| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. (Chemical Entities of Biological Interest Ontology, CHEBI_3766) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135398737 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Clozapine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NEB | nebulin | 2.39 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | 1.99 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.43 |
| ZSWIM1 | zinc finger, SWIM-type containing 1 | 1.15 |
| PICK1 | protein interacting with PRKCA 1 | 1.15 |
| FTL | ferritin, light polypeptide | 1.12 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | 1.06 |
| TSPAN3 | tetraspanin 3 | 1.01 |
| FGF2 | fibroblast growth factor 2 (basic) | 0.88 |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.87 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.81 |
| KSR1 | kinase suppressor of ras 1 | 0.74 |
| TJP3 | tight junction protein 3 | 0.68 |
| ILRUN | inflammation and lipid regulator with UBA-like and NBR1-like domains | 0.63 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.62 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.59 |
| LMX1B | LIM homeobox transcription factor 1, beta | 0.58 |
| ATF3 | activating transcription factor 3 | 0.56 |
| KDM4D | lysine (K)-specific demethylase 4D | 0.55 |
| PIP | prolactin-induced protein | 0.54 |
| ONECUT3 | one cut homeobox 3 | 0.53 |
| DOCK3 | dedicator of cytokinesis 3 | 0.53 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.53 |
| VASN | vasorin | 0.51 |
| ATXN7L3 | ataxin 7-like 3 | 0.49 |
| USP33 | ubiquitin specific peptidase 33 | 0.49 |
| HRH1 | histamine receptor H1 | 0.49 |
| TUBAL3 | tubulin, alpha-like 3 | 0.48 |
| CD63 | CD63 molecule | 0.47 |
| ZSCAN25 | zinc finger and SCAN domain containing 25 | 0.46 |
| PCDH1 | protocadherin 1 | 0.45 |
| JRK | Jrk homolog (mouse) | 0.45 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.44 |
| MFSD8 | major facilitator superfamily domain containing 8 | 0.44 |
| TXNDC11 | thioredoxin domain containing 11 | 0.43 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.42 |
| TRIM62 | tripartite motif containing 62 | 0.42 |
| CENPP | centromere protein P | 0.42 |
| S100A14 | S100 calcium binding protein A14 | 0.42 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.41 |
| ESAM | endothelial cell adhesion molecule | 0.41 |
| NRM | nurim (nuclear envelope membrane protein) | 0.4 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.4 |
| CHKB | choline kinase beta | 0.39 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.39 |
| TEN1 | TEN1 CST complex subunit | 0.39 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.38 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.38 |
| PRF1 | perforin 1 (pore forming protein) | 0.38 |
| VSNL1 | visinin-like 1 | 0.37 |
| SCARB1 | scavenger receptor class B, member 1 | 0.37 |
| TTC38 | tetratricopeptide repeat domain 38 | 0.37 |
| GAS2L1 | growth arrest-specific 2 like 1 | 0.37 |
| KLHL23 | kelch-like family member 23 | 0.37 |
| NDRG1 | N-myc downstream regulated 1 | 0.36 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | 0.35 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.35 |
| POC1B | POC1 centriolar protein B | 0.35 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.35 |
| TMEM59 | transmembrane protein 59 | 0.35 |
| PARP3 | poly (ADP-ribose) polymerase family, member 3 | 0.34 |
| INHBA | inhibin, beta A | 0.33 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.33 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | 0.33 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.33 |
| TAPBP | TAP binding protein (tapasin) | 0.33 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.33 |
| OPTN | optineurin | 0.32 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.32 |
| RUNDC1 | RUN domain containing 1 | 0.32 |
| AZI2 | 5-azacytidine induced 2 | 0.32 |
| NIN | ninein (GSK3B interacting protein) | 0.32 |
| UBQLN2 | ubiquilin 2 | 0.32 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.32 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 0.32 |
| AFF1 | AF4/FMR2 family, member 1 | 0.32 |
| BLOC1S6 | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin | 0.32 |
| CALU | calumenin | 0.32 |
| HPCAL4 | hippocalcin like 4 | 0.31 |
| SDCBP | syndecan binding protein (syntenin) | 0.31 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.31 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.31 |
| PLAUR | plasminogen activator, urokinase receptor | 0.31 |
| NCOA4 | nuclear receptor coactivator 4 | 0.31 |
| SMAP1 | small ArfGAP 1 | 0.3 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.3 |
| TULP3 | tubby like protein 3 | 0.3 |
| TMUB2 | transmembrane and ubiquitin-like domain containing 2 | 0.3 |
| MEX3A | mex-3 RNA binding family member A | 0.3 |
| FPGT | fucose-1-phosphate guanylyltransferase | 0.3 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | 0.29 |
| MKS1 | Meckel syndrome, type 1 | 0.29 |
| TANGO2 | transport and golgi organization 2 homolog (Drosophila) | 0.29 |
| PRIMPOL | primase and polymerase (DNA-directed) | 0.29 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | 0.29 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | 0.29 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.28 |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.28 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.28 |
