Clotrimazole_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 0.117518
DPH6 diphthamine biosynthesis 6 0.0840506
CEMIP cell migration inducing protein, hyaluronan binding 0.0787755
EXT1 exostosin glycosyltransferase 1 0.0762991
VCL vinculin 0.0699035
PLAT plasminogen activator, tissue 0.0634507
LIMCH1 LIM and calponin homology domains 1 0.0612744
TPR translocated promoter region, nuclear basket protein 0.0586231
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0579259
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0560108
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0555406
PRRC2C proline-rich coiled-coil 2C 0.0554376
MYO6 myosin VI 0.0549588
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0525155
BBX bobby sox homolog (Drosophila) 0.0509839
ASPH aspartate beta-hydroxylase 0.0503299
ATXN1 ataxin 1 0.0489614
THSD4 thrombospondin, type I, domain containing 4 0.0481639
USP34 ubiquitin specific peptidase 34 0.0461859
PCBP2 poly(rC) binding protein 2 0.046076
CENPF centromere protein F, 350/400kDa 0.0444135
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0443735
B2M beta-2-microglobulin 0.0442749
SKIL SKI-like proto-oncogene 0.0439869
AKAP13 A kinase (PRKA) anchor protein 13 0.0417816
MEF2A myocyte enhancer factor 2A 0.0417384
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0412969
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0412455
SENP6 SUMO1/sentrin specific peptidase 6 0.0411504
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0407467
PTK2 protein tyrosine kinase 2 0.0401969
TLE4 transducin-like enhancer of split 4 0.040038
DLG1 discs, large homolog 1 (Drosophila) 0.0395228
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0392918
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0391172
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0389106
RTN4 reticulon 4 0.0388809
TIMP3 TIMP metallopeptidase inhibitor 3 0.0387571
ANKRD17 ankyrin repeat domain 17 0.0372827
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0372716
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.036719
TAS2R14 taste receptor, type 2, member 14 0.0363306
TOP1 topoisomerase (DNA) I 0.036124
DSCAM Down syndrome cell adhesion molecule 0.0359994
CARD16 caspase recruitment domain family, member 16 0.0359709
CDK19 cyclin-dependent kinase 19 0.0356303
MBNL1 muscleblind-like splicing regulator 1 0.0353471
TCF12 transcription factor 12 0.0346796
TRIO trio Rho guanine nucleotide exchange factor 0.0346465
SRRM2 serine/arginine repetitive matrix 2 0.0346398
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0345928
NRG1 neuregulin 1 0.0345658
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0345315
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0344087
ANO6 anoctamin 6 0.0343793
PDE4D phosphodiesterase 4D, cAMP-specific 0.0343588
ZSWIM6 zinc finger, SWIM-type containing 6 0.0338405
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0335941
EZR ezrin 0.033218
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.032976
FMN1 formin 1 0.032894
MACF1 microtubule-actin crosslinking factor 1 0.0328389
DTNA dystrobrevin, alpha 0.0328227
BRD2 bromodomain containing 2 0.0327004
FHIT fragile histidine triad 0.0323177
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0322239
ARB2A ARB2 cotranscriptional regulator A 0.0318545
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0313615
RAD51B RAD51 paralog B 0.0312209
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0311925
FLT1 fms-related tyrosine kinase 1 0.0311292
PTEN phosphatase and tensin homolog 0.0310883
EFNA5 ephrin-A5 0.0308773
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0308077
CBX3 chromobox homolog 3 0.0307923
TNRC6A trinucleotide repeat containing 6A 0.0304911
PGK1 phosphoglycerate kinase 1 0.0303421
RBM6 RNA binding motif protein 6 0.0302303
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0301772
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0300829
AUTS2 autism susceptibility candidate 2 0.0298668
RCOR1 REST corepressor 1 0.0298528
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0296182
NAP1L1 nucleosome assembly protein 1-like 1 0.0295928
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0294853
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0294387
PDLIM5 PDZ and LIM domain 5 0.0292814
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0292033
PTPRM protein tyrosine phosphatase, receptor type, M 0.029148
COPA coatomer protein complex, subunit alpha 0.0289301
SRPK2 SRSF protein kinase 2 0.0289119
SH3PXD2A SH3 and PX domains 2A 0.0286002
PICALM phosphatidylinositol binding clathrin assembly protein 0.0285734
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0284615
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0284581
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0282314
GOLGA4 golgin A4 0.027539
VMP1 vacuole membrane protein 1 0.0273851
FLNB filamin B, beta 0.0273652
UBE2H ubiquitin-conjugating enzyme E2H 0.0270143

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.385768
