Clotrimazole_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Clotrimazole_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.219744
RPS12 ribosomal protein S12 0.103154
RPS6 ribosomal protein S6 0.10166
MT2A metallothionein 2A 0.0926288
TPT1 tumor protein, translationally-controlled 1 0.0913126
RPL37A ribosomal protein L37a 0.0831721
EFNA5 ephrin-A5 0.0825498
RPL31 ribosomal protein L31 0.0789279
RPS8 ribosomal protein S8 0.0780154
MAML3 mastermind-like 3 (Drosophila) 0.0731973
RPS3 ribosomal protein S3 0.0680389
RPS19 ribosomal protein S19 0.0675184
RPS17 ribosomal protein S17 0.0644947
RPL26 ribosomal protein L26 0.0594499
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0588586
RPL12 ribosomal protein L12 0.058133
RPS23 ribosomal protein S23 0.0577745
VIM vimentin 0.0573891
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0569929
DST dystonin 0.0567374
COL5A2 collagen, type V, alpha 2 0.052221
FMNL2 formin-like 2 0.0510271
PRKN parkin RBR E3 ubiquitin protein ligase 0.0488906
CDH13 cadherin 13 0.0487538
RPS29 ribosomal protein S29 0.0486316
FTL ferritin, light polypeptide 0.0483735
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0471952
RPL36 ribosomal protein L36 0.0471761
RPLP2 ribosomal protein, large, P2 0.0466202
RPL37 ribosomal protein L37 0.0465718
RPL23 ribosomal protein L23 0.0457177
RPS2 ribosomal protein S2 0.0456701
RPL36A ribosomal protein L36a 0.0455913
RPS21 ribosomal protein S21 0.0449895
RPL34 ribosomal protein L34 0.0437634
RPL19 ribosomal protein L19 0.0416847
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.040781
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0391014
RPL9 ribosomal protein L9 0.0387927
COL4A5 collagen, type IV, alpha 5 0.0382066
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0375235
PTPRM protein tyrosine phosphatase, receptor type, M 0.0371716
RPS27 ribosomal protein S27 0.0349749
NPAS2 neuronal PAS domain protein 2 0.0346164
AUTS2 autism susceptibility candidate 2 0.0341331
RPL35A ribosomal protein L35a 0.0338131
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0334655
NDRG1 N-myc downstream regulated 1 0.0330672
RPLP1 ribosomal protein, large, P1 0.0327987
RAD51B RAD51 paralog B 0.03274
PRELID2 PRELI domain containing 2 0.0326693
RPL27 ribosomal protein L27 0.0325966
RPS13 ribosomal protein S13 0.0319668
COL8A1 collagen, type VIII, alpha 1 0.0317802
MFSD12 major facilitator superfamily domain containing 12 0.0316911
RPL13A ribosomal protein L13a 0.0305991
AKAP12 A kinase (PRKA) anchor protein 12 0.030024
RPS25 ribosomal protein S25 0.0299071
MAP7 microtubule-associated protein 7 0.0294983
WWTR1 WW domain containing transcription regulator 1 0.0293672
COL4A6 collagen, type IV, alpha 6 0.0292396
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0288398
IGFBP3 insulin-like growth factor binding protein 3 0.0288012
RPL11 ribosomal protein L11 0.028658
RPL38 ribosomal protein L38 0.0281782
MT1X metallothionein 1X 0.0280209
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0261184
NRG1 neuregulin 1 0.026078
GPC6 glypican 6 0.0260427
ASTN2 astrotactin 2 0.0259134
GMDS GDP-mannose 4,6-dehydratase 0.0258761
DISP1 dispatched homolog 1 (Drosophila) 0.0252103
RPL5 ribosomal protein L5 0.0246014
RPL7A ribosomal protein L7a 0.0244627
RPL14 ribosomal protein L14 0.0243275
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0241402
NHSL1 NHS-like 1 0.023911
RPS24 ribosomal protein S24 0.0238692
RPL28 ribosomal protein L28 0.0238471
RPS14 ribosomal protein S14 0.0236729
RPL32 ribosomal protein L32 0.0234694
NFE2L2 nuclear factor, erythroid 2-like 2 0.0234509
SQSTM1 sequestosome 1 0.0234376
INTS6 integrator complex subunit 6 0.0234318
AKAP9 A kinase (PRKA) anchor protein 9 0.0225765
ZSWIM6 zinc finger, SWIM-type containing 6 0.0222804
RPS11 ribosomal protein S11 0.0216866
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0215289
UNC5D unc-5 homolog D (C. elegans) 0.0215234
IGF1R insulin-like growth factor 1 receptor 0.0214172
SMOC1 SPARC related modular calcium binding 1 0.0214089
RACK1 receptor for activated C kinase 1 0.0213336
RABGAP1L RAB GTPase activating protein 1-like 0.0213053
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0212329
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0210411
RPS10 ribosomal protein S10 0.0205608
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0205006
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0201617
CUX1 cut-like homeobox 1 0.0201532
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0201273

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.181698
FN1 fibronectin 1 -0.179866
TM4SF1 transmembrane 4 L six family member 1 -0.0922221
NAMPT nicotinamide phosphoribosyltransferase -0.0855501
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0850008
