Cloxacillin (sodium)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.0697743
ANXA1 annexin A1 0.0403736
HSPA8 heat shock 70kDa protein 8 0.0400205
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.033634
LAMB3 laminin, beta 3 0.0321598
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0296666
EZR ezrin 0.0289344
ANXA2 annexin A2 0.0260156
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0204994
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0196902
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.019158
ESYT2 extended synaptotagmin-like protein 2 0.0187286
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0182261
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0180152
KLF5 Kruppel-like factor 5 (intestinal) 0.0178853
SQSTM1 sequestosome 1 0.0177834
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0175298
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0175199
GOLGA4 golgin A4 0.017069
EMP1 epithelial membrane protein 1 0.0160937
FERMT1 fermitin family member 1 0.0158023
CKAP5 cytoskeleton associated protein 5 0.0154042
VMP1 vacuole membrane protein 1 0.0151695
LAMC2 laminin, gamma 2 0.0148501
CENPF centromere protein F, 350/400kDa 0.0147898
SLK STE20-like kinase 0.0145671
MYO5B myosin VB 0.0143833
ANXA3 annexin A3 0.0141762
DSG2 desmoglein 2 0.0141184
OSBPL3 oxysterol binding protein-like 3 0.0141129
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0134858
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0133427
FOXO1 forkhead box O1 0.0131158
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0129159
TOP2B topoisomerase (DNA) II beta 180kDa 0.0127154
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0123824
XRN1 5'-3' exoribonuclease 1 0.0123369
PDLIM5 PDZ and LIM domain 5 0.0122353
SERINC5 serine incorporator 5 0.0120314
THOC2 THO complex 2 0.0120018
BRWD3 bromodomain and WD repeat domain containing 3 0.0118839
TMF1 TATA element modulatory factor 1 0.0115705
DSC3 desmocollin 3 0.0115168
ARL8B ADP-ribosylation factor-like 8B 0.0115125
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0114896
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0112559
NBAS neuroblastoma amplified sequence 0.0111516
MTUS1 microtubule associated tumor suppressor 1 0.0111243
ZBTB7C zinc finger and BTB domain containing 7C 0.0111019
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0107634
TUT4 terminal uridylyl transferase 4 0.0106522
TCERG1 transcription elongation regulator 1 0.010547
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0105156
LRPPRC leucine-rich pentatricopeptide repeat containing 0.010433
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0102458
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0102399
AFF4 AF4/FMR2 family, member 4 0.0102276
H1-4 H1.4 linker histone, cluster member 0.010224
TSC22D2 TSC22 domain family, member 2 0.0101548
MXI1 MAX interactor 1, dimerization protein 0.010061
WDR75 WD repeat domain 75 0.0100059
AFDN afadin, adherens junction formation factor 0.010004
GOLGA2 golgin A2 0.00989236
SFXN1 sideroflexin 1 0.0098547
MDN1 MDN1, midasin homolog (yeast) 0.00983231
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.00979651
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.00973502
TBC1D15 TBC1 domain family, member 15 0.00968378
ARHGAP12 Rho GTPase activating protein 12 0.00966562
RNMT RNA (guanine-7-) methyltransferase 0.00966413
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.00962728
SRP54 signal recognition particle 54kDa 0.00957401
CLTC clathrin, heavy chain (Hc) 0.00948554
IPO5 importin 5 0.00948376
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.00939206
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.00934683
TPR translocated promoter region, nuclear basket protein 0.00925916
SNX9 sorting nexin 9 0.00923775
NUP58 nucleoporin 58 0.0091666
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00910193
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00910013
SMC5 structural maintenance of chromosomes 5 0.00906317
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00898752
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00896826
COPB1 coatomer protein complex, subunit beta 1 0.00894856
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.00892003
ARFGEF3 ARFGEF family member 3 0.00889395
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.00876286
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.00871217
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.00869431
TPP2 tripeptidyl peptidase II 0.0086604
EWSR1 EWS RNA-binding protein 1 0.00859342
BMP2K BMP2 inducible kinase 0.00851094
