Clotrimazole_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.273907
ANXA2 annexin A2 0.101265
GCLC glutamate-cysteine ligase, catalytic subunit 0.091705
EXT1 exostosin glycosyltransferase 1 0.0872498
EZR ezrin 0.0866768
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0824003
AREG amphiregulin 0.0796199
B2M beta-2-microglobulin 0.0774194
FNDC3B fibronectin type III domain containing 3B 0.0738905
TSC22D1 TSC22 domain family, member 1 0.073113
INTS6 integrator complex subunit 6 0.0725305
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0720857
SQSTM1 sequestosome 1 0.0691294
AKAP13 A kinase (PRKA) anchor protein 13 0.066886
STS steroid sulfatase (microsomal), isozyme S 0.0648434
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0631044
EGR1 early growth response 1 0.0608711
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0555977
EPS8 epidermal growth factor receptor pathway substrate 8 0.0526454
DSCAM Down syndrome cell adhesion molecule 0.0503542
VMP1 vacuole membrane protein 1 0.0497849
FTH1 ferritin, heavy polypeptide 1 0.0481327
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0479523
ZSWIM6 zinc finger, SWIM-type containing 6 0.0466328
IGFBP3 insulin-like growth factor binding protein 3 0.0460949
NDRG1 N-myc downstream regulated 1 0.0449737
FTL ferritin, light polypeptide 0.0448102
RAB7A RAB7A, member RAS oncogene family 0.0442405
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0440233
DST dystonin 0.0438159
LPP LIM domain containing preferred translocation partner in lipoma 0.0422751
EFNB2 ephrin-B2 0.0416057
ERRFI1 ERBB receptor feedback inhibitor 1 0.040917
MT2A metallothionein 2A 0.0387447
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0375001
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0374972
DUSP10 dual specificity phosphatase 10 0.0369725
BAIAP2L1 BAI1-associated protein 2-like 1 0.0367204
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.036305
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0362646
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.035364
MCL1 myeloid cell leukemia 1 0.0349241
DIAPH1 diaphanous-related formin 1 0.034826
KYNU kynureninase 0.0347976
CXCL8 chemokine (C-X-C motif) ligand 8 0.034787
SPAG9 sperm associated antigen 9 0.0347101
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0340293
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0339826
ASPH aspartate beta-hydroxylase 0.0339046
DSPP dentin sialophosphoprotein 0.033807
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0332849
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0332631
ZNF292 zinc finger protein 292 0.0328271
SMAD3 SMAD family member 3 0.0328246
MYO1E myosin IE 0.0325378
MUC13 mucin 13, cell surface associated 0.0321951
TXNRD1 thioredoxin reductase 1 0.032036
AHI1 Abelson helper integration site 1 0.0309291
APOL1 apolipoprotein L, 1 0.0308608
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0307696
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0298882
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.029821
LAMB3 laminin, beta 3 0.0290564
PLSCR2 phospholipid scramblase 2 0.0284281
ANXA1 annexin A1 0.028149
AKR1C2 aldo-keto reductase family 1, member C2 0.0281259
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0279517
USP53 ubiquitin specific peptidase 53 0.0279205
ITPKC inositol-trisphosphate 3-kinase C 0.0278732
MORF4L2 mortality factor 4 like 2 0.0278659
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0275793
SDCBP2 syndecan binding protein (syntenin) 2 0.027178
RND3 Rho family GTPase 3 0.0270957
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0270042
JUN jun proto-oncogene 0.0268918
PHF3 PHD finger protein 3 0.0265376
SPDYA speedy/RINGO cell cycle regulator family member A 0.0265365
GOLGB1 golgin B1 0.026395
ERBIN erbb2 interacting protein 0.0260566
KIF16B kinesin family member 16B 0.0258198
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0257988
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0256129
SDC4 syndecan 4 0.0254998
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0248553
CYSTM1 cysteine-rich transmembrane module containing 1 0.024812
C6ORF132 chromosome 6 open reading frame 132 0.024723
CDHR2 cadherin-related family member 2 0.0246419
HKDC1 hexokinase domain containing 1 0.0244174
DDIT3 DNA-damage-inducible transcript 3 0.024184
SEC31A SEC31 homolog A (S. cerevisiae) 0.0241695
IRF1 interferon regulatory factor 1 0.0238861
FRMD5 FERM domain containing 5 0.0237983
FNIP2 folliculin interacting protein 2 0.0237785
SDCBP syndecan binding protein (syntenin) 0.0237031
CATSPERB catsper channel auxiliary subunit beta 0.0236876
PKM pyruvate kinase, muscle 0.0236732
ESYT2 extended synaptotagmin-like protein 2 0.0234183
MYO5B myosin VB 0.0232649
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0230953
KLF5 Kruppel-like factor 5 (intestinal) 0.0229739

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.103918
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0992711
