Cloxacillin (sodium)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.0934273
CXCL8 chemokine (C-X-C motif) ligand 8 0.0923241
ELL2 elongation factor, RNA polymerase II, 2 0.0888583
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0751176
FNDC3B fibronectin type III domain containing 3B 0.0635739
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0626569
DST dystonin 0.0608238
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0596619
MED13L mediator complex subunit 13-like 0.0583441
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0582275
KYNU kynureninase 0.0581704
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0574781
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0570672
STC1 stanniocalcin 1 0.0542463
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0526311
FLNB filamin B, beta 0.051417
AKAP12 A kinase (PRKA) anchor protein 12 0.0498286
KTN1 kinectin 1 (kinesin receptor) 0.0496626
SLMAP sarcolemma associated protein 0.0491108
TRA2A transformer 2 alpha homolog (Drosophila) 0.0477899
ATXN1 ataxin 1 0.0475429
TRIO trio Rho guanine nucleotide exchange factor 0.0472135
AHR aryl hydrocarbon receptor 0.0459993
NAMPT nicotinamide phosphoribosyltransferase 0.04597
WAC WW domain containing adaptor with coiled-coil 0.0459159
COPA coatomer protein complex, subunit alpha 0.0456344
RND3 Rho family GTPase 3 0.0455505
SOD2 superoxide dismutase 2, mitochondrial 0.0455395
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0455332
MAP1B microtubule-associated protein 1B 0.0450731
SBF2 SET binding factor 2 0.0449509
PDE10A phosphodiesterase 10A 0.0447446
LOX lysyl oxidase 0.0442491
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0435168
PGK1 phosphoglycerate kinase 1 0.0428012
COL6A3 collagen, type VI, alpha 3 0.0406563
ITGA6 integrin, alpha 6 0.0406207
MYH9 myosin, heavy chain 9, non-muscle 0.0404057
C3 complement component 3 0.0402595
ANXA5 annexin A5 0.0396438
EHBP1 EH domain binding protein 1 0.0395076
TXNIP thioredoxin interacting protein 0.0393609
RTN4 reticulon 4 0.0393279
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0385172
DTNA dystrobrevin, alpha 0.0374267
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0372581
VEGFA vascular endothelial growth factor A 0.0371298
RORA RAR-related orphan receptor A 0.0371172
NAV2 neuron navigator 2 0.036786
GLS2 glutaminase 2 (liver, mitochondrial) 0.0367018
LCOR ligand dependent nuclear receptor corepressor 0.0361711
PRKCSH protein kinase C substrate 80K-H 0.0359551
PM20D1 peptidase M20 domain containing 1 0.0359161
NRG1 neuregulin 1 0.0357102
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0356493
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0353059
CCNL1 cyclin L1 0.0348964
ENO1 enolase 1, (alpha) 0.0348596
BRD4 bromodomain containing 4 0.0348242
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0347427
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0345193
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0343718
PTPRM protein tyrosine phosphatase, receptor type, M 0.0342863
ANLN anillin, actin binding protein 0.0341089
OGA O-GlcNAcase 0.0335015
BASP1 brain abundant, membrane attached signal protein 1 0.0333581
TNIP1 TNFAIP3 interacting protein 1 0.0333013
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0329981
TMEM263 transmembrane protein 263 0.0327638
RAD51B RAD51 paralog B 0.0323301
SDK1 sidekick cell adhesion molecule 1 0.0321894
CTNND1 catenin (cadherin-associated protein), delta 1 0.0321737
UGCG UDP-glucose ceramide glucosyltransferase 0.0320376
SESTD1 SEC14 and spectrin domains 1 0.0319033
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0317471
METTL15 methyltransferase like 15 0.0317314
PHF3 PHD finger protein 3 0.0314793
CANX calnexin 0.031337
PDGFC platelet derived growth factor C 0.0311902
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0311818
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.031117
AUTS2 autism susceptibility candidate 2 0.0310569
ITPKC inositol-trisphosphate 3-kinase C 0.0308332
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0307751
JMJD1C jumonji domain containing 1C 0.0303933
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.030326
WDFY3 WD repeat and FYVE domain containing 3 0.0301826
ASPH aspartate beta-hydroxylase 0.0299323
PCBP3 poly(rC) binding protein 3 0.0298689
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0297874
ENKUR enkurin, TRPC channel interacting protein 0.0296195
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0295827
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0295566
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.029556
VMP1 vacuole membrane protein 1 0.0295542
USP9X ubiquitin specific peptidase 9, X-linked 0.0293616
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0293601
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.029315
PRSS23 protease, serine, 23 0.029274
BHLHE40 basic helix-loop-helix family, member e40 0.0291635

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.215438
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.168741
