Clotrimazole_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.137683
TMSB10 thymosin beta 10 0.135723
RPS12 ribosomal protein S12 0.119479
LMO7 LIM domain 7 0.113791
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.112441
RPS8 ribosomal protein S8 0.103015
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0824138
ASPH aspartate beta-hydroxylase 0.0809399
MYO1E myosin IE 0.0791302
MT2A metallothionein 2A 0.0791018
AREG amphiregulin 0.0790599
RPS6 ribosomal protein S6 0.0774318
RPS19 ribosomal protein S19 0.0739188
EXT1 exostosin glycosyltransferase 1 0.0691877
FAT1 FAT atypical cadherin 1 0.0690738
ONECUT3 one cut homeobox 3 0.0657681
RPL9 ribosomal protein L9 0.0621592
FTL ferritin, light polypeptide 0.0600733
RPS3 ribosomal protein S3 0.0590997
RPL26 ribosomal protein L26 0.0590567
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0590021
RPS17 ribosomal protein S17 0.0569523
RPL37A ribosomal protein L37a 0.0558698
B2M beta-2-microglobulin 0.0547787
RPLP2 ribosomal protein, large, P2 0.0537474
RPL23 ribosomal protein L23 0.051098
RPL12 ribosomal protein L12 0.0493606
RPL31 ribosomal protein L31 0.0489832
RPS21 ribosomal protein S21 0.0458832
RPS23 ribosomal protein S23 0.0436228
EGFR epidermal growth factor receptor 0.0435994
RPL36 ribosomal protein L36 0.0417274
KRT8 keratin 8, type II 0.0411057
RPL34 ribosomal protein L34 0.040984
KLF5 Kruppel-like factor 5 (intestinal) 0.0409777
RPS2 ribosomal protein S2 0.0396166
S100A9 S100 calcium binding protein A9 0.0385045
RPS24 ribosomal protein S24 0.036673
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0350067
USP53 ubiquitin specific peptidase 53 0.0343792
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0335579
MT1X metallothionein 1X 0.0326086
VEGFA vascular endothelial growth factor A 0.0325331
PDLIM5 PDZ and LIM domain 5 0.0321735
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0320691
S100A10 S100 calcium binding protein A10 0.032016
RPL35A ribosomal protein L35a 0.0315832
RPL27 ribosomal protein L27 0.0314077
RPS14 ribosomal protein S14 0.0314026
RPS27 ribosomal protein S27 0.0296849
ENO2 enolase 2 (gamma, neuronal) 0.02911
EPS8 epidermal growth factor receptor pathway substrate 8 0.029058
RPL18 ribosomal protein L18 0.0290113
PTPRR protein tyrosine phosphatase, receptor type, R 0.0288357
RPL14 ribosomal protein L14 0.0287501
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0282585
ISG15 ISG15 ubiquitin-like modifier 0.0277209
MARCHF3 membrane associated ring-CH-type finger 3 0.0276954
RPL19 ribosomal protein L19 0.0276725
RPS13 ribosomal protein S13 0.0276412
RPS11 ribosomal protein S11 0.0275116
RPL28 ribosomal protein L28 0.0274942
RPL37 ribosomal protein L37 0.027439
PTPRB protein tyrosine phosphatase, receptor type, B 0.0268566
RPS27A ribosomal protein S27a 0.0264948
RPS4X ribosomal protein S4, X-linked 0.0264472
RPL36AL ribosomal protein L36a-like 0.0261796
N4BP2L2 NEDD4 binding protein 2-like 2 0.0259464
GOLGB1 golgin B1 0.0258643
RPL5 ribosomal protein L5 0.0249016
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0247184
RPS29 ribosomal protein S29 0.0245938
TMEM45B transmembrane protein 45B 0.0243366
AKAP13 A kinase (PRKA) anchor protein 13 0.0242532
MT1E metallothionein 1E 0.0238571
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0236195
TMSB4X thymosin beta 4, X-linked 0.023242
RPS16 ribosomal protein S16 0.0231084
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0229801
KTN1 kinectin 1 (kinesin receptor) 0.0229328
MCL1 myeloid cell leukemia 1 0.0229262
RPS5 ribosomal protein S5 0.0229167
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.022865
TFF1 trefoil factor 1 0.0228393
LURAP1L leucine rich adaptor protein 1-like 0.0226949
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0226847
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0225489
S100P S100 calcium binding protein P 0.0224851
SLC38A2 solute carrier family 38, member 2 0.0221797
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0219621
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0219181
HSPA8 heat shock 70kDa protein 8 0.0218107
ZSWIM6 zinc finger, SWIM-type containing 6 0.0217538
ASTN2 astrotactin 2 0.0216143
IGFL2 IGF-like family member 2 0.0215586
MACF1 microtubule-actin crosslinking factor 1 0.0213727
RPS10 ribosomal protein S10 0.0208498
SMAD2 SMAD family member 2 0.0204019
CD44 CD44 molecule (Indian blood group) 0.0202061
RPL32 ribosomal protein L32 0.0199261

decreased expression

Symbol Name Standardized Value
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.121795
PTMA prothymosin, alpha -0.121773
NPSR1 neuropeptide S receptor 1 -0.117755
GPHN gephyrin -0.10725
