Cloxacillin (sodium)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.148494
AKAP12 A kinase (PRKA) anchor protein 12 0.112173
ESYT2 extended synaptotagmin-like protein 2 0.0879449
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0869906
ITGA6 integrin, alpha 6 0.0839778
ANXA2 annexin A2 0.0829778
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0677466
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0664683
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0618302
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0555385
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0532288
ASPH aspartate beta-hydroxylase 0.0531932
MACF1 microtubule-actin crosslinking factor 1 0.0527752
SNX9 sorting nexin 9 0.049451
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0481158
AHNAK AHNAK nucleoprotein 0.0481106
EMP1 epithelial membrane protein 1 0.0474581
BACE2 beta-site APP-cleaving enzyme 2 0.0473178
ENO1 enolase 1, (alpha) 0.0464183
ERRFI1 ERBB receptor feedback inhibitor 1 0.0461361
GOLGA4 golgin A4 0.0450579
DSPP dentin sialophosphoprotein 0.043393
MYH9 myosin, heavy chain 9, non-muscle 0.043286
FNIP1 folliculin interacting protein 1 0.0425558
ETNK1 ethanolamine kinase 1 0.0407392
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0405455
HSPA8 heat shock 70kDa protein 8 0.0404035
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0383203
TPM4 tropomyosin 4 0.0380117
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0378697
RTN4 reticulon 4 0.0378292
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0377856
ANXA3 annexin A3 0.0368341
ZNF292 zinc finger protein 292 0.0362916
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0360305
ARF4 ADP-ribosylation factor 4 0.0359505
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0359464
PDGFA platelet-derived growth factor alpha polypeptide 0.0337744
VMP1 vacuole membrane protein 1 0.0334147
LDHA lactate dehydrogenase A 0.0333222
FRMD5 FERM domain containing 5 0.0330842
TMEM41B transmembrane protein 41B 0.0330325
MYOF myoferlin 0.0325971
CLIP2 CAP-GLY domain containing linker protein 2 0.0323755
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.032079
CANX calnexin 0.031598
BHLHE40 basic helix-loop-helix family, member e40 0.0307993
ANO1 anoctamin 1, calcium activated chloride channel 0.0305816
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0302013
NKD1 naked cuticle homolog 1 (Drosophila) 0.0298461
ANKRD28 ankyrin repeat domain 28 0.0297319
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0291761
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0291534
RPL3 ribosomal protein L3 0.0288662
TPM3 tropomyosin 3 0.0286808
SET SET nuclear proto-oncogene 0.0285488
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.028513
MACC1 metastasis associated in colon cancer 1 0.0284543
KDM3A lysine (K)-specific demethylase 3A 0.0284425
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0284112
MSN moesin 0.0281671
CD44 CD44 molecule (Indian blood group) 0.0278172
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0270976
NDRG1 N-myc downstream regulated 1 0.0267045
PDIA3 protein disulfide isomerase family A, member 3 0.0266329
KDM7A lysine (K)-specific demethylase 7A 0.0266008
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0259631
PGK1 phosphoglycerate kinase 1 0.0255432
SQSTM1 sequestosome 1 0.0248506
EIF4B eukaryotic translation initiation factor 4B 0.024567
SDC4 syndecan 4 0.0244803
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0243654
IPO7 importin 7 0.0242367
PDIA6 protein disulfide isomerase family A, member 6 0.0241411
SEC31A SEC31 homolog A (S. cerevisiae) 0.0237986
JUN jun proto-oncogene 0.0236463
USP9X ubiquitin specific peptidase 9, X-linked 0.0235026
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0234866
ARHGAP32 Rho GTPase activating protein 32 0.023369
LMCD1 LIM and cysteine-rich domains 1 0.0232786
SLK STE20-like kinase 0.0232657
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0230687
CALU calumenin 0.0228693
BAIAP2L1 BAI1-associated protein 2-like 1 0.0223075
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0222523
COBL cordon-bleu WH2 repeat protein 0.0221199
LMO7 LIM domain 7 0.0220574
CORO1C coronin, actin binding protein, 1C 0.0219269
YEATS2 YEATS domain containing 2 0.0218861
TMF1 TATA element modulatory factor 1 0.0218068
SDK1 sidekick cell adhesion molecule 1 0.0218024
ANLN anillin, actin binding protein 0.0216697
USP24 ubiquitin specific peptidase 24 0.0216348
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0214475
TNIK TRAF2 and NCK interacting kinase 0.0214116
CHKA choline kinase alpha 0.0213172
IGFBP3 insulin-like growth factor binding protein 3 0.0210796
