Cloxacillin (sodium)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.145415
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0822195
VMP1 vacuole membrane protein 1 0.0816537
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0748136
SLITRK6 SLIT and NTRK-like family, member 6 0.0729424
FNDC3B fibronectin type III domain containing 3B 0.0693248
LSAMP limbic system-associated membrane protein 0.06789
LINGO2 leucine rich repeat and Ig domain containing 2 0.0625731
CEMIP cell migration inducing protein, hyaluronan binding 0.0625148
THSD4 thrombospondin, type I, domain containing 4 0.0579854
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0568463
IGFBP3 insulin-like growth factor binding protein 3 0.0538814
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0532229
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0524822
PDE4D phosphodiesterase 4D, cAMP-specific 0.0522036
PCBP3 poly(rC) binding protein 3 0.051882
ANTXR1 anthrax toxin receptor 1 0.0516367
PLAT plasminogen activator, tissue 0.050736
PDE10A phosphodiesterase 10A 0.0507344
PRKCA protein kinase C, alpha 0.0501058
FLT1 fms-related tyrosine kinase 1 0.0495051
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0474185
MEF2A myocyte enhancer factor 2A 0.0440101
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0432569
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.043082
PTPRD protein tyrosine phosphatase, receptor type, D 0.0428701
MACF1 microtubule-actin crosslinking factor 1 0.0427449
SET SET nuclear proto-oncogene 0.0426017
VEGFA vascular endothelial growth factor A 0.0417531
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.040957
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0404662
PTEN phosphatase and tensin homolog 0.0400795
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0378981
SMC5 structural maintenance of chromosomes 5 0.037095
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.036955
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0361334
PTPRM protein tyrosine phosphatase, receptor type, M 0.035947
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0357031
PCBP2 poly(rC) binding protein 2 0.0356666
NBEA neurobeachin 0.0343761
SLIT2 slit homolog 2 (Drosophila) 0.0338756
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0337276
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0336632
TPM1 tropomyosin 1 (alpha) 0.0330561
DST dystonin 0.0323895
PACS1 phosphofurin acidic cluster sorting protein 1 0.0322657
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0320767
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0320457
MYH9 myosin, heavy chain 9, non-muscle 0.0319218
TET1 tet methylcytosine dioxygenase 1 0.0317989
ITPRID2 ITPR interacting domain containing 2 0.0316714
EGR1 early growth response 1 0.0314189
ZNF644 zinc finger protein 644 0.0309662
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0309065
JMJD1C jumonji domain containing 1C 0.0307606
ENAH enabled homolog (Drosophila) 0.0300269
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0299812
EXT1 exostosin glycosyltransferase 1 0.0299415
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0297227
RNF150 ring finger protein 150 0.0296953
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0295374
RNF145 ring finger protein 145 0.0292386
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.029124
ZCCHC7 zinc finger, CCHC domain containing 7 0.0289396
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0287807
ARHGAP9 Rho GTPase activating protein 9 0.0287549
PICALM phosphatidylinositol binding clathrin assembly protein 0.0284313
RPL3 ribosomal protein L3 0.0283526
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0278587
FAM107B family with sequence similarity 107, member B 0.0276087
FRMD5 FERM domain containing 5 0.0275366
TMF1 TATA element modulatory factor 1 0.0274953
MRTFA myocardin related transcription factor A 0.0272098
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0269039
TIMP2 TIMP metallopeptidase inhibitor 2 0.0268691
RPTOR regulatory associated protein of MTOR, complex 1 0.0264093
HILPDA hypoxia inducible lipid droplet-associated 0.0263205
GPBP1 GC-rich promoter binding protein 1 0.0262107
SYTL3 synaptotagmin-like 3 0.0262061
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0261425
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0257868
CADM1 cell adhesion molecule 1 0.025662
IGFBP5 insulin-like growth factor binding protein 5 0.0256278
CHD4 chromodomain helicase DNA binding protein 4 0.0255547
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0254825
ZMIZ1 zinc finger, MIZ-type containing 1 0.0253744
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0253725
DNM3 dynamin 3 0.025236
CCNL1 cyclin L1 0.025095
ZSWIM6 zinc finger, SWIM-type containing 6 0.0250845
PDLIM5 PDZ and LIM domain 5 0.0249402
PRKCE protein kinase C, epsilon 0.0245214
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0244895
