Cloxacillin (sodium)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.100407
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.095735
JMJD1C jumonji domain containing 1C 0.0847362
USP9X ubiquitin specific peptidase 9, X-linked 0.0688137
EGLN1 egl-9 family hypoxia-inducible factor 1 0.06534
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0638988
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0625965
ZNF638 zinc finger protein 638 0.0623282
ZNF292 zinc finger protein 292 0.0622866
SMYD3 SET and MYND domain containing 3 0.0562634
DST dystonin 0.0556214
NGLY1 N-glycanase 1 0.0551233
KDM3A lysine (K)-specific demethylase 3A 0.0540953
NFIA nuclear factor I/A 0.053083
HELZ helicase with zinc finger 0.0509061
OGA O-GlcNAcase 0.0496742
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0487447
KMT2C lysine (K)-specific methyltransferase 2C 0.0479092
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0478606
NALF1 NALCN channel auxiliary factor 1 0.0472673
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0471114
ZNF608 zinc finger protein 608 0.0470533
PCM1 pericentriolar material 1 0.0462425
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0459924
AUTS2 autism susceptibility candidate 2 0.0457551
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0442324
ARFGEF3 ARFGEF family member 3 0.0422975
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0422618
KDM2A lysine (K)-specific demethylase 2A 0.041979
USP34 ubiquitin specific peptidase 34 0.0415098
CABIN1 calcineurin binding protein 1 0.0409371
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0401205
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0394705
ATRN attractin 0.0392839
KMT2E lysine (K)-specific methyltransferase 2E 0.0391303
PUM2 pumilio RNA-binding family member 2 0.0385325
MED13 mediator complex subunit 13 0.0380416
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0379392
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0377718
MYH10 myosin, heavy chain 10, non-muscle 0.0374728
SRSF4 serine/arginine-rich splicing factor 4 0.0365293
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0361684
GYS1 glycogen synthase 1 (muscle) 0.0360662
SETD5 SET domain containing 5 0.0353964
DSCAM Down syndrome cell adhesion molecule 0.0350612
KDM6A lysine (K)-specific demethylase 6A 0.0349957
ARID1B AT rich interactive domain 1B (SWI1-like) 0.034807
ATP11A ATPase, class VI, type 11A 0.0342481
TPD52 tumor protein D52 0.0339513
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0339191
XPO1 exportin 1 0.0338333
RBM33 RNA binding motif protein 33 0.0335123
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0334572
PHF21A PHD finger protein 21A 0.0330922
RLF rearranged L-myc fusion 0.0329301
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0328398
SUN1 Sad1 and UNC84 domain containing 1 0.0328109
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.032087
ESYT2 extended synaptotagmin-like protein 2 0.0318014
TOP2B topoisomerase (DNA) II beta 180kDa 0.0317541
RSRC2 arginine/serine-rich coiled-coil 2 0.0316999
NCOR1 nuclear receptor corepressor 1 0.0316382
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0316322
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0314501
NSD3 nuclear receptor binding SET domain protein 3 0.031336
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0309656
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0308453
CHD7 chromodomain helicase DNA binding protein 7 0.0308339
ATAD2 ATPase family, AAA domain containing 2 0.0307777
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0305774
ANKRD36 ankyrin repeat domain 36 0.0304765
RIGI RNA sensor RIG-I 0.0292375
GSK3B glycogen synthase kinase 3 beta 0.0291546
RNF130 ring finger protein 130 0.0291504
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0291087
RTN4 reticulon 4 0.0289789
PDS5B PDS5 cohesin associated factor B 0.0288638
MED13L mediator complex subunit 13-like 0.0285935
YEATS2 YEATS domain containing 2 0.0283499
PIAS2 protein inhibitor of activated STAT, 2 0.0280917
FBXO11 F-box protein 11 0.0280884
SMAP1 small ArfGAP 1 0.0279836
QKI QKI, KH domain containing, RNA binding 0.0279794
SFPQ splicing factor proline/glutamine-rich 0.0278485
VCL vinculin 0.0278351
ELF2 E74-like factor 2 (ets domain transcription factor) 0.027825
H1-0 H1.0 linker histone 0.0277765
MATR3 matrin 3 0.0275043
JARID2 jumonji, AT rich interactive domain 2 0.0274463
USP37 ubiquitin specific peptidase 37 0.0271514
MKI67 marker of proliferation Ki-67 0.0270639
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0269786
NUP58 nucleoporin 58 0.0269565
PHIP pleckstrin homology domain interacting protein 0.026771
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.026599
BRWD3 bromodomain and WD repeat domain containing 3 0.0265448
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0265087
UBA6 ubiquitin-like modifier activating enzyme 6 0.0264418
