Cloxacillin (sodium)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.0835485
LAMB3 laminin, beta 3 0.0769543
SAMD4A sterile alpha motif domain containing 4A 0.0719958
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0661783
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0650401
DTNA dystrobrevin, alpha 0.0614256
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0609108
APP amyloid beta (A4) precursor protein 0.0563865
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0536388
CANX calnexin 0.0514763
IGFBP3 insulin-like growth factor binding protein 3 0.0512845
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0488091
FAM13A family with sequence similarity 13, member A 0.0464546
LAMC2 laminin, gamma 2 0.0454419
CXCL8 chemokine (C-X-C motif) ligand 8 0.0410637
OGA O-GlcNAcase 0.0400642
NAMPT nicotinamide phosphoribosyltransferase 0.0393685
SMAD3 SMAD family member 3 0.0378074
APLP2 amyloid beta (A4) precursor-like protein 2 0.0365275
GOLGB1 golgin B1 0.0353368
MYH9 myosin, heavy chain 9, non-muscle 0.0345258
BACE2 beta-site APP-cleaving enzyme 2 0.0340474
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0329671
PPARD peroxisome proliferator-activated receptor delta 0.0317867
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0316978
FAM107B family with sequence similarity 107, member B 0.0311282
ESYT2 extended synaptotagmin-like protein 2 0.0302053
LMO7 LIM domain 7 0.0297903
GRB10 growth factor receptor-bound protein 10 0.0296834
SDC4 syndecan 4 0.0289435
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0287847
AFF4 AF4/FMR2 family, member 4 0.0283529
BZW1 basic leucine zipper and W2 domains 1 0.0281778
TTC3 tetratricopeptide repeat domain 3 0.0271119
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0265452
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0265396
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.02648
ELL2 elongation factor, RNA polymerase II, 2 0.0263215
SUCO SUN domain containing ossification factor 0.0260355
GOLGA4 golgin A4 0.0259216
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0256578
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0251333
SRP54 signal recognition particle 54kDa 0.0247282
AKAP12 A kinase (PRKA) anchor protein 12 0.024517
SQSTM1 sequestosome 1 0.0235161
TMSB4X thymosin beta 4, X-linked 0.0233569
OPTN optineurin 0.0229991
ANKRD11 ankyrin repeat domain 11 0.022819
AKAP13 A kinase (PRKA) anchor protein 13 0.0226772
ATF3 activating transcription factor 3 0.0226055
RBM39 RNA binding motif protein 39 0.0225079
RAI14 retinoic acid induced 14 0.0222395
DSPP dentin sialophosphoprotein 0.0221133
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0219586
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0219285
DENND4A DENN/MADD domain containing 4A 0.0216912
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.021279
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0212568
MXI1 MAX interactor 1, dimerization protein 0.0212228
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0209655
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0206498
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0204873
FNIP1 folliculin interacting protein 1 0.0202691
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0201569
AHNAK2 AHNAK nucleoprotein 2 0.0199039
RAB8B RAB8B, member RAS oncogene family 0.0197964
PLEC plectin 0.019582
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0195633
JMJD1C jumonji domain containing 1C 0.0194812
HDLBP high density lipoprotein binding protein 0.019355
TRIO trio Rho guanine nucleotide exchange factor 0.0192392
EZR ezrin 0.0191914
BTBD9 BTB (POZ) domain containing 9 0.0191276
ZFC3H1 zinc finger, C3H1-type containing 0.0189939
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0187736
ERRFI1 ERBB receptor feedback inhibitor 1 0.0187046
SOD2 superoxide dismutase 2, mitochondrial 0.0186976
YME1L1 YME1-like 1 ATPase 0.0186507
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0186438
SGMS2 sphingomyelin synthase 2 0.0185433
HOOK2 hook microtubule-tethering protein 2 0.0184309
FNDC3B fibronectin type III domain containing 3B 0.0182289
HSPA8 heat shock 70kDa protein 8 0.0180639
CCNY cyclin Y 0.0178003
BARX2 BARX homeobox 2 0.0177695
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0177221
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0176533
IRF6 interferon regulatory factor 6 0.0176297
EIF4A2 eukaryotic translation initiation factor 4A2 0.0176066
KDM2A lysine (K)-specific demethylase 2A 0.0175253
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0173205
BIRC3 baculoviral IAP repeat containing 3 0.0171274
SKP1 S-phase kinase-associated protein 1 0.0167587
HBP1 HMG-box transcription factor 1 0.0167165
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0166568
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0166369