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0775293
UBC ubiquitin C -0.0769155
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0756347
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.068819
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0611061
CANX calnexin -0.0555995
SPAG9 sperm associated antigen 9 -0.0538437
TFPI2 tissue factor pathway inhibitor 2 -0.0528448
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0487703
ELL2 elongation factor, RNA polymerase II, 2 -0.0458143
S100A6 S100 calcium binding protein A6 -0.0446829
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0443471
NCOA7 nuclear receptor coactivator 7 -0.0440063
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.039748
PDIA3 protein disulfide isomerase family A, member 3 -0.0393535
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0388075
TXNRD1 thioredoxin reductase 1 -0.0380001
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0375536
LDHA lactate dehydrogenase A -0.0364347
ATAD1 ATPase family, AAA domain containing 1 -0.036328
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0361806
LIMCH1 LIM and calponin homology domains 1 -0.0361049
SMYD3 SET and MYND domain containing 3 -0.0352608
GNAS GNAS complex locus -0.034633
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0340241
MYOF myoferlin -0.032962
ABLIM1 actin binding LIM protein 1 -0.0325256
WARS1 tryptophanyl-tRNA synthetase 1 -0.0324212
RGS2 regulator of G-protein signaling 2 -0.0320948
LAMA1 laminin, alpha 1 -0.0317403
ATP5F1B ATP synthase F1 subunit beta -0.0311626
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0302982
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0302733
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0291257
IFIH1 interferon induced with helicase C domain 1 -0.0286836
SLC16A6 solute carrier family 16, member 6 -0.028274
PDIA4 protein disulfide isomerase family A, member 4 -0.0281693
CD109 CD109 molecule -0.0279472
LMAN1 lectin, mannose-binding, 1 -0.0273832
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0272337
PALLD palladin, cytoskeletal associated protein -0.0269551
PDIA6 protein disulfide isomerase family A, member 6 -0.0267426
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0267257
MATR3 matrin 3 -0.0265833
PRKD3 protein kinase D3 -0.0260185
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0255995
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0252573
SERBP1 SERPINE1 mRNA binding protein 1 -0.024803
SRGN serglycin -0.0244112
ZBTB38 zinc finger and BTB domain containing 38 -0.0236672
RTN4 reticulon 4 -0.0235513
MKI67 marker of proliferation Ki-67 -0.0234831
LAMB1 laminin, beta 1 -0.0232486
AGTPBP1 ATP/GTP binding protein 1 -0.0232144
POTEF POTE ankyrin domain family, member F -0.0231574
BZW1 basic leucine zipper and W2 domains 1 -0.0230929
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0230265
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0229795
BRWD3 bromodomain and WD repeat domain containing 3 -0.0228715
CALU calumenin -0.022608
CENPF centromere protein F, 350/400kDa -0.0222213
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0222103
SAR1A secretion associated, Ras related GTPase 1A -0.0221344
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.021927
GNS glucosamine (N-acetyl)-6-sulfatase -0.0217301
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0216997
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0215699
TPI1 triosephosphate isomerase 1 -0.0215381
RPLP0 ribosomal protein, large, P0 -0.0211932
YBX3 Y box binding protein 3 -0.0208314
BZW2 basic leucine zipper and W2 domains 2 -0.0207268
ENO1 enolase 1, (alpha) -0.0207176
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0207006
PRSS23 protease, serine, 23 -0.0206508
ADGRB3 adhesion G protein-coupled receptor B3 -0.0206199
PRDX1 peroxiredoxin 1 -0.020607
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0200489
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0198757
IL6 interleukin 6 -0.0197186
TENT5A terminal nucleotidyltransferase 5A -0.0191371
MORF4L2 mortality factor 4 like 2 -0.0189821
LOC112694756 uncharaterized LOC112694756 -0.0189796
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0187006
NUP58 nucleoporin 58 -0.0186478
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0185796
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0184828
PTGR1 prostaglandin reductase 1 -0.018453
PCBP2 poly(rC) binding protein 2 -0.0181938
ATP13A3 ATPase type 13A3 -0.0181811
BIRC6 baculoviral IAP repeat containing 6 -0.0181463
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0180308
USP3 ubiquitin specific peptidase 3 -0.0179948
KPNB1 karyopherin (importin) beta 1 -0.0179067
FNDC3A fibronectin type III domain containing 3A -0.0178661
JMJD1C jumonji domain containing 1C -0.0178657