Cloxacillin (sodium)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.101597
AKAP12 A kinase (PRKA) anchor protein 12 0.0822069
BIRC3 baculoviral IAP repeat containing 3 0.0717367
CAPRIN2 caprin family member 2 0.0715265
FMNL2 formin-like 2 0.070187
RIGI RNA sensor RIG-I 0.0694768
ESYT2 extended synaptotagmin-like protein 2 0.0684668
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0683369
KTN1 kinectin 1 (kinesin receptor) 0.0674682
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0665075
MSN moesin 0.0626692
YAP1 Yes-associated protein 1 0.0610088
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0591743
BASP1 brain abundant, membrane attached signal protein 1 0.0585937
RBM39 RNA binding motif protein 39 0.0579329
FNIP1 folliculin interacting protein 1 0.0561724
YBX3 Y box binding protein 3 0.0552675
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.054514
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0529901
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0528745
ERBIN erbb2 interacting protein 0.0520839
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0518597
SAMD4A sterile alpha motif domain containing 4A 0.0513569
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0503767
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0501902
FN1 fibronectin 1 0.0499696
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.049529
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0470595
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0456832
GLS2 glutaminase 2 (liver, mitochondrial) 0.0451616
PKM pyruvate kinase, muscle 0.0445294
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0443292
MYH9 myosin, heavy chain 9, non-muscle 0.0428772
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0420629
APLP2 amyloid beta (A4) precursor-like protein 2 0.0415773
SETD5 SET domain containing 5 0.0415507
RSRC2 arginine/serine-rich coiled-coil 2 0.0415015
RBM25 RNA binding motif protein 25 0.0414652
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0409145
EFNA5 ephrin-A5 0.0404576
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0401411
OGA O-GlcNAcase 0.0396678
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0390763
DSCAM Down syndrome cell adhesion molecule 0.0388871
WNK1 WNK lysine deficient protein kinase 1 0.0385402
CHD1 chromodomain helicase DNA binding protein 1 0.0384688
PBX3 pre-B-cell leukemia homeobox 3 0.0380495
ELL2 elongation factor, RNA polymerase II, 2 0.0372495
IGFBP3 insulin-like growth factor binding protein 3 0.0368665
ACTN1 actinin, alpha 1 0.0361975
TSC22D2 TSC22 domain family, member 2 0.0360232
PCBP2 poly(rC) binding protein 2 0.0358392
ATP13A3 ATPase type 13A3 0.0356514
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0355771
OXSR1 oxidative stress responsive 1 0.0354775
GIGYF2 GRB10 interacting GYF protein 2 0.0354094
CEMIP2 cell migration inducing hyaluronidase 2 0.0352953
DERA deoxyribose-phosphate aldolase (putative) 0.0349436
MYO9B myosin IXB 0.0344736
BRD4 bromodomain containing 4 0.0344273
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0337974
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0334215
HILPDA hypoxia inducible lipid droplet-associated 0.033256
PTK2 protein tyrosine kinase 2 0.0330488
DGKD diacylglycerol kinase, delta 130kDa 0.0328287
RTN4 reticulon 4 0.0325303
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0321456
FAM13A family with sequence similarity 13, member A 0.0320238
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0318947
DTNA dystrobrevin, alpha 0.0316043
WAC WW domain containing adaptor with coiled-coil 0.0314774
ANXA1 annexin A1 0.0312081
IQGAP1 IQ motif containing GTPase activating protein 1 0.0309861
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0309025
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.030899
PAWR PRKC, apoptosis, WT1, regulator 0.0306622
MTREX Mtr4 exosome RNA helicase 0.0304273
SEPTIN2 septin 2 0.0304207
SVIL supervillin 0.0303806
ADAM17 ADAM metallopeptidase domain 17 0.0301541
RNF145 ring finger protein 145 0.0298234
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0294564
AHCTF1 AT hook containing transcription factor 1 0.0290917
TPR translocated promoter region, nuclear basket protein 0.0290901
TENT2 terminal nucleotidyltransferase 2 0.0290885
AFF4 AF4/FMR2 family, member 4 0.0287569
JMJD1C jumonji domain containing 1C 0.0287062
DYNC2I1 dynein 2 intermediate chain 1 0.0286815
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0285379
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0285186
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0284941
STK24 serine/threonine kinase 24 0.0280188
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0278235
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0277287
SCAF11 SR-related CTD-associated factor 11 0.027678
LOC102724023 ES1 protein homolog, mitochondrial 0.0275163
SKIL SKI-like proto-oncogene 0.0274003
NPTN neuroplastin 0.0273926
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0273332