COL3A1 collagen, type III, alpha 1 -0.106067
TRIB2 tribbles pseudokinase 2 -0.073095
COL1A1 collagen, type I, alpha 1 -0.0714631
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0649427
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.058627
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0560514
DNAH14 dynein, axonemal, heavy chain 14 -0.0547274
SYT1 synaptotagmin I -0.0532399
NCAM2 neural cell adhesion molecule 2 -0.0467627
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0446767
ARF1 ADP-ribosylation factor 1 -0.0442298
VGF VGF nerve growth factor inducible -0.0405076
AHNAK AHNAK nucleoprotein -0.0388416
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0368237
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0362082
FNBP1 formin binding protein 1 -0.0359882
LSAMP limbic system-associated membrane protein -0.0357078
SOD2 superoxide dismutase 2, mitochondrial -0.0340022
RGS4 regulator of G-protein signaling 4 -0.033397
PTPRD protein tyrosine phosphatase, receptor type, D -0.0331894
NREP neuronal regeneration related protein -0.0330497
NPEPPS aminopeptidase puromycin sensitive -0.0328806
HSPA8 heat shock 70kDa protein 8 -0.0328088
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0327073
CCDC47 coiled-coil domain containing 47 -0.0323446
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0319035
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.031803
FREM1 FRAS1 related extracellular matrix 1 -0.03079
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0305031
CLINT1 clathrin interactor 1 -0.030199
THOC2 THO complex 2 -0.0301987
KLHL13 kelch-like family member 13 -0.0295509
CANX calnexin -0.0294122
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0293815
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.02891
PSD3 pleckstrin and Sec7 domain containing 3 -0.028803
COL4A5 collagen, type IV, alpha 5 -0.0286093
FRMD4A FERM domain containing 4A -0.0283375
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.028286
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0280508
WDR45B WD repeat domain 45B -0.0279838
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0279097
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0278857
COL4A6 collagen, type IV, alpha 6 -0.0276603
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.0274926
CALD1 caldesmon 1 -0.0270346
CORIN corin, serine peptidase -0.0268126
RPL26 ribosomal protein L26 -0.0267079
PRPF3 pre-mRNA processing factor 3 -0.0266802
MAPK10 mitogen-activated protein kinase 10 -0.0265262
KDM3A lysine (K)-specific demethylase 3A -0.0265032
H1-0 H1.0 linker histone -0.0260146
FAM107B family with sequence similarity 107, member B -0.0260043
PTPRS protein tyrosine phosphatase, receptor type, S -0.0256239
ZNF124 zinc finger protein 124 -0.0255816
MARCHF6 membrane associated ring-CH-type finger 6 -0.0254837
HAND2 heart and neural crest derivatives expressed 2 -0.0251604
TMEM123 transmembrane protein 123 -0.0250896
PIBF1 progesterone immunomodulatory binding factor 1 -0.0250158
ACTG1 actin gamma 1 -0.0248748
OGA O-GlcNAcase -0.0247435
ATRNL1 attractin-like 1 -0.0246381
NCOR1 nuclear receptor corepressor 1 -0.0246124
KIF26B kinesin family member 26B -0.0245576
TMEM263 transmembrane protein 263 -0.0245525
SOS1 son of sevenless homolog 1 (Drosophila) -0.0245106
TBC1D16 TBC1 domain family, member 16 -0.0242452
UBE2O ubiquitin-conjugating enzyme E2O -0.0242234
PRPF8 pre-mRNA processing factor 8 -0.0239299
IRS1 insulin receptor substrate 1 -0.0234832
CSMD3 CUB and Sushi multiple domains 3 -0.0233613
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0232556
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0231953
FKBP10 FK506 binding protein 10, 65 kDa -0.0230988
RCOR3 REST corepressor 3 -0.0230263
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0229462
GRK5 G protein-coupled receptor kinase 5 -0.0226901
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0223366
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0222581
SCG2 secretogranin II -0.0221693
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.021984
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.0218497
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.02175
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0217256
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0216043
NAMPT nicotinamide phosphoribosyltransferase -0.0212512
FBXO22 F-box protein 22 -0.0211072
PTMA prothymosin, alpha -0.0210837
TFRC transferrin receptor -0.0210462
FNDC3B fibronectin type III domain containing 3B -0.0208544
PCDH15 protocadherin-related 15 -0.0208067
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0206633
ZC3H15 zinc finger CCCH-type containing 15 -0.0206461
RPTOR regulatory associated protein of MTOR, complex 1 -0.0205233
LRP1B low density lipoprotein receptor-related protein 1B -0.0204796
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0203764
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -0.0203753
RPL6 ribosomal protein L6 -0.0203624
ADAR adenosine deaminase, RNA-specific -0.0203002