Cloxacillin (sodium)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0800094
FNDC3B fibronectin type III domain containing 3B 0.0747012
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0701178
MSN moesin 0.051503
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0492397
NOTCH2 notch 2 0.0474925
NAV2 neuron navigator 2 0.0462543
TPM3 tropomyosin 3 0.0397806
IGFBP3 insulin-like growth factor binding protein 3 0.0395852
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0383142
ESYT2 extended synaptotagmin-like protein 2 0.0364195
LINGO2 leucine rich repeat and Ig domain containing 2 0.0332863
HELZ helicase with zinc finger 0.0329145
MYH9 myosin, heavy chain 9, non-muscle 0.0318186
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0316067
SUCO SUN domain containing ossification factor 0.0310902
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0308011
AFDN afadin, adherens junction formation factor 0.0304834
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0297431
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0287439
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0284138
DSCAM Down syndrome cell adhesion molecule 0.0283507
ELL2 elongation factor, RNA polymerase II, 2 0.0283083
DST dystonin 0.0282573
SPAG9 sperm associated antigen 9 0.0279253
CXCL8 chemokine (C-X-C motif) ligand 8 0.0278564
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0275938
HDAC9 histone deacetylase 9 0.0275194
PTK2 protein tyrosine kinase 2 0.0270018
RPL3 ribosomal protein L3 0.026766
CCNL1 cyclin L1 0.0267225
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0262939
NFE2L1 nuclear factor, erythroid 2-like 1 0.0260902
FAM219A family with sequence similarity 219, member A 0.0260144
BHLHE40 basic helix-loop-helix family, member e40 0.0257362
DCAF6 DDB1 and CUL4 associated factor 6 0.0254666
EP300 E1A binding protein p300 0.0252954
AKAP13 A kinase (PRKA) anchor protein 13 0.0250932
OPHN1 oligophrenin 1 0.0250922
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0244614
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0244365
FMNL2 formin-like 2 0.0244116
PKM pyruvate kinase, muscle 0.0238461
CD44 CD44 molecule (Indian blood group) 0.0237413
MED13L mediator complex subunit 13-like 0.0235375
NCKAP1 NCK-associated protein 1 0.0232586
KMT2E lysine (K)-specific methyltransferase 2E 0.0232376
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0231947
CANX calnexin 0.0224517
CLIC4 chloride intracellular channel 4 0.0221845
SOX6 SRY (sex determining region Y)-box 6 0.0221688
GOLGB1 golgin B1 0.0221077
POM121 POM121 transmembrane nucleoporin 0.0220035
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0218752
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.021704
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0215487
ATP13A3 ATPase type 13A3 0.0211954
SEC31A SEC31 homolog A (S. cerevisiae) 0.0210559
KDM7A lysine (K)-specific demethylase 7A 0.0207146
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0206678
WASL Wiskott-Aldrich syndrome-like 0.0205501
RNF145 ring finger protein 145 0.0205084
NBAS neuroblastoma amplified sequence 0.0204397
PHF21A PHD finger protein 21A 0.0203902
AMOTL1 angiomotin like 1 0.0203423
ECPAS Ecm29 proteasome adaptor and scaffold 0.0200348
CSNK1A1 casein kinase 1, alpha 1 0.0199973
CDK19 cyclin-dependent kinase 19 0.0199304
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0199276
SOD2 superoxide dismutase 2, mitochondrial 0.0199127
MACF1 microtubule-actin crosslinking factor 1 0.0197596
CHD1 chromodomain helicase DNA binding protein 1 0.0197477
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0197136
CRYBG3 beta-gamma crystallin domain containing 3 0.0197004
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0196817
MMP12 matrix metallopeptidase 12 0.0194047
FER fer (fps/fes related) tyrosine kinase 0.0193555
GLS2 glutaminase 2 (liver, mitochondrial) 0.0192799
DIAPH1 diaphanous-related formin 1 0.0191551
RUNX1 runt-related transcription factor 1 0.0190661
XRN1 5'-3' exoribonuclease 1 0.0189358
CORO1C coronin, actin binding protein, 1C 0.0188196
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0187073
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.018705
SND1 staphylococcal nuclease and tudor domain containing 1 0.0184814
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0183012
SEC24A SEC24 family member A 0.0182601
NGLY1 N-glycanase 1 0.0182467
NBPF15 neuroblastoma breakpoint family, member 15 0.0182061
TFG TRK-fused gene 0.0181563
AHR aryl hydrocarbon receptor 0.0181411
UBA6 ubiquitin-like modifier activating enzyme 6 0.0179624
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0178815
DLG1 discs, large homolog 1 (Drosophila) 0.0178345
TLN1 talin 1 0.0177882
LAMP2 lysosomal-associated membrane protein 2 0.0177762
