Cloxacillin (sodium)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.314268
COL6A3 collagen, type VI, alpha 3 0.132117
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0772187
TRIO trio Rho guanine nucleotide exchange factor 0.0735155
MYH9 myosin, heavy chain 9, non-muscle 0.0683312
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0637294
CADM1 cell adhesion molecule 1 0.0611735
FNDC3B fibronectin type III domain containing 3B 0.0543564
VEGFA vascular endothelial growth factor A 0.0528354
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0525968
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0483045
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0462845
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0453829
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0450314
SOD2 superoxide dismutase 2, mitochondrial 0.039199
FBN1 fibrillin 1 0.0346778
PDE10A phosphodiesterase 10A 0.0342989
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0321369
JARID2 jumonji, AT rich interactive domain 2 0.0314314
NAV2 neuron navigator 2 0.0308734
AHNAK AHNAK nucleoprotein 0.0305861
COL5A1 collagen, type V, alpha 1 0.0304762
CXCL8 chemokine (C-X-C motif) ligand 8 0.0295959
CDH13 cadherin 13 0.0295669
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0292544
CANX calnexin 0.0278127
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0272954
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0263767
ANKRD11 ankyrin repeat domain 11 0.0261154
GOLGB1 golgin B1 0.0261098
COPA coatomer protein complex, subunit alpha 0.0251805
TTC3 tetratricopeptide repeat domain 3 0.0247519
ESYT2 extended synaptotagmin-like protein 2 0.0245674
PDIA6 protein disulfide isomerase family A, member 6 0.0244891
RUNX1 runt-related transcription factor 1 0.0244646
FMNL2 formin-like 2 0.0238852
COL7A1 collagen, type VII, alpha 1 0.0235739
CCNY cyclin Y 0.0231048
HOOK2 hook microtubule-tethering protein 2 0.0226811
PTK2 protein tyrosine kinase 2 0.0226656
SUCO SUN domain containing ossification factor 0.0223199
PICALM phosphatidylinositol binding clathrin assembly protein 0.0222077
ANXA1 annexin A1 0.0220518
HYOU1 hypoxia up-regulated 1 0.020922
PLEC plectin 0.0205309
FNIP1 folliculin interacting protein 1 0.0201022
MACF1 microtubule-actin crosslinking factor 1 0.0200882
BRD2 bromodomain containing 2 0.0196399
SFPQ splicing factor proline/glutamine-rich 0.019527
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0192756
ZSWIM6 zinc finger, SWIM-type containing 6 0.0191891
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0191304
SPAG9 sperm associated antigen 9 0.0189498
APP amyloid beta (A4) precursor protein 0.0189063
NAMPT nicotinamide phosphoribosyltransferase 0.0188935
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0185619
HILPDA hypoxia inducible lipid droplet-associated 0.0185564
CAMTA1 calmodulin binding transcription activator 1 0.0183923
ERRFI1 ERBB receptor feedback inhibitor 1 0.0183411
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0178954
EFNA5 ephrin-A5 0.0178893
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0178193
TNS1 tensin 1 0.0177277
CHD1 chromodomain helicase DNA binding protein 1 0.0176496
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0175984
PDIA5 protein disulfide isomerase family A, member 5 0.0175403
QKI QKI, KH domain containing, RNA binding 0.0172134
NBAS neuroblastoma amplified sequence 0.0170666
KMT2C lysine (K)-specific methyltransferase 2C 0.0170662
FGFR1 fibroblast growth factor receptor 1 0.0167978
EGFR epidermal growth factor receptor 0.01679
MRTFA myocardin related transcription factor A 0.0164359
ECPAS Ecm29 proteasome adaptor and scaffold 0.016405
PDIA3 protein disulfide isomerase family A, member 3 0.0163993
LPP LIM domain containing preferred translocation partner in lipoma 0.0162585
CLINT1 clathrin interactor 1 0.0161785
DOCK7 dedicator of cytokinesis 7 0.0161004
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0160526
GOLGA4 golgin A4 0.0158954
SQSTM1 sequestosome 1 0.015746
IARS1 isoleucyl-tRNA synthetase 1 0.0156863
SND1 staphylococcal nuclease and tudor domain containing 1 0.0156525
CD109 CD109 molecule 0.015602
PTPRM protein tyrosine phosphatase, receptor type, M 0.0155575
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0155483
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0155478
ADAM17 ADAM metallopeptidase domain 17 0.0155025
HELZ helicase with zinc finger 0.0154996
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0154834
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0154606
TRA2A transformer 2 alpha homolog (Drosophila) 0.0154295
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.015233
RND3 Rho family GTPase 3 0.0151757
KDM2A lysine (K)-specific demethylase 2A 0.0148933
TENT4A terminal nucleotidyltransferase 4A 0.0148226
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0148047
EEF2 eukaryotic translation elongation factor 2 0.014757
