231065
RAI14 retinoic acid induced 14 -0.0230965
HMGA2 high mobility group AT-hook 2 -0.0230629
MYO10 myosin X -0.0225998
FAM3C family with sequence similarity 3, member C -0.0225319
PTPRK protein tyrosine phosphatase, receptor type, K -0.0224463
BICD1 bicaudal D homolog 1 (Drosophila) -0.0223511
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0219346
CAMK4 calcium/calmodulin-dependent protein kinase IV -0.0215561
EGR1 early growth response 1 -0.0215216
LRRC49 leucine rich repeat containing 49 -0.0212492
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0210829
NALCN sodium leak channel, non selective -0.0209754
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0207695
ANKRD11 ankyrin repeat domain 11 -0.0202743
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.020082
TRAK1 trafficking protein, kinesin binding 1 -0.0199666
DOCK9 dedicator of cytokinesis 9 -0.0198526
SLC38A2 solute carrier family 38, member 2 -0.0198468
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0198153
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0197988
COL5A1 collagen, type V, alpha 1 -0.0197957
ACTG1 actin gamma 1 -0.0197462
CLEC2D C-type lectin domain family 2, member D -0.0196416
INTS6 integrator complex subunit 6 -0.0194685
LAMA5 laminin, alpha 5 -0.0193675
CYTH1 cytohesin 1 -0.0190088
MAP1B microtubule-associated protein 1B -0.0188998
DSE dermatan sulfate epimerase -0.018822
HLA-C major histocompatibility complex, class I, C -0.018723
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0186528
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0184433
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0183831
RNF213 ring finger protein 213 -0.0182761
CEMIP2 cell migration inducing hyaluronidase 2 -0.0182193
ZMYND8 zinc finger, MYND-type containing 8 -0.0181638
ZNF438 zinc finger protein 438 -0.0180943
SDK1 sidekick cell adhesion molecule 1 -0.0179905
PLEC plectin -0.0176178
PLAUR plasminogen activator, urokinase receptor -0.0175162
NBAS neuroblastoma amplified sequence -0.0174474
LAMB1 laminin, beta 1 -0.0173929
TNS3 tensin 3 -0.0171878
SPDL1 spindle apparatus coiled-coil protein 1 -0.0171613
EP400 E1A binding protein p400 -0.0171091
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.01691
DPYD dihydropyrimidine dehydrogenase -0.0166924
PODXL podocalyxin-like -0.0166501
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0165723
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0165321
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0164224
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0163022
SVIL supervillin -0.0162427
LATS2 large tumor suppressor kinase 2 -0.016229
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.016227
LOXL2 lysyl oxidase-like 2 -0.0161478
IL6ST interleukin 6 signal transducer -0.0159676
EXT1 exostosin glycosyltransferase 1 -0.0157371
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0157176
OPTN optineurin -0.0156818
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0156751