Clotrimazole_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.22281
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.220709
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.157228
MTSS1 metastasis suppressor 1 0.136798
LMO7 LIM domain 7 0.130337
SLC35F3 solute carrier family 35, member F3 0.11509
PDE4D phosphodiesterase 4D, cAMP-specific 0.105654
PALM2AKAP2 PALM2 and AKAP2 fusion 0.105232
PDLIM5 PDZ and LIM domain 5 0.0976819
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0883877
DPYD dihydropyrimidine dehydrogenase 0.0872801
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0792794
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0784916
RAI14 retinoic acid induced 14 0.0722616
B2M beta-2-microglobulin 0.0712014
RASAL2 RAS protein activator like 2 0.0673351
EXT1 exostosin glycosyltransferase 1 0.0643778
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0636698
PSD3 pleckstrin and Sec7 domain containing 3 0.0617752
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0615709
ALCAM activated leukocyte cell adhesion molecule 0.0604599
HMGA2 high mobility group AT-hook 2 0.0601907
EFNA5 ephrin-A5 0.0597954
MACF1 microtubule-actin crosslinking factor 1 0.0586083
NRIP1 nuclear receptor interacting protein 1 0.0584303
CDK6 cyclin-dependent kinase 6 0.0563129
LAMC2 laminin, gamma 2 0.0560083
AKAP13 A kinase (PRKA) anchor protein 13 0.0542542
RABGAP1L RAB GTPase activating protein 1-like 0.053989
INTS6 integrator complex subunit 6 0.0517385
MECOM MDS1 and EVI1 complex locus 0.051527
ASPH aspartate beta-hydroxylase 0.0498992
PLS3 plastin 3 0.0490728
PTK2 protein tyrosine kinase 2 0.04903
MSN moesin 0.0469582
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0453892
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0449418
JMJD1C jumonji domain containing 1C 0.0445978
ZSWIM6 zinc finger, SWIM-type containing 6 0.0444089
UTRN utrophin 0.0433273
TSC22D1 TSC22 domain family, member 1 0.0432175
ANO1 anoctamin 1, calcium activated chloride channel 0.0425476
HDAC9 histone deacetylase 9 0.0415045
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0412823
BCAR3 breast cancer anti-estrogen resistance 3 0.0410448
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.040843
RAD51B RAD51 paralog B 0.0407112
ZEB1 zinc finger E-box binding homeobox 1 0.0406587
RNF217 ring finger protein 217 0.0401542
MBNL1 muscleblind-like splicing regulator 1 0.039473
DOK5 docking protein 5 0.0393513
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0385365
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0384304
DOCK5 dedicator of cytokinesis 5 0.0381511
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.03782
EGFR epidermal growth factor receptor 0.0377666
EXOC4 exocyst complex component 4 0.0371018
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0370427
THSD4 thrombospondin, type I, domain containing 4 0.0361921
PRSS23 protease, serine, 23 0.0355731
DGKH diacylglycerol kinase, eta 0.0353604
IFI44L interferon-induced protein 44-like 0.035347
KLF5 Kruppel-like factor 5 (intestinal) 0.0351443
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0350266
CALB1 calbindin 1, 28kDa 0.0347966
SULF1 sulfatase 1 0.0347756
AMOTL1 angiomotin like 1 0.0347007
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0343031
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.03424
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0330392
SULF2 sulfatase 2 0.0329183
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0325561
DST dystonin 0.0313677
N4BP2L2 NEDD4 binding protein 2-like 2 0.0312609
SMYD3 SET and MYND domain containing 3 0.0310319
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0310157
TMSB4X thymosin beta 4, X-linked 0.0308934
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0307618
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0298437
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0297193
NAV2 neuron navigator 2 0.0295081
ZMYND8 zinc finger, MYND-type containing 8 0.0293612
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0293305
APLP2 amyloid beta (A4) precursor-like protein 2 0.0291036
GRB10 growth factor receptor-bound protein 10 0.0288817
RPL37 ribosomal protein L37 0.0288285
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0288008
PICALM phosphatidylinositol binding clathrin assembly protein 0.0287649
TGM2 transglutaminase 2 0.0286416
MPRIP myosin phosphatase Rho interacting protein 0.0285882
FTH1 ferritin, heavy polypeptide 1 0.0283466
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0283287
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0282824
ZC3H12C zinc finger CCCH-type containing 12C 0.028187
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0281376
MCL1 myeloid cell leukemia 1 0.0277209
PODXL podocalyxin-like 0.0274714
SVIL supervillin 0.0274438
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0274035
LPP LIM domain containing preferred translocation partner in lipoma 0.0269949

