Cloxacillin (sodium)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.0870866
EGFR epidermal growth factor receptor 0.0828306
THSD4 thrombospondin, type I, domain containing 4 0.0780914
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0703188
FNDC3B fibronectin type III domain containing 3B 0.0702797
ASPH aspartate beta-hydroxylase 0.0683968
PTPRM protein tyrosine phosphatase, receptor type, M 0.0625947
SAMD4A sterile alpha motif domain containing 4A 0.0612084
ERRFI1 ERBB receptor feedback inhibitor 1 0.0602794
LMO7 LIM domain 7 0.0602622
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0592172
DSPP dentin sialophosphoprotein 0.0563207
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0526565
CXCL8 chemokine (C-X-C motif) ligand 8 0.0506779
JMJD1C jumonji domain containing 1C 0.048821
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0468102
SOD2 superoxide dismutase 2, mitochondrial 0.0464707
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.046463
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0450676
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0447345
AHNAK AHNAK nucleoprotein 0.0442827
GOLGB1 golgin B1 0.0435389
SLTM SAFB-like, transcription modulator 0.0422045
ENO1 enolase 1, (alpha) 0.042182
CANX calnexin 0.0418613
CEMIP cell migration inducing protein, hyaluronan binding 0.0409137
MACF1 microtubule-actin crosslinking factor 1 0.0405
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0384404
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0373293
LPP LIM domain containing preferred translocation partner in lipoma 0.0349387
MYOF myoferlin 0.0347282
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0327943
ARRDC3 arrestin domain containing 3 0.0322364
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0321027
FNIP1 folliculin interacting protein 1 0.0313011
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0308492
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0307463
ATP11A ATPase, class VI, type 11A 0.0303512
HSPA8 heat shock 70kDa protein 8 0.0302073
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0295491
PMM2 phosphomannomutase 2 0.0295395
DSCAM Down syndrome cell adhesion molecule 0.0294749
PRKCA protein kinase C, alpha 0.0293914
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0292672
MSN moesin 0.0289588
MYO1E myosin IE 0.0289406
USP53 ubiquitin specific peptidase 53 0.0288956
IGF1R insulin-like growth factor 1 receptor 0.0284987
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0283294
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0276831
GRB10 growth factor receptor-bound protein 10 0.0269054
BZW1 basic leucine zipper and W2 domains 1 0.0267505
RNF213 ring finger protein 213 0.0265766
CAV2 caveolin 2 0.0259313
ANXA2 annexin A2 0.0257834
CCSER1 coiled-coil serine-rich protein 1 0.0257769
ZNF638 zinc finger protein 638 0.0255958
SUCO SUN domain containing ossification factor 0.0254093
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0249463
IGFBP3 insulin-like growth factor binding protein 3 0.0249373
TMF1 TATA element modulatory factor 1 0.0241193
BACE2 beta-site APP-cleaving enzyme 2 0.0241152
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0240646
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0238814
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0236169
TRIO trio Rho guanine nucleotide exchange factor 0.0235579
EFNA5 ephrin-A5 0.0233526
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0231628
DOCK1 dedicator of cytokinesis 1 0.0229454
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0226962
MLF1 myeloid leukemia factor 1 0.0225697
TPM3 tropomyosin 3 0.0225302
CRY1 cryptochrome circadian clock 1 0.0222788
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0222266
PM20D1 peptidase M20 domain containing 1 0.0221619
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0219289
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0217875
ARF4 ADP-ribosylation factor 4 0.0216372
AKAP13 A kinase (PRKA) anchor protein 13 0.0216148
TTC3 tetratricopeptide repeat domain 3 0.0214483
PACS1 phosphofurin acidic cluster sorting protein 1 0.0213391
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0212222
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0211564
SEC31A SEC31 homolog A (S. cerevisiae) 0.021077
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0210527
EIF4A2 eukaryotic translation initiation factor 4A2 0.0208764
RAD51B RAD51 paralog B 0.0208587
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0206294
SMYD3 SET and MYND domain containing 3 0.0203511
SUMF1 sulfatase modifying factor 1 0.0203501
VMP1 vacuole membrane protein 1 0.0202131
ARHGAP21 Rho GTPase activating protein 21 0.0201529
SLK STE20-like kinase 0.0200404
JUN jun proto-oncogene 0.0200091
SMAD3 SMAD family member 3 0.0199567
BRD2 bromodomain containing 2 0.0197757
TBC1D5 TBC1 domain family, member 5 0.0192977
