Cloxacillin (sodium)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KMT2E lysine (K)-specific methyltransferase 2E 0.0771345
RBM39 RNA binding motif protein 39 0.0656066
KMT2C lysine (K)-specific methyltransferase 2C 0.0615094
EZR ezrin 0.0579134
FTH1 ferritin, heavy polypeptide 1 0.0572941
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0570962
ZFAND3 zinc finger, AN1-type domain 3 0.0528219
USP3 ubiquitin specific peptidase 3 0.0510272
MATR3 matrin 3 0.0508232
CCNL1 cyclin L1 0.0471549
H1-0 H1.0 linker histone 0.0455525
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0450883
XPO1 exportin 1 0.0444994
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0441003
TRA2A transformer 2 alpha homolog (Drosophila) 0.0425279
GOLGA4 golgin A4 0.0422545
ESYT2 extended synaptotagmin-like protein 2 0.0420402
LMTK2 lemur tyrosine kinase 2 0.0410824
TXNRD1 thioredoxin reductase 1 0.0410547
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0391847
RPS6 ribosomal protein S6 0.0390325
KDM2A lysine (K)-specific demethylase 2A 0.0384626
ZNRF3 zinc and ring finger 3 0.0380138
JMJD1C jumonji domain containing 1C 0.0369366
PTK2 protein tyrosine kinase 2 0.0364137
NCKAP1 NCK-associated protein 1 0.0349883
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0344271
GCLC glutamate-cysteine ligase, catalytic subunit 0.0341578
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0340829
NAMPT nicotinamide phosphoribosyltransferase 0.0338343
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0336429
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0336125
BRD2 bromodomain containing 2 0.0333611
PUM2 pumilio RNA-binding family member 2 0.0322492
CTNND1 catenin (cadherin-associated protein), delta 1 0.0319488
UBE2H ubiquitin-conjugating enzyme E2H 0.0317699
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0311341
SUCO SUN domain containing ossification factor 0.0305279
ZNF292 zinc finger protein 292 0.0303809
RICTOR RPTOR independent companion of MTOR, complex 2 0.0303531
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0302335
FXR1 fragile X mental retardation, autosomal homolog 1 0.0300329
SRPK2 SRSF protein kinase 2 0.0298421
PTEN phosphatase and tensin homolog 0.0295783
RNF145 ring finger protein 145 0.0293362
PCBP2 poly(rC) binding protein 2 0.028829
RREB1 ras responsive element binding protein 1 0.0284878
TLK1 tousled-like kinase 1 0.0284273
MTMR3 myotubularin related protein 3 0.0282664
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0278945
TSC22D2 TSC22 domain family, member 2 0.0277141
ANKRD11 ankyrin repeat domain 11 0.0274358
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0273989
ZNF148 zinc finger protein 148 0.0272083
SNX9 sorting nexin 9 0.027045
RNF43 ring finger protein 43 0.0270387
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0269555
BCLAF1 BCL2-associated transcription factor 1 0.0268512
ANKRD28 ankyrin repeat domain 28 0.0267484
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0267416
EPS8 epidermal growth factor receptor pathway substrate 8 0.0267119
TJP2 tight junction protein 2 0.0266913
SETD2 SET domain containing 2 0.0265868
SBF2 SET binding factor 2 0.0263572
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0262157
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0258444
RBM25 RNA binding motif protein 25 0.0253068
RIOK3 RIO kinase 3 0.0252508
TXNIP thioredoxin interacting protein 0.0251104
FNBP1L formin binding protein 1-like 0.0250621
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0248874
CKAP5 cytoskeleton associated protein 5 0.024816
KDM7A lysine (K)-specific demethylase 7A 0.0242527
KDM3A lysine (K)-specific demethylase 3A 0.0241075
ARHGAP12 Rho GTPase activating protein 12 0.0239291
MYH9 myosin, heavy chain 9, non-muscle 0.0239153
GARS1 glycyl-tRNA synthetase 1 0.0238743
KDM6A lysine (K)-specific demethylase 6A 0.0238623
ADAM17 ADAM metallopeptidase domain 17 0.0237876
NKTR natural killer cell triggering receptor 0.0237774
MYO10 myosin X 0.0237249
RTN4 reticulon 4 0.023678
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0236013
YAP1 Yes-associated protein 1 0.0235169
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0235108
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0231886
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0229613
FBXO11 F-box protein 11 0.0229604
PKM pyruvate kinase, muscle 0.0229098
OGA O-GlcNAcase 0.0228202
DST dystonin 0.0227933
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.022774
RNF149 ring finger protein 149 0.0226955
RAB1A RAB1A, member RAS oncogene family 0.0222078
SRRM2 serine/arginine repetitive matrix 2 0.0221916
BIRC6 baculoviral IAP repeat containing 6 0.0221306
EIF4A2 eukaryotic translation initiation factor 4A2 0.0221235
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0219955
SSBP3 single stranded DNA binding protein 3 0.0218649
PHF21A PHD finger protein 21A 0.0218602

decreased expression

Symbol Name Standardized Value
MAML2 mastermind-like 2 (Drosophila) -0.116381
