Cloxacillin (sodium)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.0851264
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0632432
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.057087
FTH1 ferritin, heavy polypeptide 1 0.0567648
TOP1 topoisomerase (DNA) I 0.0489692
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0450846
NRIP1 nuclear receptor interacting protein 1 0.0398452
EFNA5 ephrin-A5 0.037579
NPAS2 neuronal PAS domain protein 2 0.0369797
PALLD palladin, cytoskeletal associated protein 0.035929
CXCL8 chemokine (C-X-C motif) ligand 8 0.0358118
INTS6 integrator complex subunit 6 0.0353635
ZSWIM6 zinc finger, SWIM-type containing 6 0.0329553
WWTR1 WW domain containing transcription regulator 1 0.0306655
SOD2 superoxide dismutase 2, mitochondrial 0.0265341
NTN4 netrin 4 0.0259512
ERRFI1 ERBB receptor feedback inhibitor 1 0.0257766
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0254896
LTBP1 latent transforming growth factor beta binding protein 1 0.0249435
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0242831
TUFT1 tuftelin 1 0.0238136
H1-0 H1.0 linker histone 0.0233612
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0227737
ANKRD28 ankyrin repeat domain 28 0.0225227
PELO pelota homolog (Drosophila) 0.0224964
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0216764
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0212449
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0197501
ELL2 elongation factor, RNA polymerase II, 2 0.0197429
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0196782
PDLIM5 PDZ and LIM domain 5 0.0195483
WNK1 WNK lysine deficient protein kinase 1 0.0195382
RDH10 retinol dehydrogenase 10 (all-trans) 0.0192125
FERMT2 fermitin family member 2 0.0186188
RASAL2 RAS protein activator like 2 0.0181956
HILPDA hypoxia inducible lipid droplet-associated 0.0178646
HOMER1 homer scaffolding protein 1 0.0177138
HMGA2 high mobility group AT-hook 2 0.0173636
AEBP2 AE binding protein 2 0.0171569
AGO2 argonaute RISC catalytic component 2 0.0167095
MYH9 myosin, heavy chain 9, non-muscle 0.0164375
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0163914
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0155772
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0153976
ABLIM1 actin binding LIM protein 1 0.0153135
AHNAK AHNAK nucleoprotein 0.0152547
VCL vinculin 0.0151877
TTC3 tetratricopeptide repeat domain 3 0.0150982
SHB Src homology 2 domain containing adaptor protein B 0.0148895
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0148643
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0148211
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0148195
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0146876
IFRD1 interferon-related developmental regulator 1 0.014668
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0146429
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0145781
LIMCH1 LIM and calponin homology domains 1 0.0145189
RBPMS RNA binding protein with multiple splicing 0.0144679
PDIA4 protein disulfide isomerase family A, member 4 0.0143864
DSCAM Down syndrome cell adhesion molecule 0.0143167
USP9X ubiquitin specific peptidase 9, X-linked 0.0142639
EXT1 exostosin glycosyltransferase 1 0.0142456
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0142173
EPHA4 EPH receptor A4 0.0141783
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0141619
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0140164
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0139687
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0139411
FTO fat mass and obesity associated 0.0139015
BICC1 BicC family RNA binding protein 1 0.0138791
ATF6 activating transcription factor 6 0.013685
SMAD3 SMAD family member 3 0.0135689
RYK receptor-like tyrosine kinase 0.013541
ASXL1 additional sex combs like transcriptional regulator 1 0.0135026
SGMS1 sphingomyelin synthase 1 0.0133812
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0133541
JAG1 jagged 1 0.0133133
TGFB2 transforming growth factor, beta 2 0.0132786
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0131336
SMOC1 SPARC related modular calcium binding 1 0.0131323
HIPK2 homeodomain interacting protein kinase 2 0.0130838
NABP1 nucleic acid binding protein 1 0.0130292
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0130031
PTPRK protein tyrosine phosphatase, receptor type, K 0.0129498
FNDC3A fibronectin type III domain containing 3A 0.012911
ASCC3 activating signal cointegrator 1 complex subunit 3 0.012867
LOX lysyl oxidase 0.0126416
LEMD3 LEM domain containing 3 0.0126334
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0125933
RUNX1 runt-related transcription factor 1 0.0124526
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0123494
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0122497
ANKRD36C ankyrin repeat domain 36C 0.0121441
NXN nucleoredoxin 0.0121035
WDR26 WD repeat domain 26 0.012063
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0120478
RABGAP1 RAB GTPase activating protein 1 0.0120316
