| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.147511 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.146309 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.135888 |
| B2M | beta-2-microglobulin | 0.105032 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0923703 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0906687 |
| TMSB10 | thymosin beta 10 | 0.08649 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0801251 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0753521 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0725989 |
| FBN1 | fibrillin 1 | 0.0725973 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0721327 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0718825 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0711919 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0708691 |
| TENM3 | teneurin transmembrane protein 3 | 0.0695305 |
| MYOF | myoferlin | 0.0658162 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0611588 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0597139 |
| COL1A2 | collagen, type I, alpha 2 | 0.0550742 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0536031 |
| RPS6 | ribosomal protein S6 | 0.0523892 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0507548 |
| ANK2 | ankyrin 2, neuronal | 0.0502339 |
| DST | dystonin | 0.04883 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 0.0471527 |
| GPC6 | glypican 6 | 0.0455638 |
| SQSTM1 | sequestosome 1 | 0.0455223 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0451017 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0447608 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0442803 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0426904 |
| RPS3 | ribosomal protein S3 | 0.0425455 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0412587 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0378497 |
| ZNF292 | zinc finger protein 292 | 0.0377128 |
| HLA-B | major histocompatibility complex, class I, B | 0.0376907 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0376876 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0374857 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0363015 |
| S100A10 | S100 calcium binding protein A10 | 0.0362802 |
| FTL | ferritin, light polypeptide | 0.0341966 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0336182 |
| CLU | clusterin | 0.0328602 |
| SFTPA2 | surfactant protein A2 | 0.0323399 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0322587 |
| ADM | adrenomedullin | 0.0317644 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0307083 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0306786 |
| WTAP | Wilms tumor 1 associated protein | 0.0296282 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0293336 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.0293009 |
| RPL12 | ribosomal protein L12 | 0.029121 |
| RPS8 | ribosomal protein S8 | 0.0282637 |
| RPS19 | ribosomal protein S19 | 0.0272497 |
| GASK1B | golgi associated kinase 1B | 0.0272045 |
| RPL36 | ribosomal protein L36 | 0.026981 |
| SBF2 | SET binding factor 2 | 0.0268472 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.026468 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0260957 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.025864 |
| ARRDC3 | arrestin domain containing 3 | 0.0255595 |
| CTSB | cathepsin B | 0.025547 |
| RPL26 | ribosomal protein L26 | 0.0255386 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0252967 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0252198 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0249744 |
| MXRA5 | matrix-remodelling associated 5 | 0.0248877 |
| CALD1 | caldesmon 1 | 0.0247691 |
| ANXA4 | annexin A4 | 0.0246656 |
| RPL35A | ribosomal protein L35a | 0.02438 |
| RPL37A | ribosomal protein L37a | 0.0243673 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0242218 |
| RPL34 | ribosomal protein L34 | 0.0237915 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0234917 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0234029 |
| KIF13A | kinesin family member 13A | 0.0231981 |
| DTNA | dystrobrevin, alpha | 0.0227692 |
| FADS2 | fatty acid desaturase 2 | 0.0227608 |
| KIFAP3 | kinesin-associated protein 3 | 0.0227039 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0226288 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0226196 |
| PGK1 | phosphoglycerate kinase 1 | 0.0225874 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0224911 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0222662 |
| ACTG1 | actin gamma 1 | 0.0221367 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0220289 |
| LOXL2 | lysyl oxidase-like 2 | 0.0219072 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0218587 |
| FAM162A | family with sequence similarity 162, member A | 0.0217482 |
| OGA | O-GlcNAcase | 0.021744 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0215738 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0215688 |
| IRF1 | interferon regulatory factor 1 | 0.0214531 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0213965 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | 0.0209865 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0208999 |
| CXXC5 | CXXC finger protein 5 | 0.0208873 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0208437 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0207368 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.141349 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.140004 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.131914 |
| PODXL | podocalyxin-like | -0.125739 |
| CDH13 | cadherin 13 | -0.124556 |
| VIM | vimentin | -0.114181 |
| NAV1 | neuron navigator 1 | -0.112473 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.112324 |
| COL5A1 | collagen, type V, alpha 1 | -0.107668 |
| CD44 | CD44 molecule (Indian blood group) | -0.101807 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0834576 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0710667 |
| CCND1 | cyclin D1 | -0.0710057 |
| LOX | lysyl oxidase | -0.0703509 |
| AHNAK | AHNAK nucleoprotein | -0.0690199 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0661047 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0655215 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0613641 |
| FN1 | fibronectin 1 | -0.0587122 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0583985 |
| PKM | pyruvate kinase, muscle | -0.0576088 |
| UBC | ubiquitin C | -0.0570416 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0569247 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0552276 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0547199 |
| MSI2 | musashi RNA-binding protein 2 | -0.0517749 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0495063 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0492244 |
| TPM4 | tropomyosin 4 | -0.048047 |
| NAV2 | neuron navigator 2 | -0.0422669 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0420966 |
| FOSL1 | FOS-like antigen 1 | -0.0419913 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0412601 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0392075 |
| COPA | coatomer protein complex, subunit alpha | -0.0390525 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0380109 |
| POTEF | POTE ankyrin domain family, member F | -0.0379487 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0378115 |
| CALR | calreticulin | -0.0374547 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0367734 |
| SUCNR1 | succinate receptor 1 | -0.0365718 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0363899 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0355743 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0355426 |
| TPM1 | tropomyosin 1 (alpha) | -0.0352501 |
| PLXNA2 | plexin A2 | -0.0348252 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0347502 |
| APP | amyloid beta (A4) precursor protein | -0.0346244 |
| MCL1 | myeloid cell leukemia 1 | -0.0345823 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0344204 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0343452 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0338583 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.033518 |
| CENPF | centromere protein F, 350/400kDa | -0.0331541 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0329762 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0325878 |
| COL5A2 | collagen, type V, alpha 2 | -0.0323166 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0322908 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0320929 |
| EFNA5 | ephrin-A5 | -0.0320859 |
| IL7R | interleukin 7 receptor | -0.0318647 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0317567 |
| ASPH | aspartate beta-hydroxylase | -0.0315927 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0312397 |
| MAP1B | microtubule-associated protein 1B | -0.0312328 |
| THBS2 | thrombospondin 2 | -0.031102 |
| FLNA | filamin A, alpha | -0.0310757 |
| MSN | moesin | -0.0309408 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0306094 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.030213 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0301832 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0301422 |
| CANX | calnexin | -0.0300744 |
| PLEC | plectin | -0.0298387 |
| PRKCE | protein kinase C, epsilon | -0.0291611 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0290745 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0288949 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.028506 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0282866 |
| TAOK1 | TAO kinase 1 | -0.0282863 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0281593 |
| TPM3 | tropomyosin 3 | -0.0274668 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0274114 |
| SMAD3 | SMAD family member 3 | -0.0271777 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0270624 |
| RASA3 | RAS p21 protein activator 3 | -0.0270198 |
| GLIS3 | GLIS family zinc finger 3 | -0.0263291 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0260155 |
| ZNF217 | zinc finger protein 217 | -0.0259495 |
| VEGFA | vascular endothelial growth factor A | -0.0256924 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0256885 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0255653 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0251951 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.0250935 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0245742 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0245395 |
| NF1 | neurofibromin 1 | -0.0243228 |
| RNF144A | ring finger protein 144A | -0.0241823 |
| RUNX1 | runt-related transcription factor 1 | -0.0241328 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0239332 |
