Cloxacillin (sodium)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.107198
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0946375
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0796436
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0758727
COL6A3 collagen, type VI, alpha 3 0.0612225
COL5A1 collagen, type V, alpha 1 0.0577227
ASPH aspartate beta-hydroxylase 0.0483089
FAM13A family with sequence similarity 13, member A 0.0479186
PTPRM protein tyrosine phosphatase, receptor type, M 0.0431238
ERRFI1 ERBB receptor feedback inhibitor 1 0.0427004
CXCL8 chemokine (C-X-C motif) ligand 8 0.041623
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0389855
MYH9 myosin, heavy chain 9, non-muscle 0.0378469
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0361003
NAV1 neuron navigator 1 0.0354284
DTNA dystrobrevin, alpha 0.0333361
TNS1 tensin 1 0.0331794
AFF3 AF4/FMR2 family, member 3 0.0325717
AHNAK AHNAK nucleoprotein 0.032545
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.032032
RUNX1 runt-related transcription factor 1 0.0313908
MYO10 myosin X 0.0302941
AKAP12 A kinase (PRKA) anchor protein 12 0.0301337
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0274528
DST dystonin 0.0273929
TAS2R14 taste receptor, type 2, member 14 0.0251649
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.025004
JARID2 jumonji, AT rich interactive domain 2 0.0242445
NAV2 neuron navigator 2 0.0242101
RRM2 ribonucleotide reductase M2 0.0241419
COL7A1 collagen, type VII, alpha 1 0.0239968
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0239472
BACE2 beta-site APP-cleaving enzyme 2 0.0235905
PTK2 protein tyrosine kinase 2 0.0226231
MMP12 matrix metallopeptidase 12 0.0220775
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0206509
FNDC3B fibronectin type III domain containing 3B 0.0202247
MSN moesin 0.0197149
CANX calnexin 0.0194338
ENO1 enolase 1, (alpha) 0.0192665
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0189382
RASA3 RAS p21 protein activator 3 0.0187071
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0186354
HSPA8 heat shock 70kDa protein 8 0.0185157
TPM3 tropomyosin 3 0.0182809
PRELID2 PRELI domain containing 2 0.0182097
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0181497
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.017943
ZBTB38 zinc finger and BTB domain containing 38 0.0177335
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0176802
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0175124
NALF1 NALCN channel auxiliary factor 1 0.0175049
MAML3 mastermind-like 3 (Drosophila) 0.017488
AMPD3 adenosine monophosphate deaminase 3 0.0173124
FNIP1 folliculin interacting protein 1 0.0172601
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0169864
ZNF638 zinc finger protein 638 0.0168616
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0168434
PDE10A phosphodiesterase 10A 0.0167223
HELZ helicase with zinc finger 0.016452
WWOX WW domain containing oxidoreductase 0.0163364
GRB10 growth factor receptor-bound protein 10 0.0162112
ELL2 elongation factor, RNA polymerase II, 2 0.0161625
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0161417
OGA O-GlcNAcase 0.0160676
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0159777
ATXN1 ataxin 1 0.0155936
LOXL2 lysyl oxidase-like 2 0.0153615
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0153603
MAP1B microtubule-associated protein 1B 0.015351
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0150018
CFAP20DC CFAP20 domain containing 0.0149065
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0148327
PRKCA protein kinase C, alpha 0.0146286
LAMB3 laminin, beta 3 0.0145054
SEPTIN9 septin 9 0.0142125
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0142049
BTBD9 BTB (POZ) domain containing 9 0.0141526
MYO1B myosin IB 0.0141371
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0140043
MACF1 microtubule-actin crosslinking factor 1 0.0139115
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0138013
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0137313
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0135106
RAI14 retinoic acid induced 14 0.0133495
ZEB1 zinc finger E-box binding homeobox 1 0.0133213
SMAD3 SMAD family member 3 0.0132637
DOCK5 dedicator of cytokinesis 5 0.0132548
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0131161
FAM219A family with sequence similarity 219, member A 0.0130789
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0130301
KIAA1549L KIAA1549-like 0.0129243
GPC5 glypican 5 0.0128758
NGLY1 N-glycanase 1 0.0128226
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0128
SFPQ splicing factor proline/glutamine-rich 0.0125198
NBAS neuroblastoma amplified sequence 0.0125183
