Cloxacillin (sodium)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in SHP-77 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cloxacillin (sodium)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 0.065257
SMOC1 SPARC related modular calcium binding 1 0.0573307
PDE10A phosphodiesterase 10A 0.0469061
VGF VGF nerve growth factor inducible 0.0432851
MYH9 myosin, heavy chain 9, non-muscle 0.0388247
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0348999
ERRFI1 ERBB receptor feedback inhibitor 1 0.0327478
ELL2 elongation factor, RNA polymerase II, 2 0.0327111
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0292379
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0264838
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0245259
GRB10 growth factor receptor-bound protein 10 0.0234913
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0227285
FAM13A family with sequence similarity 13, member A 0.0211328
DTNA dystrobrevin, alpha 0.0197424
FAT1 FAT atypical cadherin 1 0.0194831
TMEM255B transmembrane protein 255B 0.0191724
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.018493
APP amyloid beta (A4) precursor protein 0.0174411
ADARB1 adenosine deaminase, RNA-specific, B1 0.0166873
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0165212
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0159976
DGKD diacylglycerol kinase, delta 130kDa 0.0157656
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0153577
ZSWIM6 zinc finger, SWIM-type containing 6 0.0152481
EP300 E1A binding protein p300 0.0148817
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0147548
RANBP2 RAN binding protein 2 0.0145632
ANKRD36C ankyrin repeat domain 36C 0.0145628
PTK2 protein tyrosine kinase 2 0.0145609
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0144938
HSPA8 heat shock 70kDa protein 8 0.014374
NBAS neuroblastoma amplified sequence 0.0143712
PARD3 par-3 family cell polarity regulator 0.0139684
SIK3 SIK family kinase 3 0.0137489
DST dystonin 0.0137239
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0136966
MCL1 myeloid cell leukemia 1 0.0136084
SDK1 sidekick cell adhesion molecule 1 0.0135344
TSPYL2 TSPY-like 2 0.0134244
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0133804
IQSEC1 IQ motif and Sec7 domain 1 0.0132621
MSN moesin 0.013104
BACE2 beta-site APP-cleaving enzyme 2 0.0127873
AHR aryl hydrocarbon receptor 0.012724
SSBP2 single-stranded DNA binding protein 2 0.0127176
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0123355
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0121655
TENT4A terminal nucleotidyltransferase 4A 0.0121016
EZR ezrin 0.0120733
ASPH aspartate beta-hydroxylase 0.0120597
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0120324
PICALM phosphatidylinositol binding clathrin assembly protein 0.0120126
LCOR ligand dependent nuclear receptor corepressor 0.0120089
TRIO trio Rho guanine nucleotide exchange factor 0.0120082
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0119753
IVNS1ABP influenza virus NS1A binding protein 0.0118185
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.011711
CEMIP cell migration inducing protein, hyaluronan binding 0.0116571
WAC WW domain containing adaptor with coiled-coil 0.0115488
VEGFA vascular endothelial growth factor A 0.0114068
BRD2 bromodomain containing 2 0.0112839
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0112159
DUSP10 dual specificity phosphatase 10 0.0111914
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0109964
TOP1 topoisomerase (DNA) I 0.0109162
ANKH ANKH inorganic pyrophosphate transport regulator 0.0108157
ARFGEF3 ARFGEF family member 3 0.0107765
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0107627
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0107346
LIMCH1 LIM and calponin homology domains 1 0.0106429
CCNL1 cyclin L1 0.0105045
RUNX1 runt-related transcription factor 1 0.0104897
FNDC3B fibronectin type III domain containing 3B 0.0104291
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0103531
DOCK5 dedicator of cytokinesis 5 0.0103501
PDE8A phosphodiesterase 8A 0.0103434
MPRIP myosin phosphatase Rho interacting protein 0.01033
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 0.0103258
RNF144A ring finger protein 144A 0.0102481
YEATS2 YEATS domain containing 2 0.0102314
ZNF407 zinc finger protein 407 0.0102087
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0101246
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0100589
AKAP13 A kinase (PRKA) anchor protein 13 0.0100209
SVIL supervillin 0.00985563
ATRN attractin 0.00980527
HDAC4 histone deacetylase 4 0.00977084
FAM91A1 family with sequence similarity 91, member A1 0.00968366
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00953633
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.00953071
LPP LIM domain containing preferred translocation partner in lipoma 0.00950802
SUCO SUN domain containing ossification factor 0.0094121
