Cloxacillin (sodium)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.155089
SOD2 superoxide dismutase 2, mitochondrial 0.0816844
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0776376
MYH9 myosin, heavy chain 9, non-muscle 0.0751236
TRIO trio Rho guanine nucleotide exchange factor 0.0744652
ASPH aspartate beta-hydroxylase 0.0708731
APP amyloid beta (A4) precursor protein 0.0541655
AHNAK AHNAK nucleoprotein 0.0529655
NAMPT nicotinamide phosphoribosyltransferase 0.0525881
FRMD4A FERM domain containing 4A 0.0504225
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0483564
IGFBP3 insulin-like growth factor binding protein 3 0.0466255
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.046232
ZFAND3 zinc finger, AN1-type domain 3 0.0434632
IFRD1 interferon-related developmental regulator 1 0.0424286
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0412023
NAV2 neuron navigator 2 0.04041
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0396535
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.039335
FMNL2 formin-like 2 0.0392776
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0387503
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0371524
CANX calnexin 0.0356925
ATP13A3 ATPase type 13A3 0.0354029
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0350825
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0327379
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.032619
ATF3 activating transcription factor 3 0.0326012
SPAG9 sperm associated antigen 9 0.03245
SUCO SUN domain containing ossification factor 0.0321929
PTK2 protein tyrosine kinase 2 0.0317383
CTBP2 C-terminal binding protein 2 0.0316669
ANXA5 annexin A5 0.0312839
ESYT2 extended synaptotagmin-like protein 2 0.0311384
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0310956
KDM3A lysine (K)-specific demethylase 3A 0.0307673
RAB1A RAB1A, member RAS oncogene family 0.0303062
ANKRD11 ankyrin repeat domain 11 0.0302083
HBP1 HMG-box transcription factor 1 0.030121
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0300979
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0300366
UBQLN1 ubiquilin 1 0.0294989
FAM13A family with sequence similarity 13, member A 0.0291433
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0291026
HELZ helicase with zinc finger 0.0290064
MARCHF6 membrane associated ring-CH-type finger 6 0.0289573
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0287293
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0281591
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0280041
KMT2C lysine (K)-specific methyltransferase 2C 0.0276987
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.027331
ANKRD33B ankyrin repeat domain 33B 0.027164
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.026939
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0268767
RB1CC1 RB1-inducible coiled-coil 1 0.0266921
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0266237
COG5 component of oligomeric golgi complex 5 0.0265238
RAD21 RAD21 homolog (S. pombe) 0.0257922
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0252523
OGA O-GlcNAcase 0.0247298
JAK1 Janus kinase 1 0.024665
ICAM1 intercellular adhesion molecule 1 0.0244614
GPC5 glypican 5 0.0242419
NFE2L1 nuclear factor, erythroid 2-like 1 0.0241922
PLEC plectin 0.023946
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.023848
SMAD3 SMAD family member 3 0.0238262
SDC4 syndecan 4 0.0238235
HDLBP high density lipoprotein binding protein 0.0237947
CAVIN1 caveolae associated protein 1 0.0236665
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0235748
BHLHE40 basic helix-loop-helix family, member e40 0.0233581
TRA2A transformer 2 alpha homolog (Drosophila) 0.0231362
TTC3 tetratricopeptide repeat domain 3 0.0229599
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0225838
CDK13 cyclin-dependent kinase 13 0.0224068
DOCK5 dedicator of cytokinesis 5 0.0220607
DENND4C DENN/MADD domain containing 4C 0.0220415
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0220319
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0218702
IARS1 isoleucyl-tRNA synthetase 1 0.0212311
PUM2 pumilio RNA-binding family member 2 0.0211578
CHD1 chromodomain helicase DNA binding protein 1 0.0210634
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0210595
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0209151
EIF4A2 eukaryotic translation initiation factor 4A2 0.0208898
HMGB2 high mobility group box 2 0.0208706
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0207966
USP3 ubiquitin specific peptidase 3 0.0207785
BZW1 basic leucine zipper and W2 domains 1 0.0207777
CADM1 cell adhesion molecule 1 0.0207276
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0205951
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0204624
RPS2 ribosomal protein S2 0.0202391
EIF4H eukaryotic translation initiation factor 4H 0.020214
WAC WW domain containing adaptor with coiled-coil 0.0200896
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0200645
IQGAP1 IQ motif containing GTPase activating protein 1 0.0200413
