Cloxacillin (sodium)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAV2 neuron navigator 2 0.0867427
GRB10 growth factor receptor-bound protein 10 0.083311
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0729854
SOD2 superoxide dismutase 2, mitochondrial 0.0711365
FAM13A family with sequence similarity 13, member A 0.0702663
SMAD3 SMAD family member 3 0.0676547
IGFBP3 insulin-like growth factor binding protein 3 0.0652894
ESYT2 extended synaptotagmin-like protein 2 0.0605251
MEF2A myocyte enhancer factor 2A 0.0604151
SDK1 sidekick cell adhesion molecule 1 0.0603701
NGLY1 N-glycanase 1 0.0530609
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0511739
KDM2A lysine (K)-specific demethylase 2A 0.0498748
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0489112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0478797
TRIO trio Rho guanine nucleotide exchange factor 0.0465458
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.045016
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0438906
LOXL2 lysyl oxidase-like 2 0.0434863
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.042128
PDE4D phosphodiesterase 4D, cAMP-specific 0.0419596
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0408956
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0408225
RUNX1 runt-related transcription factor 1 0.0381045
ELL2 elongation factor, RNA polymerase II, 2 0.0373935
PIAS2 protein inhibitor of activated STAT, 2 0.0364856
ZNF638 zinc finger protein 638 0.0359895
EFNA5 ephrin-A5 0.0351391
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0335507
AMPD3 adenosine monophosphate deaminase 3 0.0333312
JARID2 jumonji, AT rich interactive domain 2 0.0321429
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0319725
AKAP12 A kinase (PRKA) anchor protein 12 0.0315822
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0313633
TTC3 tetratricopeptide repeat domain 3 0.0312942
RAI14 retinoic acid induced 14 0.0308178
PRELID2 PRELI domain containing 2 0.0298472
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0293082
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0292892
DPYSL3 dihydropyrimidinase-like 3 0.028186
PYGL phosphorylase, glycogen, liver 0.0275535
BHLHE40 basic helix-loop-helix family, member e40 0.0275192
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.027054
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0266639
ANO6 anoctamin 6 0.0265027
VEGFA vascular endothelial growth factor A 0.0264812
CA12 carbonic anhydrase XII 0.0263669
LRRC8C leucine rich repeat containing 8 family, member C 0.0260411
PFKP phosphofructokinase, platelet 0.0259819
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0256085
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0251572
DOCK5 dedicator of cytokinesis 5 0.024903
FAM107B family with sequence similarity 107, member B 0.0247249
FAM219A family with sequence similarity 219, member A 0.0243741
BACE2 beta-site APP-cleaving enzyme 2 0.0242812
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0241154
CDH13 cadherin 13 0.0239707
DTNA dystrobrevin, alpha 0.0238831
ANKRD36 ankyrin repeat domain 36 0.0238029
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0234341
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0234329
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0231652
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0226319
GOLGA4 golgin A4 0.0225821
CEP250 centrosomal protein 250kDa 0.0225052
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0222619
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0222442
ANKH ANKH inorganic pyrophosphate transport regulator 0.0221424
SEPTIN9 septin 9 0.0221003
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0218553
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0217656
UBA6 ubiquitin-like modifier activating enzyme 6 0.0216479
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0214489
MARCHF3 membrane associated ring-CH-type finger 3 0.0213758
ERRFI1 ERBB receptor feedback inhibitor 1 0.0213664
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0211839
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0209637
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0209287
MTSS1 metastasis suppressor 1 0.0209093
TENT5A terminal nucleotidyltransferase 5A 0.020861
GYS1 glycogen synthase 1 (muscle) 0.0208277
PTPRM protein tyrosine phosphatase, receptor type, M 0.020431
FNIP1 folliculin interacting protein 1 0.0204156
TNS1 tensin 1 0.0203536
IGF1R insulin-like growth factor 1 receptor 0.0202081
TPD52 tumor protein D52 0.0201721
ARFGEF3 ARFGEF family member 3 0.0200115
MXI1 MAX interactor 1, dimerization protein 0.0199489
ANKRD28 ankyrin repeat domain 28 0.0199149
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.019879
MYO1E myosin IE 0.0198564
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0198037
EZR ezrin 0.0196564
MAP2K1 mitogen-activated protein kinase kinase 1 0.0195741
TENT4A terminal nucleotidyltransferase 4A 0.0193871
COL7A1 collagen, type VII, alpha 1 0.0193666
CRYBG3 beta-gamma crystallin domain containing 3 0.0193449
