Cloxacillin (sodium)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.0986513
ASPH aspartate beta-hydroxylase 0.0836202
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0627954
HMGA2 high mobility group AT-hook 2 0.0422046
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0366804
CEMIP cell migration inducing protein, hyaluronan binding 0.0366091
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0339683
MCTP2 multiple C2 domains, transmembrane 2 0.0330342
DOCK5 dedicator of cytokinesis 5 0.0317505
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0297988
IGFBP3 insulin-like growth factor binding protein 3 0.027266
NPAS2 neuronal PAS domain protein 2 0.0272081
PDE10A phosphodiesterase 10A 0.0267224
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0256566
PDLIM5 PDZ and LIM domain 5 0.0254416
BBS9 Bardet-Biedl syndrome 9 0.0246182
MMP12 matrix metallopeptidase 12 0.0230982
COL7A1 collagen, type VII, alpha 1 0.0229139
FNIP1 folliculin interacting protein 1 0.022377
ZSWIM6 zinc finger, SWIM-type containing 6 0.0220507
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0215451
FTH1 ferritin, heavy polypeptide 1 0.0211431
HPCAL1 hippocalcin-like 1 0.0205756
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0203197
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0200292
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0196576
ZCCHC7 zinc finger, CCHC domain containing 7 0.0193593
TTC3 tetratricopeptide repeat domain 3 0.0190655
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0187546
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0187504
SKAP2 src kinase associated phosphoprotein 2 0.0185341
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0184825
SETBP1 SET binding protein 1 0.0184728
MMP24OS MMP24 opposite strand 0.0183318
JARID2 jumonji, AT rich interactive domain 2 0.0179509
HOOK3 hook microtubule-tethering protein 3 0.0178275
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0174114
NBEA neurobeachin 0.0172211
DDR2 discoidin domain receptor tyrosine kinase 2 0.0171621
ARHGAP22 Rho GTPase activating protein 22 0.0167384
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0164448
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0163904
TMEM178B transmembrane protein 178B 0.016274
ZBTB20 zinc finger and BTB domain containing 20 0.0162354
TMEM14B transmembrane protein 14B 0.016084
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0160439
SLC38A2 solute carrier family 38, member 2 0.0159661
ATM ATM serine/threonine kinase 0.0159611
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.015916
FBXL2 F-box and leucine-rich repeat protein 2 0.0157377
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0156155
MYO1E myosin IE 0.015519
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0154591
AEBP2 AE binding protein 2 0.0153005
EGFR epidermal growth factor receptor 0.014992
INTS6 integrator complex subunit 6 0.0149566
RANBP2 RAN binding protein 2 0.0148393
MBNL2 muscleblind-like splicing regulator 2 0.0148256
MAGED1 melanoma antigen family D1 0.0147836
KYNU kynureninase 0.0146449
SPDYA speedy/RINGO cell cycle regulator family member A 0.0146305
AFF3 AF4/FMR2 family, member 3 0.0145478
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0144067
ZNF780B zinc finger protein 780B 0.0141091
HDAC4 histone deacetylase 4 0.0140725
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0140507
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0140332
NCOA3 nuclear receptor coactivator 3 0.0139274
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0138738
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.0137603
GPATCH2L G patch domain containing 2-like 0.013729
RNF217 ring finger protein 217 0.0135571
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0135384
SHISA5 shisa family member 5 0.0134787
ENO2 enolase 2 (gamma, neuronal) 0.0134111
BPTF bromodomain PHD finger transcription factor 0.0133754
FERMT2 fermitin family member 2 0.0130938
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0130692
AKAP12 A kinase (PRKA) anchor protein 12 0.0129941
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0129754
PHF14 PHD finger protein 14 0.0129722
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.012908
PER3 period circadian clock 3 0.0128039
EXOC4 exocyst complex component 4 0.0127827
AHNAK AHNAK nucleoprotein 0.0127427
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0126767
LCORL ligand dependent nuclear receptor corepressor-like 0.0124308
MNMIP1 manchette microtubule inner protein 1 0.0123565
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0121995
ZFYVE28 zinc finger, FYVE domain containing 28 0.0121049
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0120619
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0119724
ARHGAP12 Rho GTPase activating protein 12 0.0119048
FBN1 fibrillin 1 0.0119045
SMAD2 SMAD family member 2 0.0118835
OGA O-GlcNAcase 0.0118272
FAM177A1 family with sequence similarity 177, member A1 0.0118108