ZCCHC7 zinc finger, CCHC domain containing 7 0.0273308

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.287177
TPT1 tumor protein, translationally-controlled 1 -0.11441
TMSB10 thymosin beta 10 -0.0764135
LDHA lactate dehydrogenase A -0.0652987
VIM vimentin -0.0563782
HMGA2 high mobility group AT-hook 2 -0.056053
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0533527
LOC112694756 uncharaterized LOC112694756 -0.0528777
SMYD3 SET and MYND domain containing 3 -0.0519644
INTS6 integrator complex subunit 6 -0.0483998
OSMR oncostatin M receptor -0.045265
ZBTB20 zinc finger and BTB domain containing 20 -0.0445105
VCL vinculin -0.0439913
APOLD1 apolipoprotein L domain containing 1 -0.0425937
FMN1 formin 1 -0.0412683
RNF213 ring finger protein 213 -0.0401757
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0384336
PCNX4 pecanex 4 -0.0373367
PHF3 PHD finger protein 3 -0.0366846
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0366459
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0366073
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0359554
ATM ATM serine/threonine kinase -0.0345502
TUBB4B tubulin, beta 4B class IVb -0.0340205
DENND1A DENN/MADD domain containing 1A -0.0337353
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0337197
ACER3 alkaline ceramidase 3 -0.0333056
TPI1 triosephosphate isomerase 1 -0.0331936
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0330811
RDX radixin -0.0326571
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0326337
TVP23C-CDRT4 TVP23C-CDRT4 readthrough -0.0319904
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0317458
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0308465
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0307583
TAOK1 TAO kinase 1 -0.0303388
VDAC1 voltage-dependent anion channel 1 -0.0303202
TPM4 tropomyosin 4 -0.0301746
SLC35F3 solute carrier family 35, member F3 -0.029914
ATG7 autophagy related 7 -0.0299035
ARHGAP5 Rho GTPase activating protein 5 -0.0298535
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0297164
PRR16 proline rich 16 -0.029525
TM4SF1 transmembrane 4 L six family member 1 -0.0294857
PCED1B PC-esterase domain containing 1B -0.0288697
KPNB1 karyopherin (importin) beta 1 -0.02861
LPP LIM domain containing preferred translocation partner in lipoma -0.0282094
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.028042
C6ORF62 chromosome 6 open reading frame 62 -0.0272087
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0270946
CDCP1 CUB domain containing protein 1 -0.0266245
RPL23 ribosomal protein L23 -0.0264916
UBB ubiquitin B -0.0261737
TCF12 transcription factor 12 -0.0261328
CCDC138 coiled-coil domain containing 138 -0.0259325
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.025926
RPL35A ribosomal protein L35a -0.0255526
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0255378
DPYD dihydropyrimidine dehydrogenase -0.0254962
IARS1 isoleucyl-tRNA synthetase 1 -0.0248039
RPL26 ribosomal protein L26 -0.0247266
LRRC23 leucine rich repeat containing 23 -0.0244926
MBNL1 muscleblind-like splicing regulator 1 -0.024402
RPL9 ribosomal protein L9 -0.024371
SPDYA speedy/RINGO cell cycle regulator family member A -0.024246
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0240764
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0238884
DNAAF9 dynein axonemal assembly factor 9 -0.0237044
AHNAK AHNAK nucleoprotein -0.0236943
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0236649
RPS19 ribosomal protein S19 -0.023275
RPS21 ribosomal protein S21 -0.023058
EVI5 ecotropic viral integration site 5 -0.022591
AHNAK2 AHNAK nucleoprotein 2 -0.0224611
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0220334
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0216797
STXBP1 syntaxin binding protein 1 -0.0216408
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0214709
FBXW11 F-box and WD repeat domain containing 11 -0.0214487
RPS13 ribosomal protein S13 -0.0213325
TNRC18 trinucleotide repeat containing 18 -0.021262
RPL36AL ribosomal protein L36a-like -0.0209247
IFITM3 interferon induced transmembrane protein 3 -0.0208496
ATL3 atlastin GTPase 3 -0.0208469
PAPOLA poly(A) polymerase alpha -0.0208211
SCAPER S-phase cyclin A-associated protein in the ER -0.0208156
SMC4 structural maintenance of chromosomes 4 -0.0207385
NCOA1 nuclear receptor coactivator 1 -0.0206479
PTPRS protein tyrosine phosphatase, receptor type, S -0.0206186
MBD5 methyl-CpG binding domain protein 5 -0.0204694
RPS25 ribosomal protein S25 -0.0204385
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0203491
ZNF609 zinc finger protein 609 -0.0203048
ARF1 ADP-ribosylation factor 1 -0.0202452
TSC1 tuberous sclerosis 1 -0.0202413
DOCK3 dedicator of cytokinesis 3 -0.0202059
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.0201777
AEBP2 AE binding protein 2 -0.0200841
PURA purine-rich element binding protein A -0.0200512
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0199277