Cloxacillin (sodium)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cloxacillin (sodium) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cloxacillin (sodium)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.134005
MYH9 myosin, heavy chain 9, non-muscle 0.0702566
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0687737
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.063189
FBN1 fibrillin 1 0.0610468
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0535641
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0470206
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0469114
DST dystonin 0.0455096
FN1 fibronectin 1 0.0449608
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0426291
INTS6 integrator complex subunit 6 0.042366
SLIT2 slit homolog 2 (Drosophila) 0.0418171
CXCL8 chemokine (C-X-C motif) ligand 8 0.041778
DSCAM Down syndrome cell adhesion molecule 0.0407888
ARHGAP21 Rho GTPase activating protein 21 0.0386256
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0375071
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0355884
TTC3 tetratricopeptide repeat domain 3 0.033571
ERBIN erbb2 interacting protein 0.0333377
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0330056
COG6 component of oligomeric golgi complex 6 0.0324916
NGLY1 N-glycanase 1 0.0313667
TCF12 transcription factor 12 0.0312271
PTPRK protein tyrosine phosphatase, receptor type, K 0.0306788
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0300215
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0289205
ARHGAP22 Rho GTPase activating protein 22 0.0286726
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0278742
ATM ATM serine/threonine kinase 0.027853
GOLGB1 golgin B1 0.0274479
ZBTB38 zinc finger and BTB domain containing 38 0.0274129
PEAK1 pseudopodium-enriched atypical kinase 1 0.0273523
COL5A3 collagen, type V, alpha 3 0.0269957
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0269058
CANX calnexin 0.0267913
IPO5 importin 5 0.0264846
FTO fat mass and obesity associated 0.0264757
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0263888
LMO7 LIM domain 7 0.0258642
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0257323
SH3RF1 SH3 domain containing ring finger 1 0.0257073
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0252258
TMF1 TATA element modulatory factor 1 0.0250601
PDLIM5 PDZ and LIM domain 5 0.0249865
MAML3 mastermind-like 3 (Drosophila) 0.0248458
VEGFC vascular endothelial growth factor C 0.0245
ERRFI1 ERBB receptor feedback inhibitor 1 0.0244712
RABGAP1L RAB GTPase activating protein 1-like 0.0244504
DNER delta/notch-like EGF repeat containing 0.024221
SAMD4A sterile alpha motif domain containing 4A 0.0240348
MACF1 microtubule-actin crosslinking factor 1 0.0237947
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0236909
FBXL17 F-box and leucine-rich repeat protein 17 0.0228818
USP53 ubiquitin specific peptidase 53 0.0228345
FNDC3A fibronectin type III domain containing 3A 0.0224278
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0222569
TLN1 talin 1 0.0221008
ANKHD1 ankyrin repeat and KH domain containing 1 0.0215734
KMT2E lysine (K)-specific methyltransferase 2E 0.0214898
BBS9 Bardet-Biedl syndrome 9 0.0213937
BPTF bromodomain PHD finger transcription factor 0.0213294
TUT7 terminal uridylyl transferase 7 0.021296
STC1 stanniocalcin 1 0.0212566
CCND1 cyclin D1 0.0209365
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0208319
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0207114
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.020683
PICALM phosphatidylinositol binding clathrin assembly protein 0.0206156
BIRC6 baculoviral IAP repeat containing 6 0.0203768
RASA2 RAS p21 protein activator 2 0.0203256
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0198918
FMNL2 formin-like 2 0.0196243
GSK3B glycogen synthase kinase 3 beta 0.0195353
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0193697
USP9X ubiquitin specific peptidase 9, X-linked 0.0193433
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0192168
CFAP299 cilia and flagella associated protein 299 0.019154
NCKAP1 NCK-associated protein 1 0.0190626
APP amyloid beta (A4) precursor protein 0.0188418
BRD2 bromodomain containing 2 0.018828
ACTN4 actinin, alpha 4 0.0188102
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0186
WNT5A wingless-type MMTV integration site family, member 5A 0.0184828
NF1 neurofibromin 1 0.0184498
DGKH diacylglycerol kinase, eta 0.0184116
CDK13 cyclin-dependent kinase 13 0.0183503
XRN1 5'-3' exoribonuclease 1 0.018266
OXSR1 oxidative stress responsive 1 0.0182165
MCPH1 microcephalin 1 0.0181786
PCBP3 poly(rC) binding protein 3 0.0180511
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.017985
DPYD dihydropyrimidine dehydrogenase 0.0178197
SKIL SKI-like proto-oncogene 0.0177658
GOLGA2 golgin A2 0.0177534
GLI2 GLI family zinc finger 2 0.0176716
ALMS1 Alstrom syndrome protein 1 0.0176146
LYST lysosomal trafficking regulator 0.0175538
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0175396