| DNLZ | DNL-type zinc finger | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAAA | N-acylethanolamine acid amidase | -0.96 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.82 |
| WDR5B | WD repeat domain 5B | -0.77 |
| TTBK2 | tau tubulin kinase 2 | -0.73 |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase | -0.65 |
| EWSR1 | EWS RNA-binding protein 1 | -0.61 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.61 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | -0.6 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | -0.6 |
| USP30 | ubiquitin specific peptidase 30 | -0.53 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -0.52 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.51 |
| TRPT1 | tRNA phosphotransferase 1 | -0.49 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.49 |
| TMEM208 | transmembrane protein 208 | -0.48 |
| HMCN1 | hemicentin 1 | -0.48 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.47 |
| TC2N | tandem C2 domains, nuclear | -0.46 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.46 |
| UNC13C | unc-13 homolog C (C. elegans) | -0.43 |
| ECHS1 | enoyl CoA hydratase, short chain, 1, mitochondrial | -0.42 |
| ZNF341 | zinc finger protein 341 | -0.42 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.42 |
| MLYCD | malonyl-CoA decarboxylase | -0.42 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.41 |
| CDX2 | caudal type homeobox 2 | -0.41 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.4 |
| GAS8 | growth arrest-specific 8 | -0.4 |
| TLCD4 | TLC domain containing 4 | -0.4 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.39 |
| MRPL33 | mitochondrial ribosomal protein L33 | -0.38 |
| AP5Z1 | adaptor-related protein complex 5, zeta 1 subunit | -0.38 |
| SLC2A4RG | SLC2A4 regulator | -0.38 |
| ZNF57 | zinc finger protein 57 | -0.37 |
| RNF13 | ring finger protein 13 | -0.37 |
| CCDC158 | coiled-coil domain containing 158 | -0.37 |
| DENND4B | DENN/MADD domain containing 4B | -0.37 |
| CCNQ | cyclin Q | -0.35 |
| GATAD1 | GATA zinc finger domain containing 1 | -0.35 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | -0.35 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.35 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -0.35 |
| CC2D2A | coiled-coil and C2 domain containing 2A | -0.35 |
| ZBTB8A | zinc finger and BTB domain containing 8A | -0.34 |
| MRPL13 | mitochondrial ribosomal protein L13 | -0.34 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | -0.34 |
| DOCK11 | dedicator of cytokinesis 11 | -0.33 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.33 |
| CDC25A | cell division cycle 25A | -0.33 |
| CYTH3 | cytohesin 3 | -0.33 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.33 |
| SLC10A4 | solute carrier family 10, member 4 | -0.33 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | -0.32 |
| LYST | lysosomal trafficking regulator | -0.32 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.32 |
| SLC38A10 | solute carrier family 38, member 10 | -0.32 |
| MTRF1L | mitochondrial translational release factor 1-like | -0.32 |
| CERK | ceramide kinase | -0.32 |
| VWA3B | von Willebrand factor A domain containing 3B | -0.31 |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | -0.31 |
| AUNIP | aurora kinase A and ninein interacting protein | -0.31 |
| MRPL30 | mitochondrial ribosomal protein L30 | -0.31 |
| ICOSLG | inducible T-cell co-stimulator ligand | -0.31 |
| COQ2 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | -0.31 |
| TNS1 | tensin 1 | -0.31 |
| HSPA14 | heat shock 70kDa protein 14 | -0.31 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | -0.3 |
| RTN4R | reticulon 4 receptor | -0.3 |
| MRPL41 | mitochondrial ribosomal protein L41 | -0.3 |
| CSNK1G2 | casein kinase 1, gamma 2 | -0.3 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.3 |
| TBC1D30 | TBC1 domain family, member 30 | -0.3 |
| ZNF524 | zinc finger protein 524 | -0.3 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.3 |
| LETMD1 | LETM1 domain containing 1 | -0.29 |
| NPRL2 | nitrogen permease regulator-like 2 (S. cerevisiae) | -0.29 |
| GLUL | glutamate-ammonia ligase | -0.28 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.28 |
| OSER1 | oxidative stress responsive serine-rich 1 | -0.28 |
| MRPL3 | mitochondrial ribosomal protein L3 | -0.28 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | -0.28 |
| TIGD5 | tigger transposable element derived 5 | -0.28 |
| HBS1L | HBS1-like translational GTPase | -0.28 |
| MRPS14 | mitochondrial ribosomal protein S14 | -0.28 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.28 |
| CARD19 | caspase recruitment domain family member 19 | -0.27 |
| CCN1 | cellular communication network factor 1 | -0.27 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.27 |
| MRPL51 | mitochondrial ribosomal protein L51 | -0.27 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | -0.27 |
| ASB1 | ankyrin repeat and SOCS box containing 1 | -0.27 |
| FBXO45 | F-box protein 45 | -0.27 |
| PRMT9 | protein arginine methyltransferase 9 | -0.27 |
| HLA-C | major histocompatibility complex, class I, C | -0.27 |
| FUNDC1 | FUN14 domain containing 1 | -0.27 |
| MRPL34 | mitochondrial ribosomal protein L34 | -0.27 |
| NLRC3 | NLR family, CARD domain containing 3 | -0.27 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | -0.27 |
| ABAT | 4-aminobutyrate aminotransferase | -0.27 |
| MRPL37 | mitochondrial ribosomal protein L37 | -0.27 |