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.026258
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0261657

decreased expression

Symbol Name Standardized Value
SLIT2 slit homolog 2 (Drosophila) -0.184275
NPAS3 neuronal PAS domain protein 3 -0.125278
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115954
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0831755
RAD51B RAD51 paralog B -0.077136
TMSB10 thymosin beta 10 -0.0770393
TENM3 teneurin transmembrane protein 3 -0.0763105
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0663972
PTMA prothymosin, alpha -0.0634489
RPL11 ribosomal protein L11 -0.0603888
MCTP1 multiple C2 domains, transmembrane 1 -0.0551036
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0526028
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0514554
RPL23 ribosomal protein L23 -0.0506476
EFNA5 ephrin-A5 -0.0505687
RPS21 ribosomal protein S21 -0.0503073
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.047451
TOX thymocyte selection-associated high mobility group box -0.0466702
IFI6 interferon, alpha-inducible protein 6 -0.0430386
RPS8 ribosomal protein S8 -0.042988
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0414073
RPS11 ribosomal protein S11 -0.0408825
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.040316
MLIP muscular LMNA-interacting protein -0.040092
SOX2 SRY (sex determining region Y)-box 2 -0.0398526
GJA1 gap junction protein, alpha 1, 43kDa -0.038732
RPL19 ribosomal protein L19 -0.0379792
RPL37A ribosomal protein L37a -0.0378874
RPL32 ribosomal protein L32 -0.0378219
ACTG1 actin gamma 1 -0.0377549
SOX4 SRY (sex determining region Y)-box 4 -0.0374494
TPT1 tumor protein, translationally-controlled 1 -0.037141
HMGA1 high mobility group AT-hook 1 -0.0361532
MYL12B myosin, light chain 12B, regulatory -0.0359391
RPS24 ribosomal protein S24 -0.0354101
TPI1 triosephosphate isomerase 1 -0.0351249
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0337576
SHROOM3 shroom family member 3 -0.0336718
S100A9 S100 calcium binding protein A9 -0.0334766
RPL12 ribosomal protein L12 -0.0334697
RPS13 ribosomal protein S13 -0.0333922
HMGB1 high mobility group box 1 -0.0329454
RPLP2 ribosomal protein, large, P2 -0.0325948
RPL35A ribosomal protein L35a -0.0321973
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0317785
NEBL nebulette -0.0317167
SLF1 SMC5-SMC6 complex localization factor 1 -0.0315804
PFN1 profilin 1 -0.0314407
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.031276
RPS3 ribosomal protein S3 -0.0305667
GRID2 glutamate receptor, ionotropic, delta 2 -0.0302927
RPL9 ribosomal protein L9 -0.030261
RAP1B RAP1B, member of RAS oncogene family -0.0297245
OSBPL10 oxysterol binding protein-like 10 -0.0296
PRICKLE1 prickle homolog 1 (Drosophila) -0.0292185
RPS19 ribosomal protein S19 -0.0290414
RPL18 ribosomal protein L18 -0.0280814
RPL34 ribosomal protein L34 -0.027841
RPS27A ribosomal protein S27a -0.0277062
TOM1L2 target of myb1-like 2 (chicken) -0.0275075
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0273529
ARB2A ARB2 cotranscriptional regulator A -0.0270986
RPL31 ribosomal protein L31 -0.0270909
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0266921
ENO1 enolase 1, (alpha) -0.0264878
RPL8 ribosomal protein L8 -0.0263437
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0261338
RPL36A ribosomal protein L36a -0.0260794
RSL1D1 ribosomal L1 domain containing 1 -0.0256087
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0254754
KTN1 kinectin 1 (kinesin receptor) -0.0254052
CADM2 cell adhesion molecule 2 -0.0253903
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0252128
ISG15 ISG15 ubiquitin-like modifier -0.0251804
CBX3 chromobox homolog 3 -0.0246263
RPS25 ribosomal protein S25 -0.0244065
RACK1 receptor for activated C kinase 1 -0.0242262
FTL ferritin, light polypeptide -0.0236796
RPS4X ribosomal protein S4, X-linked -0.0230625
VIM vimentin -0.0227955
RPS6 ribosomal protein S6 -0.0227908
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0227816
RPS12 ribosomal protein S12 -0.022483
SERBP1 SERPINE1 mRNA binding protein 1 -0.0224108
RPS16 ribosomal protein S16 -0.0223724
RPL26 ribosomal protein L26 -0.021999
RPL36 ribosomal protein L36 -0.0219979
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0219814
RPS14 ribosomal protein S14 -0.0219764
ATP9A ATPase, class II, type 9A -0.0217578
TENM2 teneurin transmembrane protein 2 -0.0217411
TUBB tubulin, beta class I -0.0216289
NOP56 NOP56 ribonucleoprotein -0.0216012
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0214125
GAB2 GRB2-associated binding protein 2 -0.0213659
VEGFC vascular endothelial growth factor C -0.021359
EIF5B eukaryotic translation initiation factor 5B -0.0211816
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0210451
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0209744
CSDE1 cold shock domain containing E1, RNA-binding -0.0209151