Cloxacillin (sodium)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.148631
VEGFA vascular endothelial growth factor A 0.131092
MYH9 myosin, heavy chain 9, non-muscle 0.127112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0988436
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.094322
MSN moesin 0.0781658
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0756478
ASPH aspartate beta-hydroxylase 0.068522
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0670439
NAV2 neuron navigator 2 0.0645965
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0611999
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0607954
APLP2 amyloid beta (A4) precursor-like protein 2 0.0567943
HDAC9 histone deacetylase 9 0.0525862
EEF2 eukaryotic translation elongation factor 2 0.0507033
BRD2 bromodomain containing 2 0.0496159
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0495333
UBA6 ubiquitin-like modifier activating enzyme 6 0.0469875
IGFBP3 insulin-like growth factor binding protein 3 0.0444689
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0430512
TRIO trio Rho guanine nucleotide exchange factor 0.0424331
ZMIZ1 zinc finger, MIZ-type containing 1 0.0420373
FNIP1 folliculin interacting protein 1 0.0388476
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0388305
PGM3 phosphoglucomutase 3 0.038434
MACF1 microtubule-actin crosslinking factor 1 0.037516
PPARD peroxisome proliferator-activated receptor delta 0.0373782
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0361167
FNDC3B fibronectin type III domain containing 3B 0.0356746
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0349381
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0348551
SOD2 superoxide dismutase 2, mitochondrial 0.0332703
FAM219A family with sequence similarity 219, member A 0.0332516
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0331636
RND3 Rho family GTPase 3 0.0330726
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0328887
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0321847
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0320187
GOLGA4 golgin A4 0.0317265
TPM3 tropomyosin 3 0.0313886
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0311352
CDK19 cyclin-dependent kinase 19 0.0300959
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0300087
TMF1 TATA element modulatory factor 1 0.0297983
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0296444
TTC3 tetratricopeptide repeat domain 3 0.0295753
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0290855
KTN1 kinectin 1 (kinesin receptor) 0.0289244
DUSP10 dual specificity phosphatase 10 0.0285914
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0284542
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0284206
FTH1 ferritin, heavy polypeptide 1 0.0278801
MMP12 matrix metallopeptidase 12 0.0274411
GPC6 glypican 6 0.0271407
SFPQ splicing factor proline/glutamine-rich 0.0269354
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.026905
PICALM phosphatidylinositol binding clathrin assembly protein 0.0268734
INTS6 integrator complex subunit 6 0.0266135
FLNB filamin B, beta 0.0265217
NFE2L1 nuclear factor, erythroid 2-like 1 0.0261427
CANX calnexin 0.0259371
SND1 staphylococcal nuclease and tudor domain containing 1 0.0259078
RPL3 ribosomal protein L3 0.0257025
FMNL2 formin-like 2 0.0249199
KDM4C lysine (K)-specific demethylase 4C 0.0249039
PHF3 PHD finger protein 3 0.0246868
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0246127
VMP1 vacuole membrane protein 1 0.0245818
NGLY1 N-glycanase 1 0.0243862
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0242965
NOTCH2 notch 2 0.0241221
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.023879
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0237486
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0236642
HELZ helicase with zinc finger 0.0235559
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0232242
JMJD1C jumonji domain containing 1C 0.0226448
COPA coatomer protein complex, subunit alpha 0.0225762
PRELID2 PRELI domain containing 2 0.0224173
ERRFI1 ERBB receptor feedback inhibitor 1 0.0223658
EFNA5 ephrin-A5 0.0220991
GLS2 glutaminase 2 (liver, mitochondrial) 0.0220564
NRIP1 nuclear receptor interacting protein 1 0.0213754
ARRDC3 arrestin domain containing 3 0.0212646
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0211433
ZHX2 zinc fingers and homeoboxes 2 0.0210468
PTEN phosphatase and tensin homolog 0.0208772
DOCK5 dedicator of cytokinesis 5 0.0208326
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0208243
OPTN optineurin 0.0207273
SEPTIN9 septin 9 0.0207052
RUNX1 runt-related transcription factor 1 0.0206495
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0206085
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0205741
TIMP2 TIMP metallopeptidase inhibitor 2 0.0205255
AHR aryl hydrocarbon receptor 0.020477
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0204239