RLF rearranged L-myc fusion 0.0147375
CTBP2 C-terminal binding protein 2 0.0147299
FAM13A family with sequence similarity 13, member A 0.0145071

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.219935
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.199934
COL1A1 collagen, type I, alpha 1 -0.168662
MT2A metallothionein 2A -0.151498
TMSB10 thymosin beta 10 -0.123115
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.116019
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.110436
FN1 fibronectin 1 -0.0816333
COL1A2 collagen, type I, alpha 2 -0.0784284
STC1 stanniocalcin 1 -0.0653075
TIMP3 TIMP metallopeptidase inhibitor 3 -0.064082
FTL ferritin, light polypeptide -0.0593449
RPL35A ribosomal protein L35a -0.0504731
TGFBI transforming growth factor, beta-induced, 68kDa -0.0500522
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.049129
CD44 CD44 molecule (Indian blood group) -0.049113
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0487704
S100A9 S100 calcium binding protein A9 -0.0487251
TM4SF1 transmembrane 4 L six family member 1 -0.0472205
PTMA prothymosin, alpha -0.0452873
HLA-B major histocompatibility complex, class I, B -0.0388121
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0387601
ACTG1 actin gamma 1 -0.03838
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.038313
IER3 immediate early response 3 -0.0381055
IGFBP7 insulin-like growth factor binding protein 7 -0.0370168
B2M beta-2-microglobulin -0.0367291
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0363486
RPS8 ribosomal protein S8 -0.035509
INHBA inhibin, beta A -0.0353191
IFI6 interferon, alpha-inducible protein 6 -0.0350449
EXT1 exostosin glycosyltransferase 1 -0.0340355
RPS19 ribosomal protein S19 -0.0323334
RPL8 ribosomal protein L8 -0.0319568
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0316143
TPT1 tumor protein, translationally-controlled 1 -0.0313016
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0311893
LTBP1 latent transforming growth factor beta binding protein 1 -0.0309051
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0304861
S100A6 S100 calcium binding protein A6 -0.0298779
RPL23 ribosomal protein L23 -0.0288865
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0287348
TPM4 tropomyosin 4 -0.0281618
PFN1 profilin 1 -0.0280898
ZBTB20 zinc finger and BTB domain containing 20 -0.027796
MT1X metallothionein 1X -0.0276164
LDHA lactate dehydrogenase A -0.0272576
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0260861
MAP1B microtubule-associated protein 1B -0.0257741
RPL34 ribosomal protein L34 -0.0256118
KLF6 Kruppel-like factor 6 -0.025257
TPI1 triosephosphate isomerase 1 -0.0250074
RPL19 ribosomal protein L19 -0.0242764
RPL11 ribosomal protein L11 -0.0239409
RPL12 ribosomal protein L12 -0.0238389
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0235014
S100A10 S100 calcium binding protein A10 -0.0232085
RPL30 ribosomal protein L30 -0.0230427
RPLP2 ribosomal protein, large, P2 -0.0229809
ALCAM activated leukocyte cell adhesion molecule -0.0229322
CALD1 caldesmon 1 -0.0229178
RPS6 ribosomal protein S6 -0.0226786
OSMR oncostatin M receptor -0.0225889
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0225019
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.022228
F3 coagulation factor III (thromboplastin, tissue factor) -0.0217542
HMGA1 high mobility group AT-hook 1 -0.0216421
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0214286
RPS24 ribosomal protein S24 -0.0213956
EGR1 early growth response 1 -0.0212216
RPL32 ribosomal protein L32 -0.0208417
RPS13 ribosomal protein S13 -0.020698
GLIS3 GLIS family zinc finger 3 -0.0206282
POSTN periostin, osteoblast specific factor -0.0203449
IFITM3 interferon induced transmembrane protein 3 -0.02034
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0201242
EIF1 eukaryotic translation initiation factor 1 -0.0198945
RPL28 ribosomal protein L28 -0.0198353
ENO1 enolase 1, (alpha) -0.0197687
RPS11 ribosomal protein S11 -0.0197677
RACK1 receptor for activated C kinase 1 -0.0195608
RPL26 ribosomal protein L26 -0.0194836
RPS3 ribosomal protein S3 -0.0193603
RPLP1 ribosomal protein, large, P1 -0.0193449
DPYD dihydropyrimidine dehydrogenase -0.0193319
RPS21 ribosomal protein S21 -0.0190697
RPS5 ribosomal protein S5 -0.0187568
VCAN versican -0.0186962
TUBB tubulin, beta class I -0.0186472
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0185092
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0182908
RPS14 ribosomal protein S14 -0.0182907
PALLD palladin, cytoskeletal associated protein -0.0180203
RPLP0 ribosomal protein, large, P0 -0.0179864
RPL36 ribosomal protein L36 -0.017874
VDAC1 voltage-dependent anion channel 1 -0.0177853
FRMD4A FERM domain containing 4A -0.0176845
RPL18 ribosomal protein L18 -0.0176681
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0176412
ANXA2 annexin A2 -0.0175517