Cloxacillin (sodium)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cloxacillin (sodium)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.245609
RPS6 ribosomal protein S6 0.125729
RUNX1 runt-related transcription factor 1 0.121395
ERRFI1 ERBB receptor feedback inhibitor 1 0.117145
PBX3 pre-B-cell leukemia homeobox 3 0.102509
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0969515
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0954311
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0937332
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0932343
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0767403
CXCL8 chemokine (C-X-C motif) ligand 8 0.0720902
EXT1 exostosin glycosyltransferase 1 0.0713885
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0712861
USP34 ubiquitin specific peptidase 34 0.0672461
TXNIP thioredoxin interacting protein 0.0659501
SAMD4A sterile alpha motif domain containing 4A 0.0651556
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0649098
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0632764
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.063273
KDM3A lysine (K)-specific demethylase 3A 0.0624138
JMJD1C jumonji domain containing 1C 0.0620328
MYO10 myosin X 0.0618157
PRKCE protein kinase C, epsilon 0.0602676
EEF2 eukaryotic translation elongation factor 2 0.058738
MACF1 microtubule-actin crosslinking factor 1 0.0570002
DST dystonin 0.0569206
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0568157
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0562968
PTK2 protein tyrosine kinase 2 0.0555529
PRKG1 protein kinase, cGMP-dependent, type I 0.055548
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0541272
KTN1 kinectin 1 (kinesin receptor) 0.0500494
PGK1 phosphoglycerate kinase 1 0.0499655
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0494695
EFNA5 ephrin-A5 0.0493473
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0487292
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0484153
UBA6 ubiquitin-like modifier activating enzyme 6 0.0482548
ZEB1 zinc finger E-box binding homeobox 1 0.0476773
PICALM phosphatidylinositol binding clathrin assembly protein 0.0476752
EIF1 eukaryotic translation initiation factor 1 0.0474762
KDM2A lysine (K)-specific demethylase 2A 0.0467898
ASPH aspartate beta-hydroxylase 0.0464274
RND3 Rho family GTPase 3 0.0464252
CALD1 caldesmon 1 0.0457953
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.045651
NUP58 nucleoporin 58 0.0449119
SPAG9 sperm associated antigen 9 0.0447284
ZSWIM6 zinc finger, SWIM-type containing 6 0.0434071
BRD2 bromodomain containing 2 0.0433272
WDR45B WD repeat domain 45B 0.0431204
TTC3 tetratricopeptide repeat domain 3 0.043058
NGLY1 N-glycanase 1 0.0429977
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0428144
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0415533
JUN jun proto-oncogene 0.040743
APLP2 amyloid beta (A4) precursor-like protein 2 0.0406451
MSN moesin 0.0405077
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0403895
ARHGAP32 Rho GTPase activating protein 32 0.0402357
DOCK4 dedicator of cytokinesis 4 0.0401715
FMNL2 formin-like 2 0.0390258
ZNF638 zinc finger protein 638 0.0387544
DENR density-regulated protein 0.0385071
MXI1 MAX interactor 1, dimerization protein 0.0373361
HSPA8 heat shock 70kDa protein 8 0.0372582
MAP2K1 mitogen-activated protein kinase kinase 1 0.0368265
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0364526
DSCAM Down syndrome cell adhesion molecule 0.036356
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0362941
CORO1C coronin, actin binding protein, 1C 0.0362392
PHACTR1 phosphatase and actin regulator 1 0.0359374
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0357993
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0349057
MYH9 myosin, heavy chain 9, non-muscle 0.0346576
HOOK2 hook microtubule-tethering protein 2 0.0344962
ADAM9 ADAM metallopeptidase domain 9 0.0340391
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0338798
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0332614
RLF rearranged L-myc fusion 0.0331504
ATF3 activating transcription factor 3 0.0329343
ELL2 elongation factor, RNA polymerase II, 2 0.0328035
TRIO trio Rho guanine nucleotide exchange factor 0.0326822
ARHGAP21 Rho GTPase activating protein 21 0.0325903
ESYT2 extended synaptotagmin-like protein 2 0.0323653
GPHN gephyrin 0.0320066
RPLP1 ribosomal protein, large, P1 0.0313449
PKM pyruvate kinase, muscle 0.0313369
SMAP1 small ArfGAP 1 0.0309324
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0306089
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0305525
IRS2 insulin receptor substrate 2 0.0305158
EIF4B eukaryotic translation initiation factor 4B 0.0301448
JARID2 jumonji, AT rich interactive domain 2 0.0296296
RPL4 ribosomal protein L4 0.0295373
OSBPL8 oxysterol binding protein-like 8 0.0294064
