Cloxacillin (sodium)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.072788
NPSR1 neuropeptide S receptor 1 0.0498671
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0488804
PSD3 pleckstrin and Sec7 domain containing 3 0.0418476
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0408764
PTPRK protein tyrosine phosphatase, receptor type, K 0.0402726
LMO7 LIM domain 7 0.0309702
ALCAM activated leukocyte cell adhesion molecule 0.0303357
MYO1E myosin IE 0.0298697
LAMA4 laminin, alpha 4 0.0297036
EMP1 epithelial membrane protein 1 0.0289234
RNF217 ring finger protein 217 0.0277375
MARCHF3 membrane associated ring-CH-type finger 3 0.0276785
SVIL supervillin 0.0274944
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.027215
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0267355
SLC35F3 solute carrier family 35, member F3 0.0265528
EGFR epidermal growth factor receptor 0.0263364
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0259885
FAT1 FAT atypical cadherin 1 0.0254009
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0252032
ASPH aspartate beta-hydroxylase 0.0250874
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0244034
GLS2 glutaminase 2 (liver, mitochondrial) 0.0237862
MUC17 mucin 17, cell surface associated 0.023622
GREB1L growth regulation by estrogen in breast cancer-like 0.0227124
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0225667
EZR ezrin 0.0204967
PARD3B par-3 family cell polarity regulator beta 0.0203694
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0200093
PDE4D phosphodiesterase 4D, cAMP-specific 0.0195932
ARHGAP6 Rho GTPase activating protein 6 0.0193838
VCAN versican 0.0192274
MAML3 mastermind-like 3 (Drosophila) 0.0191532
CALB1 calbindin 1, 28kDa 0.0189171
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0186456
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0183777
AHNAK AHNAK nucleoprotein 0.0183092
CRY1 cryptochrome circadian clock 1 0.0181115
UNC13B unc-13 homolog B (C. elegans) 0.0178927
LGALS3 lectin, galactoside-binding, soluble, 3 0.0177354
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0171493
ZSWIM6 zinc finger, SWIM-type containing 6 0.0168006
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0167074
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.016372
EXT1 exostosin glycosyltransferase 1 0.0162569
ANXA1 annexin A1 0.0158673
ZFP36L2 ZFP36 ring finger protein-like 2 0.0158475
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0155292
RIGI RNA sensor RIG-I 0.0154538
CLOCK clock circadian regulator 0.0153107
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.015026
WHRN whirlin 0.0148485
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0134021
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0133264
PTPRB protein tyrosine phosphatase, receptor type, B 0.0129615
PCDH9 protocadherin 9 0.0128684
TRPS1 trichorhinophalangeal syndrome I 0.0128452
SGMS2 sphingomyelin synthase 2 0.0126399
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0125587
EHBP1 EH domain binding protein 1 0.0125316
LSAMP limbic system-associated membrane protein 0.0124442
AFF1 AF4/FMR2 family, member 1 0.0124373
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0123554
NALF1 NALCN channel auxiliary factor 1 0.0119677
SPATA13 spermatogenesis associated 13 0.0119499
MLF1 myeloid leukemia factor 1 0.0118032
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0117374
RORA RAR-related orphan receptor A 0.0115207
F3 coagulation factor III (thromboplastin, tissue factor) 0.0114801
ARHGAP21 Rho GTPase activating protein 21 0.0114204
PPARD peroxisome proliferator-activated receptor delta 0.0113179
MYO5B myosin VB 0.0110598
CCDC91 coiled-coil domain containing 91 0.0109699
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0108848
SH3D19 SH3 domain containing 19 0.0108384
SQSTM1 sequestosome 1 0.0105367
AKAP13 A kinase (PRKA) anchor protein 13 0.0105204
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.0105183
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.010474
AKAP12 A kinase (PRKA) anchor protein 12 0.0104631
TRIB1 tribbles pseudokinase 1 0.0104577
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0103892
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0103444
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0102954
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0101824
CCSER1 coiled-coil serine-rich protein 1 0.0100935
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0100841
FAM107B family with sequence similarity 107, member B 0.010069
COBL cordon-bleu WH2 repeat protein 0.0100332
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.00993002
ANTXR2 anthrax toxin receptor 2 0.0097374
LAMC2 laminin, gamma 2 0.00973528
NABP1 nucleic acid binding protein 1 0.00969477
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.00966687
DGKH diacylglycerol kinase, eta 0.00963429
TJP1 tight junction protein 1 0.00950916
