Clotrimazole_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.110057
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0743969
BIRC3 baculoviral IAP repeat containing 3 0.0709629
CD44 CD44 molecule (Indian blood group) 0.065799
FMNL2 formin-like 2 0.0596458
RBM39 RNA binding motif protein 39 0.0559707
ANKRD28 ankyrin repeat domain 28 0.0558158
YBX3 Y box binding protein 3 0.0490091
WAC WW domain containing adaptor with coiled-coil 0.0461347
ZNF292 zinc finger protein 292 0.0460473
FNDC3B fibronectin type III domain containing 3B 0.0442757
TXNRD1 thioredoxin reductase 1 0.0441701
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0431611
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.041529
YAP1 Yes-associated protein 1 0.0409378
NAMPT nicotinamide phosphoribosyltransferase 0.0404928
AKAP12 A kinase (PRKA) anchor protein 12 0.0397724
PBX3 pre-B-cell leukemia homeobox 3 0.0395827
RNF145 ring finger protein 145 0.0394754
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.039196
PCBP2 poly(rC) binding protein 2 0.0371925
EFNA5 ephrin-A5 0.0370968
CUL3 cullin 3 0.0366445
RBM25 RNA binding motif protein 25 0.0359451
RICTOR RPTOR independent companion of MTOR, complex 2 0.0357958
TRA2A transformer 2 alpha homolog (Drosophila) 0.0353553
CHD1 chromodomain helicase DNA binding protein 1 0.0352454
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0348025
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.033868
KTN1 kinectin 1 (kinesin receptor) 0.0338514
CSNK1A1 casein kinase 1, alpha 1 0.0337836
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0333458
RPL37A ribosomal protein L37a 0.0332928
RB1CC1 RB1-inducible coiled-coil 1 0.0331775
PNISR PNN-interacting serine/arginine-rich protein 0.0327951
DSCAM Down syndrome cell adhesion molecule 0.0326473
PHF20 PHD finger protein 20 0.032446
B2M beta-2-microglobulin 0.0316649
PDE4D phosphodiesterase 4D, cAMP-specific 0.0314621
DIAPH3 diaphanous-related formin 3 0.0313696
RTN4 reticulon 4 0.0311199
SET SET nuclear proto-oncogene 0.0297288
PKM pyruvate kinase, muscle 0.0290663
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0290134
CXCL8 chemokine (C-X-C motif) ligand 8 0.0288333
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0286206
ZFAND6 zinc finger, AN1-type domain 6 0.0285373
RPS12 ribosomal protein S12 0.028499
PIAS1 protein inhibitor of activated STAT, 1 0.0284537
PTBP2 polypyrimidine tract binding protein 2 0.0284435
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0283177
KMT2C lysine (K)-specific methyltransferase 2C 0.0281773
STK24 serine/threonine kinase 24 0.0280718
GIGYF2 GRB10 interacting GYF protein 2 0.0276708
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0274383
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0273966
CUL5 cullin 5 0.0272939
SENP6 SUMO1/sentrin specific peptidase 6 0.0269278
NCEH1 neutral cholesterol ester hydrolase 1 0.0268954
PCM1 pericentriolar material 1 0.0268478
TPR translocated promoter region, nuclear basket protein 0.026731
SMAD3 SMAD family member 3 0.0267174
CENPF centromere protein F, 350/400kDa 0.0267158
KIF5B kinesin family member 5B 0.0265505
NFE2L2 nuclear factor, erythroid 2-like 2 0.0265444
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0264109
H3-3B H3.3 histone B 0.0263509
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0260196
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0259764
SLMAP sarcolemma associated protein 0.0258237
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0257174
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0257099
RSRC2 arginine/serine-rich coiled-coil 2 0.0255828
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0255081
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0254841
PHIP pleckstrin homology domain interacting protein 0.0254277
KDM2A lysine (K)-specific demethylase 2A 0.025355
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0252926
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0251476
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0250901
MBD5 methyl-CpG binding domain protein 5 0.0250335
GGNBP2 gametogenetin binding protein 2 0.0249061
RPS3 ribosomal protein S3 0.0248218
AKAP9 A kinase (PRKA) anchor protein 9 0.024485
NPTN neuroplastin 0.0243593
TENT2 terminal nucleotidyltransferase 2 0.0243423
MTREX Mtr4 exosome RNA helicase 0.0241851
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.024177
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0239197
FNBP4 formin binding protein 4 0.0237731
ADAM10 ADAM metallopeptidase domain 10 0.0237122
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0236467
CEP57 centrosomal protein 57kDa 0.0234326
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.023428
CEP295 centrosomal protein 295kDa 0.0232758
FAM3C family with sequence similarity 3, member C 0.0230964
XPO1 exportin 1 0.0229428
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0227794
PFN1 profilin 1 0.0226282
UBP1 upstream binding protein 1 (LBP-1a) 0.0222458

