Clopidogrel_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0990213
SOD2 superoxide dismutase 2, mitochondrial 0.0909166
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0732852
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0677047
SOS1 son of sevenless homolog 1 (Drosophila) 0.0567388
PRRC2C proline-rich coiled-coil 2C 0.0499924
B2M beta-2-microglobulin 0.0498472
CXCL8 chemokine (C-X-C motif) ligand 8 0.0478601
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0477749
NAMPT nicotinamide phosphoribosyltransferase 0.0472449
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0460756
MT2A metallothionein 2A 0.0448011
STC2 stanniocalcin 2 0.0414647
FNDC3B fibronectin type III domain containing 3B 0.0375449
MYH9 myosin, heavy chain 9, non-muscle 0.0373637
TPR translocated promoter region, nuclear basket protein 0.0370405
CD109 CD109 molecule 0.0369796
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0368388
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0367259
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0337366
VEGFA vascular endothelial growth factor A 0.033631
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0334962
SEC23A Sec23 homolog A (S. cerevisiae) 0.031887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0309876
TTC3 tetratricopeptide repeat domain 3 0.0308654
TXNIP thioredoxin interacting protein 0.0306416
KMT2E lysine (K)-specific methyltransferase 2E 0.0301481
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0292174
XPO1 exportin 1 0.0288328
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0287473
SUCO SUN domain containing ossification factor 0.0283333
AFDN afadin, adherens junction formation factor 0.0277384
KTN1 kinectin 1 (kinesin receptor) 0.0276736
UGCG UDP-glucose ceramide glucosyltransferase 0.0268135
UBC ubiquitin C 0.0266365
JARID2 jumonji, AT rich interactive domain 2 0.0264276
SMOX spermine oxidase 0.0262035
NDRG1 N-myc downstream regulated 1 0.0261506
RICTOR RPTOR independent companion of MTOR, complex 2 0.0250081
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0249435
ADAM17 ADAM metallopeptidase domain 17 0.024397
AKAP9 A kinase (PRKA) anchor protein 9 0.0239461
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0239342
CENPF centromere protein F, 350/400kDa 0.0233858
DOCK5 dedicator of cytokinesis 5 0.0233179
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0231124
ESYT2 extended synaptotagmin-like protein 2 0.023078
AKAP12 A kinase (PRKA) anchor protein 12 0.0228707
BIRC6 baculoviral IAP repeat containing 6 0.0228557
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0227834
TMF1 TATA element modulatory factor 1 0.0226065
HIPK2 homeodomain interacting protein kinase 2 0.0225883
CREBRF CREB3 regulatory factor 0.0223991
PICALM phosphatidylinositol binding clathrin assembly protein 0.0222044
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0220503
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0215652
TMEM165 transmembrane protein 165 0.0215257
COPA coatomer protein complex, subunit alpha 0.021291
DSCAM Down syndrome cell adhesion molecule 0.0211831
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0211633
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0209313
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0203989
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0203711
KDM6A lysine (K)-specific demethylase 6A 0.0202232
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0200982
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0199782
FAT1 FAT atypical cadherin 1 0.0199074
WAC WW domain containing adaptor with coiled-coil 0.0196555
SRRM2 serine/arginine repetitive matrix 2 0.0196063
RNF145 ring finger protein 145 0.0195803
RPS18 ribosomal protein S18 0.0192778
SPAG9 sperm associated antigen 9 0.019213
NEK7 NIMA-related kinase 7 0.0191164
ARRDC3 arrestin domain containing 3 0.0188535
GOLGA4 golgin A4 0.0188241
ZSWIM6 zinc finger, SWIM-type containing 6 0.0186845
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0186632
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0186343
RAB8B RAB8B, member RAS oncogene family 0.0185657
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0185516
ETNK1 ethanolamine kinase 1 0.0184
EXT1 exostosin glycosyltransferase 1 0.0183325
RO60 Ro60, Y RNA binding protein 0.0183242
NRIP1 nuclear receptor interacting protein 1 0.0182554
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0181349
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0180697
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0179599
HDGF hepatoma-derived growth factor 0.017899
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0178853
MBNL1 muscleblind-like splicing regulator 1 0.0178568
JMJD1C jumonji domain containing 1C 0.0178511
PCBP3 poly(rC) binding protein 3 0.017826
ZNF148 zinc finger protein 148 0.0177948
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0177525
SBF2 SET binding factor 2 0.0176212
SSBP2 single-stranded DNA binding protein 2 0.0176172