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0119996
RAB27B RAB27B, member RAS oncogene family 0.0119967
PPARG peroxisome proliferator-activated receptor gamma 0.0119908

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.199461
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.173828
IFI27 interferon, alpha-inducible protein 27 -0.161533
PTMA prothymosin, alpha -0.154467
TMSB10 thymosin beta 10 -0.138853
S100A6 S100 calcium binding protein A6 -0.123132
HLA-B major histocompatibility complex, class I, B -0.117602
VIM vimentin -0.102333
NAMPT nicotinamide phosphoribosyltransferase -0.100838
MT2A metallothionein 2A -0.0848202
CENPF centromere protein F, 350/400kDa -0.0733469
B2M beta-2-microglobulin -0.0731868
LOC102724023 ES1 protein homolog, mitochondrial -0.0728204
STC2 stanniocalcin 2 -0.0700096
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0672224
FN1 fibronectin 1 -0.0665179
TMSB4X thymosin beta 4, X-linked -0.0645849
TMEM165 transmembrane protein 165 -0.0641975
FTL ferritin, light polypeptide -0.0630739
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0609752
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0607373
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0602098
TPT1 tumor protein, translationally-controlled 1 -0.0592631
FNDC3B fibronectin type III domain containing 3B -0.0579784
PKM pyruvate kinase, muscle -0.0565016
SYT1 synaptotagmin I -0.0560904
PRRC2C proline-rich coiled-coil 2C -0.0551785
MRPS6 mitochondrial ribosomal protein S6 -0.0550428
HMGA1 high mobility group AT-hook 1 -0.0537576
RTN4 reticulon 4 -0.0530354
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0529672
OSMR oncostatin M receptor -0.0519392
SOX4 SRY (sex determining region Y)-box 4 -0.0519325
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0491688
RPL9 ribosomal protein L9 -0.0487507
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0485105
RPL37A ribosomal protein L37a -0.0481565
SFTPA2 surfactant protein A2 -0.0479
RPL35A ribosomal protein L35a -0.0475641
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0468889
TRIO trio Rho guanine nucleotide exchange factor -0.0467028
RPL31 ribosomal protein L31 -0.0464661
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0462087
RPS6 ribosomal protein S6 -0.0459721
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0453327
S100A9 S100 calcium binding protein A9 -0.0447422
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.044701
LY6E lymphocyte antigen 6 complex, locus E -0.0440636
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0427793
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.042461
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0421701
TPI1 triosephosphate isomerase 1 -0.0415544
NAP1L1 nucleosome assembly protein 1-like 1 -0.0412795
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0407157
S100A10 S100 calcium binding protein A10 -0.0404809
PLIN2 perilipin 2 -0.0404792
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0397044
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0392916
LMNA lamin A/C -0.0391538
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0383291
MAML2 mastermind-like 2 (Drosophila) -0.0379122
ACTG1 actin gamma 1 -0.0377403
IFI6 interferon, alpha-inducible protein 6 -0.0374622
MKI67 marker of proliferation Ki-67 -0.0374399
CALU calumenin -0.0373588
RPS3 ribosomal protein S3 -0.0370548
RPS25 ribosomal protein S25 -0.0370324
ZMYND8 zinc finger, MYND-type containing 8 -0.0367038
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0365438
FNBP1 formin binding protein 1 -0.0364204
CTSD cathepsin D -0.0362536
POTEF POTE ankyrin domain family, member F -0.0358964
RPS21 ribosomal protein S21 -0.0356573
KLHL5 kelch-like family member 5 -0.0351089
ENO2 enolase 2 (gamma, neuronal) -0.034793
MATR3 matrin 3 -0.0346778
EGR1 early growth response 1 -0.0345627
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0345139
RPL37 ribosomal protein L37 -0.0341594
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0338368
RPS12 ribosomal protein S12 -0.0333068
ZBTB20 zinc finger and BTB domain containing 20 -0.0332539
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0321066
ETV1 ets variant 1 -0.0320262
APP amyloid beta (A4) precursor protein -0.0317928
KTN1 kinectin 1 (kinesin receptor) -0.0314615
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0314183
TNS3 tensin 3 -0.031383
CDCP1 CUB domain containing protein 1 -0.0311222
JMJD1C jumonji domain containing 1C -0.03103
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0306136
FAF2 Fas associated factor family member 2 -0.0303534
RPS24 ribosomal protein S24 -0.0301977
WSB1 WD repeat and SOCS box containing 1 -0.0301846
IFITM1 interferon induced transmembrane protein 1 -0.0301167
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0297833
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0294885
ITGA1 integrin, alpha 1 -0.0294714
IER3 immediate early response 3 -0.0294669
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0294655