Cloxacillin (sodium)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0501204
FNDC3B fibronectin type III domain containing 3B 0.0492319
MYOF myoferlin 0.0475626
APLP2 amyloid beta (A4) precursor-like protein 2 0.0442296
PTK2 protein tyrosine kinase 2 0.0432073
SMAD3 SMAD family member 3 0.0425025
MSN moesin 0.0413357
TRIO trio Rho guanine nucleotide exchange factor 0.0405369
INTS6 integrator complex subunit 6 0.039399
NAV2 neuron navigator 2 0.0322348
MBNL2 muscleblind-like splicing regulator 2 0.0304845
PICALM phosphatidylinositol binding clathrin assembly protein 0.0296343
FNIP1 folliculin interacting protein 1 0.0291464
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0287425
ESYT2 extended synaptotagmin-like protein 2 0.0284374
NRIP1 nuclear receptor interacting protein 1 0.0276866
TGM2 transglutaminase 2 0.0260016
ITCH itchy E3 ubiquitin protein ligase 0.0251654
PCDH1 protocadherin 1 0.0251435
ZCCHC7 zinc finger, CCHC domain containing 7 0.02451
TSC22D1 TSC22 domain family, member 1 0.0244013
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0243504
MBNL1 muscleblind-like splicing regulator 1 0.0236704
AKAP13 A kinase (PRKA) anchor protein 13 0.0228574
DOCK5 dedicator of cytokinesis 5 0.0227142
COG6 component of oligomeric golgi complex 6 0.0227135
MYH9 myosin, heavy chain 9, non-muscle 0.0226843
SFPQ splicing factor proline/glutamine-rich 0.022577
FRMD6 FERM domain containing 6 0.0219501
CEMIP cell migration inducing protein, hyaluronan binding 0.0216044
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0213817
PDLIM5 PDZ and LIM domain 5 0.0207206
PRELID2 PRELI domain containing 2 0.0202965
PCBP2 poly(rC) binding protein 2 0.0202235
C1D C1D nuclear receptor corepressor 0.0197428
CYB5R3 cytochrome b5 reductase 3 0.0197155
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0195849
RICTOR RPTOR independent companion of MTOR, complex 2 0.0193013
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0192169
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0188936
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0188715
LAMA5 laminin, alpha 5 0.0188316
TRA2A transformer 2 alpha homolog (Drosophila) 0.0187608
HMGA2 high mobility group AT-hook 2 0.0186295
LRRC8C leucine rich repeat containing 8 family, member C 0.0179804
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0179529
RNF145 ring finger protein 145 0.0178881
ZNF638 zinc finger protein 638 0.0177896
KDM4C lysine (K)-specific demethylase 4C 0.0177809
CAPRIN2 caprin family member 2 0.0175852
DLG1 discs, large homolog 1 (Drosophila) 0.0175353
ZNF292 zinc finger protein 292 0.0174153
YAP1 Yes-associated protein 1 0.0172956
ARRDC3 arrestin domain containing 3 0.017171
CTNNBL1 catenin, beta like 1 0.0171211
HELZ helicase with zinc finger 0.0170391
PLS3 plastin 3 0.0168335
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.01673
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0166893
KDM2A lysine (K)-specific demethylase 2A 0.0166691
ANKRD28 ankyrin repeat domain 28 0.0166313
KIF16B kinesin family member 16B 0.0165962
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0165221
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0164205
TFG TRK-fused gene 0.0163971
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0163822
ZZZ3 zinc finger, ZZ-type containing 3 0.0163672
ZSWIM6 zinc finger, SWIM-type containing 6 0.0161445
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.01608
NUP58 nucleoporin 58 0.0158981
NCOR2 nuclear receptor corepressor 2 0.0158939
PTBP3 polypyrimidine tract binding protein 3 0.0158273
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0158219
ANO6 anoctamin 6 0.0157177
KTN1 kinectin 1 (kinesin receptor) 0.0156446
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0156254
ANKRD11 ankyrin repeat domain 11 0.0154565
JAG1 jagged 1 0.0154262
NUMA1 nuclear mitotic apparatus protein 1 0.0153985
PCCA propionyl CoA carboxylase, alpha polypeptide 0.015391
WDR26 WD repeat domain 26 0.01539
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0152914
ANXA1 annexin A1 0.0152713
DIAPH1 diaphanous-related formin 1 0.0150373
GRB10 growth factor receptor-bound protein 10 0.0149881
SUCO SUN domain containing ossification factor 0.0148458
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0148345
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0147512
AMOTL1 angiomotin like 1 0.0147244
LPAR1 lysophosphatidic acid receptor 1 0.0147206
FAT1 FAT atypical cadherin 1 0.0146219
KLF12 Kruppel-like factor 12 0.0145964
GPR176 G protein-coupled receptor 176 0.0145934
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0145658
ABHD2 abhydrolase domain containing 2 0.0145575
UBAC2 UBA domain containing 2 0.0145218
RBM39 RNA binding motif protein 39 0.0145158