TGFBR3 transforming growth factor, beta receptor III 0.00942497
MT2A metallothionein 2A 0.00937039
SIK3 SIK family kinase 3 0.00928789

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.23349
PTMA prothymosin, alpha -0.180841
RPS6 ribosomal protein S6 -0.117225
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0890297
GOLGA4 golgin A4 -0.0824853
CEMIP cell migration inducing protein, hyaluronan binding -0.0824374
TMSB10 thymosin beta 10 -0.0823956
NDRG1 N-myc downstream regulated 1 -0.0818877
DSCAM Down syndrome cell adhesion molecule -0.0798983
TPT1 tumor protein, translationally-controlled 1 -0.0789817
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0782696
RNF43 ring finger protein 43 -0.0768967
RPS2 ribosomal protein S2 -0.0763429
TNS4 tensin 4 -0.0720687
EREG epiregulin -0.0640995
ZFAND3 zinc finger, AN1-type domain 3 -0.063407
ANKRD11 ankyrin repeat domain 11 -0.0628998
RPL35A ribosomal protein L35a -0.0617075
RBM39 RNA binding motif protein 39 -0.0611948
PNISR PNN-interacting serine/arginine-rich protein -0.0589893
EIF1 eukaryotic translation initiation factor 1 -0.0587649
RPS12 ribosomal protein S12 -0.0584794
GPHN gephyrin -0.0574786
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0567289
RPLP1 ribosomal protein, large, P1 -0.0567083
FTL ferritin, light polypeptide -0.0565449
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0564495
RPL11 ribosomal protein L11 -0.0555546
RPS19 ribosomal protein S19 -0.0549821
RPS8 ribosomal protein S8 -0.0548839
RPLP2 ribosomal protein, large, P2 -0.0544127
RPL37A ribosomal protein L37a -0.0542129
SETD5 SET domain containing 5 -0.0538247
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0517115
RPL23 ribosomal protein L23 -0.0513352
RPS3 ribosomal protein S3 -0.0511663
RPL12 ribosomal protein L12 -0.0505062
AREG amphiregulin -0.0495396
RPL26 ribosomal protein L26 -0.0485763
RPS23 ribosomal protein S23 -0.048052
NCOR1 nuclear receptor corepressor 1 -0.0474045
RPL9 ribosomal protein L9 -0.0471938
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0459629
RNF145 ring finger protein 145 -0.0455989
S100P S100 calcium binding protein P -0.0452782
EEF2 eukaryotic translation elongation factor 2 -0.0448925
PRRC2C proline-rich coiled-coil 2C -0.0441555
RPL19 ribosomal protein L19 -0.0438074
MED13L mediator complex subunit 13-like -0.0437703
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0435866
RPL7 ribosomal protein L7 -0.0433274
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0428129
RPL36 ribosomal protein L36 -0.0425874
RPL34 ribosomal protein L34 -0.0422752
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0419764
RPS24 ribosomal protein S24 -0.0410124
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0409518
FAM13A family with sequence similarity 13, member A -0.0407658
RPS29 ribosomal protein S29 -0.0402923
RPL5 ribosomal protein L5 -0.0401059
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0396743
RAB1A RAB1A, member RAS oncogene family -0.0395486
GARS1 glycyl-tRNA synthetase 1 -0.0388241
CSNK1A1 casein kinase 1, alpha 1 -0.0386482
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0384814
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0384253
RPL31 ribosomal protein L31 -0.0375781
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0370291
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0370254
RPS25 ribosomal protein S25 -0.0365419
PKM pyruvate kinase, muscle -0.0360265
OGA O-GlcNAcase -0.0359785
WAC WW domain containing adaptor with coiled-coil -0.0358815
EPCAM epithelial cell adhesion molecule -0.03532
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0352511
RPS13 ribosomal protein S13 -0.0346175
KIF5B kinesin family member 5B -0.0335853
TRIM2 tripartite motif containing 2 -0.0333877
ESRP1 epithelial splicing regulatory protein 1 -0.0333037
KMT2E lysine (K)-specific methyltransferase 2E -0.033194
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0328106
ZNF292 zinc finger protein 292 -0.0324865
ARL15 ADP-ribosylation factor-like 15 -0.0324841
PUM2 pumilio RNA-binding family member 2 -0.0324284
RPL7A ribosomal protein L7a -0.0323716
ATF4 activating transcription factor 4 -0.0323361
RPS27A ribosomal protein S27a -0.0322264
COG5 component of oligomeric golgi complex 5 -0.0320037
PIGR polymeric immunoglobulin receptor -0.0318055
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0317765
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0317443
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.031261
RPL32 ribosomal protein L32 -0.0309839
RPS27 ribosomal protein S27 -0.030897
CD46 CD46 molecule, complement regulatory protein -0.0308108
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0307572
DDIT4 DNA-damage-inducible transcript 4 -0.0307142
ANXA2 annexin A2 -0.0307024
MON2 MON2 homolog (S. cerevisiae) -0.0306449
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0306148