Clotrimazole_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clotrimazole perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clotrimazole_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.139399
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.097371
AKAP12 A kinase (PRKA) anchor protein 12 0.0912757
TRIO trio Rho guanine nucleotide exchange factor 0.0858288
NDRG1 N-myc downstream regulated 1 0.0808852
B2M beta-2-microglobulin 0.0801701
VEGFA vascular endothelial growth factor A 0.0764073
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0738691
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0738042
COPA coatomer protein complex, subunit alpha 0.0671751
STC2 stanniocalcin 2 0.0651679
CXCL8 chemokine (C-X-C motif) ligand 8 0.0627382
ZSWIM6 zinc finger, SWIM-type containing 6 0.0626707
SMAD3 SMAD family member 3 0.0603258
RAI14 retinoic acid induced 14 0.0602065
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0597911
APLP2 amyloid beta (A4) precursor-like protein 2 0.0586075
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.058205
AKAP9 A kinase (PRKA) anchor protein 9 0.056816
NRIP1 nuclear receptor interacting protein 1 0.0565964
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0552538
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0552164
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0531413
RNF145 ring finger protein 145 0.0529939
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0527065
ENO2 enolase 2 (gamma, neuronal) 0.0526394
TXNIP thioredoxin interacting protein 0.0523053
RICTOR RPTOR independent companion of MTOR, complex 2 0.0522904
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0512365
MT2A metallothionein 2A 0.0510399
PTK2 protein tyrosine kinase 2 0.0496611
TTC3 tetratricopeptide repeat domain 3 0.0467893
DOCK5 dedicator of cytokinesis 5 0.0464469
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0461515
MBNL1 muscleblind-like splicing regulator 1 0.0461176
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0461104
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0455208
GRB10 growth factor receptor-bound protein 10 0.0451458
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0448341
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0446241
SKAP2 src kinase associated phosphoprotein 2 0.0445087
NPAS2 neuronal PAS domain protein 2 0.0441656
AKAP13 A kinase (PRKA) anchor protein 13 0.0437433
CD109 CD109 molecule 0.0423085
ZC3H12C zinc finger CCCH-type containing 12C 0.0419647
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0419023
SEC23A Sec23 homolog A (S. cerevisiae) 0.0417382
HILPDA hypoxia inducible lipid droplet-associated 0.0417101
HIPK2 homeodomain interacting protein kinase 2 0.0412978
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0410891
FNDC3A fibronectin type III domain containing 3A 0.0410546
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0405229
TPR translocated promoter region, nuclear basket protein 0.0404399
ESYT2 extended synaptotagmin-like protein 2 0.0401984
SUCO SUN domain containing ossification factor 0.0401233
EFNA5 ephrin-A5 0.0391561
FTL ferritin, light polypeptide 0.039134
PDLIM5 PDZ and LIM domain 5 0.0391269
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0389194
DST dystonin 0.0384947
PALLD palladin, cytoskeletal associated protein 0.0377077
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0374334
KMT2E lysine (K)-specific methyltransferase 2E 0.0374149
RASAL2 RAS protein activator like 2 0.0371116
EPS8 epidermal growth factor receptor pathway substrate 8 0.0368482
VEGFC vascular endothelial growth factor C 0.0365085
MYOF myoferlin 0.0361858
GOLGA4 golgin A4 0.0358948
KTN1 kinectin 1 (kinesin receptor) 0.0350854
SPAG9 sperm associated antigen 9 0.0350298
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0345391
ZCCHC7 zinc finger, CCHC domain containing 7 0.0342753
GPC6 glypican 6 0.0340401
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0334508
BIRC6 baculoviral IAP repeat containing 6 0.0330738
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0324411
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0324269
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0321083
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0316668
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0316334
LTBP1 latent transforming growth factor beta binding protein 1 0.0313598
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0310601
TXNRD1 thioredoxin reductase 1 0.0305984
ZFP36L1 ZFP36 ring finger protein-like 1 0.0302943
RBPMS RNA binding protein with multiple splicing 0.0299576
ZNF638 zinc finger protein 638 0.029939
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0297953
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0297426
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.029337
HELZ helicase with zinc finger 0.029312
PARD3 par-3 family cell polarity regulator 0.0290332
KDM2A lysine (K)-specific demethylase 2A 0.028933
GOLGB1 golgin B1 0.0282782
FNDC3B fibronectin type III domain containing 3B 0.0282137
VCL vinculin 0.0281972
FAM13A family with sequence similarity 13, member A 0.028165
