Cloxacillin (sodium)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD109 CD109 molecule 0.11757
IFRD1 interferon-related developmental regulator 1 0.0963715
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0838333
NAMPT nicotinamide phosphoribosyltransferase 0.0796541
TIMP3 TIMP metallopeptidase inhibitor 3 0.0731885
GPC6 glypican 6 0.0713783
ESYT2 extended synaptotagmin-like protein 2 0.070982
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.070256
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0666197
CALU calumenin 0.0650877
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0639781
KDM3A lysine (K)-specific demethylase 3A 0.059392
FMNL2 formin-like 2 0.050217
IGFBP3 insulin-like growth factor binding protein 3 0.0491607
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0490612
PDIA4 protein disulfide isomerase family A, member 4 0.0487643
TBC1D22A TBC1 domain family, member 22A 0.046117
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0459235
BACE2 beta-site APP-cleaving enzyme 2 0.0429197
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0425833
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0419338
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0387915
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0369936
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0363245
JUN jun proto-oncogene 0.0362352
ZYX zyxin 0.0357664
RUNX1 runt-related transcription factor 1 0.0353201
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0352471
GOLGA4 golgin A4 0.0335524
CANX calnexin 0.0329884
MYO1E myosin IE 0.0328867
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0321931
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0304636
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0299013
KIRREL1 kirre like nephrin family adhesion molecule 1 0.029473
TFRC transferrin receptor 0.0293997
PPME1 protein phosphatase methylesterase 1 0.0291543
EFR3B EFR3 homolog B (S. cerevisiae) 0.0290599
PRELID2 PRELI domain containing 2 0.0290565
RASA3 RAS p21 protein activator 3 0.028971
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0287108
AKAP12 A kinase (PRKA) anchor protein 12 0.028084
POM121 POM121 transmembrane nucleoporin 0.0274254
MEF2A myocyte enhancer factor 2A 0.0272829
IL1RAP interleukin 1 receptor accessory protein 0.0269398
ARFGEF3 ARFGEF family member 3 0.0265477
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.026412
COG5 component of oligomeric golgi complex 5 0.0259984
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0248733
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0246648
HOOK2 hook microtubule-tethering protein 2 0.0244239
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.024257
ERRFI1 ERBB receptor feedback inhibitor 1 0.0241987
COPA coatomer protein complex, subunit alpha 0.0241468
TPR translocated promoter region, nuclear basket protein 0.0241086
BHLHE40 basic helix-loop-helix family, member e40 0.0236797
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0236241
IGFBP5 insulin-like growth factor binding protein 5 0.0235936
VGF VGF nerve growth factor inducible 0.0235682
IVNS1ABP influenza virus NS1A binding protein 0.0227963
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.02276
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0223977
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0222921
ADM adrenomedullin 0.0222376
EGLN1 egl-9 family hypoxia-inducible factor 1 0.022046
CTTNBP2 cortactin binding protein 2 0.0214717
WSB1 WD repeat and SOCS box containing 1 0.0214522
SCFD2 sec1 family domain containing 2 0.0214309
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0213634
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0213086
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0212913
RGS2 regulator of G-protein signaling 2 0.0211677
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0211601
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0209902
ZMYND8 zinc finger, MYND-type containing 8 0.0207236
NPR2 natriuretic peptide receptor 2 0.0205633
HDAC9 histone deacetylase 9 0.0204372
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0200693
USP37 ubiquitin specific peptidase 37 0.0199622
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0199447
PTPRM protein tyrosine phosphatase, receptor type, M 0.0199025
MRTFA myocardin related transcription factor A 0.0196934
CUL3 cullin 3 0.019684
RYBP RING1 and YY1 binding protein 0.0196734
VCL vinculin 0.0195379
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0192617
GLS2 glutaminase 2 (liver, mitochondrial) 0.0189314
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0189192
RAB5A RAB5A, member RAS oncogene family 0.0186502
PDE10A phosphodiesterase 10A 0.018644
SSBP2 single-stranded DNA binding protein 2 0.0183603
ITGB8 integrin, beta 8 0.0183549
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0182393
RNMT RNA (guanine-7-) methyltransferase 0.0180931
CDC73 cell division cycle 73 0.0180428
NBAS neuroblastoma amplified sequence 0.0174649
SEC31A SEC31 homolog A (S. cerevisiae) 0.0172903
