Cloxacillin (sodium)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.259004
ERRFI1 ERBB receptor feedback inhibitor 1 0.118628
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.104267
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0795105
FNDC3B fibronectin type III domain containing 3B 0.0577027
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0528089
TF transferrin 0.0509455
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0502714
TNS1 tensin 1 0.0473739
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0433664
FAM13A family with sequence similarity 13, member A 0.0407101
DSPP dentin sialophosphoprotein 0.0402521
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0388693
BHLHE40 basic helix-loop-helix family, member e40 0.0361924
PEG3 paternally expressed 3 0.0360533
JMJD1C jumonji domain containing 1C 0.0335822
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.032415
SAMD4A sterile alpha motif domain containing 4A 0.0306403
TRIO trio Rho guanine nucleotide exchange factor 0.0303018
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0289795
ARFGEF3 ARFGEF family member 3 0.0264992
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.025409
DTNA dystrobrevin, alpha 0.0253694
KDM3A lysine (K)-specific demethylase 3A 0.0244808
RUNX1 runt-related transcription factor 1 0.0230578
VEGFA vascular endothelial growth factor A 0.0228484
CRY1 cryptochrome circadian clock 1 0.0223826
AFDN afadin, adherens junction formation factor 0.0222124
HOOK2 hook microtubule-tethering protein 2 0.0220701
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0220051
RYBP RING1 and YY1 binding protein 0.0219322
ELL2 elongation factor, RNA polymerase II, 2 0.0215786
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0214644
NAMPT nicotinamide phosphoribosyltransferase 0.0213987
RAI14 retinoic acid induced 14 0.0213414
GRB10 growth factor receptor-bound protein 10 0.0212823
MAP2K1 mitogen-activated protein kinase kinase 1 0.0211597
SVIL supervillin 0.0210983
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0209971
DDIT4 DNA-damage-inducible transcript 4 0.0208693
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0207208
RBM39 RNA binding motif protein 39 0.0206233
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0205736
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0204958
EIF4B eukaryotic translation initiation factor 4B 0.0203695
TMEM181 transmembrane protein 181 0.020025
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0199365
ESYT2 extended synaptotagmin-like protein 2 0.0193801
ZNF292 zinc finger protein 292 0.0193791
FAM117B family with sequence similarity 117, member B 0.0190587
ARHGAP21 Rho GTPase activating protein 21 0.0185361
NGLY1 N-glycanase 1 0.018482
MYO1B myosin IB 0.0182861
RLF rearranged L-myc fusion 0.018283
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0178076
BIRC3 baculoviral IAP repeat containing 3 0.0178033
INSIG2 insulin induced gene 2 0.0173967
CAMTA1 calmodulin binding transcription activator 1 0.0172895
ATF3 activating transcription factor 3 0.0171809
RPL3 ribosomal protein L3 0.0167015
KIAA1217 KIAA1217 0.0164451
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0163432
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0163355
IGFBP3 insulin-like growth factor binding protein 3 0.0162205
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0159308
SPAG9 sperm associated antigen 9 0.0158136
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0157876
HELZ helicase with zinc finger 0.0157054
WWC2 WW and C2 domain containing 2 0.0157013
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0156707
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0154827
ARRDC3 arrestin domain containing 3 0.0154032
CCNY cyclin Y 0.0153512
GCLC glutamate-cysteine ligase, catalytic subunit 0.0153306
FTH1 ferritin, heavy polypeptide 1 0.0152199
ADAM17 ADAM metallopeptidase domain 17 0.0149167
SOS1 son of sevenless homolog 1 (Drosophila) 0.0148994
TCIM transcriptional and immune response regulator 0.0147244
NDRG1 N-myc downstream regulated 1 0.0147023
RB1CC1 RB1-inducible coiled-coil 1 0.0146212
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0146203
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0146161
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0146128
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0146061
MTSS1 metastasis suppressor 1 0.0144599
ZBTB10 zinc finger and BTB domain containing 10 0.0144386
PDE8A phosphodiesterase 8A 0.0142605
MYH9 myosin, heavy chain 9, non-muscle 0.0141307
PER2 period circadian clock 2 0.0140946
PCCA propionyl CoA carboxylase, alpha polypeptide 0.014071
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0140189
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0139885
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0139392
WDR45B WD repeat domain 45B 0.0138816
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0138136
EXT1 exostosin glycosyltransferase 1 0.0136506
