Clotrimazole_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.108713
TMSB4X thymosin beta 4, X-linked 0.0874005
TPT1 tumor protein, translationally-controlled 1 0.0593184
EIF4A2 eukaryotic translation initiation factor 4A2 0.0413454
RPL13A ribosomal protein L13a 0.0396062
MT2A metallothionein 2A 0.0353409
OGA O-GlcNAcase 0.0352126
TXNIP thioredoxin interacting protein 0.0329147
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0315011
RPL14 ribosomal protein L14 0.0298501
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0269607
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0269147
AZIN1 antizyme inhibitor 1 0.0257288
FHIT fragile histidine triad 0.0256988
FTL ferritin, light polypeptide 0.0250163
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0245419
RPS27A ribosomal protein S27a 0.0235836
GOLGA4 golgin A4 0.0233603
RPS6 ribosomal protein S6 0.0223612
VIM vimentin 0.0221481
MON2 MON2 homolog (S. cerevisiae) 0.021901
TMSB10 thymosin beta 10 0.0213201
WSB1 WD repeat and SOCS box containing 1 0.0212631
KDM3A lysine (K)-specific demethylase 3A 0.021055
PNISR PNN-interacting serine/arginine-rich protein 0.0200826
RRBP1 ribosome binding protein 1 0.020057
TRA2A transformer 2 alpha homolog (Drosophila) 0.0199287
TFG TRK-fused gene 0.0196715
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0193822
JUN jun proto-oncogene 0.0193578
HDLBP high density lipoprotein binding protein 0.0192335
FAM13A family with sequence similarity 13, member A 0.0191743
RPL35A ribosomal protein L35a 0.0190422
B2M beta-2-microglobulin 0.0189436
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0189216
HELZ helicase with zinc finger 0.0188546
RHEB Ras homolog enriched in brain 0.0188322
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0183917
FTH1 ferritin, heavy polypeptide 1 0.0183911
ABI1 abl-interactor 1 0.018384
COPA coatomer protein complex, subunit alpha 0.0181158
RPS3 ribosomal protein S3 0.0175572
CASC3 cancer susceptibility candidate 3 0.0175567
HBP1 HMG-box transcription factor 1 0.0175279
NCOA3 nuclear receptor coactivator 3 0.0174021
PIBF1 progesterone immunomodulatory binding factor 1 0.01716
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 0.0170391
PNRC1 proline-rich nuclear receptor coactivator 1 0.0168898
TPST1 tyrosylprotein sulfotransferase 1 0.0168099
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0166536
KDM5B lysine (K)-specific demethylase 5B 0.016441
TMEM263 transmembrane protein 263 0.016426
RSL1D1 ribosomal L1 domain containing 1 0.0163892
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0162188
CLIP2 CAP-GLY domain containing linker protein 2 0.0160478
USP9X ubiquitin specific peptidase 9, X-linked 0.0158759
RAB18 RAB18, member RAS oncogene family 0.015865
PTBP2 polypyrimidine tract binding protein 2 0.0157215
MARCHF6 membrane associated ring-CH-type finger 6 0.0154537
ZNF292 zinc finger protein 292 0.0154515
RPS19 ribosomal protein S19 0.0153283
RPS21 ribosomal protein S21 0.0151264
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.015077
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0150156
PER1 period circadian clock 1 0.0149286
RPS24 ribosomal protein S24 0.0147738
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0147222
RPS23 ribosomal protein S23 0.0146934
RPL31 ribosomal protein L31 0.0146761
RSRC2 arginine/serine-rich coiled-coil 2 0.0146379
KDM1A lysine (K)-specific demethylase 1A 0.0146344
PDGFC platelet derived growth factor C 0.0146163
ZNF654 zinc finger protein 654 0.0145295
INVS inversin 0.0145017
USP3 ubiquitin specific peptidase 3 0.0144884
ANKRD28 ankyrin repeat domain 28 0.0142781
RPL34 ribosomal protein L34 0.0140695
FAM133B family with sequence similarity 133, member B 0.014023
DNM1L dynamin 1-like 0.0139926
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0139231
QKI QKI, KH domain containing, RNA binding 0.0138603
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0137104
KLHL24 kelch-like family member 24 0.0136328
NOP58 NOP58 ribonucleoprotein 0.0136032
AREG amphiregulin 0.0135948
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0134959
UBP1 upstream binding protein 1 (LBP-1a) 0.0134874
CD47 CD47 molecule 0.0134335
TMEM123 transmembrane protein 123 0.0133629
TTLL10 tubulin tyrosine ligase-like family member 10 0.0133549
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0132765
DCP1A decapping mRNA 1A 0.0132613
BST2 bone marrow stromal cell antigen 2 0.0131889
COG5 component of oligomeric golgi complex 5 0.0131658
ADAM9 ADAM metallopeptidase domain 9 0.0131045
HMGB2 high mobility group box 2 0.0130677
DARS1 aspartyl-tRNA synthetase 1 0.0130385
MYL12B myosin, light chain 12B, regulatory 0.0129874
SOD1 superoxide dismutase 1, soluble 0.0129574
ITSN2 intersectin 2 0.0129511

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.152347
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.139651
