| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Cobimetinib perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Cobimetinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.185379 |
| IGF2 | insulin-like growth factor 2 | 0.137807 |
| PTMA | prothymosin, alpha | 0.111679 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0992982 |
| HELZ | helicase with zinc finger | 0.0924698 |
| FAM13A | family with sequence similarity 13, member A | 0.0813866 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0756975 |
| H3-3B | H3.3 histone B | 0.0688397 |
| OGA | O-GlcNAcase | 0.0664913 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0658766 |
| VIM | vimentin | 0.0616643 |
| MAP1B | microtubule-associated protein 1B | 0.0582666 |
| RPL23 | ribosomal protein L23 | 0.0575187 |
| MEF2A | myocyte enhancer factor 2A | 0.0555633 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0555019 |
| RPL34 | ribosomal protein L34 | 0.0546549 |
| FTL | ferritin, light polypeptide | 0.0536833 |
| RPL37A | ribosomal protein L37a | 0.052667 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0523579 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0495023 |
| RPS6 | ribosomal protein S6 | 0.048756 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0476168 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.047591 |
| RPS3 | ribosomal protein S3 | 0.0465913 |
| RPL35A | ribosomal protein L35a | 0.0453919 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0434521 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0427972 |
| RPL19 | ribosomal protein L19 | 0.0427589 |
| LPIN1 | lipin 1 | 0.0419748 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0414662 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0402849 |
| ZNF292 | zinc finger protein 292 | 0.0397152 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0394601 |
| MEIS2 | Meis homeobox 2 | 0.0394009 |
| RPS2 | ribosomal protein S2 | 0.0384492 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0381666 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.038066 |
| RPL36 | ribosomal protein L36 | 0.0380175 |
| RPS12 | ribosomal protein S12 | 0.0375913 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0374219 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0371995 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0371298 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0371254 |
| GOLGA4 | golgin A4 | 0.0363726 |
| NDRG1 | N-myc downstream regulated 1 | 0.0360948 |
| SEPTIN2 | septin 2 | 0.0357843 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0354135 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0349047 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0347648 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0337763 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0335038 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0334228 |
| TMSB10 | thymosin beta 10 | 0.0333973 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0333103 |
| RPL12 | ribosomal protein L12 | 0.0330344 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0329617 |
| RPL26 | ribosomal protein L26 | 0.0322348 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 | 0.0321774 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0321011 |
| CDC27 | cell division cycle 27 | 0.0320445 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0319747 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | 0.0316977 |
| YTHDC1 | YTH domain containing 1 | 0.031663 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0315772 |
| PHIP | pleckstrin homology domain interacting protein | 0.0315598 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0314912 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0313608 |
| RPL7 | ribosomal protein L7 | 0.0313276 |
| WDR45B | WD repeat domain 45B | 0.0311494 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0311294 |
| CASC3 | cancer susceptibility candidate 3 | 0.0310743 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0307378 |
| CLTC | clathrin, heavy chain (Hc) | 0.0306911 |
| C1ORF21 | chromosome 1 open reading frame 21 | 0.0306755 |
| RBM39 | RNA binding motif protein 39 | 0.0303262 |
| HMGB2 | high mobility group box 2 | 0.030194 |
| ENO1 | enolase 1, (alpha) | 0.030143 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0299322 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0294515 |
| MSI2 | musashi RNA-binding protein 2 | 0.0293809 |
| RTN4 | reticulon 4 | 0.0292989 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.028952 |
| AHNAK | AHNAK nucleoprotein | 0.0288798 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0288377 |
| COPA | coatomer protein complex, subunit alpha | 0.0286741 |
| S100A9 | S100 calcium binding protein A9 | 0.0284729 |
| PDE8A | phosphodiesterase 8A | 0.0283275 |
| COL1A1 | collagen, type I, alpha 1 | 0.0283024 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0279883 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0279193 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0277747 |
| RPS19 | ribosomal protein S19 | 0.0276513 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0275375 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0272847 |
| LDHB | lactate dehydrogenase B | 0.0272476 |
| RLF | rearranged L-myc fusion | 0.0271742 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0271544 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0270085 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0266177 |