PCBP3 poly(rC) binding protein 3 0.0123688
MLPH melanophilin 0.0123656
GLS2 glutaminase 2 (liver, mitochondrial) 0.0123407

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.309666
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.306527
TMSB10 thymosin beta 10 -0.133818
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.102368
PTMA prothymosin, alpha -0.06918
MT2A metallothionein 2A -0.0683865
IGF2 insulin-like growth factor 2 -0.0612798
FN1 fibronectin 1 -0.0589876
TPT1 tumor protein, translationally-controlled 1 -0.0527461
EGR1 early growth response 1 -0.0508709
ACTG1 actin gamma 1 -0.050479
NDRG1 N-myc downstream regulated 1 -0.0502034
RPL35A ribosomal protein L35a -0.0459523
RPLP1 ribosomal protein, large, P1 -0.0434792
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.040711
RPL23 ribosomal protein L23 -0.0361819
FTL ferritin, light polypeptide -0.0315238
RPS19 ribosomal protein S19 -0.0291906
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.029007
LGALS1 lectin, galactoside-binding, soluble, 1 -0.027248
RPS24 ribosomal protein S24 -0.0270032
RPLP2 ribosomal protein, large, P2 -0.0254341
RPS6 ribosomal protein S6 -0.0254155
S100A10 S100 calcium binding protein A10 -0.0253202
RPS16 ribosomal protein S16 -0.0250729
TGFBI transforming growth factor, beta-induced, 68kDa -0.0243809
RPS13 ribosomal protein S13 -0.023738
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0235099
RPL34 ribosomal protein L34 -0.02319
RPL31 ribosomal protein L31 -0.0231231
RPS8 ribosomal protein S8 -0.0229832
CCND1 cyclin D1 -0.0227469
RPL9 ribosomal protein L9 -0.0225635
LOC112694756 uncharaterized LOC112694756 -0.0221436
GNAS GNAS complex locus -0.0219426
COL1A1 collagen, type I, alpha 1 -0.0207851
IER3 immediate early response 3 -0.0205899
CAVIN1 caveolae associated protein 1 -0.0203311
RPS27A ribosomal protein S27a -0.0203181
TENM2 teneurin transmembrane protein 2 -0.0202863
RPL37A ribosomal protein L37a -0.0201531
S100A6 S100 calcium binding protein A6 -0.0195738
RPS20 ribosomal protein S20 -0.0194888
RPL19 ribosomal protein L19 -0.0191647
NECTIN2 nectin cell adhesion molecule 2 -0.0187649
RPS14 ribosomal protein S14 -0.0186661
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0186617
EIF1 eukaryotic translation initiation factor 1 -0.0183539
RPS23 ribosomal protein S23 -0.0180857
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0176981
LOX lysyl oxidase -0.0169675
RPL38 ribosomal protein L38 -0.0167143
RPS25 ribosomal protein S25 -0.0164392
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0162729
HMGA2 high mobility group AT-hook 2 -0.0162538
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0161096
VCL vinculin -0.0160287
RPL15 ribosomal protein L15 -0.0159641
PKM pyruvate kinase, muscle -0.0158267
RPLP0 ribosomal protein, large, P0 -0.0158179
S100A9 S100 calcium binding protein A9 -0.0153522
RPL11 ribosomal protein L11 -0.0152756
RTN4 reticulon 4 -0.0152448
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0152076
RPL12 ribosomal protein L12 -0.0151595
RPS21 ribosomal protein S21 -0.0151572
RPL36A ribosomal protein L36a -0.0151018
RPS29 ribosomal protein S29 -0.0149653
RPL28 ribosomal protein L28 -0.0148841
RPL30 ribosomal protein L30 -0.0147347
HMGA1 high mobility group AT-hook 1 -0.0145569
ASTN2 astrotactin 2 -0.0145074
RPL27A ribosomal protein L27a -0.0141838
VDAC1 voltage-dependent anion channel 1 -0.0141174
ENO2 enolase 2 (gamma, neuronal) -0.0141032
RPL37 ribosomal protein L37 -0.0140873
RPS27 ribosomal protein S27 -0.0140822
RPL8 ribosomal protein L8 -0.0139419
RPS10 ribosomal protein S10 -0.0139196
VASP vasodilator-stimulated phosphoprotein -0.0137956
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0136748
APOLD1 apolipoprotein L domain containing 1 -0.0135108
COL6A1 collagen, type VI, alpha 1 -0.0134487
IGFBP4 insulin-like growth factor binding protein 4 -0.0132854
FTH1 ferritin, heavy polypeptide 1 -0.0131788
RPL32 ribosomal protein L32 -0.0131375
RACK1 receptor for activated C kinase 1 -0.0130544
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0126799
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0126699
RPL26 ribosomal protein L26 -0.0126627
WSB1 WD repeat and SOCS box containing 1 -0.0126092
RPL7A ribosomal protein L7a -0.0124603
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0120485
RPL5 ribosomal protein L5 -0.0120412
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0118309
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0117875
PNISR PNN-interacting serine/arginine-rich protein -0.011714
HLA-B major histocompatibility complex, class I, B -0.0116942
OSMR oncostatin M receptor -0.0116435
CDCP1 CUB domain containing protein 1 -0.0115447