C2CD2 C2 calcium-dependent domain containing 2 0.0293043
SRRM2 serine/arginine repetitive matrix 2 0.0288914
CD109 CD109 molecule 0.0287704
NBAS neuroblastoma amplified sequence 0.0283593

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.0634185
PTCHD4 patched domain containing 4 -0.0517712
PDE4D phosphodiesterase 4D, cAMP-specific -0.0513719
GPC6 glypican 6 -0.0430125
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0427524
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0423344
TMSB10 thymosin beta 10 -0.039501
RTN4 reticulon 4 -0.0376967
ALCAM activated leukocyte cell adhesion molecule -0.0373805
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.036806
OSMR oncostatin M receptor -0.035407
RPL23 ribosomal protein L23 -0.0336091
TPT1 tumor protein, translationally-controlled 1 -0.0333779
RPS24 ribosomal protein S24 -0.0329861
ERBIN erbb2 interacting protein -0.0318205
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.031159
HAS2 hyaluronan synthase 2 -0.0304865
SMAD3 SMAD family member 3 -0.0302495
HMGA1 high mobility group AT-hook 1 -0.0297872
NLGN1 neuroligin 1 -0.0292515
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0285718
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0285541
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0281899
CD44 CD44 molecule (Indian blood group) -0.0277064
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0272059
KLF7 Kruppel-like factor 7 (ubiquitous) -0.027155
PCDH11X protocadherin 11 X-linked -0.0268682
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0268287
RAD21 RAD21 homolog (S. pombe) -0.0258367
GNAS GNAS complex locus -0.025726
SMC4 structural maintenance of chromosomes 4 -0.0256927
ETV6 ets variant 6 -0.0250786
IFI16 interferon, gamma-inducible protein 16 -0.0250414
RPLP0 ribosomal protein, large, P0 -0.0250038
RIGI RNA sensor RIG-I -0.0245693
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0245199
STK17A serine/threonine kinase 17a -0.024085
HMGB1 high mobility group box 1 -0.0239157
FN1 fibronectin 1 -0.0238437
EGFR epidermal growth factor receptor -0.0236751
KLF6 Kruppel-like factor 6 -0.0231663
PHF3 PHD finger protein 3 -0.0230873
ZNF217 zinc finger protein 217 -0.0230437
STC1 stanniocalcin 1 -0.0226306
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0225986
MYOF myoferlin -0.0223276
TNNC1 troponin C type 1 (slow) -0.0217978
MBD5 methyl-CpG binding domain protein 5 -0.02174
TUBB tubulin, beta class I -0.0217294
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0216691
NT5E 5'-nucleotidase, ecto (CD73) -0.0216635
NRP2 neuropilin 2 -0.0216237
ZBTB20 zinc finger and BTB domain containing 20 -0.0212884
AKAP12 A kinase (PRKA) anchor protein 12 -0.0210238
PFN1 profilin 1 -0.0210213
TPX2 TPX2, microtubule-associated -0.0209003
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0203707
CAV1 caveolin 1, caveolae protein, 22kDa -0.020246
RPS21 ribosomal protein S21 -0.0200695
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0200528
CENPE centromere protein E, 312kDa -0.0199259
PRSS23 protease, serine, 23 -0.0198788
SAMD3 sterile alpha motif domain containing 3 -0.019746
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0195996
NPC1 Niemann-Pick disease, type C1 -0.0194615
TPI1 triosephosphate isomerase 1 -0.0193842
RAD51B RAD51 paralog B -0.0193535
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.019006
SOD2 superoxide dismutase 2, mitochondrial -0.0189086
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0188702
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0188623
GLMN glomulin, FKBP associated protein -0.0188146
LOXL2 lysyl oxidase-like 2 -0.0187991
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0187871
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.01851
PTMA prothymosin, alpha -0.0180223
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0179922
TRPS1 trichorhinophalangeal syndrome I -0.0177865
TUBB6 tubulin, beta 6 class V -0.0177794
ZMYND8 zinc finger, MYND-type containing 8 -0.0176113
CSNK1A1 casein kinase 1, alpha 1 -0.0175921
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0175324
PCNX4 pecanex 4 -0.0172682
RNF213 ring finger protein 213 -0.0172443
BMAL2 basic helix-loop-helix ARNT like 2 -0.0172356
KDM5A lysine (K)-specific demethylase 5A -0.0171634
SON SON DNA binding protein -0.017127
CBX3 chromobox homolog 3 -0.0169882
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0169014
ACTN1 actinin, alpha 1 -0.0168969
HMGA2 high mobility group AT-hook 2 -0.0168576
FNDC3B fibronectin type III domain containing 3B -0.0167638
PMP22 peripheral myelin protein 22 -0.0167285
AEBP2 AE binding protein 2 -0.0165887
INHBA inhibin, beta A -0.0165677
NAV1 neuron navigator 1 -0.0165493
ANKRD28 ankyrin repeat domain 28 -0.0163118
CAPNS1 calpain, small subunit 1 -0.0161315
ZNF804A zinc finger protein 804A -0.0160719
ZNF207 zinc finger protein 207 -0.0160717