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0852808
LYZ lysozyme -0.0780896
RABGAP1L RAB GTPase activating protein 1-like -0.0694299
EPHB2 EPH receptor B2 -0.0645598
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.06354
PTMA prothymosin, alpha -0.0533696
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0518369
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0518218
VCL vinculin -0.0511633
NKD1 naked cuticle homolog 1 (Drosophila) -0.0509589
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0488475
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0474404
SPATA13 spermatogenesis associated 13 -0.0472867
TMEM62 transmembrane protein 62 -0.0445862
RUNX1 runt-related transcription factor 1 -0.0444519
RIGI RNA sensor RIG-I -0.0425974
PTBP3 polypyrimidine tract binding protein 3 -0.0407665
TNS4 tensin 4 -0.0402818
MX2 MX dynamin-like GTPase 2 -0.038559
RHOBTB3 Rho-related BTB domain containing 3 -0.0385406
ZBTB20 zinc finger and BTB domain containing 20 -0.0368107
NPSR1 neuropeptide S receptor 1 -0.0361596
ATP11A ATPase, class VI, type 11A -0.0356247
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.035586
MX1 MX dynamin-like GTPase 1 -0.0352995
SP100 SP100 nuclear antigen -0.0323193
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0322249
MKI67 marker of proliferation Ki-67 -0.0316396
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0311305
PLSCR1 phospholipid scramblase 1 -0.0308391
PMP22 peripheral myelin protein 22 -0.0307695
TXNIP thioredoxin interacting protein -0.0304398
XAF1 XIAP associated factor 1 -0.0301821
DIAPH3 diaphanous-related formin 3 -0.030154
RNF43 ring finger protein 43 -0.0297682
SREBF2 sterol regulatory element binding transcription factor 2 -0.02965
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0294209
IFI6 interferon, alpha-inducible protein 6 -0.0287871
LCN2 lipocalin 2 -0.0285378
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0276423
HLA-B major histocompatibility complex, class I, B -0.0264758
MPHOSPH8 M-phase phosphoprotein 8 -0.0261326
PATJ PATJ crumbs cell polarity complex component -0.0261252
FOXP1 forkhead box P1 -0.0259956
CENPF centromere protein F, 350/400kDa -0.0259327
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0253467
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.023664
RBM26 RNA binding motif protein 26 -0.023001
BRCA2 breast cancer 2, early onset -0.0224224
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0218928
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.021824
CDK6 cyclin-dependent kinase 6 -0.0216016
SAMHD1 SAM domain and HD domain 1 -0.0214599
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0211623
AOPEP aminopeptidase O (putative) -0.020568
NCKAP5 NCK-associated protein 5 -0.0203819
RPL7L1 ribosomal protein L7-like 1 -0.020153
MAP7 microtubule-associated protein 7 -0.0200881
SGK1 serum/glucocorticoid regulated kinase 1 -0.0198173
SCLT1 sodium channel and clathrin linker 1 -0.0196833
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0193845
IFI27 interferon, alpha-inducible protein 27 -0.0193597
CLYBL citrate lyase beta like -0.0189253
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0185073
PDE4D phosphodiesterase 4D, cAMP-specific -0.0181982
HLA-C major histocompatibility complex, class I, C -0.0181629
ZNFX1 zinc finger, NFX1-type containing 1 -0.0180119
ARHGAP26 Rho GTPase activating protein 26 -0.0179898
ATXN1 ataxin 1 -0.0179797
WWOX WW domain containing oxidoreductase -0.0177688
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0177456
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0176295
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -0.0174642
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0174083
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0173703
SMYD3 SET and MYND domain containing 3 -0.017342
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0172801
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0172133
GSK3B glycogen synthase kinase 3 beta -0.0171437
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0169432
SERINC5 serine incorporator 5 -0.0167205
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0166698
CAB39 calcium binding protein 39 -0.0166619
CHD6 chromodomain helicase DNA binding protein 6 -0.0165658
ADAR adenosine deaminase, RNA-specific -0.0164701
CDC42SE2 CDC42 small effector 2 -0.0163411
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0162976
MICU2 mitochondrial calcium uptake 2 -0.0161223
PHF11 PHD finger protein 11 -0.0159979
UBXN4 UBX domain protein 4 -0.0159689
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0158799
RFC3 replication factor C (activator 1) 3, 38kDa -0.0158081
TNRC6B trinucleotide repeat containing 6B -0.0158054
FAAH2 fatty acid amide hydrolase 2 -0.0156986
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0156296
PIAS1 protein inhibitor of activated STAT, 1 -0.0155439
OARD1 O-acyl-ADP-ribose deacylase 1 -0.0155107
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0152927