Clotrimazole_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked 0.0933917
AKAP12 A kinase (PRKA) anchor protein 12 0.0889067
GPC6 glypican 6 0.0799163
B2M beta-2-microglobulin 0.0710669
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.068141
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0606491
RPS12 ribosomal protein S12 0.0597343
RPL14 ribosomal protein L14 0.0523946
HDAC9 histone deacetylase 9 0.0523869
NRIP1 nuclear receptor interacting protein 1 0.0510149
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0502059
EHBP1 EH domain binding protein 1 0.0495917
COL6A3 collagen, type VI, alpha 3 0.0493967
ATXN1 ataxin 1 0.0468884
AHNAK AHNAK nucleoprotein 0.0437045
OGA O-GlcNAcase 0.0421314
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0413565
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0388463
VCAN versican 0.0387508
TPT1 tumor protein, translationally-controlled 1 0.0386015
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0375523
ABTB3 ankyrin repeat and BTB domain containing 3 0.0374149
GLIS3 GLIS family zinc finger 3 0.0360558
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0352134
VCL vinculin 0.0349849
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0338291
WFDC10B WAP four-disulfide core domain 10B 0.0329319
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0328853
GOLGB1 golgin B1 0.0314229
FER fer (fps/fes related) tyrosine kinase 0.0310271
BICC1 BicC family RNA binding protein 1 0.030706
RPS17 ribosomal protein S17 0.0305303
AKAP9 A kinase (PRKA) anchor protein 9 0.0305292
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0301817
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0297471
ZSWIM6 zinc finger, SWIM-type containing 6 0.0297128
DSCAM Down syndrome cell adhesion molecule 0.0294631
SMAD3 SMAD family member 3 0.0288305
ASPH aspartate beta-hydroxylase 0.0285295
CD2AP CD2-associated protein 0.027888
CEP250 centrosomal protein 250kDa 0.0276419
TAS2R14 taste receptor, type 2, member 14 0.0272544
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0261721
RAB7A RAB7A, member RAS oncogene family 0.0251806
PTPRF protein tyrosine phosphatase, receptor type, F 0.0246093
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0242717
PCBP3 poly(rC) binding protein 3 0.0232899
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0232652
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0232467
MT1X metallothionein 1X 0.0231211
SDC4 syndecan 4 0.0230213
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.022962
FHIT fragile histidine triad 0.0228217
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0222461
EXT1 exostosin glycosyltransferase 1 0.022144
BTBD9 BTB (POZ) domain containing 9 0.0219665
ANKRD11 ankyrin repeat domain 11 0.0219015
THBS2 thrombospondin 2 0.0218678
ANGPTL4 angiopoietin-like 4 0.0216547
HDAC8 histone deacetylase 8 0.0214779
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.021367
ZC3H12B zinc finger CCCH-type containing 12B 0.0213368
SH3BP4 SH3-domain binding protein 4 0.0207588
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0207272
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.020713
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0206966
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0205077
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0203993
EZR ezrin 0.0200488
MAPK8 mitogen-activated protein kinase 8 0.0197662
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0197595
TMEM132D transmembrane protein 132D 0.0196856
ATM ATM serine/threonine kinase 0.0195838
ARHGAP5 Rho GTPase activating protein 5 0.0195543
PHF3 PHD finger protein 3 0.0194053
EGFR epidermal growth factor receptor 0.0193733
FBXL2 F-box and leucine-rich repeat protein 2 0.0192947
SCAPER S-phase cyclin A-associated protein in the ER 0.0191878
CHD9 chromodomain helicase DNA binding protein 9 0.0189764
ERBIN erbb2 interacting protein 0.0187155
CTNND1 catenin (cadherin-associated protein), delta 1 0.0187041
RPL12 ribosomal protein L12 0.0186463
FMNL2 formin-like 2 0.0185497
AHNAK2 AHNAK nucleoprotein 2 0.0185345
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0184978
NFE2L2 nuclear factor, erythroid 2-like 2 0.0184785
ADORA2B adenosine A2b receptor 0.0183938
ZNF644 zinc finger protein 644 0.018285
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0182603
SETX senataxin 0.0182467
TRA2A transformer 2 alpha homolog (Drosophila) 0.0179983
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0178758
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0177545
ANKLE2 ankyrin repeat and LEM domain containing 2 0.017427
CHIC2 cysteine-rich hydrophobic domain 2 0.0173452
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0173245
RPS3 ribosomal protein S3 0.0172913
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0172421
ARHGAP22 Rho GTPase activating protein 22 0.0170178
SOX9 SRY (sex determining region Y)-box 9 0.0169503

