Cloxacillin (sodium)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0897087
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.087668
PDLIM5 PDZ and LIM domain 5 0.0757861
AHNAK AHNAK nucleoprotein 0.0730983
HMGA2 high mobility group AT-hook 2 0.0652906
EGFR epidermal growth factor receptor 0.0647714
ITPRID2 ITPR interacting domain containing 2 0.0631392
ZSWIM6 zinc finger, SWIM-type containing 6 0.0580457
GREB1L growth regulation by estrogen in breast cancer-like 0.0567974
INTS6 integrator complex subunit 6 0.0564958
SLC35F3 solute carrier family 35, member F3 0.0534821
EFNA5 ephrin-A5 0.0527894
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0513593
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0502797
PSD3 pleckstrin and Sec7 domain containing 3 0.0500151
SAMD4A sterile alpha motif domain containing 4A 0.0495757
PPARD peroxisome proliferator-activated receptor delta 0.0495361
THSD4 thrombospondin, type I, domain containing 4 0.049016
RASAL2 RAS protein activator like 2 0.0486674
FMNL2 formin-like 2 0.0485584
GLS2 glutaminase 2 (liver, mitochondrial) 0.0483828
MPRIP myosin phosphatase Rho interacting protein 0.0482249
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.047244
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0450254
LAMA4 laminin, alpha 4 0.0449282
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0426354
DOCK5 dedicator of cytokinesis 5 0.0423148
NPSR1 neuropeptide S receptor 1 0.0419139
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0400738
AKAP13 A kinase (PRKA) anchor protein 13 0.039582
ACTN4 actinin, alpha 4 0.0394355
ABTB3 ankyrin repeat and BTB domain containing 3 0.0383642
BMP6 bone morphogenetic protein 6 0.0379516
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0367592
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0351037
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0349013
NRIP1 nuclear receptor interacting protein 1 0.0346817
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0341982
AHRR aryl-hydrocarbon receptor repressor 0.0339135
LARP4B La ribonucleoprotein domain family, member 4B 0.0334789
HDAC9 histone deacetylase 9 0.0329011
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0328204
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0306211
ZBTB20 zinc finger and BTB domain containing 20 0.030465
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0304259
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0298079
FLNB filamin B, beta 0.0295147
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0293459
TMEM164 transmembrane protein 164 0.0292351
TRIP12 thyroid hormone receptor interactor 12 0.0291495
EHBP1 EH domain binding protein 1 0.0289228
VCAN versican 0.0288574
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0288343
RCOR1 REST corepressor 1 0.0285506
FNDC3B fibronectin type III domain containing 3B 0.0282636
RABGAP1L RAB GTPase activating protein 1-like 0.0279537
PLEC plectin 0.0278909
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0272226
PTK2 protein tyrosine kinase 2 0.0271581
TGM2 transglutaminase 2 0.027011
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0268834
PRELID2 PRELI domain containing 2 0.0267822
PDE4D phosphodiesterase 4D, cAMP-specific 0.0265755
NABP1 nucleic acid binding protein 1 0.026338
FBXO11 F-box protein 11 0.0262525
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.025659
ZMIZ1 zinc finger, MIZ-type containing 1 0.0256548
VCL vinculin 0.024897
ZCCHC7 zinc finger, CCHC domain containing 7 0.0247541
MACF1 microtubule-actin crosslinking factor 1 0.0247516
PMM2 phosphomannomutase 2 0.0243891
TGFA transforming growth factor, alpha 0.0239034
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0236672
MSN moesin 0.0234757
MAML2 mastermind-like 2 (Drosophila) 0.0234356
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0232896
SMAD3 SMAD family member 3 0.0232597
CAPRIN2 caprin family member 2 0.0232371
RAD51B RAD51 paralog B 0.0232053
GRB10 growth factor receptor-bound protein 10 0.0228694
MOSMO modulator of smoothened 0.0227473
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0227463
CDK13 cyclin-dependent kinase 13 0.0224615
NCOR2 nuclear receptor corepressor 2 0.0223551
LPP LIM domain containing preferred translocation partner in lipoma 0.0223287
THRB thyroid hormone receptor, beta 0.0222378
SULF2 sulfatase 2 0.0221332
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0216125
EFNB2 ephrin-B2 0.0216108
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0214334
DIAPH2 diaphanous-related formin 2 0.0213598
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0212866
EXT1 exostosin glycosyltransferase 1 0.0210169
PRKG1 protein kinase, cGMP-dependent, type I 0.0209915
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0209688
MYO5B myosin VB 0.0209222
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0208636