DSCAM Down syndrome cell adhesion molecule 0.0203464
GOLGB1 golgin B1 0.020302
ZBTB38 zinc finger and BTB domain containing 38 0.0202061

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.266913
FRMD4A FERM domain containing 4A -0.218157
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.193144
TPT1 tumor protein, translationally-controlled 1 -0.166191
FN1 fibronectin 1 -0.14499
HLA-B major histocompatibility complex, class I, B -0.141353
IER3 immediate early response 3 -0.1375
TMSB10 thymosin beta 10 -0.133128
GLIS3 GLIS family zinc finger 3 -0.0932277
FTL ferritin, light polypeptide -0.0922138
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0859541
BICC1 BicC family RNA binding protein 1 -0.0730414
RPS24 ribosomal protein S24 -0.0676667
PGK1 phosphoglycerate kinase 1 -0.0667325
VCL vinculin -0.0632209
ANXA2 annexin A2 -0.0599994
MT2A metallothionein 2A -0.0584354
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0581755
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0581558
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0555024
SLC38A1 solute carrier family 38, member 1 -0.0554838
GNAS GNAS complex locus -0.0551101
ZMYND8 zinc finger, MYND-type containing 8 -0.0535862
TMSB4X thymosin beta 4, X-linked -0.0522502
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0518681
HLA-E major histocompatibility complex, class I, E -0.0507182
EXT1 exostosin glycosyltransferase 1 -0.050288
RPL36A ribosomal protein L36a -0.0494564
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0491261
RPL35A ribosomal protein L35a -0.0481823
LDHA lactate dehydrogenase A -0.0469114
THBS2 thrombospondin 2 -0.0454608
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0441534
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0435898
EIF1 eukaryotic translation initiation factor 1 -0.0435383
RPL23 ribosomal protein L23 -0.0426455
DIAPH2 diaphanous-related formin 2 -0.0412356
RPS4X ribosomal protein S4, X-linked -0.0410567
IFI6 interferon, alpha-inducible protein 6 -0.0409728
KLF6 Kruppel-like factor 6 -0.0408521
COL1A1 collagen, type I, alpha 1 -0.0394798
IFITM3 interferon induced transmembrane protein 3 -0.0393359
RPS23 ribosomal protein S23 -0.0387794
TUBB tubulin, beta class I -0.0387218
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.038707
RPL12 ribosomal protein L12 -0.0386683
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0386635
CADM1 cell adhesion molecule 1 -0.037996
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0374638
BASP1 brain abundant, membrane attached signal protein 1 -0.0366006
HLA-A major histocompatibility complex, class I, A -0.0365174
ACTG1 actin gamma 1 -0.0364733
PTMA prothymosin, alpha -0.0363331
VDAC1 voltage-dependent anion channel 1 -0.036224
RRBP1 ribosome binding protein 1 -0.0358116
CTSB cathepsin B -0.0357873
WSB1 WD repeat and SOCS box containing 1 -0.035733
RPLP1 ribosomal protein, large, P1 -0.034488
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.034293
LOC112694756 uncharaterized LOC112694756 -0.0336879
CAVIN1 caveolae associated protein 1 -0.0334073
CTSD cathepsin D -0.0333188
RPL37A ribosomal protein L37a -0.0331999
PNRC1 proline-rich nuclear receptor coactivator 1 -0.032403
TNNC1 troponin C type 1 (slow) -0.0322728
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0322514
KPNB1 karyopherin (importin) beta 1 -0.0321183
RPS21 ribosomal protein S21 -0.0320402
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0318115
NAMPT nicotinamide phosphoribosyltransferase -0.0314662
SLC35F3 solute carrier family 35, member F3 -0.0314398
RPL19 ribosomal protein L19 -0.0310736
RACK1 receptor for activated C kinase 1 -0.0308536
THBS1 thrombospondin 1 -0.0308119
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0306541
PALLD palladin, cytoskeletal associated protein -0.0305492
RPLP2 ribosomal protein, large, P2 -0.0304017
RPS19 ribosomal protein S19 -0.0303885
RPL38 ribosomal protein L38 -0.0303794
RPS27A ribosomal protein S27a -0.0302485
PTPRK protein tyrosine phosphatase, receptor type, K -0.030052
SFRP1 secreted frizzled-related protein 1 -0.0300123
RPL32 ribosomal protein L32 -0.0299638
ICAM1 intercellular adhesion molecule 1 -0.0295891
RPL34 ribosomal protein L34 -0.0295383
RPLP0 ribosomal protein, large, P0 -0.029168
RPL37 ribosomal protein L37 -0.0282235
ZFAND3 zinc finger, AN1-type domain 3 -0.0281849
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.027831
RPL31 ribosomal protein L31 -0.0276808
RPL11 ribosomal protein L11 -0.0276746
PTPRF protein tyrosine phosphatase, receptor type, F -0.0276487
NRN1 neuritin 1 -0.0274086
OSMR oncostatin M receptor -0.0273286
RPL26 ribosomal protein L26 -0.0270846
EGR1 early growth response 1 -0.0262729
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0260981
BTG1 B-cell translocation gene 1, anti-proliferative -0.0260735
TENM2 teneurin transmembrane protein 2 -0.0259674
RPS13 ribosomal protein S13 -0.024953