ZNF37A zinc finger protein 37A 0.00847451
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.00845624
EGLN1 egl-9 family hypoxia-inducible factor 1 0.00844105
EPCAM epithelial cell adhesion molecule 0.00840479
DSPP dentin sialophosphoprotein 0.00833572
TNNC1 troponin C type 1 (slow) 0.00833413
TXNIP thioredoxin interacting protein 0.00832738

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165856
TMSB10 thymosin beta 10 -0.156294
PTMA prothymosin, alpha -0.146083
RPS6 ribosomal protein S6 -0.116916
RPL35A ribosomal protein L35a -0.104867
TPT1 tumor protein, translationally-controlled 1 -0.0900913
RPLP1 ribosomal protein, large, P1 -0.0899258
RPS19 ribosomal protein S19 -0.0815235
IER3 immediate early response 3 -0.0791278
RPS8 ribosomal protein S8 -0.0752649
RPL37A ribosomal protein L37a -0.0725556
RPL23 ribosomal protein L23 -0.0706437
EEF2 eukaryotic translation elongation factor 2 -0.0688537
RPS29 ribosomal protein S29 -0.0681838
RPLP2 ribosomal protein, large, P2 -0.0649085
RPS27A ribosomal protein S27a -0.064774
RPL34 ribosomal protein L34 -0.0640343
RPS24 ribosomal protein S24 -0.0624157
RPS25 ribosomal protein S25 -0.0622165
RPL11 ribosomal protein L11 -0.0614649
RPL5 ribosomal protein L5 -0.0601824
RPL31 ribosomal protein L31 -0.0584116
RPS3 ribosomal protein S3 -0.0583893
RPL12 ribosomal protein L12 -0.0580742
ACTG1 actin gamma 1 -0.0562879
FLOT1 flotillin 1 -0.0558499
RPS23 ribosomal protein S23 -0.0548936
AREG amphiregulin -0.0537864
EIF1 eukaryotic translation initiation factor 1 -0.0517633
RPS13 ribosomal protein S13 -0.0517538
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0497626
RPL26 ribosomal protein L26 -0.0491797
CD36 CD36 molecule (thrombospondin receptor) -0.0484272
RPL19 ribosomal protein L19 -0.0458074
RPS17 ribosomal protein S17 -0.0456636
RPLP0 ribosomal protein, large, P0 -0.0450295
RPS4X ribosomal protein S4, X-linked -0.0440855
RPL9 ribosomal protein L9 -0.0439587
RPS12 ribosomal protein S12 -0.0435491
RPS14 ribosomal protein S14 -0.0432523
RAD51B RAD51 paralog B -0.0432306
RPL36 ribosomal protein L36 -0.0422602
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0421875
ATXN1 ataxin 1 -0.0420136
RPS21 ribosomal protein S21 -0.0417306
RPL8 ribosomal protein L8 -0.0416041
UBC ubiquitin C -0.0408744
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0406627
MT2A metallothionein 2A -0.0402355
RPL15 ribosomal protein L15 -0.0397436
RPS5 ribosomal protein S5 -0.0390082
RPS16 ribosomal protein S16 -0.0376884
RPL32 ribosomal protein L32 -0.0372152
HMGA1 high mobility group AT-hook 1 -0.036807
FTL ferritin, light polypeptide -0.0362042
PKM pyruvate kinase, muscle -0.0358495
RPL37 ribosomal protein L37 -0.0358199
RPS11 ribosomal protein S11 -0.035365
EEF1G eukaryotic translation elongation factor 1 gamma -0.0347811
RPL7A ribosomal protein L7a -0.0344408
RPL36A ribosomal protein L36a -0.0341204
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0338763
S100A10 S100 calcium binding protein A10 -0.0337512
RPL35 ribosomal protein L35 -0.0332531
RPS15 ribosomal protein S15 -0.032745
RNF43 ring finger protein 43 -0.0326287
HLA-B major histocompatibility complex, class I, B -0.0321151
S100A6 S100 calcium binding protein A6 -0.0319466
EGR1 early growth response 1 -0.0311177
RPL28 ribosomal protein L28 -0.0307004
RPS10 ribosomal protein S10 -0.0299216
FHIT fragile histidine triad -0.0294315
RACK1 receptor for activated C kinase 1 -0.0289639
ENO1 enolase 1, (alpha) -0.0280679
RPS27 ribosomal protein S27 -0.0276865
ITPKC inositol-trisphosphate 3-kinase C -0.0275965
EGFR epidermal growth factor receptor -0.0272271
RPS20 ribosomal protein S20 -0.0264209
PCBP2 poly(rC) binding protein 2 -0.026337
VCL vinculin -0.0260612
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0257144
HMGA2 high mobility group AT-hook 2 -0.0255709
HLA-A major histocompatibility complex, class I, A -0.0245192
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0245114
SEPTIN9 septin 9 -0.0244159
RPL27A ribosomal protein L27a -0.0242908
SMAD3 SMAD family member 3 -0.0242834
RPL27 ribosomal protein L27 -0.0242109
AHNAK AHNAK nucleoprotein -0.0238105
RPL30 ribosomal protein L30 -0.0237107
RPL38 ribosomal protein L38 -0.0233049
RPS28 ribosomal protein S28 -0.0231165
PDE4D phosphodiesterase 4D, cAMP-specific -0.022988
CD9 CD9 molecule -0.0224816
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0224601
SKAP1 src kinase associated phosphoprotein 1 -0.0223002
PFN1 profilin 1 -0.0217301
RPL18 ribosomal protein L18 -0.0213865
CUX1 cut-like homeobox 1 -0.0213747
S100A9 S100 calcium binding protein A9 -0.0212941