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.180195
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.170492
NAMPT nicotinamide phosphoribosyltransferase -0.14063
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.12831
PTMA prothymosin, alpha -0.0960602
FN1 fibronectin 1 -0.0951986
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0919382
UGCG UDP-glucose ceramide glucosyltransferase -0.0867602
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0853708
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0853315
FRMD4A FERM domain containing 4A -0.0790988
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0755404
CD44 CD44 molecule (Indian blood group) -0.0709697
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0682818
IGFBP3 insulin-like growth factor binding protein 3 -0.0678886
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0672662
FTH1 ferritin, heavy polypeptide 1 -0.0638054
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0610859
FNDC3B fibronectin type III domain containing 3B -0.061084
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.060428
PDIA3 protein disulfide isomerase family A, member 3 -0.057633
RPS6 ribosomal protein S6 -0.0572916
ZMYND8 zinc finger, MYND-type containing 8 -0.0544177
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0535866
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0527777
PDE10A phosphodiesterase 10A -0.0511049
KYNU kynureninase -0.0509408
STC1 stanniocalcin 1 -0.0508537
TPM4 tropomyosin 4 -0.0505959
C3 complement component 3 -0.0490919
CDH13 cadherin 13 -0.0490635
HLA-B major histocompatibility complex, class I, B -0.0481304
SLC38A1 solute carrier family 38, member 1 -0.047587
NDRG1 N-myc downstream regulated 1 -0.047155
NAP1L1 nucleosome assembly protein 1-like 1 -0.0465863
POTEF POTE ankyrin domain family, member F -0.0462603
PKM pyruvate kinase, muscle -0.0457256
SFTPA2 surfactant protein A2 -0.0455282
TPM1 tropomyosin 1 (alpha) -0.045444
HLA-E major histocompatibility complex, class I, E -0.0453681
PCBP2 poly(rC) binding protein 2 -0.0447437
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0446637
TGFBI transforming growth factor, beta-induced, 68kDa -0.0441926
RPLP1 ribosomal protein, large, P1 -0.0422334
ADM adrenomedullin -0.0421894
RPL35A ribosomal protein L35a -0.0419202
PLIN2 perilipin 2 -0.0416404
LOC112694756 uncharaterized LOC112694756 -0.0411757
IFITM1 interferon induced transmembrane protein 1 -0.040737
HMGA1 high mobility group AT-hook 1 -0.0405787
FTL ferritin, light polypeptide -0.0404513
MXI1 MAX interactor 1, dimerization protein -0.0397918
SPAG9 sperm associated antigen 9 -0.0397164
CENPF centromere protein F, 350/400kDa -0.0388416
CALR calreticulin -0.0388407
ADAM12 ADAM metallopeptidase domain 12 -0.0387398
GNAS GNAS complex locus -0.0387281
COL1A2 collagen, type I, alpha 2 -0.0380409
KMT2E lysine (K)-specific methyltransferase 2E -0.0372902
ANLN anillin, actin binding protein -0.0372627
RPL7 ribosomal protein L7 -0.0364937
VEGFA vascular endothelial growth factor A -0.0362732
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0362708
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0356621
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0356351
MSN moesin -0.0352713
TXNIP thioredoxin interacting protein -0.0352591
TPX2 TPX2, microtubule-associated -0.0347367
MKI67 marker of proliferation Ki-67 -0.0346776
CCNL1 cyclin L1 -0.0343675
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0342912
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0340471
BTG1 B-cell translocation gene 1, anti-proliferative -0.0337887
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0336939
CADM1 cell adhesion molecule 1 -0.0331017
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0328578
TAGLN2 transgelin 2 -0.0322259
TKT transketolase -0.0321799
IFITM3 interferon induced transmembrane protein 3 -0.0320085
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0318773
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.031794
RPS23 ribosomal protein S23 -0.0317655
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0316357
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0315287
CTSB cathepsin B -0.0311475
KPNB1 karyopherin (importin) beta 1 -0.0311167
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0307945
LAMP2 lysosomal-associated membrane protein 2 -0.0307808
MATR3 matrin 3 -0.0307415
WDFY1 WD repeat and FYVE domain containing 1 -0.0306778
ESYT2 extended synaptotagmin-like protein 2 -0.0305965
CTSD cathepsin D -0.0302645
CLMP CXADR-like membrane protein -0.0302141
SAMHD1 SAM domain and HD domain 1 -0.0301666
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0300496
SOX5 SRY (sex determining region Y)-box 5 -0.029849
COL1A1 collagen, type I, alpha 1 -0.0298385
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.029834
MAP4 microtubule-associated protein 4 -0.0298287
RPL39 ribosomal protein L39 -0.0297692