FAM13A family with sequence similarity 13, member A 0.0244579
KLHL13 kelch-like family member 13 0.0243801
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0243576
BICD1 bicaudal D homolog 1 (Drosophila) 0.0243521
CALD1 caldesmon 1 0.0242631
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 0.0242226
PARD3 par-3 family cell polarity regulator 0.0239304

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.221628
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127273
PTMA prothymosin, alpha -0.125487
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123326
TRIB2 tribbles pseudokinase 2 -0.104562
IGF2 insulin-like growth factor 2 -0.10424
VIM vimentin -0.090057
RPL23 ribosomal protein L23 -0.0732969
RPS24 ribosomal protein S24 -0.0627547
ACTG1 actin gamma 1 -0.0624762
MEIS2 Meis homeobox 2 -0.0624242
RPL38 ribosomal protein L38 -0.0609924
SYT1 synaptotagmin I -0.0573399
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0553023
GNAS GNAS complex locus -0.0550212
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0538473
LMNA lamin A/C -0.0532169
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0523686
COL1A1 collagen, type I, alpha 1 -0.0517468
KDM3A lysine (K)-specific demethylase 3A -0.0511921
TMSB10 thymosin beta 10 -0.0506598
TPT1 tumor protein, translationally-controlled 1 -0.0490689
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0480131
RNF213 ring finger protein 213 -0.0473108
RPLP1 ribosomal protein, large, P1 -0.0437457
NCOR1 nuclear receptor corepressor 1 -0.0432539
LPIN1 lipin 1 -0.0432406
RPL35A ribosomal protein L35a -0.0427428
VDAC1 voltage-dependent anion channel 1 -0.0426979
GARS1 glycyl-tRNA synthetase 1 -0.0419446
FTL ferritin, light polypeptide -0.0390874
FMN1 formin 1 -0.0378566
PRRC2C proline-rich coiled-coil 2C -0.037589
UNC5C unc-5 homolog C (C. elegans) -0.0372846
RPS27A ribosomal protein S27a -0.0372152
GPC5 glypican 5 -0.0369905
NPEPPS aminopeptidase puromycin sensitive -0.0368715
RPLP0 ribosomal protein, large, P0 -0.0361506
NAMPT nicotinamide phosphoribosyltransferase -0.0361439
ANXA2 annexin A2 -0.0357657
WDR45B WD repeat domain 45B -0.0357319
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0349635
LMAN1 lectin, mannose-binding, 1 -0.0348344
NCAM2 neural cell adhesion molecule 2 -0.0339546
GOLGA4 golgin A4 -0.0337746
RFC3 replication factor C (activator 1) 3, 38kDa -0.0325462
NREP neuronal regeneration related protein -0.0318826
UBE2H ubiquitin-conjugating enzyme E2H -0.0316947
TRIO trio Rho guanine nucleotide exchange factor -0.0314097
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0313039
SEPTIN2 septin 2 -0.0312579
OGA O-GlcNAcase -0.031156
H3-3B H3.3 histone B -0.0310213
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0307655
ARF1 ADP-ribosylation factor 1 -0.030754
CCND1 cyclin D1 -0.0307382
CDC27 cell division cycle 27 -0.0306791
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0303705
DLG1 discs, large homolog 1 (Drosophila) -0.0303292
LRP1B low density lipoprotein receptor-related protein 1B -0.0302406
ZMYM2 zinc finger, MYM-type 2 -0.0301602
HMGA1 high mobility group AT-hook 1 -0.0299703
MATR3 matrin 3 -0.0298923
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0298416
CLTC clathrin, heavy chain (Hc) -0.0298077
MDN1 MDN1, midasin homolog (yeast) -0.0297561
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.0292709
SOS1 son of sevenless homolog 1 (Drosophila) -0.0292134
TULP4 tubby like protein 4 -0.0291616
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0289084
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0288661
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0287756
PHF3 PHD finger protein 3 -0.0286184
FKBP10 FK506 binding protein 10, 65 kDa -0.0285939
PRR11 proline rich 11 -0.0285092
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0284555
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0283383
FOXK2 forkhead box K2 -0.0281395
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0281082
RPL35 ribosomal protein L35 -0.0276987
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0276541
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0273679
TENT5A terminal nucleotidyltransferase 5A -0.0273617
SRP72 signal recognition particle 72kDa -0.0269887
RPL37A ribosomal protein L37a -0.0267043
CANX calnexin -0.0266846
HMGB1 high mobility group box 1 -0.0266154
ZNF804A zinc finger protein 804A -0.0264314
FNBP4 formin binding protein 4 -0.0263393
BMERB1 bMERB domain containing 1 -0.0261175
USP3 ubiquitin specific peptidase 3 -0.0261037
SEC62 SEC62 homolog (S. cerevisiae) -0.0259798
GDF15 growth differentiation factor 15 -0.0256323
RPL12 ribosomal protein L12 -0.025624
KPNB1 karyopherin (importin) beta 1 -0.0256065
GPHN gephyrin -0.0255651
CD36 CD36 molecule (thrombospondin receptor) -0.0255268
FBXL20 F-box and leucine-rich repeat protein 20 -0.0254925
CRABP2 cellular retinoic acid binding protein 2 -0.0253599
HMGB2 high mobility group box 2 -0.0251375