RARB retinoic acid receptor, beta 0.0192288
SEC24A SEC24 family member A 0.0191221
AHNAK AHNAK nucleoprotein 0.0190988

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.235616
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.218675
VIM vimentin -0.189125
GLCCI1 glucocorticoid induced 1 -0.117847
FTL ferritin, light polypeptide -0.104544
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0961227
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0800924
CD44 CD44 molecule (Indian blood group) -0.0800343
TFPI2 tissue factor pathway inhibitor 2 -0.0732533
PTMA prothymosin, alpha -0.0722731
S100A6 S100 calcium binding protein A6 -0.0708896
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0670827
MT2A metallothionein 2A -0.064031
TPT1 tumor protein, translationally-controlled 1 -0.062228
OSMR oncostatin M receptor -0.056203
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0558848
ARHGAP5 Rho GTPase activating protein 5 -0.0548371
STC1 stanniocalcin 1 -0.0543047
DPYD dihydropyrimidine dehydrogenase -0.0526114
WSB1 WD repeat and SOCS box containing 1 -0.0516936
HMGA2 high mobility group AT-hook 2 -0.0508801
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0496873
NRP1 neuropilin 1 -0.0475616
NTN4 netrin 4 -0.04726
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0465776
RPS21 ribosomal protein S21 -0.0463895
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0434613
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.043144
TM4SF1 transmembrane 4 L six family member 1 -0.0428823
EGR1 early growth response 1 -0.041464
RPL35A ribosomal protein L35a -0.0413685
HMGA1 high mobility group AT-hook 1 -0.041016
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0407747
VCL vinculin -0.0398993
RPLP2 ribosomal protein, large, P2 -0.0397048
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0395135
B2M beta-2-microglobulin -0.0393423
RPS19 ribosomal protein S19 -0.0385994
EIF1 eukaryotic translation initiation factor 1 -0.0384651
IFI6 interferon, alpha-inducible protein 6 -0.0384517
PRRC2C proline-rich coiled-coil 2C -0.0383699
HLA-B major histocompatibility complex, class I, B -0.038349
TNNC1 troponin C type 1 (slow) -0.0379674
ZMYND8 zinc finger, MYND-type containing 8 -0.0369003
POTEF POTE ankyrin domain family, member F -0.036376
S100A10 S100 calcium binding protein A10 -0.0357164
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0344796
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0341013
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0336952
RPL34 ribosomal protein L34 -0.0335141
VRK2 vaccinia related kinase 2 -0.0330674
RPS24 ribosomal protein S24 -0.0329681
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0325094
RAP1B RAP1B, member of RAS oncogene family -0.0324544
NCOA7 nuclear receptor coactivator 7 -0.03236
LOX lysyl oxidase -0.0322905
RPLP1 ribosomal protein, large, P1 -0.0318693
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0314377
NUMB numb homolog (Drosophila) -0.0312339
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0312333
RAB27B RAB27B, member RAS oncogene family -0.0311695
SAMD9 sterile alpha motif domain containing 9 -0.0309994
PRSS23 protease, serine, 23 -0.0309956
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0308963
C15ORF48 chromosome 15 open reading frame 48 -0.0300052
NF1 neurofibromin 1 -0.0291349
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0290431
ACTG1 actin gamma 1 -0.0284047
RPL37A ribosomal protein L37a -0.0282092
TMEM131 transmembrane protein 131 -0.0278746
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0276205
ENO2 enolase 2 (gamma, neuronal) -0.0273571
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0271415
SP100 SP100 nuclear antigen -0.0268956
SOX4 SRY (sex determining region Y)-box 4 -0.0264647
RPL36 ribosomal protein L36 -0.0262093
ZBTB7A zinc finger and BTB domain containing 7A -0.0261854
IFIH1 interferon induced with helicase C domain 1 -0.0260228
ZNF804A zinc finger protein 804A -0.0259817
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0259397
SLC38A1 solute carrier family 38, member 1 -0.0256913
CCNI cyclin I -0.0256542
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0254451
MAP1B microtubule-associated protein 1B -0.0253519
GLIS3 GLIS family zinc finger 3 -0.0253469
GCC2 GRIP and coiled-coil domain containing 2 -0.0252444
KYNU kynureninase -0.0251613
PID1 phosphotyrosine interaction domain containing 1 -0.0251307
RPS8 ribosomal protein S8 -0.0249123
COL12A1 collagen, type XII, alpha 1 -0.0248548
IER3 immediate early response 3 -0.0248141
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0246797
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0246405
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0245373
IFI16 interferon, gamma-inducible protein 16 -0.0244768
RPL32 ribosomal protein L32 -0.0243807
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0242594
THBD thrombomodulin -0.0242144
TMSB4X thymosin beta 4, X-linked -0.0241186
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0237526