HILPDA hypoxia inducible lipid droplet-associated 0.0117533
GPR173 G protein-coupled receptor 173 0.0116302
CADM1 cell adhesion molecule 1 0.0116271

decreased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 -0.178031
FN1 fibronectin 1 -0.16695
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165108
STC1 stanniocalcin 1 -0.157737
HLA-B major histocompatibility complex, class I, B -0.140493
B2M beta-2-microglobulin -0.139852
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.137211
STAT1 signal transducer and activator of transcription 1, 91kDa -0.133511
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.13201
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.113408
COL6A1 collagen, type VI, alpha 1 -0.108603
NDRG1 N-myc downstream regulated 1 -0.103165
CD44 CD44 molecule (Indian blood group) -0.0902844
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0875836
FNDC3B fibronectin type III domain containing 3B -0.0875669
TGFBI transforming growth factor, beta-induced, 68kDa -0.0820968
MT2A metallothionein 2A -0.0792238
ZEB1 zinc finger E-box binding homeobox 1 -0.0762795
IFI6 interferon, alpha-inducible protein 6 -0.0741923
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0704921
COL6A2 collagen, type VI, alpha 2 -0.066477
POTEF POTE ankyrin domain family, member F -0.063389
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.062648
TNNC1 troponin C type 1 (slow) -0.0574509
ZNF292 zinc finger protein 292 -0.0564558
FRMD4A FERM domain containing 4A -0.0562555
COL1A2 collagen, type I, alpha 2 -0.0527749
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.052353
PTMA prothymosin, alpha -0.052319
HLA-C major histocompatibility complex, class I, C -0.051888
VIM vimentin -0.0483272
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0477787
RBM39 RNA binding motif protein 39 -0.0474669
TFPI2 tissue factor pathway inhibitor 2 -0.0473374
XPO1 exportin 1 -0.046914
MYH9 myosin, heavy chain 9, non-muscle -0.0465268
TMSB10 thymosin beta 10 -0.0460709
ZNFX1 zinc finger, NFX1-type containing 1 -0.045069
ANXA2 annexin A2 -0.0442948
CDH13 cadherin 13 -0.0442545
CALU calumenin -0.0441076
COL4A2 collagen, type IV, alpha 2 -0.043967
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0430581
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0421772
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0420005
SP100 SP100 nuclear antigen -0.0418355
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0416844
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0414406
TPT1 tumor protein, translationally-controlled 1 -0.0413921
IER3 immediate early response 3 -0.0411308
SEPTIN7 septin 7 -0.0401558
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0394714
TPM4 tropomyosin 4 -0.0393572
SAMD9 sterile alpha motif domain containing 9 -0.0377375
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0375937
HLA-A major histocompatibility complex, class I, A -0.0373103
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0371647
SPAG9 sperm associated antigen 9 -0.0370084
IFIH1 interferon induced with helicase C domain 1 -0.0367312
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0366968
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0365546
COL5A1 collagen, type V, alpha 1 -0.0362162
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.035978
PALM2AKAP2 PALM2 and AKAP2 fusion -0.035749
RPS6 ribosomal protein S6 -0.0355579
ZMYND8 zinc finger, MYND-type containing 8 -0.0355516
MX1 MX dynamin-like GTPase 1 -0.0354271
ZBTB38 zinc finger and BTB domain containing 38 -0.0353494
GOLGA4 golgin A4 -0.0350239
RAB1A RAB1A, member RAS oncogene family -0.0347985
RYBP RING1 and YY1 binding protein -0.0347445
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0338323
VCAN versican -0.0331902
KIF5B kinesin family member 5B -0.0331139
CTSB cathepsin B -0.0328224
DDIT4 DNA-damage-inducible transcript 4 -0.0326856
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0323166
ANGPTL4 angiopoietin-like 4 -0.032079
MED13L mediator complex subunit 13-like -0.0319478
IL1B interleukin 1, beta -0.0316468
PKM pyruvate kinase, muscle -0.0315754
LDHA lactate dehydrogenase A -0.031426
TPM1 tropomyosin 1 (alpha) -0.0314176
ANLN anillin, actin binding protein -0.0313037
CDCP1 CUB domain containing protein 1 -0.0308591
ADAR adenosine deaminase, RNA-specific -0.0308518
TGM2 transglutaminase 2 -0.0306506
TNS3 tensin 3 -0.0304187
PTK2 protein tyrosine kinase 2 -0.0301689
RPS2 ribosomal protein S2 -0.0300379
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0299372
PRRC2C proline-rich coiled-coil 2C -0.0298872
DSTN destrin (actin depolymerizing factor) -0.0295654
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0294726
KDM3A lysine (K)-specific demethylase 3A -0.0290988
ALCAM activated leukocyte cell adhesion molecule -0.0290903
RUNX1 runt-related transcription factor 1 -0.0290455
KMT2E lysine (K)-specific methyltransferase 2E -0.0289636
NCKAP1 NCK-associated protein 1 -0.0288441
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0288155