Clotrimazole_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.117106
ASPH aspartate beta-hydroxylase 0.103649
KYNU kynureninase 0.102238
LIMCH1 LIM and calponin homology domains 1 0.0911678
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0902612
EGFR epidermal growth factor receptor 0.0897674
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0870381
STC1 stanniocalcin 1 0.079963
SDK1 sidekick cell adhesion molecule 1 0.0773945
EFNA5 ephrin-A5 0.0722565
APP amyloid beta (A4) precursor protein 0.0696707
LMO7 LIM domain 7 0.0694323
MT2A metallothionein 2A 0.0658189
LAMC2 laminin, gamma 2 0.0646751
RAD51B RAD51 paralog B 0.0639013
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0601194
FMN1 formin 1 0.0599923
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0590428
DST dystonin 0.0561491
B2M beta-2-microglobulin 0.0537006
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0533487
DOCK5 dedicator of cytokinesis 5 0.0528706
AK1 adenylate kinase 1 0.0523155
FER fer (fps/fes related) tyrosine kinase 0.0502305
EXOC6B exocyst complex component 6B 0.0497951
FNIP1 folliculin interacting protein 1 0.0495842
PSD3 pleckstrin and Sec7 domain containing 3 0.0488667
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0487974
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.047157
OFD1 oral-facial-digital syndrome 1 0.0451807
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.04486
FHIT fragile histidine triad 0.0446745
ANTXR2 anthrax toxin receptor 2 0.0445371
IGF1R insulin-like growth factor 1 receptor 0.0438271
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0436688
LAMA4 laminin, alpha 4 0.0435749
AKAP12 A kinase (PRKA) anchor protein 12 0.0432929
MCTP1 multiple C2 domains, transmembrane 1 0.0432845
ARB2A ARB2 cotranscriptional regulator A 0.0430861
RAB10 RAB10, member RAS oncogene family 0.043042
TM4SF1 transmembrane 4 L six family member 1 0.0428836
MACF1 microtubule-actin crosslinking factor 1 0.0427291
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0423411
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0412558
NLGN1 neuroligin 1 0.0412388
PRELID2 PRELI domain containing 2 0.040622
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.040441
SCFD1 sec1 family domain containing 1 0.0404159
MCL1 myeloid cell leukemia 1 0.0395711
FLNB filamin B, beta 0.0388519
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0386191
PRKCA protein kinase C, alpha 0.0382057
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0378088
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0375253
ALCAM activated leukocyte cell adhesion molecule 0.0367764
EZR ezrin 0.0363558
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0358679
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0356842
PRKG1 protein kinase, cGMP-dependent, type I 0.0356806
STK24 serine/threonine kinase 24 0.0356353
NPAS2 neuronal PAS domain protein 2 0.0353153
PHACTR4 phosphatase and actin regulator 4 0.0351625
IER3 immediate early response 3 0.0350369
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.0348598
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.0345447
UBE3C ubiquitin protein ligase E3C 0.0345115
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0343079
SMAD3 SMAD family member 3 0.0341924
SPIRE1 spire-type actin nucleation factor 1 0.0340913
ANKRD17 ankyrin repeat domain 17 0.0337522
MYO9A myosin IXA 0.0336977
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0332568
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0329929
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0328378
TXNRD1 thioredoxin reductase 1 0.0327979
TAS2R14 taste receptor, type 2, member 14 0.0327919
FNDC3B fibronectin type III domain containing 3B 0.0323492
VMP1 vacuole membrane protein 1 0.0318564
BACE2 beta-site APP-cleaving enzyme 2 0.0316082
HLA-B major histocompatibility complex, class I, B 0.0315392
IFI6 interferon, alpha-inducible protein 6 0.0314937
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0314789
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.031347
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0312229
SAMD4A sterile alpha motif domain containing 4A 0.0311655
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0310916
METTL15 methyltransferase like 15 0.0310673
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0309064
RPS8 ribosomal protein S8 0.0304739
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0304048
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0303498
MYO1D myosin ID 0.0302083
REEP3 receptor accessory protein 3 0.0299749
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.0297532
MXD1 MAX dimerization protein 1 0.0296502
EPHB2 EPH receptor B2 0.0292093
MAP4 microtubule-associated protein 4 0.0292063
BCAR3 breast cancer anti-estrogen resistance 3 0.0290363
VCL vinculin 0.0289998
SPIDR scaffolding protein involved in DNA repair 0.0288959

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.124881
NCOA3 nuclear receptor coactivator 3 -0.109148
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0992217
IGFBP3 insulin-like growth factor binding protein 3 -0.093344
