Cloxacillin (sodium)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0949757
PTMA prothymosin, alpha 0.0544142
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0541225
RPS6 ribosomal protein S6 0.0469844
EZR ezrin 0.0443887
FNDC3B fibronectin type III domain containing 3B 0.0440114
FRMD5 FERM domain containing 5 0.0432003
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0407484
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0401326
RPLP1 ribosomal protein, large, P1 0.0372905
ESYT2 extended synaptotagmin-like protein 2 0.036953
RREB1 ras responsive element binding protein 1 0.0368743
INTS6 integrator complex subunit 6 0.0356223
MYH9 myosin, heavy chain 9, non-muscle 0.0342527
LRRC23 leucine rich repeat containing 23 0.0342131
USP34 ubiquitin specific peptidase 34 0.0341218
CTBP2 C-terminal binding protein 2 0.0332948
GMDS GDP-mannose 4,6-dehydratase 0.032971
PTK2 protein tyrosine kinase 2 0.0320162
CCSER1 coiled-coil serine-rich protein 1 0.0319698
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0318172
NCOR2 nuclear receptor corepressor 2 0.0308546
EIF4A2 eukaryotic translation initiation factor 4A2 0.0308079
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0294498
TRA2A transformer 2 alpha homolog (Drosophila) 0.0290049
RNF145 ring finger protein 145 0.0289289
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0287295
PKM pyruvate kinase, muscle 0.0278932
DST dystonin 0.0277687
KDM3B lysine (K)-specific demethylase 3B 0.027687
TRIO trio Rho guanine nucleotide exchange factor 0.0273155
DOCK5 dedicator of cytokinesis 5 0.0270963
MPRIP myosin phosphatase Rho interacting protein 0.0269346
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0269007
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0267488
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0266827
HSPH1 heat shock 105kDa/110kDa protein 1 0.0266517
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0261998
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0258742
EP400 E1A binding protein p400 0.0250893
IGF1R insulin-like growth factor 1 receptor 0.0246421
WWOX WW domain containing oxidoreductase 0.0245313
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0243371
BRD2 bromodomain containing 2 0.0243193
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0241279
RIMKLB ribosomal modification protein rimK-like family member B 0.0238892
FUS FUS RNA binding protein 0.0238736
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0236948
ZNF638 zinc finger protein 638 0.0235465
EEF1G eukaryotic translation elongation factor 1 gamma 0.0235149
SETD5 SET domain containing 5 0.0233248
TMCC1 transmembrane and coiled-coil domain family 1 0.0231741
RPS29 ribosomal protein S29 0.0230532
PDE4D phosphodiesterase 4D, cAMP-specific 0.0230333
KMT2E lysine (K)-specific methyltransferase 2E 0.0229375
AFF1 AF4/FMR2 family, member 1 0.0227908
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0222703
FBXL17 F-box and leucine-rich repeat protein 17 0.0222509
UBA6 ubiquitin-like modifier activating enzyme 6 0.0219316
TXNIP thioredoxin interacting protein 0.02164
CLIP1 CAP-GLY domain containing linker protein 1 0.0216256
NRDC nardilysin convertase 0.0215303
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0213332
MCL1 myeloid cell leukemia 1 0.021328
NPSR1 neuropeptide S receptor 1 0.0211467
RPL3 ribosomal protein L3 0.0211158
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0210395
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.020955
MACF1 microtubule-actin crosslinking factor 1 0.0208384
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0205918
UBE3C ubiquitin protein ligase E3C 0.0204974
PPARG peroxisome proliferator-activated receptor gamma 0.0204596
PARP12 poly (ADP-ribose) polymerase family, member 12 0.0202071
USP3 ubiquitin specific peptidase 3 0.0201376
CELF1 CUGBP, Elav-like family member 1 0.0200878
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0200568
SPIDR scaffolding protein involved in DNA repair 0.0200118
ZNF292 zinc finger protein 292 0.019996
ARRDC3 arrestin domain containing 3 0.0199857
DNM2 dynamin 2 0.0197359
ITPRID2 ITPR interacting domain containing 2 0.0197102
JMJD1C jumonji domain containing 1C 0.0196312
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0196091
EGFR epidermal growth factor receptor 0.0195152
RCC1 regulator of chromosome condensation 1 0.019449
PSEN1 presenilin 1 0.0192043
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0191694
SRRM2 serine/arginine repetitive matrix 2 0.019151
KDM2A lysine (K)-specific demethylase 2A 0.0189745
VEGFA vascular endothelial growth factor A 0.0188879
RAB6A RAB6A, member RAS oncogene family 0.0188537
DENND1A DENN/MADD domain containing 1A 0.0187569
MED13L mediator complex subunit 13-like 0.0187471
TSC22D2 TSC22 domain family, member 2 0.0187213
PCSK6 proprotein convertase subtilisin/kexin type 6 0.0187145