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0210642
APP amyloid beta (A4) precursor protein 0.0208388
PICALM phosphatidylinositol binding clathrin assembly protein 0.020799

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.183329
TMSB10 thymosin beta 10 -0.162162
RPL35A ribosomal protein L35a -0.125622
INTS6 integrator complex subunit 6 -0.119352
RPL23 ribosomal protein L23 -0.0972837
RPLP2 ribosomal protein, large, P2 -0.0962151
RPLP1 ribosomal protein, large, P1 -0.0947636
RPS19 ribosomal protein S19 -0.0913296
SYT1 synaptotagmin I -0.0849325
RPS24 ribosomal protein S24 -0.0756122
RPS6 ribosomal protein S6 -0.0683735
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0654612
RPL12 ribosomal protein L12 -0.0620623
RPS3 ribosomal protein S3 -0.0616828
RPL26 ribosomal protein L26 -0.0610002
RPL5 ribosomal protein L5 -0.0580963
RPS13 ribosomal protein S13 -0.0580354
RPS4X ribosomal protein S4, X-linked -0.0573418
RPS21 ribosomal protein S21 -0.0571553
TPT1 tumor protein, translationally-controlled 1 -0.0569665
RPL31 ribosomal protein L31 -0.05696
ACTG1 actin gamma 1 -0.0544716
RPL32 ribosomal protein L32 -0.054113
RPL11 ribosomal protein L11 -0.054093
RPS23 ribosomal protein S23 -0.0537985
RPL9 ribosomal protein L9 -0.0506098
RPL36A ribosomal protein L36a -0.0505073
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0504698
MT2A metallothionein 2A -0.0488749
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0472257
RPS11 ribosomal protein S11 -0.0471926
RPL37A ribosomal protein L37a -0.047149
RPS25 ribosomal protein S25 -0.0469663
RPL36 ribosomal protein L36 -0.0465459
RPL19 ribosomal protein L19 -0.0459369
RPL7A ribosomal protein L7a -0.0457682
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0445441
WWOX WW domain containing oxidoreductase -0.0442774
RPL18 ribosomal protein L18 -0.0437266
RPS14 ribosomal protein S14 -0.0424061
RPL28 ribosomal protein L28 -0.0422045
RPL27A ribosomal protein L27a -0.0416659
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0415379
NAP1L1 nucleosome assembly protein 1-like 1 -0.0407553
RPS16 ribosomal protein S16 -0.0406493
RPL35 ribosomal protein L35 -0.0403544
RPS27A ribosomal protein S27a -0.0400036
RPL34 ribosomal protein L34 -0.0398302
RPL38 ribosomal protein L38 -0.0397423
RPLP0 ribosomal protein, large, P0 -0.0395547
RPS29 ribosomal protein S29 -0.0392745
RPS5 ribosomal protein S5 -0.0387344
DIAPH3 diaphanous-related formin 3 -0.0365202
RPL37 ribosomal protein L37 -0.0364585
RPL8 ribosomal protein L8 -0.0358958
SOX4 SRY (sex determining region Y)-box 4 -0.0357573
HMGA1 high mobility group AT-hook 1 -0.0352017
FOXP1 forkhead box P1 -0.0346989
TNS3 tensin 3 -0.034441
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0337689
EEF2 eukaryotic translation elongation factor 2 -0.0333667
RPS15 ribosomal protein S15 -0.0332829
RPL7 ribosomal protein L7 -0.0327302
RPS20 ribosomal protein S20 -0.0325534
OXR1 oxidation resistance 1 -0.0324499
RPS8 ribosomal protein S8 -0.031443
HMGB1 high mobility group box 1 -0.0314087
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0313905
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0311561
MYL12B myosin, light chain 12B, regulatory -0.0305982
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0302617
RACK1 receptor for activated C kinase 1 -0.0302439
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0300468
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0296439
FTL ferritin, light polypeptide -0.0295123
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0294126
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0293082
NACA nascent polypeptide-associated complex alpha subunit -0.0283011
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0279896
SMC4 structural maintenance of chromosomes 4 -0.0270803
H3-3B H3.3 histone B -0.0268767
SYK spleen tyrosine kinase -0.0267571
RNF43 ring finger protein 43 -0.0265395
MBD5 methyl-CpG binding domain protein 5 -0.0264138
GNAS GNAS complex locus -0.0262552
S100A9 S100 calcium binding protein A9 -0.0261753
DEK DEK proto-oncogene -0.0260491
EIF1 eukaryotic translation initiation factor 1 -0.0259825
PFN1 profilin 1 -0.0258093
PABPN1 poly(A) binding protein, nuclear 1 -0.0254628
RPS27 ribosomal protein S27 -0.0249871
RPS10 ribosomal protein S10 -0.0248711
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0248426
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.024189
PHF14 PHD finger protein 14 -0.0241885
RPL13A ribosomal protein L13a -0.0241742
ATP5F1E ATP synthase F1 subunit epsilon -0.0236986
RPL27 ribosomal protein L27 -0.0235418
SMYD3 SET and MYND domain containing 3 -0.0228869
BMP5 bone morphogenetic protein 5 -0.0228479