RAB6A RAB6A, member RAS oncogene family 0.0144512
SVIL supervillin 0.0144004
RNF217 ring finger protein 217 0.0143905

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.29936
TPT1 tumor protein, translationally-controlled 1 -0.174836
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.16716
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128809
NDRG1 N-myc downstream regulated 1 -0.0995459
PGK1 phosphoglycerate kinase 1 -0.084741
FLNB filamin B, beta -0.0837246
HLA-B major histocompatibility complex, class I, B -0.0827201
S100A10 S100 calcium binding protein A10 -0.0810015
TMSB4X thymosin beta 4, X-linked -0.0795475
MT2A metallothionein 2A -0.0781802
ENO1 enolase 1, (alpha) -0.0714412
SULF1 sulfatase 1 -0.0705348
PTMA prothymosin, alpha -0.0651104
LDHA lactate dehydrogenase A -0.0645196
B2M beta-2-microglobulin -0.064506
TMSB10 thymosin beta 10 -0.0639888
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0636416
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0603866
STC1 stanniocalcin 1 -0.0593624
HLA-E major histocompatibility complex, class I, E -0.0573991
ZMYND8 zinc finger, MYND-type containing 8 -0.0561851
ANXA2 annexin A2 -0.0554487
RPS24 ribosomal protein S24 -0.0549047
RPLP1 ribosomal protein, large, P1 -0.0547078
AHNAK AHNAK nucleoprotein -0.0543878
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0539336
CAV1 caveolin 1, caveolae protein, 22kDa -0.0538508
IFITM1 interferon induced transmembrane protein 1 -0.0530418
IFITM3 interferon induced transmembrane protein 3 -0.0468397
PALM2AKAP2 PALM2 and AKAP2 fusion -0.045627
ABI3BP ABI family, member 3 (NESH) binding protein -0.0454568
RPS21 ribosomal protein S21 -0.0452985
RPL11 ribosomal protein L11 -0.0448788
RPS8 ribosomal protein S8 -0.0446397
LAMC2 laminin, gamma 2 -0.0446249
CAVIN1 caveolae associated protein 1 -0.0445678
GNAS GNAS complex locus -0.0438091
LOC112694756 uncharaterized LOC112694756 -0.0436589
RPS13 ribosomal protein S13 -0.0433467
RPL34 ribosomal protein L34 -0.0427311
DUSP6 dual specificity phosphatase 6 -0.0425968
RPL37 ribosomal protein L37 -0.041977
CD9 CD9 molecule -0.041771
CALB1 calbindin 1, 28kDa -0.0413217
SULF2 sulfatase 2 -0.0403122
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0401419
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0397692
RPL12 ribosomal protein L12 -0.0396837
IFI16 interferon, gamma-inducible protein 16 -0.0395264
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0389643
RPS19 ribosomal protein S19 -0.0388099
RPLP0 ribosomal protein, large, P0 -0.038106
RPLP2 ribosomal protein, large, P2 -0.0380662
EMP1 epithelial membrane protein 1 -0.0377638
VDAC1 voltage-dependent anion channel 1 -0.0376097
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0373479
TM4SF1 transmembrane 4 L six family member 1 -0.0370683
RPL37A ribosomal protein L37a -0.0370566
RPL35A ribosomal protein L35a -0.0370008
S100A11 S100 calcium binding protein A11 -0.0364992
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0363129
RPS3 ribosomal protein S3 -0.0362771
FTL ferritin, light polypeptide -0.0360161
PODXL podocalyxin-like -0.0359827
S100A6 S100 calcium binding protein A6 -0.035911
LMNA lamin A/C -0.0358498
PLAT plasminogen activator, tissue -0.0357678
RPS6 ribosomal protein S6 -0.034509
EGR1 early growth response 1 -0.0338553
BZW1 basic leucine zipper and W2 domains 1 -0.0338237
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0337545
RPL7A ribosomal protein L7a -0.0333984
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.033115
EIF1 eukaryotic translation initiation factor 1 -0.0330905
IFIH1 interferon induced with helicase C domain 1 -0.0325739
IER3 immediate early response 3 -0.032453
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0323834
IGF2 insulin-like growth factor 2 -0.0321361
THBD thrombomodulin -0.0321093
MECOM MDS1 and EVI1 complex locus -0.0320589
ZNFX1 zinc finger, NFX1-type containing 1 -0.0313987
DPYD dihydropyrimidine dehydrogenase -0.0313586
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0313065
PRRC2C proline-rich coiled-coil 2C -0.0305798
KLF6 Kruppel-like factor 6 -0.0302825
RAI14 retinoic acid induced 14 -0.0302758
HM13 histocompatibility (minor) 13 -0.0296967
RPL8 ribosomal protein L8 -0.0292912
RPS25 ribosomal protein S25 -0.0292731
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0288131
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0285787
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0285609
CSTB cystatin B (stefin B) -0.0285122
TPM4 tropomyosin 4 -0.0283086
IFI6 interferon, alpha-inducible protein 6 -0.0282695
RPS12 ribosomal protein S12 -0.0279203
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.027629
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0275425
RPL26 ribosomal protein L26 -0.0275246