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.118098
EGFR epidermal growth factor receptor -0.117984
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0983962
PKM pyruvate kinase, muscle -0.0958524
PDE4B phosphodiesterase 4B, cAMP-specific -0.0943581
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.092093
FOXP1 forkhead box P1 -0.0871105
PTMA prothymosin, alpha -0.0845436
CCND1 cyclin D1 -0.0837522
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0718433
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0713655
NPAS2 neuronal PAS domain protein 2 -0.0698826
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0691807
BMP10 bone morphogenetic protein 10 -0.0687728
FLNB filamin B, beta -0.0668335
GLI2 GLI family zinc finger 2 -0.0662708
AHNAK AHNAK nucleoprotein -0.0638159
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0633545
DPYD dihydropyrimidine dehydrogenase -0.0602603
POTEF POTE ankyrin domain family, member F -0.0595332
ADAM10 ADAM metallopeptidase domain 10 -0.059487
EZR ezrin -0.0563593
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0535762
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0520938
TTC28 tetratricopeptide repeat domain 28 -0.0507255
GLI3 GLI family zinc finger 3 -0.0506139
RPS2 ribosomal protein S2 -0.0462623
SLC38A2 solute carrier family 38, member 2 -0.0442719
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.043599
DLG1 discs, large homolog 1 (Drosophila) -0.0412842
EFNA5 ephrin-A5 -0.040934
TJP1 tight junction protein 1 -0.0403202
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.040307
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0398761
NF1 neurofibromin 1 -0.0397572
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0393222
RAB10 RAB10, member RAS oncogene family -0.0388794
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0383082
GSE1 Gse1 coiled-coil protein -0.0372049
PTPRG protein tyrosine phosphatase, receptor type, G -0.0371427
EVI5 ecotropic viral integration site 5 -0.0368112
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0367756
CUX1 cut-like homeobox 1 -0.036372
TBC1D22A TBC1 domain family, member 22A -0.0363715
CLTC clathrin, heavy chain (Hc) -0.0354978
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0351664
NCEH1 neutral cholesterol ester hydrolase 1 -0.0349263
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0348097
ANXA1 annexin A1 -0.0330929
RPL7 ribosomal protein L7 -0.0329882
LOC112694756 uncharaterized LOC112694756 -0.0326947
ARL4C ADP-ribosylation factor-like 4C -0.0326225
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0317795
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0314684
MED13 mediator complex subunit 13 -0.0310264
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0308513
MKI67 marker of proliferation Ki-67 -0.0307485
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0307209
EBNA1BP2 EBNA1 binding protein 2 -0.0301275
TAS2R14 taste receptor, type 2, member 14 -0.0300644
CENPF centromere protein F, 350/400kDa -0.0300331
DIAPH3 diaphanous-related formin 3 -0.0299811
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0295427
ZNF438 zinc finger protein 438 -0.029333
RFC3 replication factor C (activator 1) 3, 38kDa -0.0291108
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0290446
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0289118
PLCE1 phospholipase C, epsilon 1 -0.0287725
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0284042
ZNF217 zinc finger protein 217 -0.0281216
UBC ubiquitin C -0.0280294
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0279294
MAP4 microtubule-associated protein 4 -0.0278779
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0278315
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0276155
NBEA neurobeachin -0.027609
SRRM2 serine/arginine repetitive matrix 2 -0.0275089
DSCAM Down syndrome cell adhesion molecule -0.0273991
VCL vinculin -0.0272564
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.027205
SFPQ splicing factor proline/glutamine-rich -0.0271491
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0271476
USP34 ubiquitin specific peptidase 34 -0.027135
HDAC9 histone deacetylase 9 -0.0270866
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0270714
SPIDR scaffolding protein involved in DNA repair -0.0270304
ZBTB38 zinc finger and BTB domain containing 38 -0.0263538
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0260138
MYO5C myosin VC -0.0256014
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0254815
LDHA lactate dehydrogenase A -0.0253536
NFIA nuclear factor I/A -0.0249779
EML4 echinoderm microtubule associated protein like 4 -0.0248306
FER1L6 fer-1-like family member 6 -0.0245752
SOS1 son of sevenless homolog 1 (Drosophila) -0.0244518
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0244114
S100A4 S100 calcium binding protein A4 -0.0240459
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0239218