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0171946
FLNB filamin B, beta 0.0166011
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0165762

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.349438
VIM vimentin -0.19037
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.156266
MT2A metallothionein 2A -0.137284
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.093913
TMSB10 thymosin beta 10 -0.0825926
FN1 fibronectin 1 -0.0803593
S100A6 S100 calcium binding protein A6 -0.060816
TAGLN2 transgelin 2 -0.0553037
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0531832
HLA-B major histocompatibility complex, class I, B -0.0501272
DCT dopachrome tautomerase -0.0488058
POTEF POTE ankyrin domain family, member F -0.0480561
IFI16 interferon, gamma-inducible protein 16 -0.045563
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.043089
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.042633
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0423178
KMT2E lysine (K)-specific methyltransferase 2E -0.0415801
RPS19 ribosomal protein S19 -0.0407595
CENPF centromere protein F, 350/400kDa -0.0402746
GNAS GNAS complex locus -0.0398305
GDF15 growth differentiation factor 15 -0.0385678
ACTG1 actin gamma 1 -0.037957
IFI6 interferon, alpha-inducible protein 6 -0.0371032
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0369024
MT1X metallothionein 1X -0.0359665
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0348262
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.034812
SRPK2 SRSF protein kinase 2 -0.0347385
RPLP2 ribosomal protein, large, P2 -0.034483
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0343888
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0341288
PKM pyruvate kinase, muscle -0.0332258
PFN1 profilin 1 -0.0330038
FTL ferritin, light polypeptide -0.0330028
IFITM1 interferon induced transmembrane protein 1 -0.0329608
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0328609
PTMA prothymosin, alpha -0.0320723
RPL37A ribosomal protein L37a -0.0318903
RPL35A ribosomal protein L35a -0.0318128
IFITM3 interferon induced transmembrane protein 3 -0.0313408
MTPN myotrophin -0.0311271
ZBTB20 zinc finger and BTB domain containing 20 -0.0290796
NAV1 neuron navigator 1 -0.0287831
CYB5R3 cytochrome b5 reductase 3 -0.0277631
RPS8 ribosomal protein S8 -0.0277526
RPLP1 ribosomal protein, large, P1 -0.0267337
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0259224
HMGA1 high mobility group AT-hook 1 -0.0255405
S100A10 S100 calcium binding protein A10 -0.0252756
TPI1 triosephosphate isomerase 1 -0.0251631
AHR aryl hydrocarbon receptor -0.0248251
NDRG1 N-myc downstream regulated 1 -0.0247291
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0247185
PDE4D phosphodiesterase 4D, cAMP-specific -0.0246804
RPL36 ribosomal protein L36 -0.0244058
CD63 CD63 molecule -0.0241806
FRMD4A FERM domain containing 4A -0.0240541
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0240372
TOP2A topoisomerase (DNA) II alpha 170kDa -0.023882
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0238731
SEM1 SEM1 26S proteasome subunit -0.0237103
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0236725
ICAM1 intercellular adhesion molecule 1 -0.0234163
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0229168
RNF145 ring finger protein 145 -0.0229141
HSPB1 heat shock 27kDa protein 1 -0.0228511
RPLP0 ribosomal protein, large, P0 -0.0226617
B2M beta-2-microglobulin -0.0218463
DUSP6 dual specificity phosphatase 6 -0.0218378
RPL19 ribosomal protein L19 -0.0218203
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0217727
IGFBP7 insulin-like growth factor binding protein 7 -0.0217201
ANKRD28 ankyrin repeat domain 28 -0.021558
DIAPH3 diaphanous-related formin 3 -0.0213034
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0209748
SOX5 SRY (sex determining region Y)-box 5 -0.0208743
RPS12 ribosomal protein S12 -0.0206404
RPS23 ribosomal protein S23 -0.0205962
TPT1 tumor protein, translationally-controlled 1 -0.0205273
SMC4 structural maintenance of chromosomes 4 -0.0203993
EGR1 early growth response 1 -0.0203489
HLA-DRA major histocompatibility complex, class II, DR alpha -0.0202347
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0200709
MBNL2 muscleblind-like splicing regulator 2 -0.019987
LY6E lymphocyte antigen 6 complex, locus E -0.0195221
RPS13 ribosomal protein S13 -0.0194794
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0192553
ATP5F1E ATP synthase F1 subunit epsilon -0.0192369
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0192353
NPC1 Niemann-Pick disease, type C1 -0.0191296
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0190581
HMCN1 hemicentin 1 -0.0189666
RPS6 ribosomal protein S6 -0.0189527
RPS14 ribosomal protein S14 -0.0186074
S100A9 S100 calcium binding protein A9 -0.0184165
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0183769
NHSL1 NHS-like 1 -0.0183599
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0183292
UBE2H ubiquitin-conjugating enzyme E2H -0.0181901