Cobimetinib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cobimetinib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cobimetinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 0.197392
TENM3 teneurin transmembrane protein 3 0.15365
RPS12 ribosomal protein S12 0.109022
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.104312
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0933135
HSPB1 heat shock 27kDa protein 1 0.0931567
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.090745
EPHA6 EPH receptor A6 0.0868372
CNRIP1 cannabinoid receptor interacting protein 1 0.0867625
MGAT4C MGAT4 family, member C 0.0848189
NLGN1 neuroligin 1 0.0729641
SYT1 synaptotagmin I 0.0728438
RPS8 ribosomal protein S8 0.0709293
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0708788
RPS3 ribosomal protein S3 0.0702627
RPS2 ribosomal protein S2 0.069752
FSTL5 follistatin-like 5 0.0694694
ANXA1 annexin A1 0.0692007
CPOX coproporphyrinogen oxidase 0.0633492
ANKRD12 ankyrin repeat domain 12 0.0620323
MED13L mediator complex subunit 13-like 0.0588445
RPS6 ribosomal protein S6 0.0587779
EIF1 eukaryotic translation initiation factor 1 0.0584726
NRXN3 neurexin 3 0.0583116
RPL37A ribosomal protein L37a 0.0576055
RPS19 ribosomal protein S19 0.0575528
EPHA5 EPH receptor A5 0.0564651
ZNF292 zinc finger protein 292 0.0553486
CCSER1 coiled-coil serine-rich protein 1 0.0546926
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0521157
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0473151
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0429746
EEF2 eukaryotic translation elongation factor 2 0.0426376
PRR16 proline rich 16 0.0420556
DSCAM Down syndrome cell adhesion molecule 0.040745
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0407435
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0398947
RAB6A RAB6A, member RAS oncogene family 0.0387762
FTL ferritin, light polypeptide 0.0383447
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0381028
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0372595
SET SET nuclear proto-oncogene 0.0370902
LPP LIM domain containing preferred translocation partner in lipoma 0.0370479
TPI1 triosephosphate isomerase 1 0.0360124
RPL23 ribosomal protein L23 0.0358911
RPL26 ribosomal protein L26 0.0357735
SMYD3 SET and MYND domain containing 3 0.0355446
PTMS parathymosin 0.0348503
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0339708
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0335829
CDK6 cyclin-dependent kinase 6 0.0332503
DST dystonin 0.0320144
CXADR coxsackie virus and adenovirus receptor 0.031907
RPL35A ribosomal protein L35a 0.0319013
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0316467
ENO1 enolase 1, (alpha) 0.0316388
PDIA6 protein disulfide isomerase family A, member 6 0.0316055
FNDC3B fibronectin type III domain containing 3B 0.031576
YEATS2 YEATS domain containing 2 0.0311147
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0309664
RPS29 ribosomal protein S29 0.03092
RPL36 ribosomal protein L36 0.0300932
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0299883
PDGFC platelet derived growth factor C 0.0298276
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0298043
CISD1 CDGSH iron sulfur domain 1 0.02951
KLHL24 kelch-like family member 24 0.0292376
NAP1L1 nucleosome assembly protein 1-like 1 0.0290203
OXR1 oxidation resistance 1 0.0285295
PREPL prolyl endopeptidase-like 0.0284047
SQSTM1 sequestosome 1 0.0279717
RPS27 ribosomal protein S27 0.0274152
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0274076
KMT2E lysine (K)-specific methyltransferase 2E 0.0271698
MPG N-methylpurine-DNA glycosylase 0.0271292
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0271292
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0267684
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0265324
WNK1 WNK lysine deficient protein kinase 1 0.0264975
NBEAL1 neurobeachin-like 1 0.0260819
RPS17 ribosomal protein S17 0.0259544
WSB1 WD repeat and SOCS box containing 1 0.0258132
HDAC9 histone deacetylase 9 0.0254539
RPL34 ribosomal protein L34 0.0254487
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0253709
RPL9 ribosomal protein L9 0.0253007
ARRDC3 arrestin domain containing 3 0.0249475
GNAS GNAS complex locus 0.0248639
PRKCI protein kinase C, iota 0.0247297
ZMYM2 zinc finger, MYM-type 2 0.0246962
NEGR1 neuronal growth regulator 1 0.0246384
CDK19 cyclin-dependent kinase 19 0.0243223
ARHGAP12 Rho GTPase activating protein 12 0.0242763
RPL12 ribosomal protein L12 0.0242477
TBC1D5 TBC1 domain family, member 5 0.0241976
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0241763
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0237348
NFE2L1 nuclear factor, erythroid 2-like 1 0.023718
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0236571
COL5A2 collagen, type V, alpha 2 0.0236526

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.13203
AREG amphiregulin -0.114483
PCDH7 protocadherin 7 -0.107831