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0710265
NAMPT nicotinamide phosphoribosyltransferase -0.0590493
H1-0 H1.0 linker histone -0.0510866
PTMA prothymosin, alpha -0.0473694
KRT17 keratin 17, type I -0.0472844
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0449592
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0439977
OGA O-GlcNAcase -0.0367355
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0358522
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0351212
ANLN anillin, actin binding protein -0.0349646
NDRG1 N-myc downstream regulated 1 -0.0338359
KDM3A lysine (K)-specific demethylase 3A -0.0336287
LOC112694756 uncharaterized LOC112694756 -0.0332903
TMSB10 thymosin beta 10 -0.0323599
EMP1 epithelial membrane protein 1 -0.0320209
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0313116
LMNA lamin A/C -0.026818
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0260857
NPEPPS aminopeptidase puromycin sensitive -0.0258614
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0255781
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0254028
CEMIP cell migration inducing protein, hyaluronan binding -0.0244964
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.024492
YBX3 Y box binding protein 3 -0.0243965
ANKRD33B ankyrin repeat domain 33B -0.024318
ANXA2 annexin A2 -0.0237846
GOLGA4 golgin A4 -0.0234847
LMAN1 lectin, mannose-binding, 1 -0.0233788
FSCN1 fascin actin-bundling protein 1 -0.02306
RBM39 RNA binding motif protein 39 -0.0229434
SLC45A4 solute carrier family 45, member 4 -0.0225392
GNAS GNAS complex locus -0.022445
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0219573
RLF rearranged L-myc fusion -0.021386
SPAG9 sperm associated antigen 9 -0.0212703
MORF4L2 mortality factor 4 like 2 -0.0211136
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0206246
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0204418
CUL4B cullin 4B -0.0198741
AHNAK AHNAK nucleoprotein -0.0196003
CAVIN1 caveolae associated protein 1 -0.0193105
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0188972
S100A2 S100 calcium binding protein A2 -0.018781
CD99 CD99 molecule -0.0182995
S100A6 S100 calcium binding protein A6 -0.0181827
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0179137
SYPL1 synaptophysin-like 1 -0.0178033
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0178029
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0177973
MARCHF6 membrane associated ring-CH-type finger 6 -0.0177267
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0176338
GATA6 GATA binding protein 6 -0.017493
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.017356
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0172732
MT1X metallothionein 1X -0.0170515
COPB1 coatomer protein complex, subunit beta 1 -0.0170334
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0169696
RAB6A RAB6A, member RAS oncogene family -0.0169343
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0168595
KDM5B lysine (K)-specific demethylase 5B -0.0167564
WSB1 WD repeat and SOCS box containing 1 -0.0165229
SRP54 signal recognition particle 54kDa -0.0165118
IER3 immediate early response 3 -0.0162976
SEC31A SEC31 homolog A (S. cerevisiae) -0.0162646
S100A4 S100 calcium binding protein A4 -0.0162597
STC1 stanniocalcin 1 -0.0162336
BRWD3 bromodomain and WD repeat domain containing 3 -0.0162323
CLU clusterin -0.0161282
NDFIP1 Nedd4 family interacting protein 1 -0.0158725
TKT transketolase -0.01586
VDAC1 voltage-dependent anion channel 1 -0.0156602
S100A10 S100 calcium binding protein A10 -0.0155246
CAV1 caveolin 1, caveolae protein, 22kDa -0.0155156
KIAA1217 KIAA1217 -0.0154462
IGF2 insulin-like growth factor 2 -0.0152717
NUP58 nucleoporin 58 -0.0151477
NRG1 neuregulin 1 -0.0151445
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.015119
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0150604
BZW2 basic leucine zipper and W2 domains 2 -0.0148838
KRT14 keratin 14, type I -0.0146666
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.014653
TMEM263 transmembrane protein 263 -0.0146451
SUCO SUN domain containing ossification factor -0.014626
ARRDC3 arrestin domain containing 3 -0.0145443
DLG1 discs, large homolog 1 (Drosophila) -0.0143159
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0142037
CKAP2 cytoskeleton associated protein 2 -0.014165
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0141317
HELZ helicase with zinc finger -0.0141304
PNISR PNN-interacting serine/arginine-rich protein -0.0141227
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0141041
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0140158
ZNF217 zinc finger protein 217 -0.0138296
ARF1 ADP-ribosylation factor 1 -0.0138175
DSTN destrin (actin depolymerizing factor) -0.0137637
CD47 CD47 molecule -0.0137582
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0136227
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0136125