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0966808
ANXA2 annexin A2 -0.0833236
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0819739
AHNAK AHNAK nucleoprotein -0.0792326
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0762507
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0650452
ALCAM activated leukocyte cell adhesion molecule -0.0604997
EPCAM epithelial cell adhesion molecule -0.0603679
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0596409
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0588585
TNS4 tensin 4 -0.0553125
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.052803
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0526908
NALF1 NALCN channel auxiliary factor 1 -0.0520777
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0512512
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0512065
NFIA nuclear factor I/A -0.050109
EZR ezrin -0.04969
GMDS GDP-mannose 4,6-dehydratase -0.0493473
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0485216
MED13L mediator complex subunit 13-like -0.0476184
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0466401
PIGR polymeric immunoglobulin receptor -0.045718
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0451609
MLEC malectin -0.0411075
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0403114
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0402395
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0385908
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.038497
CANX calnexin -0.0360085
FAM13A family with sequence similarity 13, member A -0.035656
ACACA acetyl-CoA carboxylase alpha -0.0349696
KDM7A lysine (K)-specific demethylase 7A -0.0343177
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0340894
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0334405
TFRC transferrin receptor -0.0333892
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0331411
RTN4 reticulon 4 -0.0326473
MYO1D myosin ID -0.032631
PKP2 plakophilin 2 -0.0326289
NF1 neurofibromin 1 -0.0325331
TXNIP thioredoxin interacting protein -0.0321895
COBL cordon-bleu WH2 repeat protein -0.0321803
TMEM123 transmembrane protein 123 -0.0320427
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0317983
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0317168
RAD51B RAD51 paralog B -0.0315054
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0313167
PDIA3 protein disulfide isomerase family A, member 3 -0.0312074
NCOR1 nuclear receptor corepressor 1 -0.0305654
EHBP1 EH domain binding protein 1 -0.029455
TMEM135 transmembrane protein 135 -0.028872
PUM1 pumilio RNA-binding family member 1 -0.02863
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0285954
FNBP1L formin binding protein 1-like -0.0285617
MUC17 mucin 17, cell surface associated -0.0284655
SETD5 SET domain containing 5 -0.0283827
MMP12 matrix metallopeptidase 12 -0.0282363
FERMT1 fermitin family member 1 -0.0282072
PCDHB16 protocadherin beta 16 -0.0281538
GREB1L growth regulation by estrogen in breast cancer-like -0.028061
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0279782
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0278873
ACTN4 actinin, alpha 4 -0.0273879
LDHA lactate dehydrogenase A -0.027056
SBF2 SET binding factor 2 -0.0268824
CALB1 calbindin 1, 28kDa -0.026816
ANXA11 annexin A11 -0.0265829
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0265153
SENP6 SUMO1/sentrin specific peptidase 6 -0.0264795
SRPK1 SRSF protein kinase 1 -0.0262756
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0262535
ANKRD28 ankyrin repeat domain 28 -0.0261672
SERINC5 serine incorporator 5 -0.0261355
KIF13A kinesin family member 13A -0.0259991
MSI2 musashi RNA-binding protein 2 -0.0259868
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0259734
EPHB2 EPH receptor B2 -0.0259059
DLG1 discs, large homolog 1 (Drosophila) -0.0258292
MAML2 mastermind-like 2 (Drosophila) -0.0257457
USP3 ubiquitin specific peptidase 3 -0.025556
MECOM MDS1 and EVI1 complex locus -0.02547
IARS1 isoleucyl-tRNA synthetase 1 -0.0251196
FNDC3B fibronectin type III domain containing 3B -0.025042
H1-0 H1.0 linker histone -0.0248897
RNF217 ring finger protein 217 -0.0247118
MATR3 matrin 3 -0.024579
TBC1D5 TBC1 domain family, member 5 -0.0245321
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0244946
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0242002
ZNF292 zinc finger protein 292 -0.0241623
PKP4 plakophilin 4 -0.0238666
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0237994
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0237498
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0236098
PUM2 pumilio RNA-binding family member 2 -0.0235791