Cloxacillin (sodium)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.0972301
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0642068
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0481609
INTS6 integrator complex subunit 6 0.0369478
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0330631
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0301738
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0282272
COG6 component of oligomeric golgi complex 6 0.0268906
BTBD9 BTB (POZ) domain containing 9 0.0267815
MYH9 myosin, heavy chain 9, non-muscle 0.0266709
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.025908
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0214377
SMAD3 SMAD family member 3 0.0213762
CEMIP2 cell migration inducing hyaluronidase 2 0.020622
VMP1 vacuole membrane protein 1 0.0196662
SHB Src homology 2 domain containing adaptor protein B 0.0184
FNIP1 folliculin interacting protein 1 0.0183103
AFF1 AF4/FMR2 family, member 1 0.0180298
SEC24D SEC24 family member D 0.0175161
DUSP10 dual specificity phosphatase 10 0.0174996
ERRFI1 ERBB receptor feedback inhibitor 1 0.0171881
MBNL2 muscleblind-like splicing regulator 2 0.0171302
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0169259
SAMD4A sterile alpha motif domain containing 4A 0.0166275
TUFT1 tuftelin 1 0.0163315
PMM2 phosphomannomutase 2 0.0163182
BICRAL BICRA like chromatin remodeling complex associated protein 0.0161076
YAP1 Yes-associated protein 1 0.0160768
PRELID2 PRELI domain containing 2 0.0156263
KDM6A lysine (K)-specific demethylase 6A 0.0155942
DST dystonin 0.0155867
RNF43 ring finger protein 43 0.0151754
COPA coatomer protein complex, subunit alpha 0.0148967
PDZD8 PDZ domain containing 8 0.0144748
C3ORF52 chromosome 3 open reading frame 52 0.0142693
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.01398
TOX3 TOX high mobility group box family member 3 0.0138613
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.013785
OGA O-GlcNAcase 0.0135857
SPRED1 sprouty-related, EVH1 domain containing 1 0.0135067
NRIP1 nuclear receptor interacting protein 1 0.013436
AOPEP aminopeptidase O (putative) 0.0131834
HDAC4 histone deacetylase 4 0.0130192
FNIP2 folliculin interacting protein 2 0.0129939
ZCCHC7 zinc finger, CCHC domain containing 7 0.012675
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0126098
EHF ets homologous factor 0.0125682
ZNF638 zinc finger protein 638 0.0124675
MLPH melanophilin 0.0124428
RBM26 RNA binding motif protein 26 0.0124163
HELZ helicase with zinc finger 0.0123989
NAMPT nicotinamide phosphoribosyltransferase 0.0122268
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0121487
RBM39 RNA binding motif protein 39 0.0119102
PUM2 pumilio RNA-binding family member 2 0.011893
PHF3 PHD finger protein 3 0.011861
TMEM39A transmembrane protein 39A 0.0118174
SEC31A SEC31 homolog A (S. cerevisiae) 0.0117182
TTC3 tetratricopeptide repeat domain 3 0.0116432
SUCO SUN domain containing ossification factor 0.0116407
ESYT2 extended synaptotagmin-like protein 2 0.0116139
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.011294
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0112217
PAPOLA poly(A) polymerase alpha 0.0111224
CYTH1 cytohesin 1 0.0110174
SDCBP syndecan binding protein (syntenin) 0.0109768
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0109586
TFG TRK-fused gene 0.0109077
METTL15 methyltransferase like 15 0.0108996
ANO6 anoctamin 6 0.0108599
CCNL1 cyclin L1 0.0108542
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0107842
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0107497
EXT1 exostosin glycosyltransferase 1 0.0107473
NDEL1 nudE neurodevelopment protein 1-like 1 0.0106689
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0105586
RUNX1 runt-related transcription factor 1 0.0104946
LARP4B La ribonucleoprotein domain family, member 4B 0.0104808
FNDC3B fibronectin type III domain containing 3B 0.0104675
USP12 ubiquitin specific peptidase 12 0.0103179
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0100961
DPP4 dipeptidyl-peptidase 4 0.00997472
CEMIP cell migration inducing protein, hyaluronan binding 0.00990474
PNPLA7 patatin-like phospholipase domain containing 7 0.00987041
CTBP2 C-terminal binding protein 2 0.00977247
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0097003
USP54 ubiquitin specific peptidase 54 0.00970021
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00961304
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.00961025
LIMCH1 LIM and calponin homology domains 1 0.00957154
PGM3 phosphoglucomutase 3 0.00949817
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00946381
ATM ATM serine/threonine kinase 0.00945125
DMXL2 Dmx-like 2 0.00943307
COG3 component of oligomeric golgi complex 3 0.0094188
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00939695
EIF4B eukaryotic translation initiation factor 4B 0.0093921