CUL3 cullin 3 0.0175904
GPC6 glypican 6 0.0175376
TRIO trio Rho guanine nucleotide exchange factor 0.0174999
AKAP13 A kinase (PRKA) anchor protein 13 0.0174955

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.203711
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.118505
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0776609
NRG1 neuregulin 1 -0.0715642
TMSB10 thymosin beta 10 -0.0664966
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0605064
SQSTM1 sequestosome 1 -0.0577677
GLIS3 GLIS family zinc finger 3 -0.0558849
ASPH aspartate beta-hydroxylase -0.0498585
FTH1 ferritin, heavy polypeptide 1 -0.0493318
ITGA1 integrin, alpha 1 -0.0489379
SYT1 synaptotagmin I -0.0461398
HLA-B major histocompatibility complex, class I, B -0.0428264
IFI27 interferon, alpha-inducible protein 27 -0.0423276
RPL35A ribosomal protein L35a -0.040486
HMGA2 high mobility group AT-hook 2 -0.039812
TPT1 tumor protein, translationally-controlled 1 -0.0345024
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0330402
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0328076
ACTN4 actinin, alpha 4 -0.0324104
ARF1 ADP-ribosylation factor 1 -0.029914
PTMA prothymosin, alpha -0.0292132
RPLP1 ribosomal protein, large, P1 -0.029148
IFI16 interferon, gamma-inducible protein 16 -0.0286191
RPS24 ribosomal protein S24 -0.0273597
RIGI RNA sensor RIG-I -0.0256481
NRP1 neuropilin 1 -0.0255549
GNAS GNAS complex locus -0.0255462
RPL23 ribosomal protein L23 -0.025319
S100A6 S100 calcium binding protein A6 -0.0246731
RPS20 ribosomal protein S20 -0.0246703
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0244518
ETV1 ets variant 1 -0.0243194
LOC112694756 uncharaterized LOC112694756 -0.0241814
RPS21 ribosomal protein S21 -0.0237222
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0233102
RACK1 receptor for activated C kinase 1 -0.0229456
IER3 immediate early response 3 -0.022525
ENO1 enolase 1, (alpha) -0.0223263
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0215174
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0211419
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0208853
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0208528
TGFA transforming growth factor, alpha -0.0203658
RRBP1 ribosome binding protein 1 -0.0194962
RPL31 ribosomal protein L31 -0.0193653
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0188202
FOXP1 forkhead box P1 -0.0184767
RPL37 ribosomal protein L37 -0.0181766
RPL37A ribosomal protein L37a -0.0176929
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0176278
RPL12 ribosomal protein L12 -0.0175074
RPL26 ribosomal protein L26 -0.0172806
RPS8 ribosomal protein S8 -0.0172341
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0172329
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0170228
RPL36 ribosomal protein L36 -0.0168067
MAP1B microtubule-associated protein 1B -0.0167016
HILPDA hypoxia inducible lipid droplet-associated -0.0164723
HMGB1 high mobility group box 1 -0.0164284
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0162466
TENT5A terminal nucleotidyltransferase 5A -0.0161528
RPL34 ribosomal protein L34 -0.0156986
RNF213 ring finger protein 213 -0.0155652
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0155392
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0154052
LRMDA leucine rich melanocyte differentiation associated -0.0153142
RPS28 ribosomal protein S28 -0.0150416
KPNB1 karyopherin (importin) beta 1 -0.0150199
RPS29 ribosomal protein S29 -0.0149987
RPL28 ribosomal protein L28 -0.0149986
FTL ferritin, light polypeptide -0.014826
ACTG1 actin gamma 1 -0.0148074
NCOA7 nuclear receptor coactivator 7 -0.0147748
GANAB glucosidase, alpha; neutral AB -0.0143778
SDCBP syndecan binding protein (syntenin) -0.0142673
NPR2 natriuretic peptide receptor 2 -0.0140819
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.014008
S100A9 S100 calcium binding protein A9 -0.0137319
GLIPR1 GLI pathogenesis-related 1 -0.0136414
LY6E lymphocyte antigen 6 complex, locus E -0.0135835
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0135084
KLHL5 kelch-like family member 5 -0.0134976
DNAH5 dynein, axonemal, heavy chain 5 -0.013346
IFITM3 interferon induced transmembrane protein 3 -0.0133202
RPL38 ribosomal protein L38 -0.0132862
RPS19 ribosomal protein S19 -0.0132842
ZBTB20 zinc finger and BTB domain containing 20 -0.0132375
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0131391
TRPS1 trichorhinophalangeal syndrome I -0.0128698
FAM20C family with sequence similarity 20, member C -0.0128096
IFI44L interferon-induced protein 44-like -0.012753
BSG basigin (Ok blood group) -0.0126404
TPI1 triosephosphate isomerase 1 -0.0126313
VEGFC vascular endothelial growth factor C -0.0125862
RPS27 ribosomal protein S27 -0.0125651
EGR1 early growth response 1 -0.0124983
TGFBI transforming growth factor, beta-induced, 68kDa -0.0124804
VCAN versican -0.0122356
MARCHF6 membrane associated ring-CH-type finger 6 -0.0121772