Cloxacillin (sodium)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.128582
VEGFA vascular endothelial growth factor A 0.0820687
SFPQ splicing factor proline/glutamine-rich 0.0693072
IGF2 insulin-like growth factor 2 0.0651849
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0581282
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0568274
PNN pinin, desmosome associated protein 0.0486405
TRIO trio Rho guanine nucleotide exchange factor 0.0478035
PDE4D phosphodiesterase 4D, cAMP-specific 0.0477963
FNDC3B fibronectin type III domain containing 3B 0.0460587
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0458292
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0429949
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.042392
CCNL1 cyclin L1 0.0415345
SCAF8 SR-related CTD-associated factor 8 0.0412681
BRD4 bromodomain containing 4 0.0397061
SRRM2 serine/arginine repetitive matrix 2 0.0395353
SOS1 son of sevenless homolog 1 (Drosophila) 0.0389269
UTRN utrophin 0.0385046
PDE10A phosphodiesterase 10A 0.0369292
PCDH7 protocadherin 7 0.0358436
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0349838
KMT2E lysine (K)-specific methyltransferase 2E 0.0344271
DST dystonin 0.0335831
TRA2B transformer 2 beta homolog (Drosophila) 0.033247
ENAH enabled homolog (Drosophila) 0.033234
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0329568
EZR ezrin 0.0329108
CSDE1 cold shock domain containing E1, RNA-binding 0.0325716
RTN4 reticulon 4 0.0324038
TAOK1 TAO kinase 1 0.0323278
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.0321491
XPO1 exportin 1 0.0320777
ZMYM2 zinc finger, MYM-type 2 0.031893
MYH9 myosin, heavy chain 9, non-muscle 0.0317262
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0316594
RCOR1 REST corepressor 1 0.0311558
TRA2A transformer 2 alpha homolog (Drosophila) 0.031154
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0309406
CSNK1A1 casein kinase 1, alpha 1 0.0305625
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0304957
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0301612
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.030055
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0299469
PTK2 protein tyrosine kinase 2 0.0296706
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0295071
KIF1B kinesin family member 1B 0.0294899
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0292391
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0290814
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0290184
SMC1A structural maintenance of chromosomes 1A 0.0289587
FTH1 ferritin, heavy polypeptide 1 0.0289181
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0284354
NCKAP1 NCK-associated protein 1 0.0282667
BRD2 bromodomain containing 2 0.0281709
HMGA2 high mobility group AT-hook 2 0.0280208
TRIP12 thyroid hormone receptor interactor 12 0.0279454
WWC2 WW and C2 domain containing 2 0.0279218
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0277973
GIGYF2 GRB10 interacting GYF protein 2 0.0277606
POTEF POTE ankyrin domain family, member F 0.0277344
OGA O-GlcNAcase 0.0276431
ZFP36L1 ZFP36 ring finger protein-like 1 0.0275124
HELLS helicase, lymphoid-specific 0.0274052
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0273675
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0272996
PDE4B phosphodiesterase 4B, cAMP-specific 0.0270365
BTBD9 BTB (POZ) domain containing 9 0.0266625
ARID1A AT rich interactive domain 1A (SWI-like) 0.0265609
ARHGAP26 Rho GTPase activating protein 26 0.026409
RBM39 RNA binding motif protein 39 0.0263524
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0263501
VMP1 vacuole membrane protein 1 0.0263329
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0260654
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.026038
YAP1 Yes-associated protein 1 0.0260177
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0258203
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0256259
LUZP1 leucine zipper protein 1 0.0256119
NFYA nuclear transcription factor Y, alpha 0.0255668
ERBIN erbb2 interacting protein 0.0254918
EXOC6B exocyst complex component 6B 0.0254507
NCAPG2 non-SMC condensin II complex, subunit G2 0.0254487
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0254481
LMO7 LIM domain 7 0.0254368
EEF2 eukaryotic translation elongation factor 2 0.0253899
N4BP2L2 NEDD4 binding protein 2-like 2 0.0253734
IPO5 importin 5 0.0253311
TENT2 terminal nucleotidyltransferase 2 0.02532
IPO7 importin 7 0.0252656
TMEM41B transmembrane protein 41B 0.0251325
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0248629
NRDC nardilysin convertase 0.0248405
GMDS GDP-mannose 4,6-dehydratase 0.0247567
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0246569
ADAM17 ADAM metallopeptidase domain 17 0.0245682
