Cloxacillin (sodium)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD6 FERM domain containing 6 0.0821532
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.076068
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.055918
ZEB1 zinc finger E-box binding homeobox 1 0.0483096
KMT2E lysine (K)-specific methyltransferase 2E 0.0467422
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0467243
HDAC9 histone deacetylase 9 0.0465748
TTC3 tetratricopeptide repeat domain 3 0.042703
FNDC3B fibronectin type III domain containing 3B 0.0425969
INTS6 integrator complex subunit 6 0.0410553
OGA O-GlcNAcase 0.0405297
VMP1 vacuole membrane protein 1 0.0400007
PRELID2 PRELI domain containing 2 0.0396047
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0393963
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0393867
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0392324
EEF2 eukaryotic translation elongation factor 2 0.0375861
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0371837
RUNX1 runt-related transcription factor 1 0.03642
PICALM phosphatidylinositol binding clathrin assembly protein 0.0361435
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0359441
KDM2A lysine (K)-specific demethylase 2A 0.034995
CAPRIN2 caprin family member 2 0.0349786
FKBP15 FK506 binding protein 15, 133kDa 0.0346848
WNK1 WNK lysine deficient protein kinase 1 0.0342169
NUP58 nucleoporin 58 0.0338091
KDM6A lysine (K)-specific demethylase 6A 0.0331426
DSCAM Down syndrome cell adhesion molecule 0.0325408
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0323237
MYH9 myosin, heavy chain 9, non-muscle 0.032321
PGM3 phosphoglucomutase 3 0.0315037
APLP2 amyloid beta (A4) precursor-like protein 2 0.030636
HELZ helicase with zinc finger 0.0304502
BRD4 bromodomain containing 4 0.0293856
KMT2C lysine (K)-specific methyltransferase 2C 0.0283498
SETD5 SET domain containing 5 0.028346
CALU calumenin 0.0276726
LCORL ligand dependent nuclear receptor corepressor-like 0.0276523
PTMA prothymosin, alpha 0.0273348
SEC31A SEC31 homolog A (S. cerevisiae) 0.0270042
IQGAP1 IQ motif containing GTPase activating protein 1 0.0266772
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0265143
SFPQ splicing factor proline/glutamine-rich 0.026417
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0263183
TRA2A transformer 2 alpha homolog (Drosophila) 0.0263127
EIF5 eukaryotic translation initiation factor 5 0.0262594
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0261627
SRRM1 serine/arginine repetitive matrix 1 0.0260909
RCOR1 REST corepressor 1 0.0251032
RAB6A RAB6A, member RAS oncogene family 0.0249191
SPATS2 spermatogenesis associated, serine-rich 2 0.024854
XPC xeroderma pigmentosum, complementation group C 0.0247338
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0245937
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.024454
RLF rearranged L-myc fusion 0.0244428
KTN1 kinectin 1 (kinesin receptor) 0.0243385
SAMD4A sterile alpha motif domain containing 4A 0.0241398
CORO1C coronin, actin binding protein, 1C 0.023943
PHIP pleckstrin homology domain interacting protein 0.0239179
USP3 ubiquitin specific peptidase 3 0.0239043
AAK1 AP2 associated kinase 1 0.0237603
TOP1 topoisomerase (DNA) I 0.0237585
BCAS3 breast carcinoma amplified sequence 3 0.0237195
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0236643
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0235581
FUBP1 far upstream element (FUSE) binding protein 1 0.0234989
RB1 retinoblastoma 1 0.0233104
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0230628
COPA coatomer protein complex, subunit alpha 0.0230555
SND1 staphylococcal nuclease and tudor domain containing 1 0.0229823
GOLGB1 golgin B1 0.02292
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0227862
PHF3 PHD finger protein 3 0.022613
AGO3 argonaute RISC catalytic component 3 0.0225446
ZFAND3 zinc finger, AN1-type domain 3 0.0223488
GOLGA2 golgin A2 0.0223168
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0220551
ADAM17 ADAM metallopeptidase domain 17 0.0220093
FMNL2 formin-like 2 0.0219444
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0219158
KDM3B lysine (K)-specific demethylase 3B 0.0214489
GLS2 glutaminase 2 (liver, mitochondrial) 0.0214203
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0213812
RPL7 ribosomal protein L7 0.0213499
FAM193A family with sequence similarity 193, member A 0.0213084
NAP1L4 nucleosome assembly protein 1-like 4 0.0211564
SRP54 signal recognition particle 54kDa 0.0211449
CAMTA1 calmodulin binding transcription activator 1 0.0211435
CARD16 caspase recruitment domain family, member 16 0.0210831
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0208318
PPME1 protein phosphatase methylesterase 1 0.0207992
HYOU1 hypoxia up-regulated 1 0.0207837
DIAPH1 diaphanous-related formin 1 0.0207716
SEC24A SEC24 family member A 0.0205129
PTPRG protein tyrosine phosphatase, receptor type, G 0.0204667
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0203781