ECPAS Ecm29 proteasome adaptor and scaffold 0.0185075
TNRC18 trinucleotide repeat containing 18 0.0183297
EIF4B eukaryotic translation initiation factor 4B 0.0179477
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0179369
ARHGAP26 Rho GTPase activating protein 26 0.0178576

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.125817
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.117367
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.111985
RPLP0 ribosomal protein, large, P0 -0.0948201
RPS12 ribosomal protein S12 -0.0854615
DSG3 desmoglein 3 -0.0787821
FLNB filamin B, beta -0.0761413
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.074499
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0702798
ANXA2 annexin A2 -0.0693275
LAMA4 laminin, alpha 4 -0.0652302
LDHA lactate dehydrogenase A -0.0646682
CLDN4 claudin 4 -0.0609848
RPL12 ribosomal protein L12 -0.0600186
VCL vinculin -0.0579048
RPS2 ribosomal protein S2 -0.0577531
LAMB3 laminin, beta 3 -0.0573791
ACTG1 actin gamma 1 -0.05576
LMO7 LIM domain 7 -0.0547719
DSG2 desmoglein 2 -0.0524139
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0508837
TJP1 tight junction protein 1 -0.0503503
KLF6 Kruppel-like factor 6 -0.048262
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0479197
PTPRB protein tyrosine phosphatase, receptor type, B -0.0475675
RPL34 ribosomal protein L34 -0.0459618
MYO1E myosin IE -0.0456432
SERINC5 serine incorporator 5 -0.0442943
KRT18 keratin 18, type I -0.0436877
RPL18 ribosomal protein L18 -0.0432244
SHROOM3 shroom family member 3 -0.0430821
RPL11 ribosomal protein L11 -0.0422924
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0420497
FAT1 FAT atypical cadherin 1 -0.041817
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0406592
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0404164
EIF1 eukaryotic translation initiation factor 1 -0.0403442
SQSTM1 sequestosome 1 -0.0395464
USP15 ubiquitin specific peptidase 15 -0.0362734
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0360463
MYOF myoferlin -0.0359605
RPL9 ribosomal protein L9 -0.0352462
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0351532
RPL32 ribosomal protein L32 -0.0347611
GARS1 glycyl-tRNA synthetase 1 -0.0346039
MT2A metallothionein 2A -0.0344876
EPCAM epithelial cell adhesion molecule -0.0337664
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0336111
PKP2 plakophilin 2 -0.0329926
RPL30 ribosomal protein L30 -0.0327244
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0325487
RACK1 receptor for activated C kinase 1 -0.0318406
YBX3 Y box binding protein 3 -0.031787
NRN1 neuritin 1 -0.0315998
NACA nascent polypeptide-associated complex alpha subunit -0.0315581
CYSTM1 cysteine-rich transmembrane module containing 1 -0.031115
ACTN4 actinin, alpha 4 -0.0307887
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0304494
KLF3 Kruppel-like factor 3 (basic) -0.0303836
CALB1 calbindin 1, 28kDa -0.0295491
RPS27A ribosomal protein S27a -0.0293868
ARHGAP5 Rho GTPase activating protein 5 -0.0293571
RPS8 ribosomal protein S8 -0.0292391
RPS19 ribosomal protein S19 -0.0290951
RAB7A RAB7A, member RAS oncogene family -0.0290894
RPL37 ribosomal protein L37 -0.0287843
KLF5 Kruppel-like factor 5 (intestinal) -0.0282003
RPS24 ribosomal protein S24 -0.0279904
NT5C2 5'-nucleotidase, cytosolic II -0.0278542
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0275568
RPS3 ribosomal protein S3 -0.0273924
PTPRK protein tyrosine phosphatase, receptor type, K -0.0269727
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -0.0265835
S100A10 S100 calcium binding protein A10 -0.0260432
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0255637
TRIM2 tripartite motif containing 2 -0.0255543
LAMC2 laminin, gamma 2 -0.0254801
RPS17 ribosomal protein S17 -0.0253369
PRSS3 protease, serine, 3 -0.0249231
PERP PERP, TP53 apoptosis effector -0.024903
AKAP13 A kinase (PRKA) anchor protein 13 -0.0244168
MON2 MON2 homolog (S. cerevisiae) -0.0243721
PCDHB16 protocadherin beta 16 -0.024347
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0240129
CSDE1 cold shock domain containing E1, RNA-binding -0.0239119
RAP1B RAP1B, member of RAS oncogene family -0.0237654
ETNK1 ethanolamine kinase 1 -0.0234632
PTPRR protein tyrosine phosphatase, receptor type, R -0.0234084
HLA-B major histocompatibility complex, class I, B -0.0223375
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0222882
RPL36AL ribosomal protein L36a-like -0.0221473
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0220176
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.021793
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0217176
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0215558
RPS5 ribosomal protein S5 -0.0215432
DSC3 desmocollin 3 -0.0213141
CXADR coxsackie virus and adenovirus receptor -0.0212918
NAP1L1 nucleosome assembly protein 1-like 1 -0.0212763
RPL26 ribosomal protein L26 -0.0212323