HSPA8 heat shock 70kDa protein 8 0.0135814
ARHGAP26 Rho GTPase activating protein 26 0.0134305
TLK1 tousled-like kinase 1 0.0133491
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0132644

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.146345
MT2A metallothionein 2A -0.124564
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.114887
APOB apolipoprotein B -0.105503
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.102498
APOA2 apolipoprotein A-II -0.0896117
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0855794
TPT1 tumor protein, translationally-controlled 1 -0.0742204
TMSB10 thymosin beta 10 -0.0711614
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0653166
GPC3 glypican 3 -0.0651112
SLC38A2 solute carrier family 38, member 2 -0.0598418
RPS12 ribosomal protein S12 -0.0589556
RPL37A ribosomal protein L37a -0.0568079
TM4SF1 transmembrane 4 L six family member 1 -0.0536424
IGFBP1 insulin-like growth factor binding protein 1 -0.0534338
RPL23 ribosomal protein L23 -0.0508663
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0484991
HMGA1 high mobility group AT-hook 1 -0.0466461
RPS27A ribosomal protein S27a -0.0453093
FTL ferritin, light polypeptide -0.0418293
LRMDA leucine rich melanocyte differentiation associated -0.0416165
APOE apolipoprotein E -0.0413371
RPS19 ribosomal protein S19 -0.0383834
C3 complement component 3 -0.0379087
RPLP2 ribosomal protein, large, P2 -0.0374293
RPS24 ribosomal protein S24 -0.0373783
RPS8 ribosomal protein S8 -0.0369594
RPS6 ribosomal protein S6 -0.0367971
RPLP1 ribosomal protein, large, P1 -0.0366819
RPL11 ribosomal protein L11 -0.0365935
CPE carboxypeptidase E -0.0348169
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0339813
RPS21 ribosomal protein S21 -0.0335539
ENO1 enolase 1, (alpha) -0.0324108
RPL34 ribosomal protein L34 -0.0319222
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0314352
RPL9 ribosomal protein L9 -0.0305178
TRIM26 tripartite motif containing 26 -0.0302258
GMDS GDP-mannose 4,6-dehydratase -0.0302025
EML4 echinoderm microtubule associated protein like 4 -0.0301234
IFI6 interferon, alpha-inducible protein 6 -0.0300852
S100A9 S100 calcium binding protein A9 -0.0293271
RPL35A ribosomal protein L35a -0.029063
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0287203
VCL vinculin -0.0286804
NKD1 naked cuticle homolog 1 (Drosophila) -0.0282313
UBC ubiquitin C -0.0276004
PDLIM5 PDZ and LIM domain 5 -0.0267538
AHSG alpha-2-HS-glycoprotein -0.0264585
ZBTB20 zinc finger and BTB domain containing 20 -0.0254652
RPS3 ribosomal protein S3 -0.0254502
PTMA prothymosin, alpha -0.0249856
RPL12 ribosomal protein L12 -0.0246256
DLC1 DLC1 Rho GTPase activating protein -0.0246149
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0245624
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.024164
FRMD5 FERM domain containing 5 -0.024129
RPL28 ribosomal protein L28 -0.0238668
ITGAV integrin, alpha V -0.023756
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0233468
RPL31 ribosomal protein L31 -0.0231757
KRT8 keratin 8, type II -0.0228642
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0228095
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0227213
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0221799
ISG15 ISG15 ubiquitin-like modifier -0.0221514
RACK1 receptor for activated C kinase 1 -0.0221511
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0220632
IFITM1 interferon induced transmembrane protein 1 -0.0220459
PTCHD4 patched domain containing 4 -0.0220045
A2M alpha-2-macroglobulin -0.0218399
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0218173
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0217976
PTPRF protein tyrosine phosphatase, receptor type, F -0.0214463
RPS13 ribosomal protein S13 -0.0213381
AMBP alpha-1-microglobulin/bikunin precursor -0.0211509
RPS23 ribosomal protein S23 -0.0210726
RPL36A ribosomal protein L36a -0.0210674
ARHGAP18 Rho GTPase activating protein 18 -0.0210106
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0209674
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0208987
RPL18 ribosomal protein L18 -0.020765
TMEM123 transmembrane protein 123 -0.0206981
RPS25 ribosomal protein S25 -0.020421
MAML2 mastermind-like 2 (Drosophila) -0.020286
ZFHX3 zinc finger homeobox 3 -0.0201226
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0199973
APOA1 apolipoprotein A-I -0.0199785
UBASH3B ubiquitin associated and SH3 domain containing B -0.0198773
RPS14 ribosomal protein S14 -0.0197369
RPL37 ribosomal protein L37 -0.0195619
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0195111
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0195052
BCL2L1 BCL2-like 1 -0.019477
MRTFA myocardin related transcription factor A -0.0194429
RPL32 ribosomal protein L32 -0.0193413
POTEF POTE ankyrin domain family, member F -0.0190988
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0190932
RPL26 ribosomal protein L26 -0.0190716