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0890293
ANXA1 annexin A1 -0.0863801
NDRG1 N-myc downstream regulated 1 -0.0850362
FTL ferritin, light polypeptide -0.0822246
RPL23 ribosomal protein L23 -0.0770282
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0747705
BTG1 B-cell translocation gene 1, anti-proliferative -0.0742395
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0718299
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.070479
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0698696
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0695823
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0689434
POTEF POTE ankyrin domain family, member F -0.0689313
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0682527
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0647325
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0638022
PDE4D phosphodiesterase 4D, cAMP-specific -0.0633027
KMT2C lysine (K)-specific methyltransferase 2C -0.0629525
SREBF2 sterol regulatory element binding transcription factor 2 -0.0610572
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0593377
TMEM123 transmembrane protein 123 -0.0582892
SLC38A1 solute carrier family 38, member 1 -0.0579558
PDIA3 protein disulfide isomerase family A, member 3 -0.0578902
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0567516
RIOK3 RIO kinase 3 -0.055569
HELZ helicase with zinc finger -0.0547361
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0547164
PRRC2C proline-rich coiled-coil 2C -0.0521745
S100A8 S100 calcium binding protein A8 -0.0519369
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0516632
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0507135
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0504191
PTBP3 polypyrimidine tract binding protein 3 -0.0501216
SNX9 sorting nexin 9 -0.049814
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0490089
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0487655
FAM107B family with sequence similarity 107, member B -0.048579
TOP1 topoisomerase (DNA) I -0.048155
SPAG9 sperm associated antigen 9 -0.0479699
SRPK2 SRSF protein kinase 2 -0.0473818
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.047321
NAMPT nicotinamide phosphoribosyltransferase -0.0471923
FDPS farnesyl diphosphate synthase -0.0469575
ACBD3 acyl-CoA binding domain containing 3 -0.0468796
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0468319
TSC22D2 TSC22 domain family, member 2 -0.0468086
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0467328
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0466728
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0463374
KDM3A lysine (K)-specific demethylase 3A -0.045476
FTH1 ferritin, heavy polypeptide 1 -0.045215
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0442752
RPS6 ribosomal protein S6 -0.0442601
USP15 ubiquitin specific peptidase 15 -0.0442154
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.044163
RAD23B RAD23 homolog B (S. cerevisiae) -0.0440739
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0436045
CLINT1 clathrin interactor 1 -0.0434976
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0432228
S100A6 S100 calcium binding protein A6 -0.0430963
UBAP1 ubiquitin associated protein 1 -0.0426828
ARHGAP35 Rho GTPase activating protein 35 -0.0417438
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0411126
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0408076
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0405151
ZFAND3 zinc finger, AN1-type domain 3 -0.0402729
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0395863
RPS29 ribosomal protein S29 -0.0390122
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0390071
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0388641
CCDC6 coiled-coil domain containing 6 -0.038831
SLMAP sarcolemma associated protein -0.0386281
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0381019
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0380914
CALR calreticulin -0.0380167
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0379649
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.03784
FBXL20 F-box and leucine-rich repeat protein 20 -0.0375839
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0374755
EPSTI1 epithelial stromal interaction 1 (breast) -0.0374642
RPL35A ribosomal protein L35a -0.037102
LAMB1 laminin, beta 1 -0.0370314
COPA coatomer protein complex, subunit alpha -0.0365419
KIF13B kinesin family member 13B -0.0365327
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0363703
KDM5B lysine (K)-specific demethylase 5B -0.0362976
MYO1E myosin IE -0.0361067
PTGES2 prostaglandin E synthase 2 -0.0360854
MUC16 mucin 16, cell surface associated -0.0359672
RREB1 ras responsive element binding protein 1 -0.0359546
HILPDA hypoxia inducible lipid droplet-associated -0.0357305
RAB6A RAB6A, member RAS oncogene family -0.0353381
WAC WW domain containing adaptor with coiled-coil -0.0353036
AHNAK AHNAK nucleoprotein -0.0351556
PIAS1 protein inhibitor of activated STAT, 1 -0.0351556
PTMA prothymosin, alpha -0.0348591