RBM39 RNA binding motif protein 39 0.0203761
SGMS2 sphingomyelin synthase 2 0.0203382
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0202958
MCL1 myeloid cell leukemia 1 0.0202406

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.122813
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.103438
IFI16 interferon, gamma-inducible protein 16 -0.103146
DLC1 DLC1 Rho GTPase activating protein -0.0972687
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0703794
RPL12 ribosomal protein L12 -0.0642588
STC1 stanniocalcin 1 -0.0622924
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0598249
FLNB filamin B, beta -0.0574658
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0565408
TPT1 tumor protein, translationally-controlled 1 -0.0554612
SLC38A2 solute carrier family 38, member 2 -0.054084
BNC2 basonuclin 2 -0.0537427
MTAP methylthioadenosine phosphorylase -0.0508818
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0508023
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.049196
CALD1 caldesmon 1 -0.0483596
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.047468
G0S2 G0/G1 switch 2 -0.0469017
ASPH aspartate beta-hydroxylase -0.0468372
FRMD4A FERM domain containing 4A -0.0453393
ACTG1 actin gamma 1 -0.0429015
ANTXR2 anthrax toxin receptor 2 -0.0422236
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0418098
TCF12 transcription factor 12 -0.0408389
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0407398
RPL30 ribosomal protein L30 -0.0399163
RPLP0 ribosomal protein, large, P0 -0.0398665
ZNF438 zinc finger protein 438 -0.0394446
ALCAM activated leukocyte cell adhesion molecule -0.0393386
RPS2 ribosomal protein S2 -0.0390465
LDHA lactate dehydrogenase A -0.0382307
ANK2 ankyrin 2, neuronal -0.0378863
SAMD12 sterile alpha motif domain containing 12 -0.0378146
TMSB10 thymosin beta 10 -0.0376681
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0373349
RPS12 ribosomal protein S12 -0.0366363
TTR transthyretin -0.0363095
LOC112694756 uncharaterized LOC112694756 -0.0357407
PGK1 phosphoglycerate kinase 1 -0.035666
ZC3H12B zinc finger CCCH-type containing 12B -0.0356587
GLRX glutaredoxin (thioltransferase) -0.0350448
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0345597
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.034434
CCDC91 coiled-coil domain containing 91 -0.0343101
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0342076
BZW1 basic leucine zipper and W2 domains 1 -0.0338934
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0335376
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0333409
RPS21 ribosomal protein S21 -0.0331793
RPS6 ribosomal protein S6 -0.0329293
CAPN2 calpain 2, (m/II) large subunit -0.0321527
SERBP1 SERPINE1 mRNA binding protein 1 -0.0321455
FHIT fragile histidine triad -0.0321185
ANXA2 annexin A2 -0.0320814
RSL1D1 ribosomal L1 domain containing 1 -0.0319584
RPS24 ribosomal protein S24 -0.0318138
RPS3 ribosomal protein S3 -0.031405
HLA-C major histocompatibility complex, class I, C -0.0309794
RPL34 ribosomal protein L34 -0.0308974
RIGI RNA sensor RIG-I -0.0308347
LPP LIM domain containing preferred translocation partner in lipoma -0.0305148
RPL11 ribosomal protein L11 -0.030073
TMEM41B transmembrane protein 41B -0.0300056
RPL35 ribosomal protein L35 -0.0297582
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0295238
RPS4X ribosomal protein S4, X-linked -0.0292256
TEX10 testis expressed 10 -0.0291475
SMYD3 SET and MYND domain containing 3 -0.0289646
RPS27A ribosomal protein S27a -0.028862
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0288378
CDK6 cyclin-dependent kinase 6 -0.0285795
ZBTB20 zinc finger and BTB domain containing 20 -0.0285047
PTPRF protein tyrosine phosphatase, receptor type, F -0.0280768
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0279511
RPL9 ribosomal protein L9 -0.0274845
RPL26 ribosomal protein L26 -0.0273943
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0273604
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.027117
EFNB2 ephrin-B2 -0.0268662
ENO1 enolase 1, (alpha) -0.0268537
PLSCR1 phospholipid scramblase 1 -0.0268516
IFI6 interferon, alpha-inducible protein 6 -0.0264755
NAV3 neuron navigator 3 -0.0263948
EXOC4 exocyst complex component 4 -0.0261055
RAB3IP RAB3A interacting protein -0.026103
NPC1 Niemann-Pick disease, type C1 -0.0250813
NAP1L1 nucleosome assembly protein 1-like 1 -0.0250617
ERBIN erbb2 interacting protein -0.0248654
KDSR 3-ketodihydrosphingosine reductase -0.0247964
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0245952
NOP56 NOP56 ribonucleoprotein -0.0245212
RPL22L1 ribosomal protein L22-like 1 -0.0244022
JMJD1C jumonji domain containing 1C -0.02412
RPL32 ribosomal protein L32 -0.0240648
RPL36A ribosomal protein L36a -0.0240012
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0238837
TM4SF1 transmembrane 4 L six family member 1 -0.0238325
RPL7L1 ribosomal protein L7-like 1 -0.0237817
ARHGAP22 Rho GTPase activating protein 22 -0.0237537