Cloxacillin (sodium)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.0964502
NAMPT nicotinamide phosphoribosyltransferase 0.0751492
IGFBP3 insulin-like growth factor binding protein 3 0.0701007
MYH9 myosin, heavy chain 9, non-muscle 0.0682776
ERRFI1 ERBB receptor feedback inhibitor 1 0.0678214
TRIO trio Rho guanine nucleotide exchange factor 0.0675226
EXT1 exostosin glycosyltransferase 1 0.0635745
RUNX1 runt-related transcription factor 1 0.0549339
ZSWIM6 zinc finger, SWIM-type containing 6 0.0534302
OGA O-GlcNAcase 0.0518047
NRXN3 neurexin 3 0.0504788
EPAS1 endothelial PAS domain protein 1 0.0474419
SP100 SP100 nuclear antigen 0.0472768
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0431263
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0426934
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0425988
CD44 CD44 molecule (Indian blood group) 0.0425101
FBXL7 F-box and leucine-rich repeat protein 7 0.0418928
ASPH aspartate beta-hydroxylase 0.0416642
TAS2R14 taste receptor, type 2, member 14 0.0382899
EFNA5 ephrin-A5 0.0380965
ALK anaplastic lymphoma receptor tyrosine kinase 0.0378827
FAM20C family with sequence similarity 20, member C 0.0377903
HMGA2 high mobility group AT-hook 2 0.0373765
ZNF292 zinc finger protein 292 0.0361061
SBF2 SET binding factor 2 0.0360455
KYNU kynureninase 0.0360325
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0358729
RBM39 RNA binding motif protein 39 0.0356919
ANKRD11 ankyrin repeat domain 11 0.0342904
GSE1 Gse1 coiled-coil protein 0.0334416
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0326851
PTPRM protein tyrosine phosphatase, receptor type, M 0.0321963
RBMS3 RNA binding motif, single stranded interacting protein 3 0.03217
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0321622
PRKCA protein kinase C, alpha 0.0321469
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0316319
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0315787
FAM13A family with sequence similarity 13, member A 0.0309581
ESYT2 extended synaptotagmin-like protein 2 0.0306056
EXOC4 exocyst complex component 4 0.0305628
DLG1 discs, large homolog 1 (Drosophila) 0.0305529
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0304378
TANK TRAF family member-associated NFKB activator 0.0303356
COL7A1 collagen, type VII, alpha 1 0.0301281
WWOX WW domain containing oxidoreductase 0.0296644
VMP1 vacuole membrane protein 1 0.029548
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.029408
POM121C POM121 transmembrane nucleoporin C 0.0293886
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0293677
BTBD9 BTB (POZ) domain containing 9 0.0289214
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0284227
ZNF638 zinc finger protein 638 0.028409
MEF2A myocyte enhancer factor 2A 0.0284028
FNDC3B fibronectin type III domain containing 3B 0.0282735
CLIP2 CAP-GLY domain containing linker protein 2 0.0279853
PTK2 protein tyrosine kinase 2 0.0273908
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0272847
BLTP1 bridge-like lipid transfer protein family member 1 0.0272699
CALD1 caldesmon 1 0.0271801
BHLHE40 basic helix-loop-helix family, member e40 0.0271738
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0268242
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0267929
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0258368
MAML2 mastermind-like 2 (Drosophila) 0.0256776
KDM4C lysine (K)-specific demethylase 4C 0.025335
XPO1 exportin 1 0.0251301
AHNAK AHNAK nucleoprotein 0.0251101
ANLN anillin, actin binding protein 0.025073
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0249042
SHB Src homology 2 domain containing adaptor protein B 0.0246368
ARHGAP35 Rho GTPase activating protein 35 0.0244835
CANX calnexin 0.0243883
PRELID2 PRELI domain containing 2 0.0241222
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0240799
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0238372
NFE2L1 nuclear factor, erythroid 2-like 1 0.0234751
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0234163
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0233057
COL5A1 collagen, type V, alpha 1 0.0231762
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0227814
DENND4C DENN/MADD domain containing 4C 0.0227767
APP amyloid beta (A4) precursor protein 0.0227544
SMAD3 SMAD family member 3 0.02268
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0226107
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0225974
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.0224167
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0224095
FNIP1 folliculin interacting protein 1 0.0223857
ABLIM3 actin binding LIM protein family, member 3 0.0223026
SETBP1 SET binding protein 1 0.022159
COG5 component of oligomeric golgi complex 5 0.0220724
FUS FUS RNA binding protein 0.0220109
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0219718
RPL11 ribosomal protein L11 0.0218567
ANO6 anoctamin 6 0.0216119
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0214686
