Clotrimazole_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.255383
AREG amphiregulin 0.145718
FTL ferritin, light polypeptide 0.11939
TMSB10 thymosin beta 10 0.106525
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.106314
TENM3 teneurin transmembrane protein 3 0.0961703
RPS19 ribosomal protein S19 0.0793054
PDE4D phosphodiesterase 4D, cAMP-specific 0.0767021
CNRIP1 cannabinoid receptor interacting protein 1 0.0765446
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0672898
RPS6 ribosomal protein S6 0.0621726
ZSWIM6 zinc finger, SWIM-type containing 6 0.0606713
ANKRD12 ankyrin repeat domain 12 0.0603459
PFN1 profilin 1 0.0556742
RTN4 reticulon 4 0.0540226
WWOX WW domain containing oxidoreductase 0.0503688
RPL35A ribosomal protein L35a 0.0490581
CCSER1 coiled-coil serine-rich protein 1 0.0482395
PDGFC platelet derived growth factor C 0.0470659
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0433582
RPS21 ribosomal protein S21 0.0415901
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0375397
PRR16 proline rich 16 0.0374906
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0370769
ERBIN erbb2 interacting protein 0.0366378
CCNL1 cyclin L1 0.0364407
RPL9 ribosomal protein L9 0.0361691
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0355383
RPS23 ribosomal protein S23 0.0353832
SMC4 structural maintenance of chromosomes 4 0.0353226
CCDC88A coiled-coil domain containing 88A 0.0340071
RPL37A ribosomal protein L37a 0.0328309
RPL36 ribosomal protein L36 0.0325729
RPLP1 ribosomal protein, large, P1 0.031936
YBX3 Y box binding protein 3 0.0311737
SPRED2 sprouty-related, EVH1 domain containing 2 0.0311569
NEGR1 neuronal growth regulator 1 0.030241
EPHA6 EPH receptor A6 0.0301849
NEBL nebulette 0.0297443
ZNF292 zinc finger protein 292 0.0295455
MARCHF4 membrane associated ring-CH-type finger 4 0.0290005
RPL28 ribosomal protein L28 0.028724
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0286549
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0280026
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0278888
KTN1 kinectin 1 (kinesin receptor) 0.0276718
PCM1 pericentriolar material 1 0.0275782
RPL12 ribosomal protein L12 0.0273706
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0273113
NCEH1 neutral cholesterol ester hydrolase 1 0.0270324
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0267379
ATP5F1E ATP synthase F1 subunit epsilon 0.0266471
EFNA5 ephrin-A5 0.0266224
RPS14 ribosomal protein S14 0.0258944
DST dystonin 0.0257333
TSC22D2 TSC22 domain family, member 2 0.0254419
RUNX1 runt-related transcription factor 1 0.0250933
RPS26 ribosomal protein S26 0.0250856
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.02497
B2M beta-2-microglobulin 0.0246993
DIAPH3 diaphanous-related formin 3 0.0245248
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0241427
LRP6 low density lipoprotein receptor-related protein 6 0.024062
APLP2 amyloid beta (A4) precursor-like protein 2 0.02394
FNIP1 folliculin interacting protein 1 0.0238946
OXR1 oxidation resistance 1 0.0236974
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0236921
SOS1 son of sevenless homolog 1 (Drosophila) 0.0236369
TJP1 tight junction protein 1 0.0235995
ATAD2 ATPase family, AAA domain containing 2 0.0233801
CSMD1 CUB and Sushi multiple domains 1 0.0233451
SDK1 sidekick cell adhesion molecule 1 0.0232844
MAP1B microtubule-associated protein 1B 0.0231092
AKAP9 A kinase (PRKA) anchor protein 9 0.0230332
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.023015
EXOC6B exocyst complex component 6B 0.0227077
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0226738
RSF1 remodeling and spacing factor 1 0.0226265
MBNL1 muscleblind-like splicing regulator 1 0.0225671
RPL27 ribosomal protein L27 0.0224502
ATP5F1B ATP synthase F1 subunit beta 0.0224215
TTC3 tetratricopeptide repeat domain 3 0.0223732
RPL21 ribosomal protein L21 0.0223045
EDN1 endothelin 1 0.0222102
TRA2A transformer 2 alpha homolog (Drosophila) 0.0221931
RPS27 ribosomal protein S27 0.0221759
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0219348
RPLP2 ribosomal protein, large, P2 0.0218949
EIF5B eukaryotic translation initiation factor 5B 0.0218742
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0218665
EXOC4 exocyst complex component 4 0.021805
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0215388
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0212678
ANKRD28 ankyrin repeat domain 28 0.0211129
RIMS2 regulating synaptic membrane exocytosis 2 0.0209193
RB1CC1 RB1-inducible coiled-coil 1 0.0208207
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0206076
RPS4X ribosomal protein S4, X-linked 0.0205145
UBXN4 UBX domain protein 4 0.0204933
CCN2 cellular communication network factor 2 0.0204875

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.226388
AHNAK AHNAK nucleoprotein -0.108286
ASPH aspartate beta-hydroxylase -0.0961173