decreased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.119668
AHNAK AHNAK nucleoprotein -0.078941
LDHA lactate dehydrogenase A -0.0775333
INTS6 integrator complex subunit 6 -0.0651167
IGFBP3 insulin-like growth factor binding protein 3 -0.0604467
LOC112694756 uncharaterized LOC112694756 -0.055766
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0551985
TPT1 tumor protein, translationally-controlled 1 -0.0547902
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0518559
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0499696
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.047922
ATG7 autophagy related 7 -0.0456778
CANX calnexin -0.0453995
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0428802
ZBTB20 zinc finger and BTB domain containing 20 -0.0422567
MYOF myoferlin -0.0397691
DENND1A DENN/MADD domain containing 1A -0.0393469
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0389875
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0384474
AEBP2 AE binding protein 2 -0.037593
FMN1 formin 1 -0.0374396
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0354789
SH3KBP1 SH3-domain kinase binding protein 1 -0.0345611
IGF2 insulin-like growth factor 2 -0.0343722
PCED1B PC-esterase domain containing 1B -0.0324913
ANKRD11 ankyrin repeat domain 11 -0.0324692
THSD4 thrombospondin, type I, domain containing 4 -0.0322612
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0317678
CAVIN1 caveolae associated protein 1 -0.0310151
COL5A1 collagen, type V, alpha 1 -0.0307513
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0307177
IARS1 isoleucyl-tRNA synthetase 1 -0.0304031
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0303015
NCOR1 nuclear receptor corepressor 1 -0.0297809
SOD2 superoxide dismutase 2, mitochondrial -0.0294559
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0292632
CCND1 cyclin D1 -0.0288168
ATM ATM serine/threonine kinase -0.0284186
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0280941
GPC5 glypican 5 -0.0280209
PODXL podocalyxin-like -0.0279775
DNAAF9 dynein axonemal assembly factor 9 -0.0274005
AHNAK2 AHNAK nucleoprotein 2 -0.0271624
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0270186
MBNL2 muscleblind-like splicing regulator 2 -0.0269841
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0269019
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0268352
RAI14 retinoic acid induced 14 -0.0266723
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0266114
NDRG1 N-myc downstream regulated 1 -0.0265878
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0263456
RAD51B RAD51 paralog B -0.0261084
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0259257
APOLD1 apolipoprotein L domain containing 1 -0.0256213
PLEK2 pleckstrin 2 -0.0256047
ARF1 ADP-ribosylation factor 1 -0.0253719
PCNX4 pecanex 4 -0.0253082
TPM4 tropomyosin 4 -0.0251196
DPYD dihydropyrimidine dehydrogenase -0.0250863
RNF213 ring finger protein 213 -0.0250723
PRR16 proline rich 16 -0.024892
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0248502
AFDN afadin, adherens junction formation factor -0.024795
SLC35F3 solute carrier family 35, member F3 -0.0245522
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0244386
BTG1 B-cell translocation gene 1, anti-proliferative -0.0242199
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0241195
NT5E 5'-nucleotidase, ecto (CD73) -0.0236576
EGR1 early growth response 1 -0.0234127
TMEM14B transmembrane protein 14B -0.0233453
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0232908
TVP23C-CDRT4 TVP23C-CDRT4 readthrough -0.0231922
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0230886
DST dystonin -0.0222941
THBS1 thrombospondin 1 -0.0221462
PURA purine-rich element binding protein A -0.0218217
RIGI RNA sensor RIG-I -0.0217683
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0215871
RDX radixin -0.0213048
SPDYA speedy/RINGO cell cycle regulator family member A -0.0211713
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0211465
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0210455
SKI SKI proto-oncogene -0.0210265
MPRIP myosin phosphatase Rho interacting protein -0.0209972
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0209949
TRAM2 translocation associated membrane protein 2 -0.0204739
KLF3 Kruppel-like factor 3 (basic) -0.0204276
MON2 MON2 homolog (S. cerevisiae) -0.0204122
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0202977
ZBTB38 zinc finger and BTB domain containing 38 -0.0202206
IL1RAP interleukin 1 receptor accessory protein -0.0202182
FAM114A1 family with sequence similarity 114, member A1 -0.0201482
HOOK2 hook microtubule-tethering protein 2 -0.0200996
GPC6 glypican 6 -0.0198972
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0196484
PDIA3 protein disulfide isomerase family A, member 3 -0.0196108
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0195789
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0194953
POTEF POTE ankyrin domain family, member F -0.0189273
ZNF12 zinc finger protein 12 -0.0188406