SLTM SAFB-like, transcription modulator 0.0242997
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0242921
YBX1 Y box binding protein 1 0.0242483
CEP250 centrosomal protein 250kDa 0.02404

decreased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I -0.193624
VIM vimentin -0.189128
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119202
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0924492
PTMA prothymosin, alpha -0.0902347
NFIB nuclear factor I/B -0.0901102
MGP matrix Gla protein -0.0780436
PEG10 paternally expressed 10 -0.0774304
NFIA nuclear factor I/A -0.0698362
RPS24 ribosomal protein S24 -0.0670668
TPK1 thiamin pyrophosphokinase 1 -0.0651067
TMSB10 thymosin beta 10 -0.061877
RPL35A ribosomal protein L35a -0.0582108
RPLP1 ribosomal protein, large, P1 -0.0580429
COL1A2 collagen, type I, alpha 2 -0.0555439
MEOX2 mesenchyme homeobox 2 -0.0553841
RPS4X ribosomal protein S4, X-linked -0.0551467
RPL23 ribosomal protein L23 -0.0542524
IER3 immediate early response 3 -0.053381
MT2A metallothionein 2A -0.0528831
RPS8 ribosomal protein S8 -0.0511751
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0481403
ZEB1 zinc finger E-box binding homeobox 1 -0.0470568
ACTG1 actin gamma 1 -0.0469058
RPLP2 ribosomal protein, large, P2 -0.0464988
RPS19 ribosomal protein S19 -0.0461849
RNF130 ring finger protein 130 -0.042872
IGF2R insulin-like growth factor 2 receptor -0.0427876
RPS27A ribosomal protein S27a -0.0424797
RPL37 ribosomal protein L37 -0.0420433
RPS23 ribosomal protein S23 -0.0419838
RPL12 ribosomal protein L12 -0.0411839
RPS12 ribosomal protein S12 -0.0411004
RPL37A ribosomal protein L37a -0.0408655
RPLP0 ribosomal protein, large, P0 -0.0390361
LCORL ligand dependent nuclear receptor corepressor-like -0.0389662
NAMPT nicotinamide phosphoribosyltransferase -0.0387284
SOX4 SRY (sex determining region Y)-box 4 -0.0377871
RHOBTB3 Rho-related BTB domain containing 3 -0.0375924
CENPF centromere protein F, 350/400kDa -0.036995
MARCHF6 membrane associated ring-CH-type finger 6 -0.0367161
PDGFC platelet derived growth factor C -0.0362907
RPS5 ribosomal protein S5 -0.0361487
RPL34 ribosomal protein L34 -0.0360396
RPS14 ribosomal protein S14 -0.0354945
TPT1 tumor protein, translationally-controlled 1 -0.0353448
EIF1 eukaryotic translation initiation factor 1 -0.0348823
S100A9 S100 calcium binding protein A9 -0.0347931
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0346645
RPL28 ribosomal protein L28 -0.034613
MEIS2 Meis homeobox 2 -0.03431
FBXL7 F-box and leucine-rich repeat protein 7 -0.0340884
TMSB4X thymosin beta 4, X-linked -0.033494
RPS10 ribosomal protein S10 -0.0332632
RPL31 ribosomal protein L31 -0.0331369
RAB7A RAB7A, member RAS oncogene family -0.0329437
FOXO3 forkhead box O3 -0.0326348
RPS29 ribosomal protein S29 -0.0323769
RPL36 ribosomal protein L36 -0.0323286
TUBB tubulin, beta class I -0.0323078
SREBF2 sterol regulatory element binding transcription factor 2 -0.0317889
RPS25 ribosomal protein S25 -0.0316811
KDM3B lysine (K)-specific demethylase 3B -0.0316329
RPL11 ribosomal protein L11 -0.0313936
TPST1 tyrosylprotein sulfotransferase 1 -0.0313315
RPL26 ribosomal protein L26 -0.0310869
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0310281
CHKA choline kinase alpha -0.0306206
RPL7 ribosomal protein L7 -0.0303599
ZNF532 zinc finger protein 532 -0.0295977
RPL32 ribosomal protein L32 -0.0291359
RACK1 receptor for activated C kinase 1 -0.0287463
FTL ferritin, light polypeptide -0.0285166
TET1 tet methylcytosine dioxygenase 1 -0.0283527
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0276225
RREB1 ras responsive element binding protein 1 -0.0275872
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0275535
RPS11 ribosomal protein S11 -0.0274247
MICU1 mitochondrial calcium uptake 1 -0.0270442
SBF2 SET binding factor 2 -0.0268863
RPS3 ribosomal protein S3 -0.0263186
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0262505
PGK1 phosphoglycerate kinase 1 -0.0260779
TPI1 triosephosphate isomerase 1 -0.0259311
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0258425
LOC112694756 uncharaterized LOC112694756 -0.0256972
RPS6 ribosomal protein S6 -0.0256748
EXOC4 exocyst complex component 4 -0.0255527
KANTR KDM5C adjacent non-coding transcript -0.0254781
RPL38 ribosomal protein L38 -0.0254704
JAM3 junctional adhesion molecule 3 -0.0252586
CHD6 chromodomain helicase DNA binding protein 6 -0.0249914
FOXC1 forkhead box C1 -0.0245427
FOXP1 forkhead box P1 -0.0245238
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0240712
UVRAG UV radiation resistance associated -0.0237442
RFX7 regulatory factor X, 7 -0.0236417
NPR2 natriuretic peptide receptor 2 -0.0234773
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0234103
DENND1A DENN/MADD domain containing 1A -0.0232309