PTMA prothymosin, alpha -0.0931293
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0928856
UBC ubiquitin C -0.0893328
RPS27A ribosomal protein S27a -0.0876702
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0857464
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0747007
MMP12 matrix metallopeptidase 12 -0.0744068
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0733382
EHBP1 EH domain binding protein 1 -0.0712369
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0705163
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0703783
NAP1L1 nucleosome assembly protein 1-like 1 -0.064261
MACF1 microtubule-actin crosslinking factor 1 -0.0628309
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0606921
ACTG1 actin gamma 1 -0.0589152
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0562201
ANXA1 annexin A1 -0.0541803
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0522702
CALR calreticulin -0.0522551
EEF2 eukaryotic translation elongation factor 2 -0.0512568
CANX calnexin -0.051108
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0494518
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0490205
XPOT exportin, tRNA -0.0475361
TMEM41B transmembrane protein 41B -0.0468846
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0452595
BIRC3 baculoviral IAP repeat containing 3 -0.0440945
TM4SF1 transmembrane 4 L six family member 1 -0.0428753
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0418823
HMGA2 high mobility group AT-hook 2 -0.0417741
KPNB1 karyopherin (importin) beta 1 -0.0414157
KDM3A lysine (K)-specific demethylase 3A -0.0408763
CLDN1 claudin 1 -0.0407863
S100A6 S100 calcium binding protein A6 -0.040095
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0391192
JMJD1C jumonji domain containing 1C -0.0388875
ENO1 enolase 1, (alpha) -0.0385564
SLC38A1 solute carrier family 38, member 1 -0.0378409
AKAP12 A kinase (PRKA) anchor protein 12 -0.0359342
SPDYA speedy/RINGO cell cycle regulator family member A -0.0359145
MGAT4C MGAT4 family, member C -0.0343435
RAD21 RAD21 homolog (S. pombe) -0.0335909
LOC112694756 uncharaterized LOC112694756 -0.0324566
SERBP1 SERPINE1 mRNA binding protein 1 -0.0318456
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.031717
ZNF217 zinc finger protein 217 -0.0317082
HSPA8 heat shock 70kDa protein 8 -0.0310259
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.030834
TPM4 tropomyosin 4 -0.0304859
HSPA4 heat shock 70kDa protein 4 -0.0304305
SPATS2 spermatogenesis associated, serine-rich 2 -0.0303042
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0293638
ZNF804A zinc finger protein 804A -0.0291573
FGFR1 fibroblast growth factor receptor 1 -0.029097
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0284397
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0282005
CXADR coxsackie virus and adenovirus receptor -0.0278253
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0272036
SQSTM1 sequestosome 1 -0.027102
PDIA3 protein disulfide isomerase family A, member 3 -0.0270659
BLTP2 bridge-like lipid transfer protein family member 2 -0.0270221
RPL4 ribosomal protein L4 -0.0269732
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.026956
BCHE butyrylcholinesterase -0.026387
RASAL2 RAS protein activator like 2 -0.025962
PDIA4 protein disulfide isomerase family A, member 4 -0.0259055
TMEM123 transmembrane protein 123 -0.0258482
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0256799
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0254081
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0249992
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0248968
NHSL1 NHS-like 1 -0.02487
MARS1 methionyl-tRNA synthetase 1 -0.0247855
RSL1D1 ribosomal L1 domain containing 1 -0.0247662
ARB2A ARB2 cotranscriptional regulator A -0.024374
TPM3 tropomyosin 3 -0.0242345
PREPL prolyl endopeptidase-like -0.0241895
RAB1A RAB1A, member RAS oncogene family -0.0240549
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0239713
NAV3 neuron navigator 3 -0.0237832
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0237269
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0233249
NARS1 asparaginyl-tRNA synthetase 1 -0.0233193
SET SET nuclear proto-oncogene -0.0232786
HDGF hepatoma-derived growth factor -0.0230044
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0226817
SLC38A2 solute carrier family 38, member 2 -0.0226258
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0226024
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0224151
AARS1 alanyl-tRNA synthetase 1 -0.0220728
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0220581
PCBP2 poly(rC) binding protein 2 -0.0217812
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0217161
TPT1 tumor protein, translationally-controlled 1 -0.0217151
CHD4 chromodomain helicase DNA binding protein 4 -0.0216318
LDHA lactate dehydrogenase A -0.0215884
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0214294