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.1044
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0965674
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.085716
MMP12 matrix metallopeptidase 12 -0.0816298
BIRC3 baculoviral IAP repeat containing 3 -0.0802958
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0796022
HMGA2 high mobility group AT-hook 2 -0.0785215
EGR1 early growth response 1 -0.0653974
NHSL1 NHS-like 1 -0.0642875
TMEM41B transmembrane protein 41B -0.0624814
CCN2 cellular communication network factor 2 -0.0612786
ASPH aspartate beta-hydroxylase -0.0601345
MYL12B myosin, light chain 12B, regulatory -0.0601157
YAP1 Yes-associated protein 1 -0.057656
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0575307
PDE4D phosphodiesterase 4D, cAMP-specific -0.0563994
CCND1 cyclin D1 -0.0486454
CELF2 CUGBP, Elav-like family member 2 -0.0482522
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0469751
RAB7A RAB7A, member RAS oncogene family -0.0457406
YBX3 Y box binding protein 3 -0.0453871
MARCHF4 membrane associated ring-CH-type finger 4 -0.0450491
MTAP methylthioadenosine phosphorylase -0.0438791
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0426137
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0418907
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0412506
RRM2 ribonucleotide reductase M2 -0.0410227
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0408525
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0406184
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0406143
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0390582
TM4SF1 transmembrane 4 L six family member 1 -0.0390169
IPO7 importin 7 -0.0375536
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0370191
TMSB10 thymosin beta 10 -0.0367215
CDK17 cyclin-dependent kinase 17 -0.0363542
ATP11A ATPase, class VI, type 11A -0.0360518
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0332133
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0331444
SLC38A1 solute carrier family 38, member 1 -0.0324495
EDARADD EDAR-associated death domain -0.0301547
ZNF804A zinc finger protein 804A -0.0296885
BCHE butyrylcholinesterase -0.0290453
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0290064
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0286184
PTMA prothymosin, alpha -0.0281143
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0273095
ETV5 ets variant 5 -0.0258993
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 -0.0255695
TUBA1B tubulin, alpha 1b -0.0255578
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0254251
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0252426
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0248575
YBX1 Y box binding protein 1 -0.0246819
CARD16 caspase recruitment domain family, member 16 -0.0243856
MSRB3 methionine sulfoxide reductase B3 -0.0243039
SPATS2 spermatogenesis associated, serine-rich 2 -0.0239855
NAV3 neuron navigator 3 -0.0236949
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0227868
DUSP6 dual specificity phosphatase 6 -0.0227773
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0217683
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0217302
EDN1 endothelin 1 -0.021395
MARCHF6 membrane associated ring-CH-type finger 6 -0.0213946
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0212002
NABP1 nucleic acid binding protein 1 -0.0211989
TMEM131 transmembrane protein 131 -0.0208018
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0207978
NOP58 NOP58 ribonucleoprotein -0.0205109
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.02039
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0196152
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.019486
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0193331
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0191051
JMJD1C jumonji domain containing 1C -0.0189411
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0188439
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0187523
SEPTIN10 septin 10 -0.0185889
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0185737
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0185687
LOC102724023 ES1 protein homolog, mitochondrial -0.018528
STK4 serine/threonine kinase 4 -0.0185268
STAU1 staufen double-stranded RNA binding protein 1 -0.0184269
HMGA1 high mobility group AT-hook 1 -0.0182968
THSD4 thrombospondin, type I, domain containing 4 -0.0182805
GCG glucagon -0.0181951
TPT1 tumor protein, translationally-controlled 1 -0.0181403
CMIP c-Maf inducing protein -0.0180779
RPL38 ribosomal protein L38 -0.0176506
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0175899
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0173141
RPL6 ribosomal protein L6 -0.0172645
HMGB1 high mobility group box 1 -0.0169659
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0169556
ADIPOR2 adiponectin receptor 2 -0.0167937
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0165582
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0163612