BACE2 beta-site APP-cleaving enzyme 2 -0.149581
GRB10 growth factor receptor-bound protein 10 -0.148497
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.132443
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.121822
ATOSA atos homolog A -0.121636
CMIP c-Maf inducing protein -0.101528
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0990079
SVIL supervillin -0.0947447
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0941327
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0892486
ANXA2 annexin A2 -0.0879708
PDE4D phosphodiesterase 4D, cAMP-specific -0.0849936
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0839498
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0828595
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0823164
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0751982
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0747504
SAMD4A sterile alpha motif domain containing 4A -0.0732734
FTH1 ferritin, heavy polypeptide 1 -0.072673
ERBIN erbb2 interacting protein -0.0688088
MUC16 mucin 16, cell surface associated -0.0683932
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0650822
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0616279
PLAUR plasminogen activator, urokinase receptor -0.0615816
TPT1 tumor protein, translationally-controlled 1 -0.0612502
STEAP4 STEAP family member 4 -0.0596078
CATSPERB catsper channel auxiliary subunit beta -0.0593553
CEMIP cell migration inducing protein, hyaluronan binding -0.0581923
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0572535
ABHD17C abhydrolase domain containing 17C -0.0566668
PATJ PATJ crumbs cell polarity complex component -0.0555191
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0524404
IGFBP3 insulin-like growth factor binding protein 3 -0.0521757
TXNRD1 thioredoxin reductase 1 -0.0516701
BTG1 B-cell translocation gene 1, anti-proliferative -0.0509667
SLC38A1 solute carrier family 38, member 1 -0.0509003
KLF5 Kruppel-like factor 5 (intestinal) -0.0505968
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0499191
DSCAM Down syndrome cell adhesion molecule -0.0492903
LIMCH1 LIM and calponin homology domains 1 -0.0490683
FAM13A family with sequence similarity 13, member A -0.0466413
WDR26 WD repeat domain 26 -0.046102
PARD6B par-6 family cell polarity regulator beta -0.0457548
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0453824
FOXO1 forkhead box O1 -0.0443039
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0442246
TC2N tandem C2 domains, nuclear -0.0439001
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0436895
USP3 ubiquitin specific peptidase 3 -0.0423347
MYO6 myosin VI -0.0423261
EXT1 exostosin glycosyltransferase 1 -0.0422876
SMOC1 SPARC related modular calcium binding 1 -0.0421731
OXR1 oxidation resistance 1 -0.0415223
ZMYND8 zinc finger, MYND-type containing 8 -0.0414919
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.041285
SGMS2 sphingomyelin synthase 2 -0.0409255
DENND1A DENN/MADD domain containing 1A -0.0404042
MYO1E myosin IE -0.0401108
ATP11A ATPase, class VI, type 11A -0.039425
RESF1 retroelement silencing factor 1 -0.0388369
CAPN2 calpain 2, (m/II) large subunit -0.0387699
KRT17 keratin 17, type I -0.0385806
TOP1 topoisomerase (DNA) I -0.0380314
TJP2 tight junction protein 2 -0.0376501
OSBPL10 oxysterol binding protein-like 10 -0.0374879
AFDN afadin, adherens junction formation factor -0.037378
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0366199
NEBL nebulette -0.0362745
GRB7 growth factor receptor-bound protein 7 -0.0361845
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0359326
SREBF2 sterol regulatory element binding transcription factor 2 -0.0353679
TMPRSS4 transmembrane protease, serine 4 -0.0352737
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0352711
TMCC3 transmembrane and coiled-coil domain family 3 -0.0351661
PLAU plasminogen activator, urokinase -0.0350418
ZNF644 zinc finger protein 644 -0.0349148
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0348429
RPL37A ribosomal protein L37a -0.0345412
SNX14 sorting nexin 14 -0.0330638
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.0327059
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0326988
MCTP2 multiple C2 domains, transmembrane 2 -0.0324079
RBM47 RNA binding motif protein 47 -0.0323223
SDCBP2 syndecan binding protein (syntenin) 2 -0.0321591
RIOK3 RIO kinase 3 -0.0320856
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0320357
SQSTM1 sequestosome 1 -0.0320095
MEF2A myocyte enhancer factor 2A -0.031819
KIF13B kinesin family member 13B -0.0314999
NUMB numb homolog (Drosophila) -0.0313002
BMAL2 basic helix-loop-helix ARNT like 2 -0.0312785
PALLD palladin, cytoskeletal associated protein -0.0309753
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0306342
ANTXR2 anthrax toxin receptor 2 -0.0304272
PTMA prothymosin, alpha -0.03023
TAOK3 TAO kinase 3 -0.0301876
NECTIN2 nectin cell adhesion molecule 2 -0.029722
POTEF POTE ankyrin domain family, member F -0.0294582