CRY1 cryptochrome circadian clock 1 0.0199938
ABTB3 ankyrin repeat and BTB domain containing 3 0.019927

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.139551
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.137016
ZFP36L1 ZFP36 ring finger protein-like 1 -0.136253
TMSB10 thymosin beta 10 -0.126409
FTL ferritin, light polypeptide -0.117573
CCL2 chemokine (C-C motif) ligand 2 -0.113866
PFN1 profilin 1 -0.0920364
CSF1 colony stimulating factor 1 (macrophage) -0.0786945
B2M beta-2-microglobulin -0.0742007
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0706248
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0677842
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0665614
MT2A metallothionein 2A -0.0658848
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.061946
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0618604
CBX3 chromobox homolog 3 -0.0564468
MAP1B microtubule-associated protein 1B -0.0549429
TUBA1B tubulin, alpha 1b -0.0526365
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0525987
HLA-B major histocompatibility complex, class I, B -0.0482542
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0478721
MGST1 microsomal glutathione S-transferase 1 -0.0468861
RPL35A ribosomal protein L35a -0.0458436
CYB5R3 cytochrome b5 reductase 3 -0.0452461
CD44 CD44 molecule (Indian blood group) -0.0442635
POTEF POTE ankyrin domain family, member F -0.0430118
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0429902
HSPB1 heat shock 27kDa protein 1 -0.0427691
PLIN2 perilipin 2 -0.0396549
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0395372
RPL23 ribosomal protein L23 -0.0378814
MYADM myeloid-associated differentiation marker -0.0377863
CTSD cathepsin D -0.0368862
RTN4 reticulon 4 -0.0349945
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0327084
DIAPH3 diaphanous-related formin 3 -0.0324635
UGCG UDP-glucose ceramide glucosyltransferase -0.0321408
HMGA1 high mobility group AT-hook 1 -0.0315591
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0314927
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0314912
PKM pyruvate kinase, muscle -0.0310416
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0309721
ARL4C ADP-ribosylation factor-like 4C -0.0303724
RPS6 ribosomal protein S6 -0.0303271
TSHZ2 teashirt zinc finger homeobox 2 -0.0303124
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0299104
GLIS3 GLIS family zinc finger 3 -0.0298517
GPC6 glypican 6 -0.0297098
CKAP4 cytoskeleton-associated protein 4 -0.029393
RPL9 ribosomal protein L9 -0.0289209
TUBA1C tubulin, alpha 1c -0.0287769
TAGLN2 transgelin 2 -0.0284821
S100A11 S100 calcium binding protein A11 -0.0282867
IFI44L interferon-induced protein 44-like -0.027779
S100A6 S100 calcium binding protein A6 -0.0277295
SON SON DNA binding protein -0.0277092
IFITM3 interferon induced transmembrane protein 3 -0.0276493
HM13 histocompatibility (minor) 13 -0.0269872
IFI6 interferon, alpha-inducible protein 6 -0.0263696
IFI27 interferon, alpha-inducible protein 27 -0.0260697
S100A10 S100 calcium binding protein A10 -0.0258272
UBXN4 UBX domain protein 4 -0.0255841
LITAF lipopolysaccharide-induced TNF factor -0.0251314
CXXC1 CXXC finger protein 1 -0.0250511
IFI16 interferon, gamma-inducible protein 16 -0.0246073
MX1 MX dynamin-like GTPase 1 -0.0246062
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0245653
RPL12 ribosomal protein L12 -0.0243983
SMC4 structural maintenance of chromosomes 4 -0.023984
RPS13 ribosomal protein S13 -0.0237345
EIF5B eukaryotic translation initiation factor 5B -0.0236584
NUCB2 nucleobindin 2 -0.023493
PTBP3 polypyrimidine tract binding protein 3 -0.0233289
CDCP1 CUB domain containing protein 1 -0.0230228
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0230025
LGALS1 lectin, galactoside-binding, soluble, 1 -0.022509
SMIM44 small integral membrane protein 44 -0.0224492
LY6E lymphocyte antigen 6 complex, locus E -0.0222779
RPS19 ribosomal protein S19 -0.0222011
BIRC3 baculoviral IAP repeat containing 3 -0.0221144
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.02186
RPLP2 ribosomal protein, large, P2 -0.0217975
NRP1 neuropilin 1 -0.0215709
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0215607
TMEM165 transmembrane protein 165 -0.0214496
ANPEP alanyl (membrane) aminopeptidase -0.0211761
RAI14 retinoic acid induced 14 -0.0211082
CENPF centromere protein F, 350/400kDa -0.020836
PAX8 paired box 8 -0.0207969
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0207602
PRRC2C proline-rich coiled-coil 2C -0.0205308
CALD1 caldesmon 1 -0.0204893
ARHGAP29 Rho GTPase activating protein 29 -0.0204811
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0204742
HLA-A major histocompatibility complex, class I, A -0.0204698
HLA-C major histocompatibility complex, class I, C -0.0203937
EGR1 early growth response 1 -0.0202553
TPI1 triosephosphate isomerase 1 -0.0201951
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0199453
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0196091