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0190927
TMCO3 transmembrane and coiled-coil domains 3 0.0189542
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0188337

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.2338
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194459
TMSB10 thymosin beta 10 -0.15208
MT2A metallothionein 2A -0.143642
FTL ferritin, light polypeptide -0.10638
NDRG1 N-myc downstream regulated 1 -0.102573
TPT1 tumor protein, translationally-controlled 1 -0.0939754
FTH1 ferritin, heavy polypeptide 1 -0.0734286
RPL35A ribosomal protein L35a -0.072239
TOP1 topoisomerase (DNA) I -0.0700515
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0691727
RPS3 ribosomal protein S3 -0.0587175
NAMPT nicotinamide phosphoribosyltransferase -0.0575423
OSMR oncostatin M receptor -0.0559806
RPS25 ribosomal protein S25 -0.0548768
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0532329
RPL34 ribosomal protein L34 -0.0524598
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0524192
RPS24 ribosomal protein S24 -0.050927
PRRC2C proline-rich coiled-coil 2C -0.0500511
RPLP1 ribosomal protein, large, P1 -0.0490462
RPS23 ribosomal protein S23 -0.0483943
S100A10 S100 calcium binding protein A10 -0.0478684
LRP1B low density lipoprotein receptor-related protein 1B -0.0474275
ACTG1 actin gamma 1 -0.0471697
GCLC glutamate-cysteine ligase, catalytic subunit -0.0466108
S100P S100 calcium binding protein P -0.0445149
RPL37A ribosomal protein L37a -0.04379
SLC38A1 solute carrier family 38, member 1 -0.0436413
BRWD1 bromodomain and WD repeat domain containing 1 -0.0432837
AKR1C1 aldo-keto reductase family 1, member C1 -0.0430293
RPS8 ribosomal protein S8 -0.0419798
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0411739
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0409927
SEC61G Sec61 gamma subunit -0.0400523
ANKRD12 ankyrin repeat domain 12 -0.0399389
WASF2 WAS protein family, member 2 -0.0397667
TMEM165 transmembrane protein 165 -0.0396278
MKI67 marker of proliferation Ki-67 -0.0392175
RPS27A ribosomal protein S27a -0.0383493
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0381049
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0379857
EIF1 eukaryotic translation initiation factor 1 -0.0373387
CST3 cystatin C -0.0373004
CAV1 caveolin 1, caveolae protein, 22kDa -0.035542
MGST1 microsomal glutathione S-transferase 1 -0.0354196
CAMTA1 calmodulin binding transcription activator 1 -0.035203
RPS21 ribosomal protein S21 -0.0346147
NDE1 nudE neurodevelopment protein 1 -0.0339988
RPL23 ribosomal protein L23 -0.0339564
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0334304
RPL12 ribosomal protein L12 -0.0327672
MT1X metallothionein 1X -0.0326453
CES1 carboxylesterase 1 -0.0325086
ABLIM1 actin binding LIM protein 1 -0.0324519
RPLP0 ribosomal protein, large, P0 -0.0321319
RPL31 ribosomal protein L31 -0.0319196
PTMA prothymosin, alpha -0.0314168
RPS14 ribosomal protein S14 -0.0311762
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.030791
HMGA1 high mobility group AT-hook 1 -0.0303434
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0295159
GM2A GM2 ganglioside activator -0.0294353
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0290056
RPS6 ribosomal protein S6 -0.0287371
TBC1D22A TBC1 domain family, member 22A -0.0283755
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0281029
RPS12 ribosomal protein S12 -0.0280467
RPL11 ribosomal protein L11 -0.0279775
RPLP2 ribosomal protein, large, P2 -0.0273551
BTG1 B-cell translocation gene 1, anti-proliferative -0.0273372
TKT transketolase -0.027318
RACK1 receptor for activated C kinase 1 -0.0269048
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0265596
UVRAG UV radiation resistance associated -0.0263199
LAMB3 laminin, beta 3 -0.0260691
CCNI cyclin I -0.0259452
RPL30 ribosomal protein L30 -0.0257272
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0256709
RPS4X ribosomal protein S4, X-linked -0.0254877
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0252674
RPS29 ribosomal protein S29 -0.0251776
RPL5 ribosomal protein L5 -0.0251543
GNAS GNAS complex locus -0.0251108
PLAUR plasminogen activator, urokinase receptor -0.0250748
HLA-B major histocompatibility complex, class I, B -0.0248871
C15ORF48 chromosome 15 open reading frame 48 -0.0248675
IER3 immediate early response 3 -0.0246738
LAMA4 laminin, alpha 4 -0.0242437
CDCP1 CUB domain containing protein 1 -0.0242149
RPL7 ribosomal protein L7 -0.0241118
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0239448
STC1 stanniocalcin 1 -0.0238215
S100A6 S100 calcium binding protein A6 -0.0237891
RPL8 ribosomal protein L8 -0.0234736
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0233857
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0232135
STRN3 striatin, calmodulin binding protein 3 -0.0230884
RPS16 ribosomal protein S16 -0.0229149
VDAC1 voltage-dependent anion channel 1 -0.0228055