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0175043

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.267409
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.2156
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.185124
PRKG1 protein kinase, cGMP-dependent, type I -0.158451
NDRG1 N-myc downstream regulated 1 -0.157166
NALF1 NALCN channel auxiliary factor 1 -0.133441
ADGRB3 adhesion G protein-coupled receptor B3 -0.123164
TMSB10 thymosin beta 10 -0.104373
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.102209
ABI3BP ABI family, member 3 (NESH) binding protein -0.0985102
COL6A2 collagen, type VI, alpha 2 -0.0968304
OXR1 oxidation resistance 1 -0.0939544
HLA-B major histocompatibility complex, class I, B -0.0939401
INHBA inhibin, beta A -0.0905375
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0848524
TPT1 tumor protein, translationally-controlled 1 -0.0814773
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0746
COL1A2 collagen, type I, alpha 2 -0.074583
TGFBI transforming growth factor, beta-induced, 68kDa -0.0698274
EMP1 epithelial membrane protein 1 -0.0683609
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.066943
MMP1 matrix metallopeptidase 1 -0.0635524
GLIS3 GLIS family zinc finger 3 -0.0616005
AKAP12 A kinase (PRKA) anchor protein 12 -0.0609888
FTL ferritin, light polypeptide -0.0600144
MT2A metallothionein 2A -0.0573245
RPL37A ribosomal protein L37a -0.0521664
FRMD4A FERM domain containing 4A -0.0518876
LTBP1 latent transforming growth factor beta binding protein 1 -0.0498504
RPS6 ribosomal protein S6 -0.0487856
GREM1 gremlin 1, DAN family BMP antagonist -0.0470661
B2M beta-2-microglobulin -0.0459818
FNDC3B fibronectin type III domain containing 3B -0.0459504
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0455232
CDH13 cadherin 13 -0.0432501
COL6A1 collagen, type VI, alpha 1 -0.0431442
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0427359
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0416856
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0394694
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0394286
VCAN versican -0.0393701
RPS12 ribosomal protein S12 -0.0388923
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0380971
DIAPH2 diaphanous-related formin 2 -0.0375417
RPL34 ribosomal protein L34 -0.0371131
RPLP1 ribosomal protein, large, P1 -0.0357909
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0351627
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0350779
MED13L mediator complex subunit 13-like -0.0350455
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0348484
ADM adrenomedullin -0.0342362
HILPDA hypoxia inducible lipid droplet-associated -0.0337994
RPL23 ribosomal protein L23 -0.0336782
WSB1 WD repeat and SOCS box containing 1 -0.0335304
RAI14 retinoic acid induced 14 -0.0331172
PFN1 profilin 1 -0.032496
ANXA2 annexin A2 -0.0323863
TTC23L tetratricopeptide repeat domain 23-like -0.0320785
RPL31 ribosomal protein L31 -0.0316991
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0316166
RPL35A ribosomal protein L35a -0.0313065
EFCAB13 EF-hand calcium binding domain 13 -0.0312563
PRRX1 paired related homeobox 1 -0.0307886
GNAS GNAS complex locus -0.0305144
TENT5A terminal nucleotidyltransferase 5A -0.030388
MEIS1 Meis homeobox 1 -0.0296808
RPS8 ribosomal protein S8 -0.0290464
LOC112694756 uncharaterized LOC112694756 -0.0280813
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.028002
PRR16 proline rich 16 -0.0278846
RPL9 ribosomal protein L9 -0.0276841
RPS19 ribosomal protein S19 -0.0270689
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0269805
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0264704
COL5A1 collagen, type V, alpha 1 -0.0259268
RPS13 ribosomal protein S13 -0.0259257
CD59 CD59 molecule, complement regulatory protein -0.0256017
EIF1 eukaryotic translation initiation factor 1 -0.0255602
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0252881
NAMPT nicotinamide phosphoribosyltransferase -0.0251792
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0249847
RPL12 ribosomal protein L12 -0.0243937
DDR2 discoidin domain receptor tyrosine kinase 2 -0.024256
RAB1A RAB1A, member RAS oncogene family -0.0242516
RPS16 ribosomal protein S16 -0.024229
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0240964
SBF2 SET binding factor 2 -0.0240315
KIAA1549L KIAA1549-like -0.0239326
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0238215
TMEM165 transmembrane protein 165 -0.0235918
RPL28 ribosomal protein L28 -0.0234268
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0233966
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0232648
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0232526
TRAM2 translocation associated membrane protein 2 -0.0231891
HLA-A major histocompatibility complex, class I, A -0.0230418
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0229925
RPS23 ribosomal protein S23 -0.0226227
RPLP0 ribosomal protein, large, P0 -0.0226
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0225435