Cloxacillin (sodium)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0962696
EZR ezrin 0.0823773
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0740386
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.072607
ESYT2 extended synaptotagmin-like protein 2 0.0670219
RPS6 ribosomal protein S6 0.0666481
NDRG1 N-myc downstream regulated 1 0.0659753
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0656576
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0651215
VEGFA vascular endothelial growth factor A 0.0619042
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.061577
LMO7 LIM domain 7 0.061066
AHNAK AHNAK nucleoprotein 0.060703
SQSTM1 sequestosome 1 0.0584822
CANX calnexin 0.0564988
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0555073
TXNIP thioredoxin interacting protein 0.0549787
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0541913
FMNL2 formin-like 2 0.0538376
BACE2 beta-site APP-cleaving enzyme 2 0.0527534
PTMA prothymosin, alpha 0.0527376
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0527132
DSPP dentin sialophosphoprotein 0.0525851
KDM2A lysine (K)-specific demethylase 2A 0.0519292
BRD2 bromodomain containing 2 0.0512961
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0508217
KDM5B lysine (K)-specific demethylase 5B 0.0499453
MACF1 microtubule-actin crosslinking factor 1 0.0493255
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0491249
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0478953
TMSB4X thymosin beta 4, X-linked 0.0470548
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0467365
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0458345
PTK2 protein tyrosine kinase 2 0.0456281
ZSWIM6 zinc finger, SWIM-type containing 6 0.0453991
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0449562
ATF3 activating transcription factor 3 0.0449243
NAMPT nicotinamide phosphoribosyltransferase 0.0445369
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0441056
MYO5B myosin VB 0.0439194
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.043526
LPP LIM domain containing preferred translocation partner in lipoma 0.0431038
JARID2 jumonji, AT rich interactive domain 2 0.0422773
NAV2 neuron navigator 2 0.0421031
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.042099
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0420651
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0419566
RIMKLB ribosomal modification protein rimK-like family member B 0.0419459
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0413378
PCBP2 poly(rC) binding protein 2 0.0409871
OXSR1 oxidative stress responsive 1 0.0389844
MYH9 myosin, heavy chain 9, non-muscle 0.0388877
LAMB3 laminin, beta 3 0.038596
APLP2 amyloid beta (A4) precursor-like protein 2 0.0384047
RNF213 ring finger protein 213 0.0382553
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0382151
SDC4 syndecan 4 0.0379404
FN1 fibronectin 1 0.0376574
CD47 CD47 molecule 0.037524
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0365472
FOXO3 forkhead box O3 0.0362203
H1-0 H1.0 linker histone 0.0355623
TNIP1 TNFAIP3 interacting protein 1 0.0354293
IGFBP3 insulin-like growth factor binding protein 3 0.0353466
TPM4 tropomyosin 4 0.0351575
PLAUR plasminogen activator, urokinase receptor 0.0348816
CDYL chromodomain protein, Y-like 0.034791
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0347233
RICTOR RPTOR independent companion of MTOR, complex 2 0.034669
RAB6A RAB6A, member RAS oncogene family 0.0344763
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.034429
PKM pyruvate kinase, muscle 0.0343887
OGA O-GlcNAcase 0.0341139
BTBD9 BTB (POZ) domain containing 9 0.0338455
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0338233
EIF4A2 eukaryotic translation initiation factor 4A2 0.0337661
SET SET nuclear proto-oncogene 0.0334124
SMAD3 SMAD family member 3 0.0332853
JMJD1C jumonji domain containing 1C 0.0329324
XPO1 exportin 1 0.032443
KIAA1671 KIAA1671 0.0321475
RBM39 RNA binding motif protein 39 0.0317437
YAP1 Yes-associated protein 1 0.0316507
BBX bobby sox homolog (Drosophila) 0.0316248
RPS12 ribosomal protein S12 0.0314359
TPM3 tropomyosin 3 0.0313213
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.03082
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0307049
MYO6 myosin VI 0.0306684
AKAP13 A kinase (PRKA) anchor protein 13 0.0305943
AFDN afadin, adherens junction formation factor 0.0305466
H2AC6 H2A clustered histone 6 0.030534
THSD4 thrombospondin, type I, domain containing 4 0.0303741
TTC3 tetratricopeptide repeat domain 3 0.0300128
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0299812
ITGA6 integrin, alpha 6 0.0299054
CCNL1 cyclin L1 0.0297622
TMF1 TATA element modulatory factor 1 0.0297529
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0295677
SKAP2 src kinase associated phosphoprotein 2 0.0294209

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.187948
LAMA4 laminin, alpha 4 -0.117654