VCL vinculin -0.112972
NCEH1 neutral cholesterol ester hydrolase 1 -0.0990048
SDK1 sidekick cell adhesion molecule 1 -0.0902696
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0895171
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0891064
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0874154
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0792684
KRT8 keratin 8, type II -0.0711869
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.068327
BCL2L1 BCL2-like 1 -0.0668558
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0657467
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0643779
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.058104
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0575794
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0570887
KRT18 keratin 18, type I -0.055974
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0559542
INTS6 integrator complex subunit 6 -0.0511884
TMSB10 thymosin beta 10 -0.0495168
MYO1E myosin IE -0.0488374
ZBTB20 zinc finger and BTB domain containing 20 -0.0488256
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0469063
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0463105
ANXA2 annexin A2 -0.0447622
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.04205
EHBP1 EH domain binding protein 1 -0.0400671
TPT1 tumor protein, translationally-controlled 1 -0.0394879
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0390787
EGR1 early growth response 1 -0.0384138
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0379617
NFIA nuclear factor I/A -0.037802
EDN1 endothelin 1 -0.0374185
PLSCR1 phospholipid scramblase 1 -0.0365022
LDHA lactate dehydrogenase A -0.0362584
CCND1 cyclin D1 -0.0360257
TAS2R14 taste receptor, type 2, member 14 -0.0353232
PTPRK protein tyrosine phosphatase, receptor type, K -0.035251
EPCAM epithelial cell adhesion molecule -0.0348989
EXOC4 exocyst complex component 4 -0.034761
COTL1 coactosin-like F-actin binding protein 1 -0.0345806
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0338857
RPL12 ribosomal protein L12 -0.0337324
TMEM123 transmembrane protein 123 -0.0331434
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0329561
GMDS GDP-mannose 4,6-dehydratase -0.0329272
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0324204
AKAP12 A kinase (PRKA) anchor protein 12 -0.0322832
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.032168
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0321541
IFRD1 interferon-related developmental regulator 1 -0.0319173
RPS21 ribosomal protein S21 -0.0318322
KLF6 Kruppel-like factor 6 -0.0312506
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0310873
PDLIM5 PDZ and LIM domain 5 -0.030976
ZBTB38 zinc finger and BTB domain containing 38 -0.0309084
WWC1 WW and C2 domain containing 1 -0.0305331
CMIP c-Maf inducing protein -0.0290398
UBAP2 ubiquitin associated protein 2 -0.0289404
TGFA transforming growth factor, alpha -0.0289112
RPS24 ribosomal protein S24 -0.0285877
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0280787
ACTG1 actin gamma 1 -0.0278503
RPLP0 ribosomal protein, large, P0 -0.0278148
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0277316
DLG1 discs, large homolog 1 (Drosophila) -0.0265931
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0260761
SMAD3 SMAD family member 3 -0.0256606
MYL12B myosin, light chain 12B, regulatory -0.0254955
ANXA3 annexin A3 -0.0254697
DLC1 DLC1 Rho GTPase activating protein -0.0253647
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0253337
SAMD4A sterile alpha motif domain containing 4A -0.0253191
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0251837
SOX4 SRY (sex determining region Y)-box 4 -0.0245056
KRT20 keratin 20, type I -0.0244955
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0244463
PARD3B par-3 family cell polarity regulator beta -0.0243604
TJP1 tight junction protein 1 -0.024131
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0239792
RND3 Rho family GTPase 3 -0.0237184
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0235922
ZNF217 zinc finger protein 217 -0.0233997
CEMIP cell migration inducing protein, hyaluronan binding -0.0233754
MALT1 MALT1 paracaspase -0.0231553
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -0.0226157
GNAS GNAS complex locus -0.0225189
IFI6 interferon, alpha-inducible protein 6 -0.0225152
SMAD2 SMAD family member 2 -0.0222753
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0221137
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0220508
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0218204
SORBS1 sorbin and SH3 domain containing 1 -0.0217732
KLF5 Kruppel-like factor 5 (intestinal) -0.0217438
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.021601
SP100 SP100 nuclear antigen -0.02145
HMGA2 high mobility group AT-hook 2 -0.0214277
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0213143
NLK nemo-like kinase -0.0211363
UBASH3B ubiquitin associated and SH3 domain containing B -0.0209559