| RPLP1 | ribosomal protein, large, P1 | 0.0265836 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.0991106 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.084052 |
| VCL | vinculin | -0.0775096 |
| LSAMP | limbic system-associated membrane protein | -0.0752764 |
| PRKCA | protein kinase C, alpha | -0.0739975 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0635317 |
| DPH6 | diphthamine biosynthesis 6 | -0.0602575 |
| TRIB2 | tribbles pseudokinase 2 | -0.0575447 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0539877 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0536757 |
| EGR1 | early growth response 1 | -0.0527282 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0525243 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0491937 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0480374 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0475917 |
| EFNA5 | ephrin-A5 | -0.046277 |
| KLHL13 | kelch-like family member 13 | -0.0462064 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.045781 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0457703 |
| IER3 | immediate early response 3 | -0.0436805 |
| MCL1 | myeloid cell leukemia 1 | -0.042337 |
| VMP1 | vacuole membrane protein 1 | -0.0420928 |
| FMN1 | formin 1 | -0.0406317 |
| RNF213 | ring finger protein 213 | -0.0400139 |
| STC1 | stanniocalcin 1 | -0.0397939 |
| PLAT | plasminogen activator, tissue | -0.0388191 |
| SMAD3 | SMAD family member 3 | -0.0387609 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0382725 |
| RUNX1 | runt-related transcription factor 1 | -0.0369177 |
| PDE10A | phosphodiesterase 10A | -0.0368614 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.036758 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0363332 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0360387 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0350902 |
| ZNF804A | zinc finger protein 804A | -0.0338147 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | -0.0333362 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0328985 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0318828 |
| TPM1 | tropomyosin 1 (alpha) | -0.0316332 |
| TLE4 | transducin-like enhancer of split 4 | -0.031549 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0312896 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0310579 |
| BPTF | bromodomain PHD finger transcription factor | -0.0301741 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.030044 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0300224 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0295469 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0290627 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0289145 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0285055 |
| ANGPT1 | angiopoietin 1 | -0.0279898 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | -0.0273251 |
| THBS1 | thrombospondin 1 | -0.0269682 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0268059 |
| SIK2 | salt-inducible kinase 2 | -0.0263928 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0260935 |
| ATXN1 | ataxin 1 | -0.0259648 |
| TBX2 | T-box 2 | -0.0257576 |
| DNM3 | dynamin 3 | -0.0254559 |
| ITGA1 | integrin, alpha 1 | -0.0253738 |
| PCBP3 | poly(rC) binding protein 3 | -0.0252186 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.025195 |
| ASPH | aspartate beta-hydroxylase | -0.0251076 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0250896 |
| UNC5C | unc-5 homolog C (C. elegans) | -0.0247225 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0245783 |
| FOXP1 | forkhead box P1 | -0.024413 |
| COL4A6 | collagen, type IV, alpha 6 | -0.024407 |
| DIAPH2 | diaphanous-related formin 2 | -0.0236418 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0235269 |
| HMGA2 | high mobility group AT-hook 2 | -0.0234674 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0232993 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0232801 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0232158 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0232023 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.022994 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0229677 |
| FRMD4A | FERM domain containing 4A | -0.022966 |
| SVIL | supervillin | -0.0228704 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0227295 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0227025 |
| RPL38 | ribosomal protein L38 | -0.0226569 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0226521 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0225202 |
| GLI3 | GLI family zinc finger 3 | -0.0222801 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0221598 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.022133 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0219533 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0218953 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0217243 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0216914 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0216521 |
| PLSCR1 | phospholipid scramblase 1 | -0.0216479 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0216345 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0213672 |
| PCNX2 | pecanex 2 | -0.021041 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0210239 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.021017 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0209946 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0209665 |
| PHF14 | PHD finger protein 14 | -0.0209394 |