APLP2 amyloid beta (A4) precursor-like protein 2 0.020835
PICALM phosphatidylinositol binding clathrin assembly protein 0.0203848
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0203509

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.200017
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.173431
TPT1 tumor protein, translationally-controlled 1 -0.149343
NDRG1 N-myc downstream regulated 1 -0.139671
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.130158
VIM vimentin -0.119212
LMTK2 lemur tyrosine kinase 2 -0.111262
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.105164
PTMA prothymosin, alpha -0.101811
S100A10 S100 calcium binding protein A10 -0.0965822
AKAP12 A kinase (PRKA) anchor protein 12 -0.0938891
B2M beta-2-microglobulin -0.0886794
FTL ferritin, light polypeptide -0.0849838
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0827498
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0753722
EIF1 eukaryotic translation initiation factor 1 -0.0752708
UBC ubiquitin C -0.0719522
S100A6 S100 calcium binding protein A6 -0.071406
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0710617
RPS3 ribosomal protein S3 -0.069629
RPS2 ribosomal protein S2 -0.0693732
TXNRD1 thioredoxin reductase 1 -0.0675907
HMGA1 high mobility group AT-hook 1 -0.0660669
RPL12 ribosomal protein L12 -0.0656344
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.064344
RPL37A ribosomal protein L37a -0.0632514
RPS13 ribosomal protein S13 -0.0612539
GOLGA4 golgin A4 -0.0612405
RPS8 ribosomal protein S8 -0.0601568
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0598058
RPS12 ribosomal protein S12 -0.0566637
FAM107B family with sequence similarity 107, member B -0.0550468
RPL11 ribosomal protein L11 -0.0531269
RPL35A ribosomal protein L35a -0.0530971
RPL31 ribosomal protein L31 -0.0530073
UBA6 ubiquitin-like modifier activating enzyme 6 -0.052754
RPLP2 ribosomal protein, large, P2 -0.0522627
KLK10 kallikrein-related peptidase 10 -0.0521279
RPS6 ribosomal protein S6 -0.0517586
ESYT2 extended synaptotagmin-like protein 2 -0.051758
RPL30 ribosomal protein L30 -0.0514512
RPLP1 ribosomal protein, large, P1 -0.0504222
RAB1A RAB1A, member RAS oncogene family -0.049227
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0485651
S100A11 S100 calcium binding protein A11 -0.0483258
RPS27 ribosomal protein S27 -0.0481634
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0481242
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0479601
LDHA lactate dehydrogenase A -0.0470078
UPP1 uridine phosphorylase 1 -0.0469698
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0468779
RPL34 ribosomal protein L34 -0.0467348
RPL26 ribosomal protein L26 -0.0466272
RPS25 ribosomal protein S25 -0.0463044
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0457379
UBE2B ubiquitin-conjugating enzyme E2B -0.0455489
RPL8 ribosomal protein L8 -0.0452342
EMP1 epithelial membrane protein 1 -0.0446785
RIOK3 RIO kinase 3 -0.0446718
SQSTM1 sequestosome 1 -0.0439318
TM4SF1 transmembrane 4 L six family member 1 -0.0436234
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0434618
RPL36A ribosomal protein L36a -0.0434171
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0432171
KDM3A lysine (K)-specific demethylase 3A -0.0420982
PLAUR plasminogen activator, urokinase receptor -0.0416472
TPM4 tropomyosin 4 -0.0415177
RPS23 ribosomal protein S23 -0.0413641
RPLP0 ribosomal protein, large, P0 -0.0411179
RPL37 ribosomal protein L37 -0.0409448
MATR3 matrin 3 -0.0409029
FTH1 ferritin, heavy polypeptide 1 -0.0407313
RPS27A ribosomal protein S27a -0.0404187
PGK1 phosphoglycerate kinase 1 -0.0396736
ACTG1 actin gamma 1 -0.0386412
DSTN destrin (actin depolymerizing factor) -0.0381832
ITGA6 integrin, alpha 6 -0.0374006
NEK7 NIMA-related kinase 7 -0.0373853
NOP58 NOP58 ribonucleoprotein -0.0372274
JMJD1C jumonji domain containing 1C -0.0370153
AKAP9 A kinase (PRKA) anchor protein 9 -0.0369991
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0366851
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0366383
RPL7 ribosomal protein L7 -0.036476
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0363569
RPS24 ribosomal protein S24 -0.0358794
RPS29 ribosomal protein S29 -0.0358769
MTDH metadherin -0.0357402
LOC112694756 uncharaterized LOC112694756 -0.035273
RTN4 reticulon 4 -0.0350904
SEPTIN7 septin 7 -0.0348185
ACBD3 acyl-CoA binding domain containing 3 -0.0347613
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0347277
SNX9 sorting nexin 9 -0.0342585
RPL23 ribosomal protein L23 -0.0341154
SPAG9 sperm associated antigen 9 -0.0337159
RPS16 ribosomal protein S16 -0.0336549
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0335332
NAMPT nicotinamide phosphoribosyltransferase -0.0333522
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0332716