Cloxacillin (sodium)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

157 genes differentially expressed following the Cloxacillin (sodium)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.148053
NCOA3 nuclear receptor coactivator 3 0.14069
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.132457
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.128108
NAMPT nicotinamide phosphoribosyltransferase 0.117381
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.114017
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.113226
ZNF292 zinc finger protein 292 0.106334
ARHGAP26 Rho GTPase activating protein 26 0.105344
ALCAM activated leukocyte cell adhesion molecule 0.102865
RPL19 ribosomal protein L19 0.100745
DST dystonin 0.091655
ANKRD11 ankyrin repeat domain 11 0.0807895
KMT2C lysine (K)-specific methyltransferase 2C 0.0772591
EHBP1 EH domain binding protein 1 0.0744775
MYO1E myosin IE 0.0729942
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0722172
IGFBP3 insulin-like growth factor binding protein 3 0.0719335
LDHA lactate dehydrogenase A 0.0675732
NDRG1 N-myc downstream regulated 1 0.0664638
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0652138
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0651242
JMJD1C jumonji domain containing 1C 0.0633347
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0625859
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0624724
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0581125
NKD1 naked cuticle homolog 1 (Drosophila) 0.053848
FNDC3B fibronectin type III domain containing 3B 0.0529285
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0525588
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0522492
LSAMP limbic system-associated membrane protein 0.0519961
PDE4D phosphodiesterase 4D, cAMP-specific 0.0515301
DSCAM Down syndrome cell adhesion molecule 0.0495231
ANKRD12 ankyrin repeat domain 12 0.047514
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0472807
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0458927
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.04566
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0456534
PRRC2C proline-rich coiled-coil 2C 0.0429665
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0427646
ERRFI1 ERBB receptor feedback inhibitor 1 0.0394799
EFNA5 ephrin-A5 0.0390305
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0371014
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0348173
TRIO trio Rho guanine nucleotide exchange factor 0.0342734
NCOR1 nuclear receptor corepressor 1 0.0337394
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0337031
MYOF myoferlin 0.0334652
DSPP dentin sialophosphoprotein 0.0331824
LMO7 LIM domain 7 0.0330521
NF1 neurofibromin 1 0.0327197
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0317447
FMNL2 formin-like 2 0.0310838
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0310463
PTMA prothymosin, alpha 0.0304851
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0302007
MED13 mediator complex subunit 13 0.0284813
RAP1B RAP1B, member of RAS oncogene family 0.0276444
NAV2 neuron navigator 2 0.0272356
ESYT2 extended synaptotagmin-like protein 2 0.0260581
GOLGA4 golgin A4 0.0254977
KTN1 kinectin 1 (kinesin receptor) 0.0234392
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0231938
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0222
NAP1L1 nucleosome assembly protein 1-like 1 0.0214474
GOLGB1 golgin B1 0.0179866
FLNB filamin B, beta 0.0173285
THSD4 thrombospondin, type I, domain containing 4 0.0160933
WSB1 WD repeat and SOCS box containing 1 0.0156042
MED13L mediator complex subunit 13-like 0.0154077
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0152462
DLG1 discs, large homolog 1 (Drosophila) 0.0120045
ZBTB20 zinc finger and BTB domain containing 20 0.0109621
EGFR epidermal growth factor receptor 0.0108888
RIGI RNA sensor RIG-I 0.00909392
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00853334
KMT2E lysine (K)-specific methyltransferase 2E 0.0063386
CD44 CD44 molecule (Indian blood group) 0.00521381
CDH13 cadherin 13 0.00207935
ATXN1 ataxin 1 6.21731E-4

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.189319
TPT1 tumor protein, translationally-controlled 1 -0.152261
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.122711
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.110433
NALF1 NALCN channel auxiliary factor 1 -0.107837
RAB10 RAB10, member RAS oncogene family -0.0988074
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0978671
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0936541
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.093648
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0933693
ASPH aspartate beta-hydroxylase -0.0931661
TMSB10 thymosin beta 10 -0.0915419
EXT1 exostosin glycosyltransferase 1 -0.0912695
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0875036
LAMB3 laminin, beta 3 -0.0862326
VIM vimentin -0.0852407
RPS6 ribosomal protein S6 -0.0822867
FTL ferritin, light polypeptide -0.0774427
FN1 fibronectin 1 -0.0729064
SMYD3 SET and MYND domain containing 3 -0.0722201
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0717574
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0688782
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0666705
PDLIM5 PDZ and LIM domain 5 -0.0637392
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.062167
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0608574
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0589046
IGF2 insulin-like growth factor 2 -0.055467
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0554314
COL6A1 collagen, type VI, alpha 1 -0.0519175
COL6A3 collagen, type VI, alpha 3 -0.0494893
RACK1 receptor for activated C kinase 1 -0.048946
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0479056
INHBA inhibin, beta A -0.0476383
TENM3 teneurin transmembrane protein 3 -0.0472948
NFIA nuclear factor I/A -0.0468592
RPL35A ribosomal protein L35a -0.0463397
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0454778
MT2A metallothionein 2A -0.0444682
PSD3 pleckstrin and Sec7 domain containing 3 -0.0435092
FAT1 FAT atypical cadherin 1 -0.042474
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0424002
MYH9 myosin, heavy chain 9, non-muscle -0.0412609
SAMD4A sterile alpha motif domain containing 4A -0.039935
LPP LIM domain containing preferred translocation partner in lipoma -0.0382279
TXNRD1 thioredoxin reductase 1 -0.0368519
CLIP1 CAP-GLY domain containing linker protein 1 -0.0357687
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0350498
PRKCA protein kinase C, alpha -0.0347941
AKAP9 A kinase (PRKA) anchor protein 9 -0.0334442
NRXN3 neurexin 3 -0.0253215
EIF5B eukaryotic translation initiation factor 5B -0.0215554
FAM13A family with sequence similarity 13, member A -0.020267
RAB6A RAB6A, member RAS oncogene family -0.0191514
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0189837
USP34 ubiquitin specific peptidase 34 -0.0187601
RPL31 ribosomal protein L31 -0.0179236
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0173017
DOCK5 dedicator of cytokinesis 5 -0.01698
MACF1 microtubule-actin crosslinking factor 1 -0.0160505
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0152751
AKAP13 A kinase (PRKA) anchor protein 13 -0.0136667
MAML3 mastermind-like 3 (Drosophila) -0.0127466
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0122227
CUX1 cut-like homeobox 1 -0.011829
WDFY3 WD repeat and FYVE domain containing 3 -0.0105367
SBF2 SET binding factor 2 -0.010144
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0101175
PARD3 par-3 family cell polarity regulator -0.00921313
CADM2 cell adhesion molecule 2 -0.00873236
GPC6 glypican 6 -0.00712093
DOCK4 dedicator of cytokinesis 4 -0.00524529
ANXA2 annexin A2 -0.00448942
GPHN gephyrin -0.00184063
RORA RAR-related orphan receptor A -0.00155141
PGK1 phosphoglycerate kinase 1 -0.0012294
PTK2 protein tyrosine kinase 2 -0.00117603