TP53BP2 tumor protein p53 binding protein 2 0.0163903
ARRDC3 arrestin domain containing 3 0.0163115
SEC24A SEC24 family member A 0.0162021
TNIP1 TNFAIP3 interacting protein 1 0.016192

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.236932
MT2A metallothionein 2A -0.226951
TMSB10 thymosin beta 10 -0.18749
IFI27 interferon, alpha-inducible protein 27 -0.113563
MT1X metallothionein 1X -0.0972799
FTL ferritin, light polypeptide -0.0922437
NDRG1 N-myc downstream regulated 1 -0.0909133
POTEF POTE ankyrin domain family, member F -0.0763821
KRT19 keratin 19, type I -0.0729747
PTMA prothymosin, alpha -0.0708565
RPL23 ribosomal protein L23 -0.0697499
HMGA1 high mobility group AT-hook 1 -0.0689151
ISG15 ISG15 ubiquitin-like modifier -0.0666425
S100A6 S100 calcium binding protein A6 -0.0615676
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0608728
VIM vimentin -0.0606773
B2M beta-2-microglobulin -0.0562063
RPL35A ribosomal protein L35a -0.0529072
IFI6 interferon, alpha-inducible protein 6 -0.0518946
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0515417
HLA-B major histocompatibility complex, class I, B -0.0502906
TPT1 tumor protein, translationally-controlled 1 -0.0485038
C15ORF48 chromosome 15 open reading frame 48 -0.0476712
S100A10 S100 calcium binding protein A10 -0.046445
ACTG1 actin gamma 1 -0.0460531
RPS19 ribosomal protein S19 -0.0458889
RPL19 ribosomal protein L19 -0.0447588
EFNA5 ephrin-A5 -0.0444759
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0439972
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0414732
ALCAM activated leukocyte cell adhesion molecule -0.0411766
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.041112
CD2AP CD2-associated protein -0.0404689
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.040161
MMP7 matrix metallopeptidase 7 -0.0392612
LY6E lymphocyte antigen 6 complex, locus E -0.0384963
RPLP1 ribosomal protein, large, P1 -0.0381786
IFITM1 interferon induced transmembrane protein 1 -0.0379228
PKM pyruvate kinase, muscle -0.0377141
BICC1 BicC family RNA binding protein 1 -0.0376652
FTH1 ferritin, heavy polypeptide 1 -0.0362521
TSC22D2 TSC22 domain family, member 2 -0.0357365
JUP junction plakoglobin -0.035442
RPS21 ribosomal protein S21 -0.0340003
SLC38A1 solute carrier family 38, member 1 -0.0339261
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0338442
RPS23 ribosomal protein S23 -0.0334948
RPS25 ribosomal protein S25 -0.0326134
RPS8 ribosomal protein S8 -0.0323881
RPL34 ribosomal protein L34 -0.0320767
EHBP1 EH domain binding protein 1 -0.0317372
PMP22 peripheral myelin protein 22 -0.0314832
TGM2 transglutaminase 2 -0.0314454
IFI16 interferon, gamma-inducible protein 16 -0.0314401
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0313502
RPL11 ribosomal protein L11 -0.0313354
CNRIP1 cannabinoid receptor interacting protein 1 -0.0308669
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0306053
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0303042
IFITM3 interferon induced transmembrane protein 3 -0.030179
RPLP0 ribosomal protein, large, P0 -0.0300593
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0299175
RPS14 ribosomal protein S14 -0.0298224
NRG3 neuregulin 3 -0.0292677
S100A11 S100 calcium binding protein A11 -0.0288392
MUC1 mucin 1, cell surface associated -0.0287765
LOC112694756 uncharaterized LOC112694756 -0.0287149
CSTB cystatin B (stefin B) -0.0286906
SP100 SP100 nuclear antigen -0.0283803
BCL2L1 BCL2-like 1 -0.0283394
EGR1 early growth response 1 -0.0282754
MUC4 mucin 4, cell surface associated -0.0276262
FAM162A family with sequence similarity 162, member A -0.0274818
PFN1 profilin 1 -0.0272067
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0271336
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0269564
RTN4 reticulon 4 -0.0269161
RNF213 ring finger protein 213 -0.0268866
RAD51B RAD51 paralog B -0.0264062
RPS24 ribosomal protein S24 -0.0263443
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0262296
TPI1 triosephosphate isomerase 1 -0.0261265
RPS29 ribosomal protein S29 -0.026007
TAGLN2 transgelin 2 -0.0255877
CD47 CD47 molecule -0.0248157
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0241475
RPS6 ribosomal protein S6 -0.0240875
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0240163
RPL9 ribosomal protein L9 -0.0239674
NPEPPS aminopeptidase puromycin sensitive -0.0238436
LCN2 lipocalin 2 -0.0237066
GNAS GNAS complex locus -0.0235236
ENO1 enolase 1, (alpha) -0.0234495
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0230131
ACTN4 actinin, alpha 4 -0.0230022
RPL37A ribosomal protein L37a -0.0227956
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0225641
RPL36 ribosomal protein L36 -0.022454
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0223547
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0223403