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0213368
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0212651
HIPK2 homeodomain interacting protein kinase 2 0.0212331

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.190088
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.18419
MT2A metallothionein 2A -0.152135
TMSB10 thymosin beta 10 -0.148937
TGFBI transforming growth factor, beta-induced, 68kDa -0.120195
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107635
HLA-B major histocompatibility complex, class I, B -0.089269
F3 coagulation factor III (thromboplastin, tissue factor) -0.0800721
COL1A2 collagen, type I, alpha 2 -0.0794056
MAP1B microtubule-associated protein 1B -0.0739861
B2M beta-2-microglobulin -0.0692261
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0667904
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0658102
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0615573
COL1A1 collagen, type I, alpha 1 -0.0592468
STC1 stanniocalcin 1 -0.0536174
HLA-A major histocompatibility complex, class I, A -0.053315
FTL ferritin, light polypeptide -0.0493946
LDHA lactate dehydrogenase A -0.0460912
TAGLN2 transgelin 2 -0.0448254
POTEF POTE ankyrin domain family, member F -0.0431194
HLA-C major histocompatibility complex, class I, C -0.0420942
PDE4D phosphodiesterase 4D, cAMP-specific -0.0418323
PTN pleiotrophin -0.0404795
MYADM myeloid-associated differentiation marker -0.0398599
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0397492
NDRG1 N-myc downstream regulated 1 -0.0395906
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0389521
LGALS1 lectin, galactoside-binding, soluble, 1 -0.038886
TENT5A terminal nucleotidyltransferase 5A -0.0388378
RAP1B RAP1B, member of RAS oncogene family -0.0381626
ANKRD28 ankyrin repeat domain 28 -0.0377853
CALU calumenin -0.0358149
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0347223
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0342153
PDIA3 protein disulfide isomerase family A, member 3 -0.0323173
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0318627
CTSD cathepsin D -0.0318577
UBC ubiquitin C -0.0317955
GLG1 golgi glycoprotein 1 -0.0315418
LMNA lamin A/C -0.0313796
CAV1 caveolin 1, caveolae protein, 22kDa -0.0308893
CCNI cyclin I -0.0308283
RPL23 ribosomal protein L23 -0.030807
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0305883
ENO1 enolase 1, (alpha) -0.0304543
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0301933
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0297793
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0296889
TM4SF1 transmembrane 4 L six family member 1 -0.0296547
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -0.0295937
TPI1 triosephosphate isomerase 1 -0.0283322
SOD2 superoxide dismutase 2, mitochondrial -0.0280644
CLINT1 clathrin interactor 1 -0.0275244
RPS4X ribosomal protein S4, X-linked -0.0274544
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0272687
SEC61G Sec61 gamma subunit -0.0270955
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.0270567
IL6 interleukin 6 -0.0269772
COL5A2 collagen, type V, alpha 2 -0.0267217
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0262144
FTH1 ferritin, heavy polypeptide 1 -0.0262091
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0260965
LAMB3 laminin, beta 3 -0.0260525
S100A9 S100 calcium binding protein A9 -0.0257057
PFN1 profilin 1 -0.0256307
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0255758
PRSS23 protease, serine, 23 -0.0254198
SCARB2 scavenger receptor class B, member 2 -0.0253966
CIRSR corepressor of RBPJ and splicing regulator -0.0253015
HDAC9 histone deacetylase 9 -0.0250204
GOLGA4 golgin A4 -0.0247855
YIPF5 Yip1 domain family, member 5 -0.0243449
CSDE1 cold shock domain containing E1, RNA-binding -0.0241773
PDIA6 protein disulfide isomerase family A, member 6 -0.0241469
RPS5 ribosomal protein S5 -0.0239624
H3-3B H3.3 histone B -0.0237805
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0236467
PDLIM5 PDZ and LIM domain 5 -0.0234554
SEC24D SEC24 family member D -0.0233318
TMEM123 transmembrane protein 123 -0.0230981
IKBIP IKBKB interacting protein -0.0230075
CYB5R3 cytochrome b5 reductase 3 -0.0229618
CDH13 cadherin 13 -0.0229051
MT1X metallothionein 1X -0.0227964
LOX lysyl oxidase -0.0227885
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0227829
UGCG UDP-glucose ceramide glucosyltransferase -0.0227048
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0226966
RND3 Rho family GTPase 3 -0.0225616
CADM1 cell adhesion molecule 1 -0.0225186
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0224935
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0224669
FLOT1 flotillin 1 -0.0224234
DCAF7 DDB1 and CUL4 associated factor 7 -0.0216263
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0216146
RPS21 ribosomal protein S21 -0.0215014
TPM2 tropomyosin 2 (beta) -0.0212888
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0212301
TAOK3 TAO kinase 3 -0.021182