IVNS1ABP influenza virus NS1A binding protein 0.00932513
ARRDC3 arrestin domain containing 3 0.00932374
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.00931125

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.235613
TPT1 tumor protein, translationally-controlled 1 -0.219838
HLA-B major histocompatibility complex, class I, B -0.132397
LCN2 lipocalin 2 -0.130573
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128576
PTMA prothymosin, alpha -0.12604
LYZ lysozyme -0.1237
IFI6 interferon, alpha-inducible protein 6 -0.12035
ZMYND8 zinc finger, MYND-type containing 8 -0.108265
EPSTI1 epithelial stromal interaction 1 (breast) -0.0945804
IFI27 interferon, alpha-inducible protein 27 -0.0911792
C6ORF132 chromosome 6 open reading frame 132 -0.0707328
RNF213 ring finger protein 213 -0.068672
LOC102724023 ES1 protein homolog, mitochondrial -0.0686665
SP100 SP100 nuclear antigen -0.0686117
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0680954
FTL ferritin, light polypeptide -0.0676338
PKM pyruvate kinase, muscle -0.0668475
XAF1 XIAP associated factor 1 -0.0638799
EGR1 early growth response 1 -0.063542
RPL35A ribosomal protein L35a -0.0635056
NPSR1 neuropeptide S receptor 1 -0.063296
MX2 MX dynamin-like GTPase 2 -0.0631745
PERP PERP, TP53 apoptosis effector -0.0629457
TMSB10 thymosin beta 10 -0.0616689
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0606933
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0606223
SLC38A1 solute carrier family 38, member 1 -0.0588703
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0588638
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0556563
RPL23 ribosomal protein L23 -0.0552483
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0539299
TXNIP thioredoxin interacting protein -0.0530998
ACTG1 actin gamma 1 -0.0520151
RPL34 ribosomal protein L34 -0.0519047
HLA-C major histocompatibility complex, class I, C -0.051052
HLA-A major histocompatibility complex, class I, A -0.0508337
ENO1 enolase 1, (alpha) -0.0506804
RPL7L1 ribosomal protein L7-like 1 -0.0499444
AREG amphiregulin -0.0498836
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0486307
MX1 MX dynamin-like GTPase 1 -0.0483054
TSHZ2 teashirt zinc finger homeobox 2 -0.048016
RPS6 ribosomal protein S6 -0.0479625
HLA-E major histocompatibility complex, class I, E -0.0474363
EIF1 eukaryotic translation initiation factor 1 -0.0464948
S100A6 S100 calcium binding protein A6 -0.0460948
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0448105
IFITM3 interferon induced transmembrane protein 3 -0.044254
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0437076
MT2A metallothionein 2A -0.0435658
PGK1 phosphoglycerate kinase 1 -0.042915
RPL19 ribosomal protein L19 -0.0410695
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0408952
RABGAP1L RAB GTPase activating protein 1-like -0.0402462
NDRG1 N-myc downstream regulated 1 -0.0399957
EPCAM epithelial cell adhesion molecule -0.0399183
RPS8 ribosomal protein S8 -0.0398648
TPI1 triosephosphate isomerase 1 -0.0390094
RPS19 ribosomal protein S19 -0.0387714
TM4SF1 transmembrane 4 L six family member 1 -0.0387499
LIMA1 LIM domain and actin binding 1 -0.0384987
PMP22 peripheral myelin protein 22 -0.0381847
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0377578
UBC ubiquitin C -0.0377524
CST3 cystatin C -0.0374372
KRT19 keratin 19, type I -0.0362247
ISG15 ISG15 ubiquitin-like modifier -0.0361179
RIGI RNA sensor RIG-I -0.0360925
RPLP1 ribosomal protein, large, P1 -0.0359027
S100A10 S100 calcium binding protein A10 -0.0348126
GCC2 GRIP and coiled-coil domain containing 2 -0.0343533
GMDS GDP-mannose 4,6-dehydratase -0.0342207
RPL11 ribosomal protein L11 -0.0339761
STS steroid sulfatase (microsomal), isozyme S -0.0337237
RPS24 ribosomal protein S24 -0.0335301
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0334202
JUN jun proto-oncogene -0.0332035
VDAC1 voltage-dependent anion channel 1 -0.0329963
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0324726
KPNB1 karyopherin (importin) beta 1 -0.0323067
LY6E lymphocyte antigen 6 complex, locus E -0.0322048
DSTN destrin (actin depolymerizing factor) -0.0321672
KLF6 Kruppel-like factor 6 -0.0318866
LOC112694756 uncharaterized LOC112694756 -0.0316024
CTSD cathepsin D -0.0314681
PTGR1 prostaglandin reductase 1 -0.0314585
RPL37A ribosomal protein L37a -0.0308821
RPL31 ribosomal protein L31 -0.0308693
RPS27 ribosomal protein S27 -0.0308292
RPL12 ribosomal protein L12 -0.0308162
S100A9 S100 calcium binding protein A9 -0.0306309
RPLP0 ribosomal protein, large, P0 -0.0306059
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0302364
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0300197
RHOBTB3 Rho-related BTB domain containing 3 -0.0300124
PRRC2C proline-rich coiled-coil 2C -0.02996
S100P S100 calcium binding protein P -0.0298762
APOL1 apolipoprotein L, 1 -0.0297666
RAB7A RAB7A, member RAS oncogene family -0.029623