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0840211
MUC4 mucin 4, cell surface associated -0.0783562
VCL vinculin -0.072895
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0691002
SMC4 structural maintenance of chromosomes 4 -0.0668771
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0666708
DIAPH3 diaphanous-related formin 3 -0.0605197
PDLIM5 PDZ and LIM domain 5 -0.0567477
RASAL2 RAS protein activator like 2 -0.0543772
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0514283
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0486117
WWC1 WW and C2 domain containing 1 -0.0480269
TMSB10 thymosin beta 10 -0.0474601
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0459524
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0458788
NCEH1 neutral cholesterol ester hydrolase 1 -0.0456718
OSMR oncostatin M receptor -0.0448188
EGFR epidermal growth factor receptor -0.0445443
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0421429
ARHGAP29 Rho GTPase activating protein 29 -0.0415477
ECT2 epithelial cell transforming 2 -0.0404319
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0384503
ADGRG6 adhesion G protein-coupled receptor G6 -0.0381305
DLC1 DLC1 Rho GTPase activating protein -0.0378746
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.037426
THBS1 thrombospondin 1 -0.037335
EGR1 early growth response 1 -0.0360114
MYOF myoferlin -0.0357309
CAV1 caveolin 1, caveolae protein, 22kDa -0.0346551
BCL2L1 BCL2-like 1 -0.0343868
BCAR3 breast cancer anti-estrogen resistance 3 -0.0335598
MKI67 marker of proliferation Ki-67 -0.0320107
RAD21 RAD21 homolog (S. pombe) -0.0316775
KRT18 keratin 18, type I -0.031138
ANLN anillin, actin binding protein -0.0308954
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0298215
TM4SF1 transmembrane 4 L six family member 1 -0.0292697
MT2A metallothionein 2A -0.0291762
LDHA lactate dehydrogenase A -0.0284336
PCLO piccolo presynaptic cytomatrix protein -0.0279386
MUC16 mucin 16, cell surface associated -0.0274654
MELTF melanotransferrin -0.0270776
ZBTB20 zinc finger and BTB domain containing 20 -0.0268259
RBMS2 RNA binding motif, single stranded interacting protein 2 -0.0264319
ANKRD33B ankyrin repeat domain 33B -0.026362
PLAT plasminogen activator, tissue -0.0258524
RPS24 ribosomal protein S24 -0.0255054
C6ORF132 chromosome 6 open reading frame 132 -0.0253528
INHBA inhibin, beta A -0.0247849
OSBPL3 oxysterol binding protein-like 3 -0.0244874
ANXA3 annexin A3 -0.0244006
S100A6 S100 calcium binding protein A6 -0.0235893
TGFB2 transforming growth factor, beta 2 -0.0231517
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.0230589
CENPF centromere protein F, 350/400kDa -0.0229062
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.0228483
HMGA1 high mobility group AT-hook 1 -0.0227968
SPIDR scaffolding protein involved in DNA repair -0.022149
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0220969
SHROOM3 shroom family member 3 -0.0219855
ACTN4 actinin, alpha 4 -0.0218894
TMEM123 transmembrane protein 123 -0.0217022
IFITM1 interferon induced transmembrane protein 1 -0.0216576
H3-3B H3.3 histone B -0.0216152
ANXA2 annexin A2 -0.0214216
SLC38A2 solute carrier family 38, member 2 -0.0213588
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0212584
MIS18BP1 MIS18 binding protein 1 -0.0212526
MAML2 mastermind-like 2 (Drosophila) -0.0208818
IL1RAP interleukin 1 receptor accessory protein -0.0206487
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0204422
INTS6 integrator complex subunit 6 -0.020362
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0203172
SENP5 SUMO1/sentrin specific peptidase 5 -0.0203089
LY6E lymphocyte antigen 6 complex, locus E -0.0202862
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0202859
UBASH3B ubiquitin associated and SH3 domain containing B -0.0201407
FRMD6 FERM domain containing 6 -0.020095
CDK6 cyclin-dependent kinase 6 -0.0200353
ALCAM activated leukocyte cell adhesion molecule -0.0199724
HLA-B major histocompatibility complex, class I, B -0.0196203
NFIB nuclear factor I/B -0.0195468
RHEB Ras homolog enriched in brain -0.0193202
IFI27 interferon, alpha-inducible protein 27 -0.0186998
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0186614
NF1 neurofibromin 1 -0.018572
SON SON DNA binding protein -0.0182013
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.0181249
TACSTD2 tumor-associated calcium signal transducer 2 -0.0179913
SCLT1 sodium channel and clathrin linker 1 -0.0179871
HLA-C major histocompatibility complex, class I, C -0.017871
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0178063
GRHL2 grainyhead-like 2 (Drosophila) -0.0173635
PITPNB phosphatidylinositol transfer protein, beta -0.0173277
METTL15 methyltransferase like 15 -0.0172194
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0171616
TUBB tubulin, beta class I -0.0170862
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0169114