PCBP3 poly(rC) binding protein 3 0.00939788
HSPH1 heat shock 105kDa/110kDa protein 1 0.00938744
HYOU1 hypoxia up-regulated 1 0.009334
TTC19 tetratricopeptide repeat domain 19 0.00929842
USPL1 ubiquitin specific peptidase like 1 0.00926603
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.00923679
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.00923513

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.179187
CALCA calcitonin-related polypeptide alpha -0.141814
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0964193
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0852911
NALF1 NALCN channel auxiliary factor 1 -0.0818046
RPS21 ribosomal protein S21 -0.0698605
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0698524
PEG10 paternally expressed 10 -0.0690119
RPS3 ribosomal protein S3 -0.0675968
CENPF centromere protein F, 350/400kDa -0.0646235
FTL ferritin, light polypeptide -0.0617564
ENO1 enolase 1, (alpha) -0.0615367
TOP2A topoisomerase (DNA) II alpha 170kDa -0.059096
ACTG1 actin gamma 1 -0.0561917
MT2A metallothionein 2A -0.055568
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.053712
IFI6 interferon, alpha-inducible protein 6 -0.0521775
STC1 stanniocalcin 1 -0.0511005
RPS8 ribosomal protein S8 -0.0509154
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0494833
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0492112
S100A9 S100 calcium binding protein A9 -0.0486348
RPL11 ribosomal protein L11 -0.0482134
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0481488
RPS6 ribosomal protein S6 -0.0467394
SCG2 secretogranin II -0.0462607
SYT1 synaptotagmin I -0.0450393
RIT2 Ras-like without CAAX 2 -0.0449469
RPLP1 ribosomal protein, large, P1 -0.0447902
RPL26 ribosomal protein L26 -0.0446524
RPL23 ribosomal protein L23 -0.0437106
RPL37A ribosomal protein L37a -0.043206
RPL37 ribosomal protein L37 -0.0421126
IGFBP5 insulin-like growth factor binding protein 5 -0.0416086
TENM1 teneurin transmembrane protein 1 -0.0405436
RPS27A ribosomal protein S27a -0.0402798
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0400964
ISG15 ISG15 ubiquitin-like modifier -0.0398751
RPL8 ribosomal protein L8 -0.039691
GNAS GNAS complex locus -0.0396766
RPS25 ribosomal protein S25 -0.0394375
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0371897
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0371795
ATP5F1E ATP synthase F1 subunit epsilon -0.036784
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0366123
SNTG1 syntrophin, gamma 1 -0.0365483
TPT1 tumor protein, translationally-controlled 1 -0.035428
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0345076
RPS16 ribosomal protein S16 -0.0344634
RPLP0 ribosomal protein, large, P0 -0.033557
TXNRD1 thioredoxin reductase 1 -0.032881
RPL35 ribosomal protein L35 -0.0325039
KPNB1 karyopherin (importin) beta 1 -0.0324865
RPS19 ribosomal protein S19 -0.0324344
CPE carboxypeptidase E -0.0318899
MAP1B microtubule-associated protein 1B -0.0314481
RPL38 ribosomal protein L38 -0.0313266
TSHZ2 teashirt zinc finger homeobox 2 -0.0304456
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0303134
RPL12 ribosomal protein L12 -0.0302603
RPL35A ribosomal protein L35a -0.0300364
RIMS2 regulating synaptic membrane exocytosis 2 -0.0300279
TMSB10 thymosin beta 10 -0.0300007
FOXC1 forkhead box C1 -0.029987
RPL32 ribosomal protein L32 -0.0299587
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.029958
RPS27 ribosomal protein S27 -0.0298952
B2M beta-2-microglobulin -0.0297201
ADGRL2 adhesion G protein-coupled receptor L2 -0.0293532
RPS12 ribosomal protein S12 -0.0290593
DEK DEK proto-oncogene -0.0289537
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0287903
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0285962
RPS23 ribosomal protein S23 -0.0282307
RPL36AL ribosomal protein L36a-like -0.0282293
RPL36 ribosomal protein L36 -0.0281673
RPL30 ribosomal protein L30 -0.0277821
RPS29 ribosomal protein S29 -0.0273782
MKI67 marker of proliferation Ki-67 -0.0271883
DGKB diacylglycerol kinase, beta 90kDa -0.0268868
RPL31 ribosomal protein L31 -0.0263195
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0261261
RPS17 ribosomal protein S17 -0.0260659
CCDC88A coiled-coil domain containing 88A -0.0260616
EIF5B eukaryotic translation initiation factor 5B -0.0256159
PFN1 profilin 1 -0.0255505
NIPSNAP2 nipsnap homolog 2 -0.0255493
RPS11 ribosomal protein S11 -0.0252562
RTN4 reticulon 4 -0.0251138
CHGA chromogranin A -0.0250244
RPS14 ribosomal protein S14 -0.0249227
RPS5 ribosomal protein S5 -0.024921
RPL7 ribosomal protein L7 -0.0246158
RPLP2 ribosomal protein, large, P2 -0.0244538
RPL19 ribosomal protein L19 -0.0244434
SMYD3 SET and MYND domain containing 3 -0.0243269
RPL5 ribosomal protein L5 -0.0242049
RACK1 receptor for activated C kinase 1 -0.024193
TUBB4B tubulin, beta 4B class IVb -0.0241487
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0238625