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0177372
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.0176452
ADAM17 ADAM metallopeptidase domain 17 0.0174903
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.017484

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.280156
LSAMP limbic system-associated membrane protein -0.164667
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.158206
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111403
RPL35A ribosomal protein L35a -0.0997112
NRG3 neuregulin 3 -0.099446
TMSB10 thymosin beta 10 -0.0822316
RPS3 ribosomal protein S3 -0.0817598
PTMA prothymosin, alpha -0.0811227
NLGN1 neuroligin 1 -0.0770023
FTL ferritin, light polypeptide -0.0756005
FRMD4A FERM domain containing 4A -0.0745889
TPT1 tumor protein, translationally-controlled 1 -0.0721183
PMEL premelanosome protein -0.0646843
FN1 fibronectin 1 -0.0645705
CCND1 cyclin D1 -0.0634451
VDAC1 voltage-dependent anion channel 1 -0.0625641
RPL23 ribosomal protein L23 -0.0616951
RPLP1 ribosomal protein, large, P1 -0.0612096
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0522436
RPS6 ribosomal protein S6 -0.0512968
RPL31 ribosomal protein L31 -0.0510761
RPL38 ribosomal protein L38 -0.0505591
ACTG1 actin gamma 1 -0.0504248
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0497522
RPS24 ribosomal protein S24 -0.0487232
RPL11 ribosomal protein L11 -0.0480052
RPL34 ribosomal protein L34 -0.0476602
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0470085
RPLP2 ribosomal protein, large, P2 -0.0461789
RPL32 ribosomal protein L32 -0.0436309
MT2A metallothionein 2A -0.0433723
RPS23 ribosomal protein S23 -0.0431927
IFI6 interferon, alpha-inducible protein 6 -0.0426337
SQSTM1 sequestosome 1 -0.042213
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0402309
RPS8 ribosomal protein S8 -0.039829
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0392772
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0387044
S100A9 S100 calcium binding protein A9 -0.038351
APOD apolipoprotein D -0.0382136
SLC39A11 solute carrier family 39, member 11 -0.0379702
RPS21 ribosomal protein S21 -0.0377158
RPL9 ribosomal protein L9 -0.0375383
RPS14 ribosomal protein S14 -0.0371795
RPS27A ribosomal protein S27a -0.0369049
RPL36A ribosomal protein L36a -0.0366554
RPS13 ribosomal protein S13 -0.0354674
RPS12 ribosomal protein S12 -0.0354558
NAP1L1 nucleosome assembly protein 1-like 1 -0.0349525
TNNC1 troponin C type 1 (slow) -0.0348092
HLA-B major histocompatibility complex, class I, B -0.0344319
LITAF lipopolysaccharide-induced TNF factor -0.0343739
RAB7A RAB7A, member RAS oncogene family -0.0327907
RPS4X ribosomal protein S4, X-linked -0.0327167
PRAME preferentially expressed antigen in melanoma -0.0325942
RPL37A ribosomal protein L37a -0.0325518
RPS19 ribosomal protein S19 -0.0325371
RPL19 ribosomal protein L19 -0.0324244
RPS29 ribosomal protein S29 -0.0324185
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0320946
RPS16 ribosomal protein S16 -0.0314853
RPL12 ribosomal protein L12 -0.0314049
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0313499
WSB1 WD repeat and SOCS box containing 1 -0.0311503
HMGA1 high mobility group AT-hook 1 -0.0310184
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0309567
RPL37 ribosomal protein L37 -0.0307431
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0306088
RPL5 ribosomal protein L5 -0.0303247
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0302252
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0301862
BCAS3 breast carcinoma amplified sequence 3 -0.0301775
CTSD cathepsin D -0.0295889
S100A6 S100 calcium binding protein A6 -0.0290739
RACK1 receptor for activated C kinase 1 -0.0290443
MAML3 mastermind-like 3 (Drosophila) -0.0288103
IER3 immediate early response 3 -0.0287205
TBCA tubulin folding cofactor A -0.0284708
RPS10 ribosomal protein S10 -0.0283292
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0280883
RPL36 ribosomal protein L36 -0.0274872
IFI16 interferon, gamma-inducible protein 16 -0.0273986
TPI1 triosephosphate isomerase 1 -0.0273592
RPL35 ribosomal protein L35 -0.0273188
GNAS GNAS complex locus -0.0272021
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.027176
KAZN kazrin, periplakin interacting protein -0.0265048
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0262575
HM13 histocompatibility (minor) 13 -0.0260477
ZMYND8 zinc finger, MYND-type containing 8 -0.0259901
CBX3 chromobox homolog 3 -0.0257576
RPS25 ribosomal protein S25 -0.0255497
RPL27 ribosomal protein L27 -0.0253118
TKT transketolase -0.0252892
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -0.0252714
LMNA lamin A/C -0.0252273
KIAA1549L KIAA1549-like -0.0251335
RPL8 ribosomal protein L8 -0.0248872
RPL28 ribosomal protein L28 -0.0247531