NRP1 neuropilin 1 0.0280862
FLNB filamin B, beta 0.0280052
NTN4 netrin 4 0.0278678
FTH1 ferritin, heavy polypeptide 1 0.0276672

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.198089
FN1 fibronectin 1 -0.146564
NRG1 neuregulin 1 -0.0876066
SQSTM1 sequestosome 1 -0.081486
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0780614
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0569738
TPT1 tumor protein, translationally-controlled 1 -0.0521867
NAMPT nicotinamide phosphoribosyltransferase -0.0505717
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.049458
HLA-B major histocompatibility complex, class I, B -0.0489032
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0377798
ETV1 ets variant 1 -0.0373911
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.036217
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.035372
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0342805
KLHL5 kelch-like family member 5 -0.0341463
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.033737
OSMR oncostatin M receptor -0.0334055
RPS24 ribosomal protein S24 -0.0329872
TGFA transforming growth factor, alpha -0.0305087
ARF1 ADP-ribosylation factor 1 -0.0286031
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0266598
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0259337
NPC1 Niemann-Pick disease, type C1 -0.0256723
RPL35A ribosomal protein L35a -0.0256398
RPL9 ribosomal protein L9 -0.0254896
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.025059
LRRC23 leucine rich repeat containing 23 -0.0244384
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0242837
LRMDA leucine rich melanocyte differentiation associated -0.0236706
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0231718
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0231206
CANX calnexin -0.0228865
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0225167
MKI67 marker of proliferation Ki-67 -0.0223961
IFI16 interferon, gamma-inducible protein 16 -0.0217919
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0208221
S100A6 S100 calcium binding protein A6 -0.0206983
RPL26 ribosomal protein L26 -0.0205165
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0203907
FOXP1 forkhead box P1 -0.0196753
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0192875
FAM20C family with sequence similarity 20, member C -0.0192504
PTMA prothymosin, alpha -0.0190934
PELO pelota homolog (Drosophila) -0.0190257
DNAH5 dynein, axonemal, heavy chain 5 -0.0184061
ADAR adenosine deaminase, RNA-specific -0.0180332
LOC112694756 uncharaterized LOC112694756 -0.0179994
NAP1L1 nucleosome assembly protein 1-like 1 -0.0175428
CDCP1 CUB domain containing protein 1 -0.0175395
CENPF centromere protein F, 350/400kDa -0.0172877
SMIM14 small integral membrane protein 14 -0.0168775
MMP13 matrix metallopeptidase 13 -0.0165076
RAD21 RAD21 homolog (S. pombe) -0.0163499
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0160306
RPLP0 ribosomal protein, large, P0 -0.0158047
CD63 CD63 molecule -0.0157771
RPH3AL rabphilin 3A-like (without C2 domains) -0.0156369
IGF2R insulin-like growth factor 2 receptor -0.0154327
RPL34 ribosomal protein L34 -0.0153682
AHNAK AHNAK nucleoprotein -0.0153001
RPL12 ribosomal protein L12 -0.015282
EWSR1 EWS RNA-binding protein 1 -0.0152164
SYT1 synaptotagmin I -0.0151817
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0150658
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0150613
TAS2R14 taste receptor, type 2, member 14 -0.0149959
ZNF217 zinc finger protein 217 -0.0149589
CTSD cathepsin D -0.0149411
HMGB1 high mobility group box 1 -0.0146757
RPS27A ribosomal protein S27a -0.0145858
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0145092
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0145065
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0144864
UBB ubiquitin B -0.0144713
RPL38 ribosomal protein L38 -0.0141713
ZMYND8 zinc finger, MYND-type containing 8 -0.0140914
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0139503
H3-3B H3.3 histone B -0.0139009
CFB complement factor B -0.0138299
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0138131
RPL4 ribosomal protein L4 -0.0137946
ZBTB20 zinc finger and BTB domain containing 20 -0.0137737
CAB39 calcium binding protein 39 -0.01375
RPL31 ribosomal protein L31 -0.0136447
GNAS GNAS complex locus -0.0135931
GNS glucosamine (N-acetyl)-6-sulfatase -0.0134365
TENM4 teneurin transmembrane protein 4 -0.013425
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0133503
EIF1 eukaryotic translation initiation factor 1 -0.0133395
RPL30 ribosomal protein L30 -0.0132503
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0130931
ZFR zinc finger RNA binding protein -0.0129551
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0128903
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0128295
BZW1 basic leucine zipper and W2 domains 1 -0.0126885
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.012658
RPS28 ribosomal protein S28 -0.0125927
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0124511
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0123967